-
Patent
Data
Cmpds
UniProt
HGNC*
Patent Title
Organization
Deposition
Downloads
-
22
PYRROLO[1,2-b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
Suven Life Sciences
05/27/25
-
555
KRAS G12C INHIBITORS
Frontier Medicines
05/27/25
-
6
HETEROCYCLIC AGONISTS
Gasherbrum Bio
05/27/25
-
52
Small molecule inhibitors of GPCR GPR68 and related receptors for treating cancer, glioblastoma, and other indications
University of Maryland, Baltimore
05/26/25
-
139
Thiadiazine derivatives
Richter Gedeon
05/26/25
-
6
Ethynyl derivatives
Hoffmann-La Roche
05/26/25
-
498
MASP-2 inhibitors and methods of use
Omeros
05/26/25
-
3
Organic compound
Intra-Cellular Therapies
05/26/25
-
11
Polyproline mimetics of proline-derived module-15
Forschungsverbund Berlin
05/26/25
-
56
Compounds having PDE9A inhibitory activity, and pharmaceutical uses thereof
Korea Research Institute of Chemical Technology
05/26/25
-
58
7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma- secretase modulators for the treatment of alzheimer's disease
Hoffmann-La Roche
05/26/25
-
28
KRAS mutant protein inhibitors
Jacobio Pharmaceuticals Co.
05/26/25
-
23
CELL-POTENT BISUBSTRATE INHIBITORS FOR NICOTINAMIDE N-METHYLTRANSFERASE (NNMT) AND USES THEREOF
Purdue Research Foundation
05/26/25
-
821
COMBINATION THERAPIES OF FASN INHIBITORS WITH THYROID HORMONE RECEPTOR AGONISTS
Sagimet Biosciences
05/26/25
-
29
BENZOFURAN SALT MORPHIC FORMS AND MIXTURES FOR THE TREATMENT OF MENTAL DISORDERS OR MENTAL ENHANCEMENT
Tactogen
05/26/25
-
25
N-(4-aminocyclohexyl)pyrimidine-4-carboxamide derivatives as CD38 inhibitors
Cerevance
05/26/25
-
20
SMALL-MOLECULAR INHIBITORS FOR THE BETA-CATENIN/ B-CELL LYMPHOMA 9 PROTEIN-PROTEIN INTERACTION
H. Lee Moffitt Cancer Center and Research Institute
05/26/25
-
73
PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF
Calico Life Sciences
05/26/25
-
35
PYRROLE[2,3-B]PYRIDINE DERIVATIVES AS TYRO3 INHIBITORS
Halia Therapeutics
05/26/25
-
5
PROCESS FOR THE SYNTHESIS OF 6-((3S,4S)-4-METHYL-1-(PYRIMIDIN-2-YLMETHYL)PYRROLIDIN-3-YL)-3-(TETRAHYDROPYRAN-4-YL-7H-IMIDAZO[1,5-a]PYRAZIN-8-ONE
Cardurion Pharmaceuticals
05/26/25
-
78
SPIROCYCLIC ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
Boehringer Ingelheim International
05/26/25
-
112
Taire family kinase inhibitors and uses thereof
Dana-Farber Cancer Institute
05/22/25
-
41
LONG-CHAIN COMPOUND THAT ACTS ON ACLY, PREPARATION METHOD THEREFOR AND USE THEREOF
Shanghaiinstitute of Materia Medica, Chinese Academy of Sciences
05/22/25
-
98
PIPERAZINYLSULFONYLARYL COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS
Hoffmann-La Roche
05/22/25
-
124
AMIDO HETEROAROMATIC COMPOUNDS
Astrazeneca
05/22/25
-
18
SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF
Lomond Therapeutics
05/22/25
-
2
SUBSTITUTED PIPERIDINYL-METHYLPURINE PYRIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING DISEASES AND CONDITIONS
K36 Therapeutics
05/22/25
-
100
Imidazo[1,2- a]pyrazine and Imidazo[1,2- a]pyridine Based Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors
The Usa, As Represented By The Secretary, Department of Health and Human Services
05/22/25
-
20
PYRAZOLO FUSED RING COMPOUND AND USE THEREOF
Soter Biopharma
05/22/25
-
1
Small molecule inhibitors of TEAD transcription factors
The General Hospital
05/20/25
-
196
Methods for antagonizing a melanocortin 4 receptor
Pfizer
05/20/25
-
48
Compounds having PDE9A inhibitory activity, and pharmaceutical uses thereof
Korea Research Institute of Chemical Technology
05/20/25
-
353
Dual ATM and DNA-PK inhibitors for use in anti-tumor therapy
Xrad Therapeutics
05/20/25
-
6
RNA virus inhibitor compounds and uses thereof
University of Alberta
05/19/25
-
500
Lactams as CBL-B inhibitors selective over C-CBL
Genentech
05/19/25
-
316
Immunomodulators, compositions and methods thereof
Betta Pharmaceuticals Co.
05/19/25
-
7
4-(Aminomethyl)-6-(1-Methyl-1H-Pyrazol-4-YL)Isoquinolin-1(2H)-One Derivatives as MTA-Cooperative Inhibitors of PRMT5
Beigene
05/15/25
-
8
GONADOTROPIN-RELEASING HORMONE ANTAGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Shandong Luye Pharmaceutical Co.
05/15/25
-
25
ARYLATED FENCHONE DERIVATIVES, COMPOSITIONS COMPRISING THEM, PROCESSES FOR THEIR PREPARATION AND USES THEREOF
Yissum Research Development Company of The Hebrew University of Jerusalem
05/15/25
-
58
BICYCLOPENTANE DERIVATIVES
Icagen
05/15/25
-
27
CYCLIC SULFONAMIDE RIBONUCLEOTIDE REDUCTASE (RNR) INHIBITORS AND USES THEREOF
Boundless Bio
05/15/25
-
24
PYRIDONE COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE
Nanjing China-Australia Institute of Translational Medicine Co.
05/15/25
-
54
Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof
Syntara
05/12/25
-
76
Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
05/12/25
-
8
Deuterated protease inhibitors
Kansas State University Research Foundation
05/12/25
-
62
Compound as protein kinase inhibitor, and pharmaceutical composition comprising thereof
Hk Inno.N
05/12/25
-
5
Azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
Hoffmann-La Roche
05/12/25
-
194
Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of FGFR tyrosine kinases
Array Biopharma
05/12/25
-
185
Substituted pyrazoles showing serotonin 5-HT receptor activity
Sumitomo Pharma Co.
05/12/25
-
713
Spirotricycle RIPK1 inhibitors and methods of uses thereof
Merck Sharp & Dohme
05/12/25
-
71
FIVE-MEMBERED RING-FUSED SIX-MEMBERED RING COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Hangzhou Polymed Biopharmaceuticals
05/07/25
-
65
CONJUGATES COMPRISING ANTIFUNGALS AND HEAT SHOCK PROTEIN 90 (HSP90) INHIBITORS AND METHODS OF USE THEREOF
Bright Angel Therapeutics
05/07/25
-
3
MODULATORS OF LIPOXYGENASE AND CYCLOOXYGENASE ENZYME ACTIVITY
Université
05/07/25
-
37
ISOINDOLINES AS PMS2 INHIBITORS
Neophore
05/07/25
-
3
SUBSTITUTED BENZOFURAN PROPYL AMINE MODULATORS OF MONOAMINERGIC TRANSPORTERS
Atai Life Sciences
05/07/25
-
40
COMPOUND BASED ON QUINAZOLINE-SUBSTITUTED GLUTARIMIDE SKELETON AND USE THEREOF
Gluetacs Therapeutics (Shanghai) Co.
05/07/25
-
59
PYRROLIDINE DERIVATIVES AS DDRS INHIBITORS
Chiesi Farmaceutici
05/07/25
-
27
FUSED BICYCLIC SUBSTITUTED N-(1H-INDOL-7-YL)BENZENESULFONAMIDES AND USES THEREOF
Triana Biomedicines
05/07/25
-
43
NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE
Temple University-of The Commonwealth System of Higher Education
05/07/25
-
71
AZETIDINYL PYRIMIDINES AND USES THEREOF
Aerie Pharmaceuticals
05/07/25
-
56
Cbl-b Inhibitors and Methods of Use Thereof
Arcus Biosciences
05/07/25
-
90
TYRO3 INHIBITORS
Halia Therapeutics
05/07/25
-
1
HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER
Artios Pharma
05/07/25
-
44
OXAZOLE, OXADIAZOLE, AND INDOLE DERIVATIVES FOR THE INHIBITION OF USP28
Carmot Therapeutics
05/07/25
-
8
COMPOUND OF THE 7A,8,9,10,11,11A-HEXAHYDRO-1H,7H-PYRANO[2,3-C]XANTHENE TYPE, METHOD OF PREPARATION THEREOF, INTERMEDIATES THEREOF AND THERAPEUTIC APPLICATIONS THEREOF
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE; UNIVERSITÉ CÔTE D''AZUR
05/07/25
-
33
NOVEL SPIROCYCLIC COMPOUNDS AS KLHDC2 LIGANDS
University of Washington
05/07/25
-
155
SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF
Merck Sharp & Dohme
05/07/25
-
7
Methods of making a cyclic dinucleotide
Takeda Pharmaceutical Company
05/05/25
-
3
Composition and methods for regulating melanogenesis
Sytheon
05/05/25
-
232
1H-indazole carboxamides as receptor-interacting protein kinase 1 inhibitors (RIPK1)
Bristol-Myers Squibb
05/05/25
-
117
Modulators of TREX1
Constellation Pharmaceuticals
05/05/25
-
19
Pyrimidines for degrading Bruton's tyrosine kinase
Abbvie
05/05/25
-
19
Heterocyclic kinase inhibitors and uses thereof
Iomx Therapeutics
05/05/25
-
2
Pharmaceutical compositions comprising heterocycle fused gamma carboline prodrugs
Intra-Cellular Therapies
05/05/25
-
207
Penicillin-binding protein inhibitors
Venatorx Pharmaceuticals
05/05/25
-
2
Weed control methods and related compositions and plants
Syngenta Crop Protection
05/05/25
-
10
DOPA AND CAFFEIC ACID ANALOGS AS NOVEL GCPII INHIBITORS
The Johns Hopkins University
05/01/25
-
63
SULFONYLPIPERAZINYL COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS
Hoffmann-La Roche
05/01/25
-
3
DUAL ANTAGONIST AND USE THEREOF
Nicoya Therapeutics (Shanghai) Co.
05/01/25
-
105
NITROGEN-CONTAINING TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF
Japan Tobacco
05/01/25
-
105
TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER
Hoffmann-La Roche
05/01/25
-
7
ASYMMETRIC BIS-BENZIMIDAZOLE STING AGONIST IMMUNOCONJUGATES AND USES THEREOF
Bolt Biotherapeutics
05/01/25
-
32
Triazolopyrimidines, their preparation and use
Columbia University
04/28/25
-
3
Spiro-lactam NMDA receptor modulators and uses thereof
Tenacia Biotechnology (Hong Kong) Co.
04/28/25
-
4
Substituted piperazines as dopamine D3/D2 receptor modulators
Richter Gedeon
04/28/25
-
22
RAS INHIBITORS, COMPOSITIONS AND METHODS OF USE THEREOF
Genetolead
04/23/25
-
5
COMPOSITION FOR PREVENTING OR TREATING GRAVES' DISEASE COMPRISING COMPOUND CONTAINING AN IMIDAZOPYRIDINE STRUCTURE AS ACTIVE INGREDIENT
Esgelbio
04/23/25
-
1
DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS
Sensorium Therapeutics
04/23/25
-
44
Disubstituted Pyrimidine Compounds for Ketohexokinase Inhibition
Centennial Therapeutics
04/23/25
-
31
SUBSTITUTED TRIAZOLOHETEROARYL COMPOUNDS AS USP1 INHIBITORS AND THE USE THEREOF
Impact Therapeutics (Shanghai)
04/23/25
-
40
NOVEL COMPOUNDS
Sitryx Therapeutics
04/23/25
-
2
DELIVERY OF THERAPEUTIC ALKALOID COMPOUNDS
Sensorium Therapeutics
04/23/25
-
112
REVERSIBLE LYSINE COVALENT MODIFIERS OF EGFR AND USES THEREOF
Terremoto Biosciences
04/23/25
-
53
Ferrochelatase inhibitors and methods of use
Indiana University
04/21/25
-
3
Polycyclic carbamoylpyridone derivatives, pharmaceutical compositions and use thereof
Jiaxing Andicon Biotech Co.
04/21/25
-
14
N-acyl-{4-[(4-aryl-phenyl)sulfonylmethyl]piperidine} compounds and their therapeutic use
Modern Biosciences
04/21/25
-
10
Human dihydroorotate dehydrogenase (hDHODH) inhibitors and their use in targeting oncological diseases sensitive to pyrimidine starvation
Drug Discovery And Clinic
04/21/25
-
19
BRD4 inhibitor as well as a preparative method and use thereof
Hinova Pharmaceuticals
04/21/25
-
5
Pyridopyrimidine derivative, preparation method therefor and medical use thereof
Jiangsu Hengrui Medicine Co.
04/21/25
-
15
Decarboxylase inhibitors for treating Parkinson's disease
Sail Biomedicines
04/21/25
-
5
FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF, AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
Espervita Therapeutics
04/16/25
-
3
INHIBITING SEROTONIN TRANSPORTER PROTEIN (5-HTT)
Sensorium Therapeutics
04/16/25
-
176
SPIROCYCLIC CYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION
Genentech
04/16/25
-
14
Methods of Treating Lymphedema
Celltaxis
04/16/25
-
231
PRC2 INHIBITORS FOR USE IN TREATING BLOOD DISORDERS
Oric Pharmaceuticals
04/16/25
-
5
COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA
Stealth Biotherapeutics
04/16/25
-
56
Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives
Gruenenthal
04/16/25
-
22
COMPOUND SERVING AS KAT6 INHIBITOR
Hangzhou Innogate Pharma
04/16/25
-
128
SPIROCYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION
Genentech
04/16/25
-
1
FOUR-MEMBERED FUSED RING COMPOUND AND PREPARATION METHOD AND USE THEREOF
Jiangsu Hansoh Pharmaceutical Group
04/16/25
-
47
HETEROARYL DERIVATIVE PARP INHIBITOR AND USE THEREOF
Haisco Pharmaceutical Group
04/16/25
-
2
SMALL MOLECULE ACTIVATORS OF THE IMMUNE SYSTEM
University of Illinois
04/16/25
-
9
Hypoxanthine compounds
Kissei Pharmaceutical
04/14/25
-
92
SUBSTITUTED PYRAZOLO [1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE
Carrick Therapeutics
04/12/25
-
32
THIOPHENE RING COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Chinese Academy of Sciences
04/12/25
-
208
OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER
Genentech
04/12/25
-
60
KRAS Modulating Compounds
Gilead Sciences
04/12/25
-
11
BENZOPYRIMIDINE COMPOUNDS AND USE THEREOF
Usynova Pharmaceuticals
04/12/25
-
93
AROMATIC ACETYLENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Zhejiang Hisun Pharmaceutical
04/11/25
-
47
BIFUNCTIONAL DEGRADERS COMPRISING A TEAD BINDER
Novartis
04/11/25
-
29
HETEROBIVALENT AND HOMOBIVALENT AGENTS TARGETING FIBROBLAST ACTIVATION PROTEIN ALPHA AND/OR PROSTATE-SPECIFIC MEMBRANE ANTIGEN
The Johns Hopkins University
04/11/25
-
39
NOVEL PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2
Hoffmann-La Roche
04/11/25
-
195
Hydroxamic Acid Compound Having ENPP1 Inhibitory Activity and Use Thereof
Haihe Biopharma
04/11/25
-
576
Cyclopropyl Fused Thiazin-2-Amine Compounds as Beta-Secretase Inhibitors and Methods of Use
Amgen
04/09/25
-
21
Tetrahydroisoquinoline compound, preparation method therefor, pharmaceutical composition containing same, and use thereof
Shanghai Institute of Materia Medica
04/08/25
-
30
Heterocyclic antiviral agents
Enanta Pharmaceuticals
04/08/25
-
129
Compounds, compositions, and therapeutic uses thereof
Breakpoint Therapeutics
04/08/25
-
1
SALT TYPES OF TRICYCLIC TETRAHYDRO ISOQUINOLINE DERIVATIVE
Jiangsu Hengrui Pharmaceuticals Co.
03/20/25
-
41
MEDICINE FOR PREVENTION AND TREATMENT OF DISEASES LINKED TO ANTI-OBESITY ACTIVITY
Shionogi
03/20/25
-
88
IRAK4 PROTACS
Astrazeneca
03/20/25
-
38
SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME
Arbutus Biopharma
03/20/25
-
232
SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
Astrazeneca
03/20/25
-
15
N-SUBSTITUTED INDOLE DERIVATIVES AS SEROTONERGIC AGENTS USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
Mindset Pharma
03/20/25
-
2
SIGMA LIGAND COMPOUNDS AND USES THEREOF
Minerva Neurosciences
03/20/25
-
6
COMPOUND AS TYK2/JAK1 PSEUDOKINASE DOMAIN INHIBITOR, AND SYNTHESIS AND USE METHODS
Zhejiang Wenda Pharmaceutical Technology
03/20/25
-
2
POLYMORPH AND APPLICATION OF PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Shanghai Haiyan Pharmaceutical Technology Co.
03/20/25
-
34
3-HYDROXY-5-(ISOXAZOL-5-YL) PYRIDINE FORMYLGLYCINE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE
China Pharmaceutical University
03/20/25
-
146
ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERED RELATED THERETO
Arena Pharmaceuticals
03/20/25
-
31
SULFOXIMINE COMPOUND AND USE THEREOF
Medshine Discovery
03/20/25
-
292
BCL-2 Inhibitor
Beigene
03/20/25
-
88
HETEROCYCLIC INHIBITORS OF ENPP1
Volastra Therapeutics
03/20/25
-
5
NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
Karyopharm Therapeutics
03/20/25
-
15
SPIRO COMPOUND AND USE THEREOF
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
03/20/25
-
8
PRMT5 INHIBITOR AND THE USE THEREOF
Cytosinlab Therapeutics
03/20/25
-
7
NEUROACTIVE STEROIDS SUBSTITUTED IN POSITION 10 WITH A CYCLIC GROUP FOR USE IN THE TREATMENT OF CNS DISORDERS
Sage Therapeutics
03/20/25
-
56
Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors and methods of use thereof
Relay Therapeutics
03/18/25
-
35
Piperidine compounds as PDE5 inhibitors
King Saud University
03/18/25
-
97
Substituted benzamides as RIPK2 inhibitors for treatment of inflammatory bowel disease
Boehringer Ingelheim International
03/18/25
-
108
Pyrido[3,2-d]pyrimidine compounds uses thereof for treating a proliferative disease
Université
03/18/25
-
12
COMPOSITIONS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS IN A PLANT CELL
Oerth Bio
03/14/25
-
14
MODULATORS OF A POTASSIUM CHANNEL AND OF TRPV1 CHANNEL AND USES THEREOF
Bsense Bio Therapeutics
03/14/25
-
14
BENZIMIDAZOLE PYRIDINE DERIVATIVES
Hoffmann-La Roche
03/14/25
-
17
MRGPRX2 ANTAGONISTS AND USES THEREOF
University of California
03/14/25
-
13
RADIOFLUORINATED AGENTS FOR PET IMAGING SELECTIVELY TARGETING FIBROBLAST ACTIVATION PROTEIN
Tufts College
03/14/25
-
11
INHIBITOR OF PROSTATE SPECIFIC MEMBRANE ANTIGEN AND PHARMACEUTICAL USE THEREOF
Tianjin Hengrui Medicine
03/14/25
-
14
PEPTIDE-UREA DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND APPLICATION THEREOF
Bivision Pharmaceuticals
03/14/25
-
49
ARYL HETEROCYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS
D.E. Shaw Research
03/14/25
-
272
Novel Dialkoxynaphtho[2,3-C]Furan-1(3H)-One Derivatives and Pharmaceutical Composition For Preventing or Treating Respiratory Disease or SARS-COV-2 Infection Disease, Comprising Same
Dong Wha Pharm.
03/14/25
-
105
HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT
Pretzel Therapeutics
03/14/25
-
83
ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
Merck Sharp & Dohme
03/14/25
-
1
BENZYLTHIOPHENE DERIVATIVES
Rosalind Franklin University
03/14/25
-
249
Compounds for the Treatment of Pain, in Particular, Neuropathic Pain, and/or Other Diseases or Disorders that are Associated with AT2R and/or AT2R Mediated Signaling
Confo Therapeutics
03/14/25
-
81
BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER
Hoffmann-La Roche
03/14/25
-
31
NOVEL ERGOLINES AND METHODS OF TREATING MOOD DISORDERS
Gilgamesh Pharmaceuticals
03/14/25
-
90
Aminopyridine-based MTA-Cooperative PRMT5 Inhibitors
Mirati Therapeutics
03/14/25
-
35
CYCLOPROPANECARBOXAMIDE-CONTAINING COMPOUNDS AND APPLICATION THEREOF
Cgenetech (Suzhou, China)
03/14/25
-
30
CINNOLINE COMPOUNDS AND USES THEREOF
Genentech
03/14/25
-
2
IMIDAZOCYCLIC COMPOUND AND APPLICATION THEREOF
Dongbao Purple Star (Hangzhou) Biopharmaceutical
03/14/25
-
63
IRAK4 DEGRADATION AGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Shanghai Leadingtac Pharmaceutical
03/14/25
-
14
SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF
Xizang Haisco Pharmaceutical
03/14/25
-
1
Crystals of tetrahydronaphthyl urea derivative
Mochida Pharmaceutical
03/12/25
-
251
TYK2 INHIBITORS
Biogen Ma
03/08/25
-
59
PHARMACEUTICAL AND FOOD COMPOSITIONS FOR THE PREVENTION, ALLEVIATION, OR TREATMENT OF INFLAMMATORY DISEASES COMPRISING 1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDIN-4-ONE AND ITS DERIVATIVES
DUKSUNG WOMEN''S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; INDUSTRY ACADEMIC COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY
03/07/25
-
12
INHIBITORS OF BRUTON'S TYROSINE KINASE
Pharmacyclics
03/07/25
-
7
COMPOUNDS FOR NEUTROPHIL ROS INHIBITION
Immunyx Pharma
03/07/25
-
29
GLUN2B-SUBUNIT SELECTIVE ANTAGONISTS OF THE N-METHYL-D-ASPARTATE RECEPTORS WITH ENHANCED POTENCY AT ACIDIC PH
Emory University
03/07/25
-
163
PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS
Actelion Pharmaceuticals
03/07/25
-
85
CYCLIN-DEPENDENT KINASE (CDK2) INHIBITORS
Novartis
03/07/25
-
214
NITRILE SUMO INHIBITORS AND USES THEREOF
Suvalent Therapeutics
03/07/25
-
147
AROYL SUBSTITUTED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Genfleet Therapeutics (Shanghai)
03/07/25
-
3
Combination of a selective histone deacetylase 3 (HDAC3) inhibitor and an immunotherapy agent for the treatment of cancer
Kdac Therapeutics
03/04/25
-
295
Heterocyclic sulfonamide derivatives and pharmaceutical uses thereof
Metrion Biosciences
03/04/25
-
10
Difluoro phenyl amide RIP1 inhibitor
Sironax
03/04/25
-
82
Chromobox protein inhibitors and uses thereof
Dana-Farber Cancer Institute
03/04/25
-
13
Diaryl macrocyclic compound and pharmaceutical composition, and use thereof
Primegene (Beijing)
03/04/25
-
13
Substituted pyrazolo[1,5-a]pyridine compound, composition containing the same and use thereof
Shenzhen Targetrx
03/04/25
-
4
CLASS OF ALKYLPHENOL COMPOUNDS AND PREPARATION METHOD THEREFOR
Shanghai Institute of Materia Medica
03/02/25
-
161
NOVEL PARP7 INHIBITOR AND USE THEREOF
Shanghai Qilu Pharmaceutical Research And Development Centre
03/02/25
-
17
NOVEL PYRIMIDINE-2,4-DIAMINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER
Korea Research Institute of Chemical Technology
03/02/25
-
130
ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF
1Cbio
03/02/25
-
2
SALT AND CRYSTAL FORM OF EGFR INHIBITOR, AND COMPOSITION AND USE THEREOF
Betta Pharmaceuticals
03/02/25
-
3
PROCESS FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID
H. Lundbeck
03/02/25
-
13
Plants having increased tolerance to herbicides
Basf
02/25/25
-
25
Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction
Rutgers, The State University of New Jersey
02/24/25
-
86
AT2R antagonists and uses thereof
Eli Lilly
02/24/25
-
10
Compounds useful for treatment of substance use disorder
High Point University
02/24/25
-
33
Pyrimidinyl group-containing tricyclic compound serving as c-Met inhibitor
Jiangsu Aosaikang Pharmaceutical
02/24/25
-
6
Antibiotics for veterinary staphylococcal infections
The George Washington University
02/24/25
-
1
PHARMACEUTICAL COMBINATION AND APPLICATION THEREOF
Guangzhou Joyo Pharmatech Co.
02/23/25
-
14
TREATMENT OF CANCERS OR NEOPLASMS BY INHIBITING KIF15
University of Kansas
02/23/25
-
102
PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS
Boehringer Ingelheim International
02/23/25
-
101
PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT
Korea Reserarch Institute of Chemical Technology
02/23/25
-
27
AAK1 INHIBITOR AND USE THEREOF
Xizang Haisco Pharmaceutical
02/23/25
-
84
PYRROLOPYRIDINE-3- AND 4-CARBOXAMIDE COMPOSITIONS AND METHODS FOR CELLULAR PROLIFERATION
Rockefeller University
02/23/25
-
40
IMIDAZOLE ORGANIC COMPOUNDS AND THEIR USE AGAINST INFLAMMATORY BOWEL DISEASE
Benevolentai Cambridge
02/23/25
-
17
Heteroaryl compounds as inhibitors of TYK2, composition and application thereof
Accro Bioscience (HK)
02/23/25
-
39
DEVELOPMENT AND OPTIMIZATION OF THIOCHROMENOTHIAZOLE-BASED MSUT2 INHIBITORS AS CANDIDATES FOR THE TREATMENT OF TAUOPATHY
Department of Veterans Affairs
02/22/25
-
24
3-phenoxyazetidin-1-yl-heteroaryl pyrrolidine derivatives and the use thereof as medicament
Boehringer Ingelheim International
02/12/25
-
1
Deuterated 1-piperazino-3-phenyl indanes for treatment of schizophrenia
H. Lundbeck
02/12/25
-
2
N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, pharmaceutical composition thereof, and use thereof
Chia Tai Tianqing Pharmaceutical Group
02/12/25
-
69
N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV 1.7 AND/OR NAV 1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME AND KITS
Eurofarma
02/10/25
-
50
SMALL MOLECULE INHIBITION OF DEUBIQUITINATING ENZYME JOSEPHIN DOMAIN CONTAINING 1 (JOSD1) AS A TARGETED THERAPY FOR LEUKEMIAS WITH MUTANT JANUS KINASE 2 (JAK2)
Dana-Farber Cancer Institute
02/10/25
-
77
1-H-PYRROLO[2,3-c]PYRIDINE COMPOUNDS
Acerta Pharma
02/10/25
-
208
N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS
Eurofarma
02/10/25
-
58
FIBROBLAST ACTIVATION PROTEIN INHIBITORS AND USE THEREOF
3 B Pharmaceuticals
02/10/25
-
2
COMPOUND SERVING AS NLRP3 INHIBITOR
Hangzhou Innogate Pharma
02/10/25
-
49
NOVEL CYCLOPROPYL COMPOUNDS
Icagen
02/10/25
-
65
COMPOSITIONS AND METHODS FOR ANTIOXIDANT AND ANTI-INFLAMMATORY THERAPEUTICS
Avanti Biosciences
02/10/25
-
42
ORGANIC PYRIDINE-PYRAZOLE COMPOUNDS AND THEIR USES
Benevolentai Cambridge
02/10/25
-
99
Compound Having Antitumor Activity And Use Thereof
Lnnovstonetherapeutics
02/10/25
-
36
3CL PROTEASE SMALL-MOLECULE INHIBITOR FOR TREATING OR PREVENTING CORONAVIRUS INFECTION, AND USE THEREOF
The Global Health Drug Discovery Institute
02/10/25
-
163
Tricyclic Derivatives Useful As PARP7 Inhibitors
Jacobio Pharmaceuticals
02/10/25
-
104
INHIBITORS OF 12/15-LIPOXYGENASE
The General Hospital
02/10/25
-
14
Selective JAK2 pseudokinase ligands and methods of use
Yale University
02/07/25
-
189
Benzimidazolone derived inhibitors of BCL6
Cancer Research Technology
02/07/25
-
59
Thiazole derivatives and pharmaceutically acceptable salts thereof
Yungjin Pharm.
02/07/25
-
182
Pyrazolo compounds and methods of use thereof
Genentech
02/06/25
-
28
METHOD FOR PRODUCING ARYLAMIDE DERIVATIVE
Chugai Seiyaku Kabushiki Kaisha
02/03/25
-
3
PREPARATION OF PHENETHYLAMINES AND CATHINONES AND STEREOISOMERS THEREOF AND PRECURSORS THEREOF
Transcend Therapeutics
02/03/25
-
37
SUBSTITUTED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS
TBA
02/03/25
-
24
TRIAZINE DERIVATIVES FOR THE TREATMENT OF TUMOURS AND NEURODEGENERATIVE DISORDERS
UNIVERSITA'' DEGLI STUDI DI MILANO
02/03/25
-
53
LACTONE AND LACTAM CONTAINING COMPOUNDS USEFUL AS IMMUNOMODULATORS
Bristol-Myers Squibb
02/03/25
-
56
NOVEL INHIBITORS OF AUTOTAXIN
Zydus Lifesciences
02/03/25
-
31
MULTI-TARGET INHIBITOR TARGETING HDAC AND NAD SYNTHESIS AND USE OF MULTI-TARGET INHIBITOR
Ocean University of China
02/03/25
-
30
KRAS G12D INHIBITOR AND USE THEREOF
Shanghai De Novo Pharmatech
02/03/25
-
129
NOVEL COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF
Breakpoint Therapeutics
02/03/25
-
9
PYRIMIDOPYRAN COMPOUND
Medshine Discovery
02/03/25
-
6
FUSED TETRACYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE
Jiangsu Hengrui Pharmaceuticals Co.
02/03/25
-
5
MACROCYCLIC PEPTIDOMIMETIC PROTEASE INHIBITOR AND USE THEREOF
Tencent Technology (Shenzhen)
02/03/25
-
31
Novel Pyridine Compounds
Icagen
01/28/25
-
729
INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF
Accent Therapeutics
01/28/25
-
13
VITAMIN D3-LIKE COMPOUND
Kanagawa University
01/28/25
-
7
METHODS OF TREATING MOOD DISORDERS
Gilgamesh Pharmaceuticals
01/28/25
-
29
Compounds for Modulating Epithelial 15-(S)-Lipoxygenase-2 and Methods of Use for Same
University of California
01/28/25
-
15
ALKYL CARBOXYLIC ACID COMPOUNDS AND APPLICATION THEREOF
Medshine Discovery
01/28/25
-
108
3-[(1H-PYRAZOL-R-YL)OXY]PYRAZIN-2-AMINE COMPOUNDS AS HPK1 INHIBITOR AND USE THEREOF
Beigene
01/28/25
-
317
PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN
Novartis
01/28/25
-
9
A NEW MOLECULAR SCAFFOLD FOR TARGETING HRPN13
Department of Health And Human Service
01/28/25
-
7
NOVEL COMPOUNDS AND THEIR USE
Debiopharm International
01/28/25
-
17
SIGMA-1 RECEPTOR ANTAGONISTS AND THEIR APPLICATIONS
Humanwell Pharmaceutical US
01/28/25
-
8
HETEROCYCLIC COMPOUND, AND INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
Wuhan LL Science and Technology Development Co.
01/28/25
-
25
INHIBITORS OF BRUTON'S TYROSINE KINASE
Pharmacyclics
01/28/25
-
147
SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS
Taiho Pharmaceutical Co.
01/28/25
-
33
Modulators of programmed death-ligand-1 and/or programmed death-ligand-2
Southern Research Institute
01/21/25
-
26
JAK1 PATHWAY INHIBITORS FOR THE TREATMENT OF ASTHMA
Incyte
01/16/25
-
72
4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS
Bayer Aktiengesellschaft; The Broad Institute, Inc.; Dana-Farber Cancer Institute, Inc.
01/16/25
-
9
METHODS FOR TREATING A PULMONARY DISEASE WITH AN ALK-5 (TGF BETA R1) INHIBITOR
Thirona Bio
01/16/25
-
2
NOVEL METHODS
Intra-Cellular Therapies
01/16/25
-
7
STEROID COMPOUND, AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
Jiangsu Simcere Pharmaceutical
01/16/25
-
27
CONFORMATIONALLY-CONSTRAINED INHIBITORS OF 3C OR 3C-LIKE PROTEASES
Kansas State University Research Foundation
01/16/25
-
89
PHOSPHODIESTERASE 3 (PDE3) INHIBITORS
Zoetis Services
01/16/25
-
158
HETEROARYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
Merck Sharp & Dohme
01/16/25
-
126
INHIBITING MONOACYLGLYCEROL LIPASE (MAGL)
Psy Therapeutics
01/16/25
-
144
O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS
Biogen Ma
01/16/25
-
6
SELECTIVE CYCLIN-DEPENDENT KINASE INHIBITORS AND METHODS OF THERAPEUTIC USE THEREOF
Virokyne Therapeutics
01/16/25
-
61
PYRAZOLO[3,4-D]PYRIMIDIN-6-YL-SULFONAMIDE DERIVATIVES FOR THE INHIBITION OF SGK-1
Thryv Therapeutics
01/16/25
-
1
THIAZOLE-LACTAM-SPIROHETEROCYCLIC COMPOUNDS AND APPLICATIONS THEREOF
D3 Bio (Wuxi)
01/16/25
-
93
Phenyltetrazole derivatives as plasma kallikrein inhibitors
Boehringer Ingelheim International
01/13/25
-
7
Rapamycin derivatives
Novartis
01/13/25
-
96
METHODS OF TREATING ACUTE RESPIRATORY DISTRESS SYNDROME WITH ACTIVATORS OF TIE-2
Aerpio Pharmaceuticals
01/08/25
-
85
ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF
Jiangsu Hengrui Pharmaceuticals
01/08/25
-
3
ARYLCYCLOHEXYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC DISORDERS
Gilgamesh Pharmaceuticals
01/08/25
-
30
IRAK4 Inhibitors
Astrazeneca
01/08/25
-
61
AMIDES AS CBL-B INHIBITORS
Genentech
01/08/25
-
132
PREPARATION OF SUBSTITUTED 1,2-DIAMINOHETEROCYCLIC COMPOUND DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS
Avelos Therapeutics
01/08/25
-
70
Substituted 6-(Pyrimidin-4-yl)Quinoline Compounds as Cyclin Dependent Kinase Inhibitors
Beigene
01/08/25
-
82
HPK1 INHIBITORS, PREPARATION METHOD AND APPLICATION THEREOF
Zhuhai Yufan Biotechnologies
01/08/25
-
21
NOVEL MODULATORS OF THE SIGMA-2 RECEPTOR AND THEIR METHOD OF USE
Temple University
01/08/25
-
14
COMPOUNDS AND THE USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
Beijing Youzhuju Network Technology Co.
01/08/25
-
3
6-SUBSTITUTED NAPHTHALENE-1,3-DISULFONIC ACID DERIVATIVES AS MODULATORS OF THE EXTRACELLULAR NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE (ENAMPT) FOR THE TREATMENT OF E.G. DIABETES
University of Manchester
01/08/25
-
4
DIMETHYL-SUBSTITUTED THIAZOLOLACTAM COMPOUND AND USE THEREOF
D3 Bio (Wuxi)
01/08/25
-
211
Biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors
Novartis
01/06/25
-
23
Methods for treating neurological symptoms associated with lysosomal storage diseases
Genzyme
01/06/25
-
38
Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same
Arbutus Biopharma
01/06/25
-
5
Triazole bisphosphonate geranylgeranyl diphosphate synthase inhibitors
University of Nebraska
01/06/25
-
25
Substituted sulfonylurea derivatives
Zydus Lifesciences
01/06/25
-
232
Indoline compounds for inhibiting KIF18A
Volastra Therapeutics
01/06/25
-
26
Indazole carboxamides as kinase inhibitors
Bristol-Myers Squibb
01/06/25
-
22
Naphthyridinone derivatives for the treatment of a disease or disorder
Novartis
01/06/25
-
75
PROTEASE INHIBITORS AND METHODS OF USE
The Cleveland Clinic Foundation
12/21/24
-
3
NOVEL AZAINDOLE DERIVATIVES AS ANTIVIRAL AGENTS
Centre National de la Recherche Scientifique
12/21/24
-
38
NAMPT ACTIVATORS FOR TREATING METABOLIC AND NEUROLOGICAL DISORDERS
University of Illinois
12/21/24
-
11
PROTEOLYSIS TARGETING CHIMERAS AND METHODS OF USE THEREOF
University of Maryland, Baltimore
12/21/24
-
30
CXCR4-TARGETED DIAGNOSTIC AND THERAPEUTIC AGENTS WITH REDUCED SPECIES SELECTIVITY
Technische University Munchen
12/21/24
-
72
USP9X Inhibitors
Prodeg
12/21/24
-
34
PYRIDAZINONE COMPOUND AS PARP7 INHIBITOR
Euregen Biopharma Co.
12/21/24
-
5
HETEROCYCLIC LACTAM COMPOUND, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
Genfleet Therapeutics (Shanghai)
12/21/24
-
29
FUSED TRI-CYCLIC COMPOUND AS A PDE3/PDE4 DUAL INHIBITOR
Chia Tai Tianqing Pharmaceutical Group
12/21/24
-
3
COVALENT HETEROCYCLES AND USES THEREOF
Kumquat Biosciences
12/21/24
-
29
IMIDAZOTRIAZINE THIOBENZAMIDE DERIVATIVE, AND PREPARATION METHOD AND APPLICATION THEREOF
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
12/21/24
-
68
CYCLOHEPTA-THIENO-DIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM
Hoffmann-La Roche
12/21/24
-
60
A CLASS OF FUSED RING COMPOUNDS, AND PREPARATION AND USE THEREOF
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
12/21/24
-
28
8-OXA-3-AZABICYCLO[3.2.1]OCTANE COMPOUNDS OR SALT THEREOF, AND PREPARATION METHOD AND USE THEREOF
Littdd Medicines
12/21/24
-
394
MACROCYCLIC COMPOUNDS AND METHODS OF USE
Amgen
12/21/24
-
1
Diarylpyrazole compound, composition comprising same, and use thereof
Shenzhen Targetrx
12/16/24
-
3
Benzamide and active compound compositions and methods of use
Translational Drug Development
12/16/24
-
27
Indane derivatives as hypoxia inducible factor-2(α) inhibitors
Nikang Therapeutics
12/16/24
-
1
Process route of compound of formula (IV), crystal form and preparation method therefor
Shandong Danhong Pharmaceutical Co.
12/16/24
-
87
Imidazopyridinone compound
Kissei Pharmaceutical
12/16/24
-
24
Substituted imidazoles for the inhibition of TGF-β and methods of treatment
Clavius Pharmaceuticals
12/16/24
-
4
Cysteine protease inhibitors and methods of use thereof
Anixa Biosciences
12/16/24
-
63
FLUORINATED TRYPTAMINE COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME
Saint Joseph'S University
12/12/24
-
197
IL4I1 INHIBITORS AND METHODS OF USE
Merck Sharp & Dohme
12/12/24
-
44
TETRAHYDROQUINOLINE (THQ) COUMPOUNDS
Centre National de la Recherche Scientifique
12/12/24
-
23
CYCLOALKYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT MODULATE IKZF2
Plexium
12/12/24
-
21
COMPOUNDS AND RADIOLIGANDS FOR TARGETING NEUROTENSIN RECEPTOR AND USES THEREOF
Full-Life Technologies HK
12/12/24
-
2
NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES
Enliven
12/12/24
-
345
6-AMINOPYRAZOLOPYRIMIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF
Japan Tobacco
12/12/24
-
29
NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM
Hoffmann-La Roche
12/12/24
-
12
Preparation and Uses of 7-Azaindenoisoquinolines
Purdue Research Foundation
12/12/24
-
2
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINES
Jiangsu Hengrui Pharmaceuticals
12/12/24
-
223
Substituted pyridines, pyridazines, pyrimidines, and 1,2,3-triazines as bruton's tyrosine kinase inhibitors
Hutchison Medipharma
12/06/24
-
3
PSMA-binding agents and uses thereof
Johns Hopkins Universty
12/06/24
-
3
Multi-targeted tyrosine kinase inhibitors effective in antitumor uses
Shanghai AB Pharmatech
12/06/24
-
39
Pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
Hoffmann-La Roche
12/06/24
-
241
Phenoxy-pyridyl-pyrimidine compounds and methods of use
Genentech
12/06/24
-
7
TLR8 agonist
Chia Tai Tianqing Pharmaceutical Group
12/06/24
-
264
HDAC6 INHIBITORS FOR TREATMENT OF DILATED CARDIOMYOPATHY
Tenaya Therapeutics
12/03/24
-
5
NOVEL COMPOUND EXHIBITING THERAPEUTIC EFFECT ON INFLAMMATORY DISEASE AS P38 MAP KINASE INHIBITOR
Prazertherapeutics
12/03/24
-
122
RECEPTOR-INTERACTING PROTEIN INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
Chengdu Biobel Biotechnology Co.
12/03/24
-
104
CDK19-Selective Inhibitors, and Methods of Use Thereof
Chan Zuckerberg Biohub
12/03/24
-
28
NEW PYRIDO DIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM
Hoffmann-La Roche
12/03/24
-
493
Pyrazolopyridinone Compounds
Beigene
12/03/24
-
22
HETEROCYCLIC COMPOUND FOR INHIBITING SHP2 ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF
Shanghai Institute of Materia Medica
12/03/24
-
18
PYRIDINO-OR PYRIMIDO-CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF
Genfleet Therapeutics (Shanghai)
12/03/24
-
4
Prodrugs of cytotoxic active agents having enzymatically cleavable groups
Bayer Aktiengesellschaft
12/02/24
-
97
Tie-2 activators targeting the Schlemm's canal
EyePoint Pharmaceuticals, Inc.
11/26/24
-
59
Arylsulfonamide derivatives
Hoffmann-La Roche
11/26/24
-
43
Dual acting FKBP12 and FKBP52 inhibitors
Plex Pharmaceuticals
11/26/24
-
123
Indazole compound or salt thereof
Taiho Pharmaceutical Co.
11/26/24
-
696
Cardiac sarcomere inhibitors
Cytokinetics
11/26/24
-
416
Inhibitors of Bruton's tyrosine kinase and method of their use
Janssen Pharmaceutica
11/26/24
-
26
Heterocyclic amide for inhibiting RIP1 kinase and uses thereof
Shanghai Institute of Materia Medica
11/26/24
-
125
COMPOUNDS
CTXT PTY LTD
11/26/24
-
19
INHIBITORS AND DEGRADERS OF PIP4K PROTEIN
Dana-Farber Cancer Institute
11/26/24
-
26
ANTIBIOTICS COMPRISING LPXH-TARGETING COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
Duke University
11/26/24
-
115
DUAL WNT SIGNALING PATHWAY INHIBITORS AND AMPK ACTIVATORS FOR TREATMENTS OF DISEASE
University of Maryland at Baltimore
11/26/24
-
468
NAMPT MODULATORS
Cytokinetics, Incorporated
11/26/24
-
201
ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM
Hoffmann-La Roche
11/26/24
-
136
HETEROCYCLIC COMPOUNDS AND METHODS OF USE
SchröDinger
11/26/24
-
6
ERGOLINE-DERIVED AGONISTS OF THE 5-HT2A RECEPTOR
Diamond Therapeutics Inc.
11/26/24
-
136
MACROCYCLIC TAK1 INHIBITORS
Aqilion AB
11/26/24
-
3
PRIDOPIDINE AND ANALOGS THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE EYE DISEASE
Prilenia Neurotherapeutics
11/25/24
-
3
COMBINATION THERAPIES
Janssen Pharmaceutica
11/25/24
-
262
NITROGEN-CONTAINING HETEROCYCLIC KETONES, PREPARATION METHODS AND MEDICINAL USES THEREOF
Hansoh Bio
11/25/24
-
190
NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST GLUCOSYLCERAMIDE SYNTHASE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESSES FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
Yuhan
11/25/24
-
1
PHARMACEUTICALLY ACCEPTABLE SALT OF PYRAZOLOHETEROARYL DERIVATIVE AND CRYSTAL FORM THEREOF
Jiangsu Hengrui Pharmaceuticals Co.
11/25/24
-
279
WILD TYPE KIT INHIBITORS
Blueprint Medicines Corporation
11/25/24
-
26
PRMT5 INHIBITING COMPOUNDS AND USES THEREOF
Antengene Discovery
11/25/24
-
54
Pharmaceutical combination comprising an ALK inhibitor and a SHP2 inhibitor
Novartis
11/21/24
-
209
Benzylamino substituted quinazolines and derivatives as SOS1 inhibitors
Boehringer Ingelheim International
11/21/24
-
2
Methods for treating pulmonary fibrosis
Reviva Pharmaceuticals
11/21/24
-
7
Benzothiophene-based selective estrogen receptor downregulator compounds
University of Illinois
11/21/24
-
31
Substituted heterocycles as aldehyde dehydrogenase inhibitors
Kayothera
11/21/24
-
1
TLR8 agonist
Chia Tai Tianqing Pharmaceutical Group
11/21/24
-
7
Pyrazolopyrimidine compound and preparation method therefor and use thereof in preparation of anti-cancer drug
Suzhou Raymon Pharmaceuticals Company
11/21/24
-
25
Substituted heterocyclic fused cyclic compound, preparation method therefor and pharmaceutical use thereof
Genfleet Therapeutics (Shanghai)Inc.
11/21/24
-
3
Multifunctional immunity-targeted micromolecule anti-cancer medicine Bestazomib (Bestazomib) and preparation method and application thereof
Shandong Hubble Kisen Biological Technonlogy Co.
11/21/24
-
1
SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FORTREATMENT OF LEPTIN-RESISTANT OBESITY
The Children’S Medical Center
11/20/24
-
31
GPR35 Agonist Compounds
Heptares Therapeutics Limited
11/20/24
-
18
SALT CONTAINING PIPERAZINE POLYCYCLIC DERIVATIVE, CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
Shanghai Hansoh Biomedical Co.
11/20/24
-
66
PREPARATION OF FUSED AZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE 0-ACYLTRANSFERASE 2 INHIBITORS
Merck Sharp & Dohme
11/20/24
-
24
AZAINDOLE ROCK INHIBITORS
Avicenna Biosciences, Inc.
11/20/24
-
6
Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia
Stealth Biotherapeutics
11/12/24
-
28
Nucleoside prodrugs and uses related thereto
Emory University
11/12/24
-
24
PERIPHERALLY RESTRICTED CB1 RECEPTOR BLOCKERS AND USES THEREOF
Bionanosim (Bns
11/08/24
-
14
SUBSTITUTED PYRIDINE-2,4-DIONE DERIVATIVES
Medshine Discovery
11/08/24
-
60
Cyclic Pyridine Derivatives as cGAS Inhibitors
Boehringer Ingelheim International
11/08/24
-
99
INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION
Ono Pharmaceutical Co.
11/08/24
-
42
Small Molecule Inhibitors of PBRM1-BD2
The Medical College of Wisconsin, Inc.
11/08/24
-
24
INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS
Chiesi Farmaceutici
11/08/24
-
121
PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS HCN2 MODULATORS
King''s College London
11/08/24
-
35
EPOXYAMIDES AS KRAS G12C AND KRAS G12D INHIBITORS AND METHODS OF USING THE SAME
Amgen
11/08/24
-
57
T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF
The Leland Stanford Junior University
11/08/24
-
7
POLYHYDROXYLATED INDOLIZIDINE AND PYRROLIZIDINE DERIVATIVES AND USES THEREOF
Academia Sinica
11/08/24
-
4
FABI INHIBITORS FOR GRAM-NEGATIVE PATHOGENS
University of Illinois
11/08/24
-
14
SPIROINDOLINE DERIVATIVE, AND PREPARATION METHOD AND MEDICAL USE THEREOF
Changchun Genescience Pharmaceutical Co.
11/08/24
-
28
NEW CYCLOPENTA-THIENO-DIAZEPINE DERIVATIVES AS GABA A GAMMA1 POSITIVE ALLOSTERIC MODULATORS
Hoffmann-La Roche
11/08/24
-
256
MK2 INHIBITORS AND USES THEREOF
Bristol-Myers Squibb
11/08/24
-
51
PLASMA KALLIKREIN INHIBITORS
Merck Sharp & Dohme
11/08/24
-
12
MACROCYCLIC 1,3-BRIDGED 6-CHLORO-7-PYRAZOL-4-YL-1 H-INDOLE-2-CARBOXYLATE AND 6-CHLORO-7-PYRIMIDIN-5-YL-1H-INDOLE-2-CARBOXYLATE DERIVATIVES AS MCL-1 INHIBITORS FOR THE TREATMENT OF CANCER
Janssen Pharmaceutica
11/08/24
-
22
Heteroaryl compounds as inhibitors of RIP2 kinase, composition and application thereof
Accro Bioscience (HK)
11/08/24
-
292
Papain-like protease (PLpro) inhibitors
Pfizer
11/07/24
-
48
Tricyclic Compounds and their Uses
Novartis
11/07/24
-
3
NOVEL TRYPTAMINES AND METHODS OF TREATING MOOD DISORDERS
Gilgamesh Pharmaceuticals
11/07/24
-
29
COMPOUNDS WITH ALK INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF
Cgenetech (Suzhou, China)
11/07/24
-
160
ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CARBOXAMIDES AS NAV1.8 INHIBITORS
Merck Sharp & Dohme
11/07/24
-
84
ARYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT MODULATE IKZF2
Plexium, Inc.
11/07/24
-
435
IL4I1 INHIBITORS AND METHODS OF USE
Merck Sharp & Dohme
11/07/24
-
8
AMINO HETEROARYL COMPOUNDS AND COMPOSITIONS
Anrui Biomedical Technology (Guangzhou) Co.
11/07/24
-
4
COMPOUND HAVING BIOLOGICAL ACTIVITY SUCH AS ANTIVIRAL ACTIVITY
National Center For Global Health And Medicine
11/07/24
-
752
SUBSTITUTED 1-ARYL-1’-HETEROARYL COMPOUNDS, SUBSTITUTED 1,1’-BIHETEROARYL COMPOUNDS, AND METHODS USING SAME
Arbutus Biopharma
11/07/24
-
24
AZAINDOLE ROCK INHIBITORS
Avicenna Biosciences, Inc.
11/07/24
-
85
PHENYLPIPERIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
Boehringer Ingelheim International
11/07/24
-
39
HETEROCYCLIC JAK INHIBITOR
Beijing Innocare Pharma Tech Co.
11/07/24
-
172
PHOSPHORUS DERIVATIVES AS NOVEL SOS1 INHIBITORS
Bayer Aktiengesellschaft
11/07/24
-
221
SUBSTITUTED 4-(3-AMINOPROP-1-YL)AMINOQUINOLINE ANALOGS AS MODULATORS OF MELANOMA-ASSOCIATED ANTIGEN 11 UBIQUITIN LIGASE
ST. JUDE CHILDREN''S RESEARCH HOSPITAL, INC.
11/07/24
-
97
Fendiline derivatives
University of Texas
11/04/24
-
63
Pyridine derivatives with c-linked cyclic substituents as cGAS inhibitors
Boehringer Ingelheim International
11/04/24
-
3
Adenosine analogs as methyltransferase inhibitors for treating cancer
Memorial Sloan-Kettering Cancer Center
11/04/24
-
1
BICYCLIC PHENOL COMPOUNDS AND USE THEREOF
Medshine Discovery
10/30/24
-
1
CRYSTAL FORM OF THIOPHENE DERIVATIVE AND PREPARATION METHOD THEREFOR
Dongbao Purple Star (Hangzhou) Biopharmaceutical Co.
10/30/24
-
94
3-AMINO PIPERIDYL SODIUM CHANNEL INHIBITORS
Genentech
10/30/24
-
82
PROTEASE INHIBITORS AND METHODS OF USE
The Cleveland Clinic Foundation
10/30/24
-
175
SOLUBLE ADENYLYL CYCLASE (SAC) INHIBITORS AND USES THEREOF
Cornell University; Tri-Institutional Therapeutics Discovery Institue, Inc.
10/30/24
-
61
SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT
Merck Sharp & Dohme
10/30/24
-
110
PKC-Theta Modulators
Exscientia AI Limited
10/30/24
-
1
CRYSTAL FORM OF PYRROLOPYRIMIDINE COMPOUND AND PREPARATION METHOD FOR CRYSTAL FORM
Zhejiang Longcharm Bio-Tech Pharma. Co.
10/30/24
-
25
MACROCYCLIC 2-ALLYLTETRAHYDROFURANS AS INHIBITORS OF MCL-1
Janssen Pharmaceutica
10/30/24
-
122
KRAS INHIBITORS AND PHARMACEUTICAL USES THEREOF
Risen (Suzhou) Pharma Tech Co.
10/30/24
-
15
SphK inhibitors and methods of making and using same
Washington University
10/24/24
-
196
Heterobicyclic compounds for inhibiting the activity of SHP2
Taiho Pharmaceutical Co.
10/24/24
-
454
ALPHA PROTEIN KINASE 1 INHIBITORS FOR USE IN TREATING KAWASAKI DISEASE
Shanghai Yao Yuan Biotechnology Co.
10/22/24
-
14
TREATMENT OF MYELOPROLIFERATIVE DISEASES AND DISORDERS WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN
Poseidon Innovation 1
10/22/24
-
60
UBIQUITIN-SPECIFIC PROTEASE 1 (USP1) INHIBITOR
Simcere Zaiming Pharmaceutical Co.
10/22/24
-
1
4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE
Gilead Sciences
10/22/24
-
7
PROTEASE INHIBITORS AND METHODS OF MAKING SAME
Variational AI
10/22/24
-
8
SULFONE- AND SULFOXIMINE-BASED SELECTIVE PARP1 INHIBITORS
Enliven
10/22/24
-
36
HETEROCYCLIC DERIVATIVE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Shanghai Hansoh Biomedical Co.
10/22/24
-
88
METHIONINE ADENOSYLTRANSFERASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Scinnohub Pharmaceutical Co.
10/22/24
-
70
ACYCLIC OXAZEPINE COMPOUNDS COMPRISING A 6-AZA MOIETY AND USES THEREOF
Genentech
10/22/24
-
15
HIF-1α inhibitor, preparation method therefor, and pharmaceutical composition for preventing or treating angiogenesis-associated eye disease, containing same as active ingredient
Seoul National University
10/21/24
-
53
Potassium channel inhibitors
Saniona
10/21/24
-
22
Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said substituted indazoles, and use of said substituted indazoles to produce drugs
Bayer Pharma Aktiengesellschaft
10/21/24
-
18
Hsp90β selective inhibitors
University of Notre Dame Du Lac
10/16/24
-
38
N-heteroaryl indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
Merck Sharp & Dohme
10/16/24
-
21
Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof
Chia Tai Tianqing Pharmaceutical Group
10/16/24
-
3
CRBN modulators
Dana-Farber Cancer Institute
10/16/24
-
15
Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof
Medshine Discovery
10/16/24
-
677
CYCLIN INHIBITORS
Circle Pharma
10/12/24
-
265
POLYCYCLIC COMPOUND AND APPLICATION THEREOF
Sichuan Huiyu Pharmaceutical Co.
10/11/24
-
51
BENZOTHIAZOLE AND QUINOLINE DERIVATIVES FOR USE IN TREATING KAWASAKI DISEASE
Shanghai Yao Yuan Biotechnology Co.
10/11/24
-
14
MODULATORS OF SORTILIN ACTIVITY
Insusense
10/11/24
-
12
IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF
Medshine Discovery
10/11/24
-
396
COMPOUND AS ADENOSINE A2a RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Chong Kun Dang Pharmaceutical
10/11/24
-
41
KRAS INHIBITORS
Bristol-Myers Squibb
10/11/24
-
14
ESTROGEN RECEPTOR ANTAGONIST
Shenzhen Forward Pharmaceuticals Co.
10/11/24
-
2
Methods
Intra-Cellular Therapies
10/08/24
-
1
Salt of LSD1 inhibitor and a polymorph thereof
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
10/08/24
-
10
INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE
Bristol-Myers Squibb
10/04/24
-
23
COMPOSITIONS AND METHODS FOR TREATING, PREVENTING OR REVERSING AGE-ASSOCIATED INFLAMMATION AND DISORDER
Brown University
10/04/24
-
167
SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF
Suzhou Zanrong Pharma
10/04/24
-
9
(R)-Glutarimide CRBN Ligands and Methods of Use
Beigene Switzerland
10/04/24
-
93
BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS
Tufts College
10/04/24
-
295
COMBINATION THERAPIES INCLUDING MYT1 INHIBITORS
Repare Therapeutics
10/04/24
-
96
SUBSTITUTED QUINOLINE DERIVATIVES HAVING SOS1 INHIBITION ACTIVITIES AND USES THEREOF
Accutar Biotechnology
10/04/24
-
4
ARYLAMINO DERIVATIVE ESTROGEN RECEPTOR MODULATOR AND USE THEREOF
Xizang Haisco Pharmaceutical
10/04/24
-
45
SMALL-MOLECULE INHIBITORS FOR BETA-CATENIN/BCELL LYMPHOMA 9 PROTEIN-PROTEIN INTERACTION
H. Lee Moffitt Cancer Center And Research Institute
10/04/24
-
9
Quinazoline Derivatives, Pharmaceutical Compositions, and Therapeutic Uses Related to Nox Inhibition
Emory University
10/04/24
-
20
6-CARBAMATE SUBSTITUTED HETEROARYL RING DERIVATIVES
Medshine Discovery
10/04/24
-
25
"Cyclopenta[c]pyrrol Negative Allosteric Modulators of NR2B"
Novartis
10/04/24
-
46
1,3,4-OXADIAZOLE THIOCARBONYL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Chong Kun Dang Pharmaceutical
10/04/24
-
26
PYRIDOPYRIMIDINES AND METHODS OF THEIR USE
Kineta
10/04/24
-
84
SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE
Individual
10/04/24
-
4
NITROGEN-CONTAINING HETEROCYCLIC POLYCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Shanghai Hansoh Biomedical Co.
10/04/24
-
8
BIVALENT LIGANDS TO UNDERSTAND DIMERIZATION OF THE MU OPIOID RECEPTOR AND THE CHEMOKINE RECEPTOR CCR5 IN NEUROLOGICAL DISORDERS
Virginia Commonwealth University
10/04/24
-
105
PHENYL AZEPINES AS RIPK1 INHIBITORS AND METHODS OF USE THEREOF
Merck Sharp & Dohme
10/04/24
-
28
COMPOUNDS FOR USE IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS
University of Barcelona
10/04/24
-
10
HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS
Chiesi Farmaceutici
10/04/24
-
47
COMPOUNDS AND METHODS FOR TREATING HYPERKALEMIA
Ardelyx
10/04/24
-
16
Inhibitors of RSV replication and applications thereof
Georgia State University Research Foundation
10/01/24
-
16
Compounds, compositions, and methods for selectively inhibiting β-glucuronidases and alleviating side effects associated with drug treatment induced diarrhea
Symberix
10/01/24
-
1
Pyrrole-substituted indolone derivative or pharmaceutically acceptable salts thereof, and preparation method therefor and application thereof
Suzhou Genhouse Pharmaceutical Co.
10/01/24
-
8
Macrocyclic derivatives acting as XIa factor inhibitor
China Resources Biopharmaceutical Company
10/01/24
-
4
METHODS AND COMPOSITIONS COMPRISING A BRAF INHIBITOR AND A PD-1 BINDING ANTAGONIST
Hoffmann-La Roche
09/24/24
-
10
SHP2-Targeting Small Molecules For Use As Anti-Cancer Agents
West Virginia University
09/24/24
-
3
DEUTERATED DHODH INHIBITORS
Immunic
09/24/24
-
29
APPLICATIONS OF BIASED LIGANDS OF THE SEROTONIN 5-HT7 RECEPTOR FOR THE TREATMENT OF PAIN, MULTIPLE SCLEROSIS AND THE CONTROL OF THERMOREGULATION
Centre National De La Recherche Scientifique
09/24/24
-
165
2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CX3CR1
Astrazeneca
09/24/24
-
17
INHIBITORS OF DYRK AND PIM
Cold Spring Harbor Laboratory
09/24/24
-
88
THIOPHENE COMPOUND AND APPLICATION THEREOF
Medshine Discovery
09/24/24
-
5
NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B
Novartis
09/24/24
-
302
SMALL MOLECULAR INHIBITORS OF NF-kB INDUCING KINASE
Janssen Pharmaceutica
09/24/24
-
5
BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
Revolution Medicines
09/24/24
-
45
NOVEL N-ACYL-[3-SUBSTITUTED]-[8-SUBSTITUTED]-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS
Ogeda
09/24/24
-
8
BICYCLIC HETEROCYCLIC FGFR4 INHIBITOR, PHARMACEUTICAL COMPOSITION AND PREPARATION COMPRISING SAME, AND APPLICATION THEREOF
Hangzhou Apeloa Medicine Research Institute Co.
09/24/24
-
29
IMIDAZO[1,2-B]PYRIDAZINE BASED TRICYCLIC COMPOUNDS AS INHIBITORS OF HASPIN AND THERAPEUTIC USES THEREOF
CNIO
09/24/24
-
2
TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS
Chiesi Farmaceutici
09/24/24
-
16
Fused Ring Derivatives Useful as KRAS G12D Inhibitors
Jacobio Pharmaceuticals
09/24/24
-
158
4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
Biosplice Therapeutics
09/24/24
-
6
GLYCOSYLTRANSFERASE INHIBITORS
California Institute Of Technology
09/24/24
-
23
Mofezolac derivatives as multi-functions selective COX-1 inhibitors
Itel Telecomunicazioni
09/19/24
-
1074
N-substituted indole derivatives as PGE2 receptor modulators
Idorsia Pharmaceuticals
09/19/24
-
17
Alpha-synuclein ligands
Washington University
09/19/24
-
277
Small molecule DCN1 inhibitors and therapeutic methods using the same
University Of Michigan
09/19/24
-
52
INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE
Bristol-Myers Squibb
09/18/24
-
27
COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS
Universitat De Barcelona
09/18/24
-
176
NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES
Boehringer Ingelheim International
09/18/24
-
1
A Crystal Form of a Fluorine-substituted Pyridopyrazole Compound and a Preparation Method Thereof
Jumbo Drug Bank Co.
09/18/24
-
13
FUSED CYCLIC COMPOUND AS WEE-1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Wigen Biomedicine Technology (Shanghai) Co.
09/18/24
-
42
MACROCYCLES AND THEIR USE
Blossomhill Therapeutics
09/18/24
-
64
MACROCYCLE COMPLEMENT FACTOR B INHIBITORS
Alexion Pharmaceuticals
09/18/24
-
549
Substituted aminoquinolones as DGKalpha inhibitors for immune activation
Bayer Aktiengesellschaft
09/09/24
-
141
Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse
University Of Kentucky Research Foundation
09/09/24
-
53
Pyrazole-containing macrophage migration inhibitory factor inhibitors
Yale University
09/09/24
-
20
1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase
Incyte
09/05/24
-
10
Methods and Compositions for Treating Cancer
Ohio Northern University
09/05/24
-
4
HIGH PURITY COPPER RADIOPHARMACEUTICAL COMPOSITIONS AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF
Nuclidium
09/05/24
-
5
METHYLQUINAZOLINONE DERIVATIVES
Hoffmann-La Roche
09/05/24
-
1
CRYSTALLINE FORMS OF (4S)-24-CHLORO-4-ETHYL-73-FLUORO-35-METHOXY-32,5-DIOXO-14-(TRIFLUORO-METHYL)-32H-6-AZA-3(4,1)-PYRIDINA-1(1)-[1,2,3]TRIAZOLA-2(1,2),7(1)-DIBENZENAHEPTAPHANE-74-CARBOXAMIDE
Bayer Aktiengesellschaft
09/05/24
-
205
KINASE MODULATORS AND METHODS OF USE THEREOF
Neuron23
09/05/24
-
17
CULLIN-RING E3 UBIQUITIN LIGASE 4 INHIBITOR COMPOUNDS AND METHODS OF THEIR USE
Icahn School Of Medicine At Mount Sinai
09/05/24
-
19
8-(PICOLINAMIDE) SUBSTITUTED COUMARIN COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Longivitron (Suzhou) Biotechnology Co.
09/05/24
-
15
NOVEL DIOXANE DERIVATIVES
Boehringer Ingelheim International
09/05/24
-
486
SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES
Janssen Biotech
09/05/24
-
108
NITROGEN-CONTAINING POLYCYCLIC FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
Applied Pharmaceutical Science
09/05/24
-
170
HETEROAROYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
Merck Sharp & Dohme
09/05/24
-
240
ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
Boehringer Ingelheim International
09/05/24
-
10
PYRIMIDINE AROMATIC RING COMPOUNDS
Medshine Discovery
09/05/24
-
182
2,8-DIAZASPIRO[4.5]DECANE COMPOUNDS
Genentech
09/05/24
-
22
Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases
Bayer Pharma Aktiengesellschaft
08/29/24
-
26
Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
Incyte
08/29/24
-
87
Compounds and probes for imaging huntingtin protein
CHDI Foundation, Inc.
08/29/24
-
29
Fused tri-cyclic compound as PDE3/PDE4 dual inhibitor
Chia Tai Tianqing Pharmaceutical Group
08/29/24
-
4
Saturated spirocyclics as antiviral agents
Enanta Pharmaceuticals
08/29/24
-
28
Preparation for 6-amino-1H-pyrazolo[3,4-d]pyrimidine-based JAK kinase inhibitor and application thereof
Peking Union Medical College
08/29/24
-
2
COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF
Dana-Farber Cancer Institute
08/27/24
-
2
NUCLEOSIDE ANALOG AND USE THEREOF
Shanghai Institute of Materia Medica
08/27/24
-
16
GALACTOPYRANOSYL-CYCLOHEXYL DERIVATIVES AS E-SELECTIN ANTAGONISTS
Glycomimetics
08/26/24
-
27
SELECTIVE LIGANDS FOR TAU AGGREGATES
Karin & Sten Mortstedt Cbd Solutions
08/26/24
-
137
COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THE SAME
University of Arizona
08/26/24
-
98
PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME
Gilgamesh Pharmaceuticals
08/26/24
-
24
FLUORINATED QUINOLINE, QUINOXALINE AND BENZO[B][1,4]OXAZINE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISEASES
Janssen Biotech, Inc.
08/26/24
-
172
AMINOHETEROARYL KINASE INHIBITORS
Anrui Biomedical Technology (Guangzhou) Co.
08/26/24
-
17
POTENT AND SELECTIVE COMPOUNDS AS SEROTONIN 1B RECEPTOR MODULATORS
Leukos Biotech
08/26/24
-
44
INHIBITORS OF MYELOPEROXIDASE
Astrazeneca
08/26/24
-
136
IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY
Imperial College Innovations
08/26/24
-
13
PYRIDOPYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Wuhan Humanwell Innovative Drug
08/26/24
-
60
1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES
Newave Pharmaceutical Inc.
08/26/24
-
10
HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS
Chiesi Farmaceutici
08/26/24
-
126
KRAS G12C INHIBITORS
BeiGene Switzerland GmbH
08/26/24
-
6
Dual-functional compounds and methods of use
Biofront Therapeutics (Beijing) Co.
08/22/24
-
592
Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto
Arena Pharmaceuticals
08/22/24
-
75
BET SUBFAMILY INHIBITORS AND METHODS USING SAME
Baylor College of Medicine
08/19/24
-
18
NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE
Oligomerix
08/19/24
-
10
TRICYCLIC COMPOUND AS HIF2-ALPHA INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Shanghai Jemincare Pharmaceuticals Co.
08/19/24
-
85
Pyrrolidine Main Protease Inhibitors as Antiviral Agents
Abbvie
08/19/24
-
157
PYRIMIDINE COMPOUND AS WEE-1 INHIBITOR
Wigen Biomedicine Technology (Shanghai) Co.
08/19/24
-
25
NOVEL BENZOFURAN, BENZOTHIOPHENE, AND INDOLE ANALOGS THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE
Oligomerix
08/19/24
-
69
RIBONUCLEOTIDE REDUCTASE (RNR) INHIBITORS AND USES THEREOF
Boundless Bio
08/19/24
-
94
NEK7 INHIBITORS
Halia Therapeutics
08/19/24
-
9
PIPERAZINE DERIVATIVE AND USE THEREOF IN MEDICINE
Chengdu Baiyu Pharmaceutical Co.
08/19/24
-
162
Nitrogen-Containing Heterocyclic Compound, Pharmaceutical Compositions thereof and Use thereof
280 Bio
08/19/24
-
4
FUSED POLYCYCLIC SUBSTITUTED 5-CARBOXYLIC ACID THIENOPYRIMIDINE DIONE COMPOUND AND USE THEREOF
Soter Biopharma
08/19/24
-
200
BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS
Janssen Biotech
08/19/24
-
85
POLYPEPTIDE COMPOUND AND APPLICATION THEREOF
Chengdu Sintanovo Biotechnology Co.
08/19/24
-
3
N-(2-(substituted-naphth-1-yl)ethyl) substituted amide compound, preparation and uses thereof
Beijing Greatway Pharmaceutical Technology Co.
08/13/24
-
3
β-lactamase inhibitors
Oxford University Innovation
08/13/24
-
11
1,7-naphthyridine derivative and preparation method and use therefor
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
08/13/24
-
12
Bicyclic pyrazolyl amines as CDK2 inhibitors
Incyte
08/13/24
-
48
Substituted thienopyrroles as PAD4 inhibitors
Bristol-Myers Squibb
08/13/24
-
20
Substituted cyclopenta[c]pyrroles as ABHD6 antagonists
Ono Pharmaceutical Co.
08/13/24
-
1
Fluoro-pyridinone phosphates and boronates useful as antibacterial agents
Pfizer
08/13/24
-
36
N-(BENZOYL)-PHENYLALANINE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF
Hangzhou Apeloa Medicine Research Institute Co.
08/09/24
-
878
SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS
Les Laboratoires Servier
08/09/24
-
15
NOVEL COMPOUNDS COMPRISING A NEW CLASS OF TRANSTHYRETIN LIGANDS FOR TREATMENT OF COMMON AGE-RELATED COMORBIDITIES
Columbia University
08/09/24
-
22
S-CONFIGURATION-CONTAINING AMINO BENZAMIDE PYRIDAZINONE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Shanghai Institute of Materia Medica
08/09/24
-
371
PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY
Hotspot Therapeutics
08/09/24
-
123
HSD17B13 INHIBITORS AND/OR DEGRADERS
Pfizer
08/09/24
-
20
FUSED RING DERIVATIVES CONTAINING 1,4-OXAZEPANE
Medshine Discovery
08/09/24
-
2
INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) BINDING PROTEIN (CBP)
Formatherapeutics
08/09/24
-
26
PURINES AND METHODS OF THEIR USE
Kineta
08/09/24
-
21
4-AMINOQUINAZOLINE COMPOUND
Astellas Pharma
08/09/24
-
67
NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF
Japan Tobacco
08/09/24
-
31
CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS
G1 Therapeutics
08/09/24
-
39
BICYCLIC PYRIDINE DERIVATIVE
Sumitomo Pharma Co.
08/09/24
-
3
OXA-IBOGAINE ANALOGUES FOR TREATMENT OF SUBSTANCE USE DISORDERS
Columbia University
08/09/24
-
36
INHIBITORS OF CYSTEINE PROTEASES
Texas A&M University
08/09/24
-
1791
PHARMACEUTICAL USE OF CYCLIC PEPTIDE COMPOUND
Chugai Seiyaku Kabushiki Kaisha
08/08/24
-
121
Monoacylglycerol lipase modulators for use in autism spectrum disorders
Janssen Pharmaceutica
08/04/24
-
13
Adenosine receptor activity of methyl/ethyl 3-(substituted benzoyl)-6,8-dimethylindolizine-2-substituted-1-carboxylates
King Faisal University
08/04/24
-
71
Isoindolin-1-on derivative, method for preparing same, and pharmaceutical composition comprising same as effective component for preventing or treating cancer
Korea Research Institute of Chemical Technology
08/04/24
-
13
INHIBITION OF KDM5A FOR PROMOTING ANTIGEN PRESENTATION, INCREASING CD8+ T CELL INFILTRATION AND BOOSTING ANTI-TUMOR IMMUNE RESPONSE
The Wistar Institute Of Anatomy And Biology
08/02/24
-
29
HETEROCYCLIC INHIBITORS OF CD73 FOR TREATMENT OF DISEASE
Teon Therapeutics
08/02/24
-
14
N6-ADENOSINE-METHYLTRANSFERASE INHIBITORS IN CANCER TREATMENT
University of Zurich
07/25/24
-
10
METHACRYLAMIDES PROTEIN BINDERS AND USES THEREOF
Yeda Research and Development Co.
07/25/24
-
272
TRICYCLIC COMPOUNDS AND USES THEREOF
Hutchmed
07/25/24
-
63
OXOINDOLINE COMPOUND FOR THE TREATMENT OF INFLAMMATORY DISEASES OR CANCER
Hoffmann-La Roche
07/25/24
-
120
PREPARATION OF TETRAHYDROINDAZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS
Merck Sharp & Dohme
07/25/24
-
15
INHIBITORS AND DEGRADERS OF JANUS KINASE 2
H. Lee Moffitt Cancer Center and Research Institute
07/25/24
-
1
INHIBITORS OF MENIN-MLL INTERACTION
Biomea Fusion
07/25/24
-
16
5,6-DIHYDROTHIENO[3,4-H]QUINAZOLINE COMPOUND
Medshine Discovery
07/25/24
-
8
ANTIVIRAL APPLICATION OF NUCLEOSIDE ANALOG OR COMBINATION FORMULATION CONTAINING NUCLEOSIDE ANALOG
Shanghai Institute of Materia Medica
07/25/24
-
8
HETEROCYCLIC INHIBITORS OF CD73 FOR TREATMENT OF DISEASE
Teon Therapeutics
07/25/24
-
35
Compounds and their use
Astrazeneca
07/22/24
-
326
Substituted benzodiazoles and use thereof in therapy
Thomas Helledays Stiftelse FÖR Medicinsk Forskning
07/22/24
-
6
TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS
Olema Pharmaceuticals
07/16/24
-
7
COMPOSITIONS AND METHODS OF TREATING CONDITIONS
The Uab Research Foundation
07/16/24
-
2
PHENOL DERIVATIVE AND APPLICATION THEREOF IN MEDICAMENTS
Hinye Pharmaceutical Co.
07/16/24
-
5
SUBSTITUTED N-(2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXOISOINDOLIN-5-YL)ARYLSULFONAMIDE ANALOGS AS MODULATORS OF CEREBLON PROTEIN
St. Jude Children'S Research Hospital
07/16/24
-
40
SULFOXIMIDE SUBSTITUTED INDAZOLE IRAK4 KINASE INHIBITOR, PREPARATION METHOD THEREOF AND USE THEREOF
Shanghai Xunhe Pharmaceutical Technology Co.
07/16/24
-
40
Benzimidazole Derivatives and Their Use As Inhibitors of ITK For The Treatment of Skin Disease
Pfizer
07/16/24
-
217
INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE
Cornell University
07/16/24
-
55
AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF
Gt Apeiron Therapeutics
07/16/24
-
1
INDOLINE COMPOUND
Medshine Discovery
07/16/24
-
1
SALT FORM AND CRYSTAL FORM OF PYRAZOLE SUBSTITUTED IMIDAZO[1,2- A]QUINOXALINE DERIVATIVE
Ocumension Therapeutics (Suzhou) Co.
07/16/24
-
3
PYRIDINE DERIVATIVES AS MODULATORS OF SORTILIN ACTIVITY
Insusense
07/16/24
-
4
MACROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF
Goharmony Therapeutics (Shenzhen) Co.
07/16/24
-
35
NRF2-ACTIVATING COMPOUND
Senju Pharmaceutical Co.
07/16/24
-
91
BORON CONTAINING PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF
Boehringer Ingelheim Animal Health Usa
07/16/24
-
315
Substituted bicyclic compounds useful as T cell activators
Bristol-Myers Squibb
07/13/24
-
49
Modulators of STING (stimulator of interferon genes)
Pfizer
07/13/24
-
50
1,3,4,7-tetrahydro-2H-pyrrolo[3′,2′:5,6]pyrido[2,3-b][1,4]oxazepine bcl-2 inhibitors
Abbvie
07/13/24
-
12
Inhibitors for coronavirus
Southwest Research Institute
07/12/24
-
8
Compounds for treating or inhibiting recurrence of acute myeloid leukemia
Flash Therapeutics
07/12/24
-
115
Substituted phenyloxazolidinones for antimicrobial therapy
The Global Alliance For Tb Drug Development
07/12/24
-
178
Arylamide derivative having antitumor activity
Chugai Seiyaku Kabushiki Kaisha
07/12/24
-
382
Substituted aminothiazoles as DGKzeta inhibitors for immune activation
Bayer Aktiengesellschaft
07/12/24
-
16
COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS
Case Western Reserve University
07/09/24
-
9
THERAPY BASED ON SYNTHETIC LETHALITY IN SWI/SNF COMPLEX-DYSFUNCTION CANCER
National Cancer Center
07/09/24
-
115
HYDROXYHETEROCYCLOALKANE-CARBAMOYL DERIVATIVES
Idorsia Pharmaceuticals
07/09/24
-
17
ATF6 INHIBITORS AND USES THEREOF
Altos Labs
07/09/24
-
119
Pyrido[2,3-D]Imidazole Derivatives and Their Use As Inhibitors of ITK for the Treatment of Skin Disease
Pfizer
07/09/24
-
43
Novel SIK Inhibitors
Pfizer
07/09/24
-
82
TRICYCLIC COMPOUND AND USE THEREOF
Nanjing Zaiming Pharmaceutical Co.
07/09/24
-
32
AZA-ERGOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Shanghaitech University
07/09/24
-
28
PIM KINASE INHIBITOR
Hangzhou Biosun Pharmaceutical Co.
07/09/24
-
54
SPIROCYCLIC-SUBSTITUTED 6,7-DIHYDRO-PYRANO[2,3-d]PYRIMIDINE INHIBITORS OF KRAS G12C MUTANT
Merck Sharp & Dohme
07/09/24
-
39
PYRIMIDINE CARBOXAMIDE COMPOUND AND USE THEREOF
Shanghai Meiyue Biotech Development Co.
07/09/24
-
3
Methods for the Treatment of Fibrotic Disease
Shy Therapeutics
07/09/24
-
19
BRANCHED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
Janssen Pharmaceutica
07/09/24
-
26
JAK1 pathway inhibitors for the treatment of vitiligo
Incyte
07/03/24
-
236
Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases
Alkahest
07/03/24
-
568
Modulators of HSD17B13 and methods of use thereof
Regeneron Pharmaceuticals
07/03/24
-
44
Pyrazole compounds, pharmaceutical compositions thereof and use thereof
Artivila (Shenzhen) Innovation Center
07/03/24
-
8
Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors
Novartis
07/03/24
-
22
Leucine-rich repeat kinase 2 (LRRK2) inhibitors
H. Lundbeck
07/03/24
-
27
Inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases
Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung
07/03/24
-
102
INHIBITION OF nSMase FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION
The Johns Hopkins University
06/29/24
-
25
SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES
THE SCRIPPS RESEARCH INSTITUTE
06/29/24
-
3
METHODS OF TREATING CANCER USING HETEROARYL-BIPHENYL AMIDE DERIVATIVES
CHEMOCENTRYX, INC.
06/29/24
-
8
QUINOLINE MERCAPTOACETATE SULFONAMIDE DERIVATIVE, INTERMEDIATE, PHARMACEUTICAL DERIVATIVE OR FORMULATION, AND PREPARATION METHOD AND USE THEREFOR
JIANGSU CHIATAI QINGJIANG PHARMACEUTICAL CO., LTD.
06/29/24
-
224
KIT KINASE INHIBITORS AND METHODS OF USE THEREOF
Deciphera Pharmaceuticals, LLC
06/29/24
-
64
BENZOTHIAZOLE AND QUINOLINE DERIVATIVES AND THEIR USE
Shanghai Yao Yuan Biotechnology Co., Ltd.
06/29/24
-
264
HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS
Ajax Therapeutics, Inc.
06/29/24
-
8
Compounds for Disease Treatment
Duke University
06/29/24
-
10
NOVEL GLUTAMINYL CYCLASE INHIBITORS AND THE USE THEREOF IN TREATMENT OF VARIOUS DISEASES
LTD "VALENTA-INTELLEKT"
06/29/24
-
20
NOVEL COMPOUNDS USEFUL AS STING AGONISTS AND USES THEREOF
Jacobio Pharmaceuticals
06/29/24
-
288
Heterocycles as WIP1 Inhibitors
PMV Pharmaceuticals, Inc.
06/29/24
-
74
COMPOUNDS AND METHODS FOR MODULATING FXR
Terns Pharmaceuticals, Inc.
06/29/24
-
3
SUBSTITUTED TRICYCLIC COMPOUND AS PRMT5 INHIBITOR AND USE THEREOF
NANJING SANHOME PHARMACEUTICAL CO., LTD.
06/29/24
-
215
IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS IRAK4 INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASE
Biogen Ma
06/29/24
-
53
HETEROAROMATIC COMPOUNDS
Astrazeneca
06/29/24
-
1044
SARS-COV2 MAIN PROTEASE INHIBITORS
Gilead Sciences
06/29/24
-
58
PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
Chiesi Farmaceutici
06/29/24
-
49
PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
Chiesi Farmaceutici
06/29/24
-
7
TARGET FOR SCREENING ANTI-TUMOR DRUG, USE THEREOF AND SCREENING METHOD THEREFOR
SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.
06/29/24
-
3
TRK inhibitors useful as anticancer drugs
TYLIGAND BIOSCIENCE (SHANGHAI) LIMITED
06/27/24
-
27
Quinolines and azaquinolines as inhibitors of CD38
Boehringer Ingelheim International
06/27/24
-
30
COMBINATION OF A T CELL THERAPY AND A DGK INHIBITOR
Juno Therapeutics
06/20/24
-
448
ALPHA PROTEIN KINASE 1 INHIBITORS AND METHODS OF USE
Shanghai Yao Yuan Biotechnology Co.
06/20/24
-
4
SERIES OF PIPERIDINE-SUBSTITUTED BENZOIC ACID COMPOUNDS, AND USE THEREOF
Medshine Discovery
06/20/24
-
363
INDAZOLE COMPOUNDS AS KINASE INHIBITORS
Tyra Biosciences
06/20/24
-
19
PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE
Abbvie
06/20/24
-
10
BENZIMIDAZOLE COMPOUND AND APPLICATION THEREOF
Medshine Discovery
06/20/24
-
69
LYSINE ACETYLTRANSFERASE 6A (KAT6A) INHIBITORS AND USES THEREOF
Insilico Medicine Ip
06/20/24
-
6
BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF
The National Institutes Of Pharmaceutical R&D Co.
06/20/24
-
22
PREPARATION AND APPLICATION METHOD OF HETEROCYCLIC COMPOUNDS AS KRAS INHIBITOR
Shanghai Kechow Pharma
06/20/24
-
84
SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF
Shanghai Haiyan Pharmaceutical Technology Co.
06/20/24
-
523
AZABICYCLIC SHP2 INHIBITORS
IRBM
06/20/24
-
135
TRICYCLIC PYRIMIDINES AS CYCLIN-DEPENDENT KINASE 7 (CDK7) INHIBITORS
Janssen Pharmaceutica
06/20/24
-
56
NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS
Boehringer Ingelheim International
06/20/24
-
101
NOVEL ACC INHIBITORS
Pfizer
06/20/24
-
485
PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS
Actelion Pharmaceuticals
06/20/24
-
245
TRIAZOLYL-METHYL SUBSTITUTED ALPHA-D-GALACTOPYRANOSIDE DERIVATIVES
Idorsia Pharmaceuticals
06/20/24
-
33
Imidazo[4,5-c]pyridine compounds as LSD-1 inhibitors
Regents Of The University Of Michigan
06/17/24
-
10
Dizocilpine derivatives as peripheral NMDA receptor antagonists
Institut National De La Sante Et De La Recherche Medicale (Inserm
06/17/24
-
65
IRE1 small molecule inhibitors
Cornell University
06/17/24
-
40
INHIBITORS OF METTL3
Strom Therapeutics
06/12/24
-
419
PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
Xenon Pharmaceuticals
06/11/24
-
217
COMPOUNDS FOR TREATING CERTAIN LEUKEMIAS
Terns Pharmaceuticals
06/11/24
-
10
PROTEIN-PROTEIN INTERACTION MODULATORS OF AURORA KINASE A AND THEIR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER
Eberhard Karls Universitat Tubingen
06/11/24
-
60
ERAP INHIBITORS
Universite De Lille
06/11/24
-
133
INHIBITORS OF QPCTL AND QPCT
TBA
06/11/24
-
20
HYDROXAMATE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Shenzhen Chipscreen Biosciences Co.
06/11/24
-
1
CRYSTAL FORM AND SALT FORM OF BROMINE DOMAIN PROTEIN INHIBITOR AND PREPARATION METHOD THEREFOR
Chia Tai Tianqing Pharmaceutical Group
06/11/24
-
95
CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
Shanghai Pharmaceuticals Holding Co.
06/11/24
-
11
TRICYCLIC KINASE INHIBITORS AND USES THEREOF
Dana-Farber Cancer Institute
06/11/24
-
9
NOVEL TETRAZOLES
Boehringer Ingelheim International
06/11/24
-
9
TRICYCLIC UBIQUITIN SPECIFIC PROTEASE 1 INHIBITOR AND USE THEREOF
Shandong Xuanzhu Pharma Co.
06/11/24
-
506
DIHYDROOXADIAZINONE COMPOUND AND PHARMACEUTICAL USE THEREOF
Japan Tobacco
06/11/24
-
3
Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders
Wayne State University
06/07/24
-
175
Heterocyclic Carboxylate Compounds as Glycolate Oxidase Inhibitors
Lilac Therapeutics
06/04/24
-
4
USE OF 5-[[4-[2-[5-ACETYLPYRIDIN-2-YL]ETHOXY]BENZYL]-1,3-THIAZOLIDINE-2,4-DIONE AND ITS SALTS
Minoryx Therapeutics
06/04/24
-
392
IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS
Theravance Biopharma R&D Ip
06/04/24
-
40
Non-Covalent Inhibitors of the Main Protease of SARS-CoV-2 and Methods of Use
Yale University
06/04/24
-
122
QUINAZOLINE COMPOUNDS AND METHODS OF USE
Iambic Therapeutics
06/04/24
-
131
Heterocycle RMB39 Modulators
Recursion Pharmaceuticals
06/04/24
-
92
DIHYDRO-CYCLOPENTA-ISOQUINOLINE SULFONAMIDES DERIVATIVES
Ucb Biopharma
06/04/24
-
86
HETEROAROMATIC COMPOUNDS AND USES THEREOF
Hutchison Medipharma
06/04/24
-
575
CONDENSED HETEROCYCLIC COMPOUND
Nissan Chemical
06/04/24
-
5
PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
Revolution Medicines
06/04/24
-
169
MNK INHIBITORS
Hepagene Therapeutics (Hk
06/04/24
-
77
MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR
Kures
06/04/24
-
15
BRIDGED COMPOUNDS AS KRAS G12D INHIBITOR AND DEGRADER AND THE USE THEREOF
Beigene Switzerland
06/04/24
-
29
NOVEL LIGANDS FOR ASIALOGLYCOPROTEIN RECEPTOR
Sanofi
06/04/24
-
34
Anti-cancer/anti-fibrosis compounds
University of California
06/01/24
-
426
2-Methyl-Quinazolines
Bayer Pharma Aktiengesellschaft
05/30/24
-
126
CYCLIC AMINE DERIVATIVES HAVING SEROTONIN RECEPTOR BINDING ACTIVITY
Shionogi
05/30/24
-
9
PYRIMIDINE CARBOXAMIDE COMPOUND AND APPLICATION THEREOF
Shanghai Meiyue Biotech Development Co.
05/30/24
-
24
OXALAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
Ifm Due
05/30/24
-
37
COMPOSITIONS AND METHODS FOR INHIBITING M PRO PROTEASE ACTIVITY AND FOR PREVENTING AND TREATING SARS-COV-2 INFECTION
Arizona Board Of Regents On Behalf Of The University Of Arizona
05/30/24
-
55
SMALL MOLECULE INHIBITOR FOR CATHEPSIN C AND MEDICINAL USE THEREOF
Reistone Biopharma Company
05/30/24
-
31
MACROCYCLIC BRANCHED 3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1
Janssen Pharmaceutica
05/30/24
-
22
Nitrogen Containing 2,3-Dihydroquinazolinone Compounds as Nav1.8 Inhibitors
Glaxosmithkline Intellectual Property Development
05/30/24
-
208
GCN2 MODULATING COMPOUNDS AND USES THEREOF
Hibercell
05/30/24
-
228
PYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS BTK INHIBITORS
Biogen Ma
05/30/24
-
13
ANTAGONISTS OF THE ADENOSINE A2A RECEPTOR
Adorx Therapeutics
05/30/24
-
135
TETRAHYDROTHIENOPYRIMIDINESULFONAMIDE COMPOUNDS
Modulus Discovery
05/30/24
-
19
Polycyclic Kinase Inhibitor
Shandong Xuanzhu Pharma Co.
05/30/24
-
14
BORATE DERIVATIVE AND USES THEREOF
Reistone Biopharma Company
05/30/24
-
161
1,2,4-triazole derivatives as tankyrase inhibitors
Oslo Universitetssykehus
05/23/24
-
46
Aminopyrazine diol compounds as PI3K-γ inhibitors
Incyte
05/23/24
-
155
Diacylglyercol kinase modulating compounds
Gilead Sciences
05/23/24
-
41
ADENOSINE A2A AND A2B RECEPTOR DUAL ANTAGONISTS FOR IMMUNO-ONCOLOGY
Merck Sharp & Dohme
05/22/24
-
55
Fused ring compound having urea structure
Sanford Burnham Prebys Medical Discovery Institute
05/17/24
-
26
Combination therapy comprising JAK pathway inhibitor and rock inhibitor
Incyte
05/17/24
-
103
Substituted pyrrolidones and piperidones as small molecule inhibitors of EZH2 and EED protein binding
Northwestern University
05/17/24
-
107
Substituted tetrahydrofurans as modulators of sodium channels
Vertex Pharmaceuticals
05/17/24
-
34
[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof
Zhuhai United Laboratories Co.
05/17/24
-
256
Inhibitors of the menin-MLL interaction
Syndax Pharmaceuticals
05/17/24
-
14
Sulfonylamide compounds as CDK2 inhibitors
Incyte
05/17/24
-
106
P2X3 andor P2X2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof
Beijing Tide Pharmaceutical Co.
05/17/24
-
191
MODIFIED PROTEINS AND PROTEIN DEGRADERS
Cullgen (Shanghai)
05/10/24
-
43
SMALL-MOLECULE MODULATORS OF THE ORPHAN NUCLEAR RECEPTOR TLX
Baylor College Of Medicine
05/10/24
-
145
PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS
Cytokinetics
05/10/24
-
9
KETOHEXOKINASE INHIBITOR AND USE THEREOF
Sichuan Haisco Pharmaceutical Co.
05/10/24
-
44
NAPHTHYRIDINE AND PYRIDO[3,4-c]PYRIDAZINE DERIVATIVES AS GABAA ALPHA 5 RECEPTOR MODULATORS
Richter Gedeon
05/10/24
-
67
HETEROCYCLIC COMPOUND AS DIACYLGLYCEROL KINASE INHIBITOR AND USE THEREOF
Lg Chem
05/10/24
-
36
MACROCYCLIC SPIROCYCLE DERIVATIVES AS MCL-1 INHIBITORS
Janssen Pharmaceutica
05/10/24
-
186
ASGPR-BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS
Avilar Therapeutics
05/10/24
-
126
Compounds
CTXT PTY
05/03/24
-
3
S6K1 protein kinase inhibitors as cancer therapeutics
Xavier University Of Louisiana
05/03/24
-
16
Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses
Shanghai AB Pharmatech
05/03/24
-
175
GCN2 and perk kinase inhibitors and methods of use thereof
Deciphera Pharmaceuticals
05/03/24
-
10
LRRK2 inhibiting compounds and use thereof for treating neurodegenerative diseases
Consejo Superior De Investigaciones Cientificas
05/03/24
-
2
Crystalline and salt forms of PPAR agonist compounds
Mitobridge
05/03/24
-
155
Isoindolinone compounds
Monte Rosa Therapeutics
05/03/24
-
331
LPA receptor antagonists and uses thereof
Gilead Sciences
05/03/24
-
639
Compounds for modulating S1P1 activity and methods of using the same
Trevena
05/03/24
-
400
6-azaindole compounds
Bristol-Myers Squibb
05/03/24
-
48
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals
05/03/24
-
4
Compound, preparation method and use thereof
Guangxi Jiufu Biotechnology Co.
05/03/24
-
47
19-nor neuroactive steroids and methods of use thereof
Sage Therpeutics
05/03/24
-
80
Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus
Southern Research Institute
04/24/24
-
13
Pyridine and Pyrazine derivative for the Treatment of CF, COPD, and Bronchiectasis
Novartis
04/24/24
-
26
TREATMENT OF URTICARIA USING JAK INHIBITORS
Incyte
04/24/24
-
3
DENDRIMER COMPOSITIONS AND METHODS FOR DRUG DELIVERY TO THE EYE
Ashvattha Therapeutics
04/24/24
-
69
HETEROCYCLIC G-PROTEIN-COUPLED RECEPTOR 52 (GPR52) AGONISTS
Board Of Regents, The University Of Texas System
04/24/24
-
36
PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
Boehringer Ingelheim International
04/24/24
-
38
THYROID HORMONE RECEPTOR b SELECTIVE AGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Shanghai Institute of Materia Medica
04/24/24
-
26
THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS
Terns Pharmaceuticals
04/24/24
-
384
ENZYME INHIBITORS
Kalvista Pharmaceuticals
04/24/24
-
30
COMPOUND CONTAINING 1,3-BENZODIOXOL STRUCTURE AND PREPARATION METHOD AND USE THEREOF
Xi'An Xintong Pharmaceutical Research
04/24/24
-
103
NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS
Merck Sharp & Dohme
04/24/24
-
513
HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE
Amgen
04/24/24
-
9
Cereblon Ligands and Uses Thereof
Regents Of The University Of Michigan
04/24/24
-
15
Cereblon Ligands and Uses Thereof
Regents Of The University Of Michigan
04/24/24
-
6
NOVEL GALACTOSIDE INHIBITOR OF GALECTINS
Galecto Biotech
04/24/24
-
6
TREATMENTS FOR OBSESSIVE COMPULSIVE DISORDER
Sirgartan Holdings
04/23/24
-
32
PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII
Hoffmann-La Roche
04/23/24
-
4
CARBORANE HYDROXAMIC ACID MATRIX METALLOPROTEINASE INHIBITORS AND AGENTS FOR BORON NEUTRON CAPTURE THERAPY
Loyola University Of Chicago
04/23/24
-
61
METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE
Design Therapeutics
04/23/24
-
66
ISOINDOLINONE COMPOUNDS
Monte Rosa Therapeutics
04/23/24
-
2
BENZOPYRAZOLE INHIBITORS OF SARM1
Disarm Therapeutics
04/23/24
-
126
HMOX1 INDUCERS
Mitobridge
04/23/24
-
51
PYRROLO[3,2-B]PYRIDINE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS
Novartis
04/23/24
-
2
4-AMINO-3-(4-PHENOXYPHENYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE DERIVATIVES AND SALTS THEREOF
Genzyme
04/23/24
-
87
SOS1 INHIBITORS AND USES THEREOF
Qilu Regor Therapeutics
04/23/24
-
30
DIACYLGLYCEROL KINASE (DGK) ALPHA INHIBITORS AND USES THEREOF
Insilico Medicine Ip
04/23/24
-
4
3-CYCLIC AMINE-INDOLE DERIVATIVES AS SEROTONERGIC AGENTS FOR THE TREATMENT OF CNS DISORDERS
Mindset Pharma
04/23/24
-
4
Inhibitors of SARM1 NADase activity and uses thereof
Washington University
04/23/24
-
13
Anti-malarial agents
University of Texas
04/23/24
-
11
Phenoxyacetic acid derivatives, preparation method thereof and use thereof as medicament
China Pharmaceutical University
04/23/24
-
120
Chemical modulators of store-operated calcium channels and their therapeutic applications
The Texas A&M University System
04/23/24
-
36
2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases
Southern Research Institute
04/23/24
-
5
Inhibitors for the B-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction
H. Lee Moffitt Cancer Center and Research Institute
04/23/24
-
72
Receptor inhibitors, pharmaceutical compositions comprising the same and use thereof
Beijing Tide Pharmaceutical
04/23/24
-
20
Isoxazolidines as RIPK1 inhibitors and use thereof
Genzyme
04/18/24
-
12
2-phenyl-3,4-dihydropyrrolo[2,1 -f] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
Topadur Pharma
04/18/24
-
83
Tricyclic heterocycles as FGFR inhibitors
Incyte
04/18/24
-
35
Pyridine macrocycle compounds as ASK1 inhibiting agents
Biogen Ma
04/18/24
-
98
ErbB/BTK inhibitors
Dizal (Jiangsu) Pharmaceutical
04/17/24
-
183
Heterocyclic GLP-1 agonists
Gasherbrum Bio
04/17/24
-
2
Indazole amine derivative, preparation method therefor and medical use thereof
Zhejiang Hisun Pharmaceutical
04/17/24
-
130
6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives as PDE3A and PDE3B inhibitors for treating cancer
Bayer Aktiengesellschaft
04/17/24
-
29
TRIAZOLONE COMPOUNDS AND USES THEREOF
Tempest Therapeutics
04/12/24
-
16
ANTI-HER2 IMMUNOCONJUGATES, AND USES THEREOF
Bolt Biotherapeutics
04/12/24
-
22
NOVEL BIPHENYL DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
Xi'An Xinton Pharmaceutcal Research
04/12/24
-
70
COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING
Neuropore Therapies
04/12/24
-
120
HETEROARYL CARBOXAMIDE COMPOUND
Astellas Pharma
04/12/24
-
372
APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
Abbvie
04/12/24
-
21
POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1
Dana-Farber Cancer Institute
04/12/24
-
25
COMPOUNDS FOR THE TREATMENT OF SARS
Purdue Research Foundation
04/12/24
-
3
1,3-DIHYDRO-2H-PYRROLO[3,4-C]PYRIDINE DERIVATIVES AS GABAA A5 RECEPTOR MODULATORS
Richter Gedeon
04/12/24
-
658
CD73 COMPOUNDS
Gilead Sciences
04/12/24
-
159
COMPOUNDS AS C5AR INHIBITORS
Kira Pharmaceuticals (Suzhou)
04/12/24
-
125
COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
Case Western Reserve University
04/12/24
-
50
SELECTIVE ESTROGEN RECEPTOR DEGRADERS AND USES THEREOF
Inventisbio
04/12/24
-
93
Small Molecule Inhibitors of KRAS G12C Mutant
Merck Sharp & Dohme
04/12/24
-
160
MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS
Cornell University
04/12/24
-
24
Tetrazole derivatives as TRPA1 inhibitors
Boehringer Ingelheim International
04/08/24
-
18
Quinolines that modulate SERCA and their use for treating disease
Neurodon
04/08/24
-
3
Sulfonamide or sulfinamide compound having effect of inducing BRD4 protein degradation and pharmaceutical use thereof
Mitsubishi Tanabe Pharma
04/08/24
-
18
HDAC6 inhibitors and imaging agents
The General Hospital
04/08/24
-
10
Small molecule modulators of pantothenate kinases
St. Jude Children'S Research Hospital
04/08/24
-
23
Indole compounds and their use
Ariagen
04/08/24
-
108
Monoacylglycerol lipase modulators
Janssen Pharmaceutica
04/08/24
-
76
Pyrazolopyridine compounds and uses thereof
Incyte
04/08/24
-
8
INHIBITORS OF POSITIVE STRAND RNA VIRUSES
National Health Research Institutes
04/04/24
-
4
CDK INHIBITORS
Qilu Regor Therapeutics
04/04/24
-
60
ANTI-PD-L1 IMMUNOCONJUGATES, AND USES THEREOF
Bolt Biotherapeutics
04/04/24
-
82
NOVEL POTASSIUM CHANNEL INHIBITORS
Saniona
04/04/24
-
35
IMIDAZOLE COMPOUNDS AS INHIBITORS OF ENPP1
Stingray Therapeutics
04/04/24
-
194
HETEROCYCLIC COMPOUND, INTERMEDIATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Wuhan Ll Science and Technology Development
04/04/24
-
47
PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS
Drug Discovery and Clinic
04/04/24
-
99
AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE
Iambic Therapeutics
04/04/24
-
293
HSD17B13 INHIBITORS AND USES THEREOF
Fl2022-001
04/04/24
-
103
Heterocyclic Derivatives as P2X7 Receptor Antagonists
Breye Therapeutics
04/04/24
-
137
TRICYCLIC COMPOUNDS AS EGFR INHIBITORS
Qilu Pharmaceutical
04/04/24
-
45
IRAK degraders and uses thereof
Kymera Therapeutics
04/03/24
-
86
Compounds and their uses as MIF inhibitors
Nanjing Immunophage Biotech Co.
03/25/24
-
2
Substituted oxopyridine derivative
Bayer Pharma Aktiengesellschaft
03/21/24
-
51
Purinone compounds and their use in treating cancer
Astrazeneca
03/21/24
-
3
Compositions and Methods for Managing Weight
Unigen
03/19/24
-
289
PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES
Hoffmann-La Roche
03/19/24
-
503
COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
Dong-A St Co.
03/19/24
-
66
SALT INDUCIBLE KINASE INHIBITORS
The General Hospital
03/19/24
-
248
PYRIMIDINE-AND NITROGEN-CONTAINING BICYCLIC COMPOUND
Asahi Kasei Pharma
03/19/24
-
11
TRIHETEROCYCLIC DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Shanghai De Novo Pharmatech
03/19/24
-
9
TETRACYCLIC COMPOUNDS AS DGK INHIBITORS
Incyte
03/19/24
-
29
COMPOUND USED AS KINASE INHIBITOR AND USE THEREOF
Tyk Medicines
03/19/24
-
108
RIPK1 INHIBITORS AND METHODS OF USE
Merck Sharp & Dohme
03/19/24
-
258
AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF
Genentech
03/19/24
-
187
TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS
Merck Patent
03/19/24
-
320
Inhibitors of peptidylarginine deiminases
Gilead Sciences
03/14/24
-
147
Bicyclic compounds and their uses
Novartis
03/14/24
-
26
COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS
Kineta
03/13/24
-
188
PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS
Chiesi Farmaceutici
03/13/24
-
24
MODULATORS OF FPR1 AND METHODS OF USING THE SAME
Biofront
03/13/24
-
46
COMPOUND HAVING INHIBITORY ACTIVITY AGAINST O-GLUSACASE AND USE THEREOF
Medifron Dbt
03/13/24
-
24
PYRIDO[4,3-b]INDOLE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
Ventus Therapeutics U.S.
03/13/24
-
83
MODIFIED IMIDAZOPYRIDINES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
Merck Sharp & Dohme
03/13/24
-
1
SALT OF COMPOUND FOR DEGRADING BTK, CRYSTAL FORM THEREOF, AND USE THEREOF IN MEDICINE
Haisco Pharmaceuticals
03/13/24
-
18
NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME
Tme Therapeutics
03/13/24
-
35
BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF
2692372 Ontario
03/13/24
-
210
CYCLIC COMPOUNDS AND METHODS OF USING SAME
SchröDinger
03/13/24
-
5
BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE
Prelude Therapeutics
03/13/24
-
11
COMPOUNDS AND METHODS FOR TREATING VIRAL INFECTIONS
Beth Israel Deaconess Medical Center
03/12/24
-
4
BROMODOMAIN INHIBITORS FOR ANDROGEN RECEPTOR-DRIVEN CANCERS
Forma Therapeutics
03/12/24
-
49
Indanes as PD-L1 inhibitors
Chemocentryx
03/07/24
-
178
Pyridazinone compounds and uses thereof
Edgewise Therapeutics
03/07/24
-
42
Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof
Shanghai Institute of Materia Medica
03/07/24
-
34
Fused pyrimidine derivatives as A2A/A2B inhibitors
Incyte
03/07/24
-
51
TETRAZOLE DERIVATIVES
Merck Patent
03/04/24
-
32
PYRIMIDINYL SULFONAMIDES AS INHIBITORS OF ACK1/TNK2 TYROSINE KINASE
H. Lee Moffitt Cancer Center and Research Institute
03/04/24
-
18
MODULATORS OF PROGRAMMED DEATH-LIGAND-1
Southern Research Institute
03/04/24
-
16
TRIAZINE DIONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE
Jiangsu Hengrui Pharmaceuticals
03/04/24
-
20
ABHD6 ANTAGONIST
Ono Pharmaceutical Co.
03/04/24
-
89
MASP INHIBITORY COMPOUNDS AND USES THEREOF
Bayer Aktiengesellschaft
03/04/24
-
107
Substituted indazoles as IRAK4 inhibitors
Astrazeneca
03/02/24
-
136
Streptococcus mutans glucosyl transferase inhibitors for dental caries therapy
Uab Research Foundation
03/02/24
-
83
Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases
Chemocentryx
03/02/24
-
288
Naphthyridinone compounds useful as T cell activators
Bristol-Myers Squibb
03/02/24
-
181
Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof
Cambridge Enterprise
03/02/24
-
210
Modulators of Cystic Fibrosis Transmembrane Conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators
Vertex Pharmaceuticals
03/02/24
-
126
COMBINATION OF AN ALPHA2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONIST WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEA
Bayer Aktiengesellschaft
02/28/24
-
12
COMPOUNDS AND USE THEREOF IN METHODS OF TREATMENT
University of Queensland
02/28/24
-
93
THERAPEUTIC COMPOUNDS AND METHODS
University of Minnesota
02/28/24
-
3
PYRIDAZINE AND 1,2,4-TRIAZINE DERIVATIVES AS FGFR KINASE INHIBITORS
Beta Pharma
02/28/24
-
11
ANTICHOLINERGIC AGENTS
Rezubio Pharmaceuticals Co.
02/28/24
-
5
PYRROLOPYRIDINE COMPOUND AND APPLICATION THEREOF
Medshine Discovery
02/28/24
-
26
REV-ERB AGONISTS
Saint Louis University
02/28/24
-
1
METHOD FOR PREPARING BTK DEGRADING AGENT
Haisco Pharmaceuticals
02/28/24
-
78
PYRIMIDINONE COMPOUNDS AND USES THEREOF
Hutchison Medipharma
02/28/24
-
421
4-ALKOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
Biosplice Therapeutics
02/28/24
-
44
SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORS
Hoffmann-La Roche
02/28/24
-
4
DEUTERIUM-MODIFIED THIENOPYRIDONE COMPOUND
Chia Tai Tianqing Pharmaceutical Group
02/28/24
-
1
SALT OF PYRROLOPYRIMIDINE COMPOUND, CRYSTALLINE FORM THEREOF, AND APPLICATION THEREOF
Guangzhou Joyo Pharmatech Co.
02/28/24
-
5
4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds as CDK inhibitors
Carrick Therapeutics
02/22/24
-
11
Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections
Emory University
02/22/24
-
48
Cathepsin L inhibitors
Biofront Therapeutics (Beijing) Co.
02/22/24
-
144
Inhibiting agents for bruton's tyrosine kinase
Biogen Ma
02/22/24
-
21
Alkyne-containing antiviral agents
Enanta Pharmaceuticals
02/22/24
-
46
Glycyrrhetinic acid derivatives for use in treating hyperkalemia
Ardelyx
02/22/24
-
15
Peptidomimetics for the treatment of Norovirus infection
Emory University
02/22/24
-
35
DIHYDROISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AND USES THEREOF
Hefei Institutes of Physical Science, Chinese Academy of Sciences
02/19/24
-
37
AMIDE COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Artivila (Shenzhen) Innovation Center
02/19/24
-
24
ADENOSINE ANALOGS FOR THE TREATMENT OF DISEASE
Biointervene
02/19/24
-
3
BENZODIAZEPINE COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF
China Pharmaceutical University
02/19/24
-
88
PYRIMIDINONE-CONTAINING 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 13 INHIBITORS
Enanta Pharmaceuticals
02/19/24
-
51
HETEROARYLQUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
Chengdu Cynogen Bio-Pharmaceutical Technology
02/19/24
-
14
SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF IN NEURODEGENERATIVE DISEASES
Artivila Biopharma
02/18/24
-
3
USE OF PRIDOPIDINE AND ANALOGS FOR TREATING RETT SYNDROME
Prilenia Neurotherapeutics
02/18/24
-
8
INHIBITION OF THE HIV-1 REPLICATION BY COMPOUNDS DIRECTED AGAINST A NEW TARGET OF THE VIRAL CYCLE
Centre National De La Recherche Scientifique
02/18/24
-
7
PSMA INHIBITOR, COMPOUND AND APPLICATION
Peking University First Hospital
02/18/24
-
137
Bicyclic amines as CDK2 inhibitors
Incyte
02/15/24
-
114
Substituted pyrazolo[1,5-A]pyrazine compounds as ret kinase inhibitors
Array Biopharma
02/15/24
-
13
Fused bicyclic pyrimidine derivatives and uses thereof
The Regents of The University of Colorado, A Body Corporate
02/15/24
-
118
Arginase inhibitors
Rijksuniversiteit Groningen
02/12/24
-
22
COMBINATIONS OF DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS AND ACETYL-COA CARBOXYLASE INHIBITOR
Pfizer
02/12/24
-
48
N-(2-(3-CYANO-2-AZABICYCLO[3.1.0]HEXAN-2-YL)-2-OXOETHYL)QUINOLINE-4-CARBOXAMIDES
Astrazeneca
02/12/24
-
2
SUBSTITUTED PYRROLO [2, 3-b] PYRIDINE AND PYRAZOLO [3, 4-b] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
Fochon Biosciences
02/12/24
-
1
Oral compositions of MK2 pathway inhibitor for treatment of immune conditions
Aclaris Therapeutics
02/08/24
-
818
Diacylglycerol kinase modulating compounds
Gilead Sciences
02/08/24
-
140
USP30 inhibitors and uses thereof
Vincere Biosciences
02/08/24
-
118
1,3-substituted cyclobutyl derivatives and uses thereof
Novartis
02/08/24
-
10
Glutaminyl cyclase inhibitors and the use thereof in treatment of various diseases
Ltd “Valenta-Intellekt”
02/08/24
-
8
Opioid compounds and uses thereof
Rhodes Technologies
02/08/24
-
7
RNA VIRUS INHIBITOR COMPOUNDS WITH IMPROVED METABOLIC STABILITY AND USES THEREOF
University of Alberta
02/03/24
-
20
CD73 INHIBITOR AND USE THEREOF
Wuhan Humanwell Innovative Drug Research and Development Center
02/03/24
-
413
Acylsulfamide Compound and Pharmaceutical Use Therefor
Japan Tobacco
02/03/24
-
99
HIGH ACTIVITY HPK1 KINASE INHIBITOR
Adlai Nortye Biopharma Co.
02/03/24
-
27
IMIDAZO[1,2-a]PYRAZINE OR PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND USE THEREOF
Tencent Technology (Shenzhen)
02/03/24
-
136
TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS
Incyte
02/03/24
-
7
ANTIBODIES FOR OPIOID TREATMENTS
The Scripps Research Institute
02/03/24
-
62
Substituted nicotinimide inhibitors of BTK for treating cancer
Guangzhou Innocare Pharma Tech Co.
02/02/24
-
15
CDK8/19 inhibitors
Joint Stock Company “Biocad”
02/02/24
-
6
Pyridinone-based epigenetic modifiers and uses thereof
University of Illinois
02/02/24
-
25
Alkynyl(hetero)aromatic compound for inhibiting protein kinase activity
Shenzhen Targetrx
02/02/24
-
1
Radiolabelled MGL pet ligands
Janssen Pharmaceutica
02/02/24
-
4
IRE1α inhibitors and uses thereof
University of California
02/02/24
-
4
Imidazopyridazine compounds and uses thereof
Incyte
02/02/24
-
456
Pyrimidine derivatives as PGE2 receptor modulators
Idorsia Pharmaceuticals
02/01/24
-
12
BIPHENYL PYRROLIDINE AND BIPHENYL DIHYDROIMIDAZOLE DERIVATIVES FOR INHIBITING ACTIVITY OF 5-HT7 SEROTONIN RECEPTOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT
Korea Institute of Science and Technology
01/28/24
-
3
USE OF PRIDOPIDINE AND ANALOGS FOR THE TREATMENT OF ANXIETY AND DEPRESSION
Prilenia Neurotherapeutics
01/28/24
-
331
INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF
Epirium Bio
01/28/24
-
12
MODULATORS OF PD-L1/PD-1 INTERACTION AND USES THEREOF
Ramot at Tel-Aviv University
01/28/24
-
123
INHIBITORS OF THE INTERACTION BETWEEN TRIP8B AND HCN CHANNELS AND USES THEREOF FOR TREATING NEUROLOGICAL DISEASES AND DISORDERS
Northwestern University
01/28/24
-
25
3-TETRAZOLYLMETHYL-1,3,5-TRIAZIN-2,4-DIONE COMPOUND INHIBITING CORONAVIRUS 3CL PROTEASE ACTIVITY AND PREPARATION METHOD AND USE THEREOF
Shaanxi Panlong Pharmaceutical Co.
01/28/24
-
120
BICYCLIC INHIBITORS OF IRAK
Rigel Pharmaceuticals
01/28/24
-
39
MODIFIED BENZOFURAN-CARBOXAMIDES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
Merck Sharp & Dohme
01/28/24
-
17
SUBSTITUTED S-ALANINATE DERIVATIVES
Bayer Aktiengesellschaft
01/28/24
-
27
IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
Dana-Farber Cancer Institute
01/28/24
-
49
METTL3 INHIBITORY COMPOUNDS
Storm Therapeutics
01/28/24
-
22
SUBSTITUTED DIARYLAMINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
Suzhou Yabao Pharmaceutical R&D Co.
01/28/24
-
65
MALT1 MODULATORS AND USES THEREOF
Rheos Medicines
01/28/24
-
322
cGAS INHIBITORS
Eli Lilly
01/28/24
-
304
Substituted indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors
1St Biotherapeutics
01/24/24
-
23
Heterocyclic compounds as pad inhibitors
Jubilant Epipad
01/23/24
-
15
1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use
Modern Biosciences
01/23/24
-
119
Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase
Agency For Science, Technology and Research
01/23/24
-
23
Substituted amino six-membered nitric heterocyclic ring compound and preparation and use thereof
Shanghai Institute of Materia Medica
01/23/24
-
1
SSTR4 agonist salts
Eli Lilly
01/23/24
-
101
Beta-lactam derivatives for the treatment of diseases
Insilico Medicine Ip
01/23/24
-
483
Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
Array Biopharma
01/23/24
-
16
Anti-cancer nuclear hormone receptor-targeting compounds
Nuvation Bio
01/23/24
-
316
HDAC6 INHIBITORS FOR TREATMENT OF METABOLIC DISEASE AND HFPEF
Tenaya Therapeutics
01/19/24
-
45
MEK INHIBITORS AND USES THEREOF
Ikena Oncology
01/19/24
-
7
Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators
Eli Lilly
01/19/24
-
31
N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
Shenzhen Edk Pharmaceutical Technology
01/19/24
-
2
CSF1R KINASE INHIBITOR AND USE THEREOF
Shanghai Institute of Materia Medica
01/19/24
-
152
COMPOUNDS FOR INHIBITING KIF18A
Volastra Therapeutics
01/19/24
-
390
SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF
The Johns Hopkins University
01/19/24
-
78
PYRAZOLEAMIDE DERIVATIVES
Hoffmann-La Roche
01/19/24
-
30
GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF
Deciphera Pharmaceuticals
01/19/24
-
6
HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF
Hutchison Medipharma
01/19/24
-
4
OXA- IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
Columbia University
01/19/24
-
55
FUSED TETRACYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2
Enliven Therapeutics
01/19/24
-
16
Anti-cancer nuclear hormone receptor-targeting compounds
Nuvation Bio
01/17/24
-
6
Conduritol aziridine derivatives and uses thereof
University of Saskatchewan
01/17/24
-
43
Pyrazine derivative and application thereof in inhibiting SHP2
Suzhou Genhouse Pharmaceutical
01/17/24
-
39
MACROCYCLIC PEPTIDE BORONATE IMMUNOMODULATORS
Bristol-Myers Squibb
01/16/24
-
64
INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF
Haisco Pharmaceuticals
01/12/24
-
212
5-SUBSTITUTED INDOLE 3-AMIDE DERIVATIVES, PREPARATION METHOD AND USE THEREOF
Origiant Pharmaceutical
01/12/24
-
38
SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF
The Broad Institute
01/12/24
-
23
N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE
Pliant Therapeutics
01/12/24
-
20
TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF
Medshine Discovery
01/12/24
-
135
PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER
The United States of America,As Represented By The Secretary,Department of Health and Human Services
01/12/24
-
49
FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28
Dana-Farber Cancer Institute
01/12/24
-
84
HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER
SchrÖDinger
01/12/24
-
13
BIPHENYL COMPOUND AS IMMUNOMODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Shenzhen Chipscreen Biosciences
01/12/24
-
79
BACTERIAL DNA GYRASE INHIBITORS AND METHODS OF USE THEREOF
The Florida International University Board of Trustees
01/11/24
-
154
COMPOUND AS BRAIN-PERMEABLE BTK OR HER2 INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
Chengdu Hyperway Pharmaceuticals
01/11/24
-
47
TRUXILLIC ACID MONOESTER-DERIVATIVES AS SELECTIVE FABP5 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
The Research Foundation For The State University of New York
01/11/24
-
88
QUINAZOLINE-2,4-DIAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT
The Asean Foundation
01/11/24
-
271
POLO LIKE KINASE 4 INHIBITORS
Oric Pharmaceuticals
01/11/24
-
784
Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof
Maze Therapeutics
01/08/24
-
92
Inhibtors of Raf kinases
Kinnate Biopharma
01/08/24
-
22
Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors
Forma Therapeutics
01/08/24
-
8
Substituted pyrrolo[2,3-d]pyrimidines and pyrazolo[3,4-d]pyrimidines as inhibitors for multi-resistant cancers
Ferris State University
01/08/24
-
54
Macrocyclic compounds for the treatment of medical disorders
Achillion Pharmaceuticals
01/08/24
-
42
SMALL MOLECULE INHIBITORS OF BACTERIAL TOXINS
Artizan Biosciences
01/04/24
-
10
PREPARATION OF BIARYL RING-LINKED AROMATIC HETEROCYCLIC DERIVATIVE AS IMMUNOMODULATOR AND USE THEREOF
Shanghai Longwood Biopharmaceuticals
01/04/24
-
69
PYRIDO[2,3-D]PYRIMIDIN-4-AMINES AS SOS1 INHIBITORS
Bayer Aktiengesellschaft
01/04/24
-
6
1H-PYRROLO[2,3-C]PYRIDINE COMPOUNDS AND APPLICATION THEREOF
Medshine Discovery
01/04/24
-
11
PYRROLOPYRIMIDINE COMPOUND AS BTK INHIBITOR AND USE THEREOF
Medshine Discovery
01/04/24
-
192
AGONISTS OF STIMULATOR OF INTERFERON GENES STING
The Scripps Research Institute
01/04/24
-
169
NEW MACROCYCLIC LRRK2 KINASE INHIBITORS
Les Laboratoires Servier
01/04/24
-
64
MACROCYCLIC COMPOUND
Asahi Kasei Pharma
01/04/24
-
31
Prevention and/or treatment of CNS disorders
Ildong Pharmaceutical
12/29/23
-
1
Site specific homogeneous with KSP inhibitors
Bayer Pharma Aktiengesellschaft
12/29/23
-
44
Sulfonamide derivatives for protein degradation
Dana-Farber Cancer Institute
12/29/23
-
13
Substituted pyrimidinones as agonists of the APJ receptor
Amgen
12/29/23
-
12
Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof
Haisco Pharmaceuticals
12/29/23
-
334
4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19)
Almac Discovery
12/29/23
-
57
Fused tetracyclic quinazoline derivatives as inhibitors of ErbB2
Enliven Therapeutics
12/29/23
-
100
INHIBITORS OF TYROSINE KINASE 2 MEDIATED SIGNALING
Abbvie
12/25/23
-
127
NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF
Txinno Bioscience
12/25/23
-
8
Toll-like receptor ligands
Inimmune
12/24/23
-
7
SULFONYLUREA DERIVATIVE AND MEDICAL USES THEREOF
Shanghai Senhui Medicine
12/20/23
-
32
Benzimidazole derivatives
Hoffmann-La Roche
12/20/23
-
33
BISPECIFIC ANTAGONISTS OF RETINOL-BINDING PROTEIN 4 THAT STABILIZE TRANSTHYRETIN TETRAMERS, THEIR PREPARATION, AND USE IN THE TREATMENT OF COMMON AGE-RELATED COMORBIDITIES
Columbia University
12/20/23
-
53
5-HT2A RECEPTOR INHIBITOR OR INVERSE AGONIST, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Geneora Pharma (Shijiazhuang) Co.
12/20/23
-
262
HETEROCYCLIC COMPOUNDS AND METHODS OF USE
SchröDinger
12/20/23
-
623
OXOPYRROLIDINE FPR2 AGONISTS
Bristol-Myers Squibb
12/20/23
-
176
GALECTIN-3 INHIBITING 2-HYDROXYCYCLOALKANE-1-CARBAMOYL DERIVATIVES
Idorsia Pharmaceuticals
12/20/23
-
319
CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE
Genzyme
12/20/23
-
29
HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF
Iomx Therapeutics
12/20/23
-
163
QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME
Repare Therapeutics
12/20/23
-
3
PYRROLIDINE COMPOUND AND USE THEREOF
Simcere Pharmaceutical
12/20/23
-
27
IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS
Deutsches Krebsforschungszentrum
12/20/23
-
23
Heteroaryl Derivative, Preparation Method Therefor, And Use Thereof
Zhejiang Hisun Pharmaceutical
12/20/23
-
30
SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS
Xinthera
12/20/23
-
46
2-AMINOPYRIMIDINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF
Guangzhou Salustier Biosciences
12/20/23
-
37
A COMPOUND HAVING INHIBITORY ACTIVITY AGAINST KRAS G12D MUTATION
Taiho Pharmaceutical
12/20/23
-
16
BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF
Pharmaxis
12/20/23
-
21
Compounds for the modulation of cyclophilins function
The University Court of The University of Edinburgh
12/13/23
-
24
2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase
Oxford Drug Design
12/13/23
-
481
Cyclobutyl amide monoacylglycerol lipase modulators
Janssen Pharmaceutica
12/13/23
-
105
2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors
Merck Sharp & Dohme
12/13/23
-
64
Azetidine and pyrrolidine PARP1 inhibitors and uses thereof
Xinthera
12/13/23
-
76
Glutarimides for medical treatment
C4 Therapeutics
12/13/23
-
188
Heterocyclic compounds as monoacylglycerol lipase inhibitors
Hoffmann-La Roche
12/13/23
-
264
BIOMARKERS FOR CANCER THERAPY USING MDM2 ANTAGONISTS
Otsuka Pharmaceutical
12/10/23
-
19
NOVEL PHARMACOLOGICAL CHAPERONE COMPOUNDS OF HUMAN ACID ALPHA-GLUCOSIDASE AND THE THERAPEUTIC USE THEREOF
UniversitÉ
12/10/23
-
4
INDAZOLE DERIVATIVES AS CANNABINOID RECEPTOR PARTIAL AGONISTS
Research Triangle Institute
12/10/23
-
60
SHP2 INHIBITOR AND COMPOSITION AND APPLICATION THEREOF
Betta Pharmaceuticals
12/10/23
-
131
AMINO ALCOHOL COMPOUNDS AND USES THEREOF
Kineta
12/10/23
-
9
HPK1 INHIBITORS AND USES THEREOF
Qilu Regor Therapeutics
12/10/23
-
128
URACIL DERIVATIVES AS MER-AXL INHIBITORS
Bristol-Myers Squibb
12/10/23
-
153
CASEIN KINASE 1 DELTA MODULATORS
Janssen Pharmaceutica
12/10/23
-
59
MODULATORS OF ALPHA-1 ANTITRYPSIN
Vertex Pharmaceuticals
12/10/23
-
54
SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
Bayer Aktiengesellschaft
12/10/23
-
29
COMPOUNDS FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISORDERS
1St Biotherapeutics
12/10/23
-
197
KRAS G12D MODULATING COMPOUNDS
Gilead Sciences
12/10/23
-
187
MACROCYCLIC HETEROCYCLES AND USES THEREOF
Kumquat Biosciences
12/10/23
-
555
STEROIDAL COMPOSITIONS AND METHODS OF TREATING LIPOGENIC CANCERS
Asteroid Therapeutics
12/10/23
-
3
Uses of a lysyl oxidase-like 2 inhibitor
Pharmakea
12/05/23
-
37
Compounds and pharmaceutical uses thereof
SyneuRx International (Taiwan)
12/05/23
-
9
Compounds for the treatment of SARS
Purdue Research Foundation
12/05/23
-
51
Tetrahydro-benzoazepine glycosidase inhibitors
Asceneuron
12/05/23
-
97
MAP4K4 inhibitors
Imperial College Innovations
12/05/23
-
122
Pyrrolotriazinones and imidazotriazinones as ubiquitin-specific protease 7 inhibitors
Valo Health
12/05/23
-
30
Substituted pyridines as PARP1 inhibitors
Xinthera
12/05/23
-
1
N-((1-BENZYLPIPERIDIN-3-YL)METHYL)-N-(2-METHOXYETHYL)NAPHTHALENE-2-SULFONAMIDE FOR THE TREATMENT OF CANINE COGNITIVE DYSFUNCTION AND OTHER FORMS OF DEMENTIA IN DOGS
Univerza V Ljubljani
12/01/23
-
78
AROMATIC ETHYLENE COMPOUND AND PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
Guangzhou Maxinovel Pharmaceuticals
12/01/23
-
73
INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY
University of Virginia Patent Foundation
12/01/23
-
15
Pyrazolopyridine Compounds and Methods of Inhibiting IRE1 Using Same
Optikira
12/01/23
-
7
NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS
Enanta Pharmaceuticals
12/01/23
-
1
INDOLO HEPTAMYL OXIME ANALOG CRYSTAL AS PARP INHIBITOR AND METHOD FOR PREPARING SAME
Chia Tai Tianqing Pharmaceutical Group
12/01/23
-
46
Pyrazolopyrimidine compounds as adenosine receptor antagonists
Exscientia
11/29/23
-
8
Methods of inhibiting cyclooxygenase
King Faisal University
11/29/23
-
2
Isoquinolinyl triazolone complexes
Takeda Pharmaceutical
11/29/23
-
79
Compound having PD-L1 inhibitory activity, preparation method therefor and use thereof
Shanghai Ennovabio Pharmaceuticals
11/29/23
-
46
Therapeutic compounds and methods of use
Genentech
11/29/23
-
255
Quaternary indazole glucocorticoid receptor antagonists
Corcept Therapeutics
11/29/23
-
7
Inhibiting ataxia telangiectasia and RAD3-related protein (ATR)
Celator Pharmaceuticals
11/29/23
-
2
Solid forms of an HPK1 inhibitor
Incyte
11/29/23
-
94
Inhibitors of VAP-1
Acucela
11/29/23
-
18
5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2 Pyridyl]Amino]Pyrazine-2-carbonitrile and therapeutic uses thereof
Cancer Research Technology
11/29/23
-
150
Plasma Kallikrein inhibitors and uses thereof
Takeda Pharmaceutical
11/29/23
-
165
Aryl piperidines as monoacylglycerol lipase modulators
Janssen Pharmaceutica
11/29/23
-
157
Dihydrobenzimidazolones for medical treatment
C4 Therapeutics
11/29/23
-
142
Diacylglyceride O-acyltransferase 2 inhibitors
Merck Sharp & Dohme
11/29/23
-
34
Substituted pyrazolo[4,3-d]pyrimidines and imidazo[5,1 -f][1,2,4]triazines as androgen receptor and phosphodiesterase dual inhibitors
Ildong Pharmaceutical
11/29/23
-
3
COMBINATION THERAPY
Pfizer
11/22/23
-
9
UNIT DOSAGE COMPOSITION OF AKT INHIBITOR
Nanjing Chia Tai Tianqing Pharmaceutical
11/22/23
-
32
NOVEL BIARYL DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF
Lg Chem
11/22/23
-
85
BROAD SPECTRUM ANTI-CANCER COMPOUNDS
University of California
11/22/23
-
16
TRIAZOLE DERIVATIVES AND THEIR USE AS TANKYRASE INHIBITORS
Oslo Universitetssykehus
11/22/23
-
37
FUSED TRICYCLIC DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF
Chia Tai Tianqing Pharmaceutical Group
11/22/23
-
178
OXADIAZOLE HDAC6 INHIBITORS AND USES THEREOF
Eikonizo Therapeutics
11/22/23
-
5
FUSED IMIDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
Jiangsu Hengrui Medicine
11/22/23
-
137
ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF
Bayer Aktiengesellschaft
11/22/23
-
32
HETEROAROMATIC RING COMPOUND AS RET KINASE INHIBITOR, AND PREPARATION AND USE THEREOF
Jiangsu Chia Tai Fenghai Pharmaceutical
11/22/23
-
29
IMIDAZOTRIAZINE AND PYRROLOPYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS
Beigene
11/22/23
-
174
PYRAZOLOPYRIDAZINONE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
Broadenbio
11/22/23
-
14
CDK9 INHIBITORS
Biolexis Therapeutics
11/22/23
-
27
ARYL PHOSPHOROUS OXIDE COMPOUNDS AND USE THEREOF
Chengdu Di''Ao Jiuhong Pharmaceutical Factory
11/22/23
-
326
NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
Sage Therapeutics
11/22/23
-
57
Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors
Orsobio
11/17/23
-
46
Substituted 3-phenoxyazetidin-1-yl-pyrazines
Boehringer Ingelheim International
11/17/23
-
34
TYK2 pseudokinase ligands
Ventyx Biosciences
11/17/23
-
1440
FGFR inhibitors and methods of use thereof
Relay Therapeutics
11/17/23
-
253
Imino sulfanone inhibitors of ENPP1
Volastra Therapeutics
11/17/23
-
56
LRRK2 inhibitors
H. Lundbeck
11/17/23
-
281
Methods for treating Crohn's disease using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
Theravance Biopharma R&D Ip
11/17/23
-
93
Substituted N-pyrimidin-4-yl-3-aminopyrrolo[3,4-C]pyrazoles as protein kinase C inhibitors
Pfizer
11/17/23
-
15
Prolyl hydroxylase domain-containing protein (PHD) inhibitors and uses thereof
Insilico Medicine Ip
11/17/23
-
20
Pyridinamine-pyridone and pyrimidinamine-pyridone compounds
Sprint Bioscience
11/17/23
-
27
COMPOUNDS WITH SEMIOCHEMICAL PROPERTIES AND BIOSENSORS
Rothamsted Research
11/13/23
-
1
QUINOLINE COMPOUNDS
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory
11/13/23
-
51
CYP46A1 INHIBITORS AND METHODS OF USE THEREOF
Sage Therapeutics
11/13/23
-
176
2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS
Merck Sharp & Dohme
11/13/23
-
13
PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF
Wenzhou Medical University
11/13/23
-
67
HYDROXYPYRROLIDINE DERIVATIVE AND MEDICINAL APPLICATION THEREOF
Mitsubishi Tanabe Pharma
11/13/23
-
229
N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES
Astrazeneca
11/13/23
-
87
ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Sichuan Kelun-Biotech Biopharmaceutical
11/13/23
-
12
RING-MODIFIED PROLINE SHORT PEPTIDE COMPOUND AND USE THEREOF
Fujian Akeylink Biotechnology
11/13/23
-
118
4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER
Centre National De La Recherche Scientifique
11/13/23
-
9
1-(5-(2-CYANOPYRIDIN-4-YL)OXAZOLE-2-CARBONYL)-4-METHYLHEXAHYDROPYRROLO[3,4-B]PYR ROLE-5(1H)-CARBONITRILE AS USP30 INHIBITOR FOR USE IN THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION, CANCER AND FIBROSIS
Mission Therapeutics
11/13/23
-
2
Salts Of Nitrogen-Containing Heterocyclic Compound, And Solid Forms Of Salts, Pharmaceutical Composition And Use Thereof
Wuhan Humanwell Innovative Drug Research and Development Center
11/13/23
-
21
1H-IMIDAZO [4,5-H] QUINAZOLINE COMPOUND AS NOVEL SELECTIVE FLT3 INHIBITORS
Shengke Pharmaceuticals (Jiangsu)
11/13/23
-
46
PTERIDINONE COMPOUNDS AND USES THEREOF
Vertex Pharmaceuticals
11/13/23
-
39
THIAZOLO[5,4-B]PYRIDINE MALT-1 INHIBITORS
Abbvie
11/13/23
-
236
PYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF
Biosplice Therapeutics
11/13/23
-
8
Substituted pyridines as DNMT1 inhibitors
Glaxosmithkline Intellectual Property Development
11/07/23
-
396
Furin inhibitors
Glaxosmithkline Intellectual Property Development
11/07/23
-
84
Methods and compounds for treating disorders
Foghorn Therapeutics
11/07/23
-
39
BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
Academy of Military Medical Sciences
11/06/23
-
9
BENZYLAMINE OR BENZYL ALCOHOL DERIVATIVE AND USES THEREOF
Chengdu Hyperway Pharmaceuticals
11/06/23
-
5
COMPOSITIONS AND METHODS FOR THE PREVENTION AND/OR TREATMENT OF MITOCHONDRIAL DISEASE, INCLUDING FRIEDREICH'S ATAXIA
Stealth Biotherapeutics
11/06/23
-
73
OXOPYRROLIDINE UREA FPR2 AGONISTS
Bristol-Myers Squibb
11/06/23
-
258
2-AMINOQUINAZOLINES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
Merck Sharp & Dohme
11/06/23
-
12
N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS
Mission Therapeutics
11/06/23
-
53
CDK6/DYRK2 DUAL-TARGET INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Jiangsu Tasly Diyi Pharmaceutical
11/06/23
-
13
PIPERAZINE SUBSTITUTED INDAZOLE COMPOUNDS AS INHIBITORS OF PARG
Ideaya Biosciences
11/06/23
-
1
CRYSTALLINE FORM OF TLR8 AGONIST
Chia Tai Tianqing Pharmaceutical Group
11/06/23
-
11
PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Sichuan Kelun-Biotech Biopharmaceutical
11/06/23
-
91
MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF
Children'S Hospital Medical Center
11/06/23
-
13
PYRIMIDINE RING COMPOUND
Medshine Discovery
11/06/23
-
2
ORALLY BIOAVAILABLE, BRAIN-PENETRANT COMPOUND WITH SELECTIVITY FOR THE CANNABINOID TYPE 2 RECEPTOR WITH POTENTIAL USE TOWARDS VISCERAL PAIN MANAGEMENT AND NEURODEGENERATIVE DISORDERS
University of Mississippi
11/06/23
-
59
4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE SUMO INHIBITORS AND USES THEREOF
Suvalent Therapeutics
11/06/23
-
13
Advantageous benzofuran compositions for mental disorders or enhancement
Tactogen
11/02/23
-
18
Nicotinamide RIPK1 inhibitors
Abbvie
11/02/23
-
44
Tricyclic pyridone compounds as JAK2 V617F inhibitors
Incyte
11/02/23
-
43
Glucose-sensitive albumin-binding derivatives
Novo Nordisk
11/02/23
-
258
ANTAGONIST COMPOUNDS
Adorx Therapeutics
10/30/23
-
137
INTEGRIN INHIBITORS AND USES THEREOF IN COMBINATION WITH OTHER AGENTS
Pliant Therapeutics
10/30/23
-
67
PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
Akebia Therapeutics
10/30/23
-
329
SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES
Gossamer Bio Services
10/30/23
-
170
COMPOUND USEFUL AS CDK7 KINASE INHIBITOR AND USE THEREOF
Tyk Medicines
10/30/23
-
94
INHIBITORS OF VAP-1
Acucela
10/30/23
-
36
NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
Chong Kun Dang Pharmaceutical
10/30/23
-
357
3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS
Janssen Pharmaceutica
10/30/23
-
29
ATX INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Suzhou Ark Biopharmaceutical
10/30/23
-
47
ATR INHIBITORS AND USES THEREOF
Antengene Discovery
10/30/23
-
128
FUSED HETEROAROMATIC PYRROLIDINONES
Calithera Biosciences
10/30/23
-
6
INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS
Sanford Burnham Prebys Medical Discovery Institute
10/30/23
-
115
SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES
Idorsia Pharmaceuticals
10/30/23
-
32
CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF
Risen (Suzhou) Pharma Tech
10/30/23
-
11
TKI permeability enhancers
City of Hope
10/29/23
-
44
Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors
University of Maryland, Baltimore
10/29/23
-
75
Methods and compositions for targeting PD-L1
Aligos Therapeutics
10/29/23
-
9
Steroids and protein-conjugates thereof
Regeneron Pharmaceuticals
10/29/23
-
58
NEPRILYSIN INHIBITORS
Theravance Biopharma R&D Ip
10/23/23
-
47
KCNT1 INHIBITORS AND METHODS OF USE
Praxis Precision Medicines
10/23/23
-
10
METHOD FOR TREATING GRAFT VERSUS HOST DISEASE CAUSED BY HEMATOPOIETIC STEM CELL TRANSPLANTATION
Beijing Tide Pharmaceutical
10/23/23
-
32
QUINAZOLINONE HSD17B13 INHIBITORS AND USES THEREOF
Inipharm
10/23/23
-
33
PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
Huyabio International
10/23/23
-
139
IL-17A MODULATORS
Sanofi
10/23/23
-
238
ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF
Biosplice Therapeutics
10/23/23
-
56
HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
Huyabio International
10/23/23
-
59
1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES
Duksung Women''S University Industry-Academic Cooperation Foundation
10/23/23
-
185
PLASMA KALLIKREIN INHIBITORS
Merck Sharp & Dohme
10/23/23
-
96
ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE
Petra Pharma
10/23/23
-
417
NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS
Italfarmaco
10/23/23
-
13
INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1
Disarm Therapeutics
10/23/23
-
3
SALT OF DIHYDROPYRIDO[2,3-D]PYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Nanjing Chia Tai Tianqing Pharmaceutical
10/23/23
-
120
BCL6 INHIBITORS
Cancer Research Technology
10/23/23
-
137
Treating primary or idiopathic hyperoxaluria with small molecule inhibitors of lactate dehydrogenase
Vanderbilt University
10/20/23
-
34
Muscarinic acetylcholine M1 receptor antagonists
Pipeline Therapeutics
10/20/23
-
57
Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders
Rugen Holdings (Cayman)
10/20/23
-
30
Disulfiram derivatives as ALDH1A1 and MAGL inhibitors
Batterjee Medical College
10/20/23
-
55
Protease inhibitors as antivirals
Acea Therapeutics
10/20/23
-
295
EIF4E inhibitors and uses thereof
Pic Therapeutics
10/20/23
-
187
DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF
Inipharm
10/18/23
-
5
DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO
Arena Pharmaceuticals
10/17/23
-
20
ROR-GAMMA MODULATORS
Escalier Biosciences
10/17/23
-
207
COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Plexxikon
10/17/23
-
34
ENPP1 Inhibitors and Their Use for the Treatment of Cancer
The Board of Trustees of The Leland Stanford Junior University
10/17/23
-
37
CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS
Astrazeneca
10/17/23
-
90
INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER
Universite Claude Bernard Lyon 1
10/17/23
-
7
NOVEL TRICYCLIC AROMATIC HETEROCYCLIC COMPOUND AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Shanghai Longwood Biopharmaceuticals
10/17/23
-
188
YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
Molecure
10/17/23
-
143
Compound containing structure of a five-membered heteroaromatic ring, pharmaceutical compositions thereof and applications thereof
280 Bio
10/17/23
-
4
IMIDAZO[1,2-A]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
Hoffmann-La Roche
10/17/23
-
26
PTGR2 INHIBITORS AND THEIR USE
National Health Research Institutes
10/17/23
-
1030
CARM1 INHIBITORS AND USES THEREOF
Epizyme
10/17/23
-
160
N/O-Linked Degrons and Degronimers for Protein Degradation
C4 Therapeutics
10/17/23
-
29
TRIAZINE COMPOUND AND COMPOSITION AND USE THEREOF
Beijing Findcure Biosciences
10/17/23
-
461
KRAS G12D INHIBITORS
Mirati Therapeutics
10/17/23
-
54
Benzimidazole Derivative Compounds and Uses Thereof
Pfizer
10/17/23
-
44
COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF
Ono Pharmaceutical
10/16/23
-
250
COMPOUNDS USEFUL AS T CELL ACTIVATORS
Gossamer Bio Services
10/16/23
-
100
AMIDE DERIVATIVES
Merck Patent
10/16/23
-
20
CONDENSED PYRAZOLE DERIVATIVES AS INHIBITORS OF SARM1
Disarm Therapeutics
10/16/23
-
3
SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE
Nanjing Chia Tai Tianqing Pharmaceutical
10/16/23
-
144
AMINO ACID COMPOUNDS AND METHODS OF USE
Pliant Therapeutics
10/16/23
-
549
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
Vertex Pharmaceuticals
10/16/23
-
98
5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER
Astrazeneca
10/16/23
-
5
PRPK INHIBITORS
Dana-Farber Cancer Institute
10/16/23
-
24
PYRAZOLOPYRIMIDINE COMPOUND USED AS ATR KINASE INHIBITOR
Beijing Tide Pharmaceutical
10/16/23
-
135
SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF
Gilead Sciences
10/15/23
-
176
COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE
Chugai Seiyaku Kabushiki Kaisha
10/15/23
-
210
BENZODIAZEPINE DERIVATIVES USEFUL IN TREATING A RESPIRATORY SYNCYTIAL VIRUS INFECTION
Reviral
10/15/23
-
164
CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR
Bayer Pharma Aktiengesellschaft
10/15/23
-
124
COMPOUNDS ACTIVE TOWARDS NUCLEAR RECEPTORS
Nuevolution
10/15/23
-
42
4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS
Ip2Ipo Innovations
10/15/23
-
76
COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY
Ifm Due
10/15/23
-
129
INHIBITORS OF APOL1 AND METHODS OF USING SAME
Vertex Pharmaceuticals
10/15/23
-
412
GLP-1R MODULATING COMPOUNDS
Ascletis Bioscience
10/15/23
-
162
2-amino-3-carbonyl imidazopyridine and pyrazolopyridine compounds
1St Biotherapeutics
10/06/23
-
10
Method of increasing platelet counts of a subject
Korea Basic Science Institute
10/06/23
-
56
ALK-5 inhibitors and uses thereof
Sumitomo Pharma Oncology
10/06/23
-
16
Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity
Shenzhen Targetrx
10/06/23
-
43
Labelled cannabinergic ligands and related analogs
Individual
10/06/23
-
22
Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof
Insilico Medicine Ip
10/01/23
-
125
Methods of inhibiting kinases
Insilico Medicine Ip
10/01/23
-
31
Acetamido-phenyltetrazole derivatives and methods of using the same
Athenex
10/01/23
-
10
Substituted pyrazlo[3,4-c]pyridines as selective BTK kinase inhibitors
Jumbo Drug Bank
10/01/23
-
5
Substituted pyrazolopyrazines, imidazopyrazines and [1,2,4]triazolopyrazines as allosteric SHP2 inhibitors
Revolution Medicines
10/01/23
-
93
SARS-CoV-2 inhibitors for treating coronavirus infections
Insilico Medicine Ip
09/26/23
-
36
Histone demethylase inhibitors
Celgene Quanticel Research
09/26/23
-
106
Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors
Alumis
09/26/23
-
105
Carboxamide compounds and uses thereof
Incyte
09/26/23
-
58
Spiro compounds as glycosidase inhibitors
Asceneuron
09/26/23
-
31
Substituted pyrazolo[3,4-d]pyrimidines as mTOR inhibitors
Galderma Research & Development
09/26/23
-
47
N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
Ogeda
09/26/23
-
41
HDAC inhibitor compounds and methods of treatment
University of Florida Research Foundation
09/25/23
-
298
Therapeutic compounds, compositions and methods of use thereof
Genentech
09/25/23
-
253
Bicyclic compound and use thereof
Sk Biopharmaceuticals
09/23/23
-
20
(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
Centrexion Therapeutics
09/23/23
-
43
Compositions and methods for inhibiting kinases
Inhibikase Therapeutics
09/23/23
-
151
Polyheterocyclic compounds as METTL3 inhibitors
Storm Therapeutics
09/23/23
-
3
Bicyclic urea kinase inhibitors and uses thereof
The General Hospital
09/23/23
-
52
Quinazoline derivatives as antitumor agents
Suzhou Zanrong Pharma
09/21/23
-
49
Methods of improving cell-based therapy
University of California
09/21/23
-
80
MCT4 inhibitors for treating disease
Vettore
09/21/23
-
176
Compounds and compositions for treating conditions associated with NLRP activity
Novartis
09/21/23
-
415
Apoptosis inhibitors
National Institute of Biological Sciences, Beijing
09/21/23
-
19
N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors
The Regents of The University of Michigan
09/17/23
-
27
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D Ip
09/17/23
-
106
Substituted pyrido[2,1-a]isoquinolines as VMAT2 inhibitors
Neurocrine Biosciences
09/17/23
-
63
Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
Ardelyx
09/17/23
-
222
Heterocyclic adenosine receptor antagonists
Exelixis
09/17/23
-
3
Treatment of spondyloarthritis
Pharmacyl
09/15/23
-
164
Compositions and methods of modulating short-chain dehydrogenase
Case Western Reserve University
09/15/23
-
570
CDK2 inhibitors
Pfizer
09/15/23
-
13
Heterocyclic compounds as immunomodulators
Incyte
09/15/23
-
25
Heparanase inhibitors and use thereof
Beta Therapeutics
09/15/23
-
1
Benzenesulfonylbenazamide compound for inhibiting BCL-2 protein and composition and use thereof
Shenzhen Targetrx
09/15/23
-
70
Inhibitors of receptor interacting protein kinase I for the treatment of disease
Board of Regents, The University of Texas System
09/15/23
-
5
Bismuth(III) compounds and methods thereof
The University of Hong Kong
09/08/23
-
332
Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
Sanford Burnham Prebys Medical Discovery Institute
09/08/23
-
187
Cyanotriazole compounds
Otsuka Pharmaceutical
09/08/23
-
107
Azole derivatives as apelin receptor agonist
Sanford Burnham Prebys Medical Discovery Institute
09/08/23
-
117
Inhibitor of lysine specific demethylase-1
Celgene Quanticel Research
09/08/23
-
3
Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor
Chia Tai Tianqing Pharmaceutical Group
09/08/23
-
9
Heterocyclic indoles for use in influenza virus infection
Janssen Sciences Ireland Uc
09/08/23
-
420
Heterocyclic sulfonamide derivative and medicine comprising same
Ea Pharma
09/08/23
-
14
Phosphodiesterase inhibitors and uses thereof
Columbia University
09/08/23
-
42
Peptide derivatives and uses thereof
Nosopharm
09/08/23
-
44
GSK-3 inhibitors
Bristol-Myers Squibb
09/04/23
-
216
2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
Bayer Aktiengesellschaft
09/04/23
-
39
5-substituted difluoropiperidine compounds with blood-brain barrier penetrable capability
Wayshine Biopharm Holding
09/04/23
-
102
Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases
Chemocentryx
09/04/23
-
12
5 to 7 membered heterocyclic amides as JAK inhibitors
Theravance Biopharma R&D Ip
09/04/23
-
143
5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
Biosplice Therapeutics
09/04/23
-
44
Inhibitors of NEK7 kinase
Halia Therapeutics
09/04/23
-
26
Heteroaryl heterocyclyl compounds for the treatment of autoimmune disease
Hoffmann-La Roche
09/04/23
-
267
Protein kinase modulators
Cylene Pharmaceuticals
08/31/23
-
218
Fused 1,4-dihydrodioxin derivatives as inhibitors of heat shock transcription factor 1
Cancer Research Technology
08/31/23
-
44
Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators
Idorsia Pharmaceuticals
08/31/23
-
34
ENPP1 inhibitors and their use for the treatment of cancer
The Board of Trustees of The Leland Stanford Junior University
08/27/23
-
89
FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto
Tufts College
08/27/23
-
410
Immunomodulator compounds
Chemocentryx
08/27/23
-
250
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
08/27/23
-
536
Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
Biocryst Pharmaceuticals
08/27/23
-
563
Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
Achillion Pharmaceuticals
08/27/23
-
122
Monoacylglycerol lipase modulators
Janssen Pharmaceutica
08/27/23
-
92
Azaindole derivatives and their use as ERK kinase inhibitors
Agv Discovery
08/27/23
-
34
Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
Novartis
08/27/23
-
30
Compounds for the treatment of kinase-dependent disorders
Exelixis
08/27/23
-
41
Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors
D. E. Shaw Research
08/18/23
-
8
Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
Genuv
08/18/23
-
34
ENPP1 inhibitors and their use for the treatment of cancer
The Board of Trustees of The Leland Stanford Junior University
08/18/23
-
9
Substituted bicyclic compounds
Bristol-Myers Squibb
08/18/23
-
143
Pyrimidinone derivatives as SHP2 antagonists
Merck Patent
08/18/23
-
36
Compounds and methods of use
Medivation Technologies
08/18/23
-
94
Pyrazolyl derivatives useful as anti-cancer agents
Novartis
08/18/23
-
34
Pyridine, pyrazine, and triazine compounds as allosteric SHP2 inhibitors
Revolution Medicines
08/18/23
-
303
Thiadiazole IRAK4 inhibitors
Gilead Sciences
08/18/23
-
2
Crystalline hydrate of a JAK inhibitor compound
Theravance Biopharma R&D Ip
08/18/23
-
98
1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte
08/18/23
-
365
SOS1 inhibitors
Mirati Therapeutics
08/18/23
-
364
Bicyclic-fused heteroaryl or aryl compounds
Pfizer
08/18/23
-
100
Carboxamide-pyrimidine derivatives as SHP2 antagonists
Merck Patent
08/11/23
-
79
Agent enhancing antitumor effect using pyrazolo[3,4-d]pyrimidine compound
Taiho Pharmaceutical
08/11/23
-
318
Substituted benzamides
Hoffmann-La Roche
08/11/23
-
264
Fused pyrimidine pyridinone compounds as JAK inhibitors
Theravance Biopharma R&D Ip
08/11/23
-
42
Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors
Eil Therapeutics
08/11/23
-
101
Inhibitors of receptor interacting protein kinase I for the treatment of disease
Board of Regents, The University of Texas System
08/06/23
-
93
Isoindoline compositions and methods for treating neurodegenerative disease
Cognition Therapeutics
08/06/23
-
21
Isoquinoline-steroid conjugates and uses thereof
Aerie Pharmaceuticals
08/06/23
-
15
2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament
Boehringer Ingelheim International
08/06/23
-
217
Therapeutic compounds and compositions
Exithera Pharmaceuticals
08/06/23
-
234
6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
Ajax Therapeutics
08/06/23
-
1
Method for preparing pyrrolidinyl urea derivative
Zhangzhou Pien Tze Huang Pharmaceutical
08/06/23
-
44
Compound having KDM5 inhibitory activity and pharmaceutical use thereof
Ono Pharmaceutical
08/06/23
-
96
Pyridazinones as PARP7 inhibtors
Ribon Therapeutics
08/06/23
-
24
Naphthyridinone compounds as JAK2 V617F inhibitors
Incyte
08/06/23
-
25
MAGL inhibitors
H. Lundbeck
08/06/23
-
82
Cyclic ether derivatives of pyrazolo[1,5-A]pyrimidine-3-carboxyamide
Boehringer Ingelheim International
08/06/23
-
80
Heterocyclic compounds, preparation methods therefor, and methods of uses thereof
Inventisbio
08/06/23
-
25
Macrocyclic immunomodulators
Chemocentryx
08/06/23
-
51
Macrocyclic indoles as Mcl-1 inhibitors
Ascentage Pharma (Suzhou)
08/06/23
-
106
Azalactam compounds as HPK1 inhibitors
Pfizer
07/31/23
-
24
Pyridinone MK2 inhibitors and uses thereof
Xinthera
07/31/23
-
245
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
07/31/23
-
82
C5a receptor modulators
Idorsia Pharmaceuticals
07/31/23
-
491
MYST family histone acetyltransferase inhibitors
Epizyme
07/31/23
-
121
ATM kinase inhibitors and compositions and methods of use thereof
Chdi Foundation
07/31/23
-
14
Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
Ocuterra Therapeutics
07/31/23
-
123
CDK inhibitors and their use as pharmaceuticals
Prelude Therapeutics
07/31/23
-
385
Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors
Dart Neuroscience
07/31/23
-
2
Methods of treating disorders using CSF1R inhibitors
Deciphera Pharmaceuticals
07/25/23
-
37
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
Astrazeneca
07/25/23
-
82
MK2 inhibitors and uses thereof
Xinthera
07/25/23
-
137
Bicycloheptane pyrrolidine orexin receptor agonists
Merck Sharp & Dohme
07/25/23
-
55
Compounds useful as RET inhibitors
Cancer Research Technology
07/25/23
-
22
Compounds and compositions as protein kinase inhibitors
Array Biopharma
07/25/23
-
16
Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors
Mekanistic Therapeutics
07/19/23
-
7
Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs
Olema Pharmaceuticals
07/16/23
-
13
Histone deacetylase inhibitors for immunomodulation in tumor microenvironment
Great Novel Therapeutics Biotech & Medicals
07/16/23
-
159
Pyridone amides as modulators of sodium channels
Vertex Pharmaceuticals
07/16/23
-
40
Amino pyrimidine derivatives
Novartis
07/16/23
-
21
Pharmaceutical compounds
Sareum
07/16/23
-
35
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
Astrazeneca
07/16/23
-
303
Isoquinolin-3-yl carboxamides and preparation and use thereof
Biosplice Therapeutics
07/16/23
-
51
Heterocyclic compounds as immunomodulators
Incyte
07/16/23
-
12
Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
Foresee Pharmaceuticals
07/16/23
-
155
5-membered and bicyclic heterocyclic amides as inhibitors of ROCK
Bristol-Myers Squibb
07/16/23
-
17
Bicyclic compounds as ATX inhibitors
Hoffmann-La Roche
07/16/23
-
88
CDK inhibitors and their use as pharmaceuticals
Prelude Therapeutics
07/16/23
-
96
Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
Incyte
07/16/23
-
11
Compounds for the treatment of kinase-dependent disorders
Exelixis
07/16/23
-
82
Polycyclic compounds as allosteric SHP2 inhibitors
Revolution Medicines
07/16/23
-
97
Methods of treating intraocular pressure with activators of Tie-2
Eyepoint Pharmaceuticals
07/09/23
-
7
Antibody-drug conjugates comprising a cyclic dinucleotide
Takeda Pharmaceutical
07/09/23
-
36
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
Astrazeneca
07/09/23
-
56
FGFR4 inhibitor, preparation method therefor, and applications thereof
Jiangsu Hansoh Pharmaceutical Group
07/09/23
-
65
Inhibitors of RAF kinases
Kinnate Biopharma
07/09/23
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
07/09/23
-
11
Fused imidazo-piperidine JAK inhibitors
Theravance Biopharma R&D Ip
07/09/23
-
50
4-substitued cytisine analogues
University of Bristol
07/09/23
-
80
RIP1K inhibitors
Rigel Pharmaceuticals
07/09/23
-
378
Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
Janssen Pharmaceutica
07/09/23
-
148
Granzyme B directed imaging and therapy
Cytosite Biopharma
07/09/23
-
204
MCL1 inhibitors
Gilead Sciences
07/09/23
-
206
Therapeutically active compounds and their methods of use
Servier Pharmaceuticals
07/09/23
-
26
Tricyclic urea compounds as JAK2 V617F inhibitors
Incyte
07/03/23
-
86
Heterocyclic compounds as RET kinase inhibitors
Cancer Research Technology
07/03/23
-
496
Imidazole-containing inhibitors of ALK2 kinase
Biocryst Pharmaceuticals
07/03/23
-
18
Tetrazole derivatives as TRPA1 inhibitors
Boehringer Ingelheim International
07/03/23
-
8
Thienopyrrole compounds
Gilead Sciences
07/03/23
-
129
Substituted 2-azabicyclo[3.1.1]heptane and 2-azabicyclo[3.2.1]octane derivatives as orexin receptor antagonists
Chronos Therapeutics
07/02/23
-
28
Treatment of Rett syndrome
Cold Spring Harbor Laboratory
07/02/23
-
87
Tricyclic compounds as histone methyltransferase inhibitors
Global Blood Therapeutics
07/02/23
-
13
MASP-2 inhibitors and methods of use
Omeros
07/02/23
-
54
Benzimidazole derivative compounds and uses thereof
Pfizer
07/02/23
-
170
ALK2 inhibitors and methods for inhibiting BMP signaling
The Brigham and Women'S Hospital
06/26/23
-
252
Pyrazole MAGL inhibitors
H. Lundbeck
06/26/23
-
37
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
Astrazeneca
06/26/23
-
32
Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
06/26/23
-
4
Glucagon-like peptide1 receptor agonists
Eli Lilly
06/26/23
-
32
Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
Hoffmann-La Roche
06/26/23
-
23
Indolizine derivatives and their application in medicine
Kind Pharmaceutical
06/26/23
-
4
Aminopyrimidinyl derivatives
Pfizer
06/26/23
-
6
Substituted piperazines as BTK inhibitors
Hutchison Medipharma
06/26/23
-
50
Selective androgen receptor degrader (SARD) ligands and methods of use
University of Tennessee Research Foundation
06/19/23
-
814
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
06/19/23
-
320
Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling
Kumquat Biosciences
06/19/23
-
81
C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
The United States of America, As Represented By The Secretary, Department of Health and Human Services
06/19/23
-
98
Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease
Petra Pharma
06/19/23
-
8
Amide compounds for treatment of immune and inflammatory disorders
Achillion Pharmaceuticals
06/19/23
-
18
Compound as mTOR inhibitor and use thereof
Medicinal Bioconvergence Research Center
06/19/23
-
18
Halo-allylamine SSAO/VAP-1 inhibitor and use thereof
Nanjing Transthera Biosciences
06/19/23
-
2
Pan-tropic entry inhibitors
Emory University
06/19/23
-
228
Substituted imidazo[1,5-a]pyrazines for IRE1 inhibition
Optikira
06/19/23
-
111
Substituted 4-phenylpiperidines, their preparation and use
Columbia University
06/19/23
-
14
Pyrazolochlorophenyl compounds, compositions and methods of use thereof
Genentech
06/19/23
-
8
7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
Eli Lilly
06/19/23
-
113
Oxadiazaspiro compounds for the treatment of drug abuse and addiction
Esteve Pharmaceuticals
06/19/23
-
663
Indazoles as hematopoietic progenitor kinase 1 (HPK1) inhibitors and methods using same
1St Biotherapeutics
06/19/23
-
2
5-HT2A agonists for use in treatment of depression
Lophora
06/11/23
-
46
Substituted benzene compounds
Epizyme
06/11/23
-
8
Compounds for degrading Tau protein aggregates and uses thereof
Aprinoia Therapeutics
06/11/23
-
9
Derivatives of 4-aminoantipyrine as anti-Alzheimers butyrylcholinesterase inhibitors
Individual
06/11/23
-
156
BRD4-kinase inhibitors as cancer therapeutics
H. Lee Moffitt Cancer Center and Research Institute
06/11/23
-
443
MCL-1 inhibitors
Gilead Sciences
06/11/23
-
11
GLP-1 receptor agonist and use thereof
Ildong Pharmaceutical
06/11/23
-
31
Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors
G1 Therapeutics
06/11/23
-
144
Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof
Japan Tobacco
06/11/23
-
10
Polypeptide compound, pharmaceutical composition, preparation method and application thereof
Chengdu Sintanovo Biotechnology
06/11/23
-
78
Compounds for the treatment of BRAF-associated diseases and disorders
Array Biopharma
06/02/23
-
53
Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
Pfizer
06/02/23
-
192
Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines
H. Lundbeck
06/02/23
-
155
Amino acid compounds and methods of use
Pliant Therapeutics
06/02/23
-
11
Dimethyl amino azetidine amides as JAK inhibitors
Theravance Biopharma R&D Ip
06/02/23
-
18
Diazaindole derivative and use thereof as CHK1 inhibitor
Medshine Discovery
06/02/23
-
124
Pharmaceutical compounds
Pfizer
06/02/23
-
22
Selective estrogen receptor degraders
Eli Lilly
06/02/23
-
99
Substituted amino triazoles useful as chitinase inhibitors
Molecure
06/02/23
-
48
Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals
06/02/23
-
14
Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors
Luoxin Pharmaceutical (Shanghai)
06/02/23
-
93
Pyrazoles
Janssen Pharmaceuticals
06/02/23
-
9
Method for controlling hematophagous or sap-feeding arthropods
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
06/01/23
-
19
Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor
Sumitomo Pharma
06/01/23
-
17
6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
Sprint Bioscience
06/01/23
-
21
Compounds and methods useful for treating or preventing cancers
The Broad Institute
06/01/23
-
253
Compounds which are inhibitors of Notum
Ucl Business
06/01/23
-
260
Sulfonamide compound or salt thereof
Taiho Pharmaceutial
06/01/23
-
313
Opioid receptor modulators
Epiodyne
06/01/23
-
90
Selective D3 dopamine receptor agonists and methods of their use
The United States of America, As Represented By The Secretary, Department of Health and Human Services
06/01/23
-
39
Lymphoid-specific tyrosine phosphatase (LYP) inhibitors
Purdue Research Foundation
05/27/23
-
57
Substituted pyridine derivatives as SARM1 inhibitors
Nura Bio
05/27/23
-
111
SHP2 phosphatase inhibitors and methods of use thereof
D. E. Shaw Research
05/27/23
-
46
Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of sodium channel activity
Praxis Precision Medicines
05/27/23
-
21
Triazolo-pyrimidine compounds and uses thereof
Dizal (Jiangsu) Pharmaceutical
05/27/23
-
32
Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
Shionogi
05/27/23
-
14
7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
Eli Lilly
05/27/23
-
2
Method of treatment with histamine-3 receptor inverse agonist
Suven Life Sciences
05/22/23
-
223
Indole carboxamide compounds
Bristol-Myers Squibb
05/22/23
-
19
Uracil compound as c-MET/AXL inhibitor
Medshine Discovery
05/22/23
-
15
Spirocyclic compounds
C4 Therapeutics
05/22/23
-
4
Protein degraders and uses thereof
Kymera Therapeutics
05/22/23
-
20
6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
Purdue Research Foundation
05/11/23
-
186
Benzoimidazoles as prolyl hydroxylase inhibitors
Janssen Pharmaceutica
05/11/23
-
1532
Aminopyrrolotriazines as kinase inhibitors
Bristol-Myers Squibb
05/11/23
-
18
Compounds active towards nuclear receptors
Nuevolution
05/10/23
-
19
Heterocyclic compounds as immunomodulators
Incyte
05/10/23
-
83
Substituted pyridotriazine compounds and uses thereof
Gilead Sciences
05/10/23
-
36
Oxysterols and methods of use thereof
Sage Therapeutics
05/10/23
-
10
Pharmaceutical formulations comprising CCR3 antagonists
Alkahest
05/09/23
-
123
Glycosidase inhibitors
Asceneuron
05/09/23
-
24
3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof
Shaanxi Panlong Pharmaceutical
05/09/23
-
302
8-aminoisoquinoline compounds and uses thereof
Genentech
05/09/23
-
62
Substituted condensed thiophenes as modulators of sting
Ctxt Pty
05/09/23
-
116
Enzyme inhibitors
Kalvista Pharmaceuticals
05/09/23
-
167
Inhibitors of RHO associated coiled-coil containing protein kinase
Kadmon
05/09/23
-
106
Bicyclic amide compounds and methods of use thereof
Genentech
05/05/23
-
9
Curcumin analogues as zinc chelators and their uses
The Research Foundation For The State University of New York
05/05/23
-
22
Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase
Industrial Technology Research Institute
05/05/23
-
161
Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
The Institute of Cancer Research: Royal Cancer Hospital
05/05/23
-
42
FGFR4 inhibitor and preparation method and use thereof
Jiangsu Hansoh Pharmaceutical Group
05/05/23
-
40
Heterocyclic compounds as immunomodulators
Incyte
05/05/23
-
138
Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
Merck Patent
05/05/23
-
5
PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
H. Lundbeck
05/05/23
-
93
Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors
Hoffmann-La Roche
05/05/23
-
19
Compounds and therapeutic uses thereof
Viogen Biosciences
04/30/23
-
34
Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
Array Biopharma
04/30/23
-
64
MTORC1 modulators and uses thereof
Aeovian Pharmaceuticals
04/30/23
-
285
PCSK9 inhibitors and methods of use thereof
Astrazeneca
04/30/23
-
26
JAK1 pathway inhibitors for the treatment of gastrointestinal disease
Incyte
04/23/23
-
3
SHP2 inhibitor compositions and methods for treating cancer
Revolution Medicines
04/23/23
-
719
Substituted indole Mcl-1 inhibitors
Vanderbilt University
04/23/23
-
20
PD-L1/STING conjugates and methods of use
Incyte
04/23/23
-
427
Monoacylglycerol lipase modulators
Janssen Pharmaceutica
04/23/23
-
19
Compounds and compositions for the treatment of parasitic diseases
Novartis
04/23/23
-
4
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
Mindset Pharma
04/23/23
-
10
Enhancing CD8+ T cells for adoptive T cell therapy by inhibiting PTPN1 (PTP1B) and PTPN2 (TC-PTP)
The Royal Institution For The Advancement of Learning/Mcgill University
04/23/23
-
53
Cyclic dinucleotides as sting agonists
Janssen Biotech
04/23/23
-
28
Benzamide compounds
Recurium Ip Holdings
04/14/23
-
14
Oxazolidinone antibiotic compounds and process of preparation
Bugworks Research
04/14/23
-
25
Indoleamine-2,3-dioxygenase inhibitor, preparation method therefor and use thereof
Hinova Pharmaceuticals
04/14/23
-
40
Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof
Stingray Therapeutics
04/14/23
-
164
Compounds, compositions, and methods
Denali Therapeutics
04/14/23
-
13
Bipyrazole derivatives as JAK inhibitors
Incyte
04/14/23
-
51
Small molecule inducers of autophagy
Board of Regents, The University of Texas System
04/14/23
-
27
Certain chemical compositions and methods of use thereof
Algen Biotechnologies
04/14/23
-
73
Inhibitors of protein arginine methyltransferase 5 (PRMT5), pharmaceutical products thereof, and methods thereof
Pharmablock Sciences (Nanjing)
04/14/23
-
26
Highly active CSF1R inhibitor compound
Xiamen Biotime Biotechnology
04/14/23
-
26
Bicyclic heterocycles as FGFR inhibitors
Incyte
04/14/23
-
99
PARP1 inhibitors and uses thereof
Xinthera
04/14/23
-
514
Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
D. E. Shaw Research
04/14/23
-
144
Pyrrolotriazine compounds as TAM inhibitors
Incyte
04/14/23
-
46
Heterocyclic compound, application thereof and pharmaceutical composition comprising same
Suzhou Sinovent Pharmaceuticals
04/14/23
-
3
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
Mindset Pharma
04/14/23
-
13
Dash inhibitors, and uses related thereto
Tufts College
04/09/23
-
73
Triazolopyrimidine derivatives for use as ghrelin o-acyl transferase (GOAT) inhibitors
Boehringer Ingelheim International
04/09/23
-
145
Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
Venenum Biodesign
04/09/23
-
479
MASP-2 inhibitors and methods of use
Omeros
04/09/23
-
4
Amino alcohol derivative, pharmaceutical composition and application thereof
Beijing Foreland Pharma
04/09/23
-
6
Compositions and methods for the prevention and/or treatment of mitochondrial disease, including Friedreich's ataxia
Stealth Biotherapeutics
04/09/23
-
22
Methods of treatment using 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
Heptares Therapeutics
04/09/23
-
2
Solid forms of a plasma kallikrein inhibitor and salts thereof
Kalvista Pharmaceuticals
04/09/23
-
15
Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof
Shanghai Yingli Pharmaceutical
04/09/23
-
27
Inhibitors of EGFR and methods of use thereof
Dana-Farber Cancer Institute
04/09/23
-
225
Substituted pyridopyrimidinonyl compounds useful as T cell activators
Bristol-Myers Squibb
04/09/23
-
80
Spirocyclic compounds
C4 Therapeutics
04/09/23
-
165
Dihydrothieno[3,2-b]pyridine compounds
Ideaya Biosciences
04/09/23
-
33
Heterocyclic compounds as BET inhibitors
Nuvation Bio
04/09/23
-
57
RIP1K inhibitors
Rigel Pharmaceuticals
04/09/23
-
64
Therapeutic agent for non-motor symptoms associated with Parkinson's disease
Sumitomo Pharma
03/31/23
-
20
Inhibiting mutant IDH-1
Forma Therapeutics
03/31/23
-
21
Compounds useful as immunomodulators
Bristol-Myers Squibb
03/31/23
-
3
Heterocyclic compounds for inhibiting TYK2 activities
Beijing Innocare Pharma Tech
03/31/23
-
282
Inhibitors of LRRK2 kinase
Halia Therapeutics
03/31/23
-
289
Fluoroalkyl-oxadiazoles and uses thereof
Tenaya Therapeutics
03/31/23
-
72
Spiro-oxazolones
Hoffmann-La Roche
03/31/23
-
22
Heterocyclic RIP1 inhibitory compounds
Rigel Pharmaceuticals
03/31/23
-
23
Thienopyrimidones
Boehringer Ingelheim International
03/31/23
-
227
Condensed ring compounds having dopamine D3 receptor antagonistic effect
Shionogi
03/31/23
-
38
Pyrazine compounds and uses thereof
Dizal (Jiangsu) Pharmaceutical
03/26/23
-
44
Antibacterial agents: arylalkylcarboxamido phloroglucinols
Rutgers, The State University of New Jersey
03/26/23
-
14
Cyanoaryl-aniline compounds for treatment of dermal disorders
Nflection Therapeutics
03/26/23
-
29
Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof
Beijing Innocare Pharma Tech
03/26/23
-
26
Inhibitor of indoleamine 2,3-dioxygenase-1 and methods of manufacture and use thereof
University Health Network
03/26/23
-
73
Pyrrolo[1,2-b]pyridazine derivatives
Gilead Sciences
03/26/23
-
40
Heterocyclic compounds as immunomodulators
Incyte
03/26/23
-
171
Inhibitors of histone deacetylase
The General Hospital
03/26/23
-
4
BRD4 inhibitor
Hinova Pharmaceuticals
03/26/23
-
452
N-cyano-7-azanorbornane derivatives and uses thereof
Amgen
03/26/23
-
2
Inhibiting mutant isocitrate dehydrogenase 1 (mIDH1)
Forma Therapeutics
03/20/23
-
4
Heterocyclic compounds as immunomodulators
Incyte
03/20/23
-
69
Bicyclic heterocycles as FGFR inhibitors
Incyte
03/20/23
-
377
Indole compounds and analogues thereof
Biocryst Pharmaceuticals
03/19/23
-
50
Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists
Tufts College
03/19/23
-
149
Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors
Pfizer
03/19/23
-
17
Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
Board of Regents, The University of Texas System
03/19/23
-
70
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
03/19/23
-
158
5-membered heteroaryl carboxamide compounds for treatment of HBV
Assembly Biosciences
03/19/23
-
17
Morpholinylpyridone compounds
Sprint Bioscience
03/19/23
-
145
Amino acid compounds and methods of use
Pliant Therapeutics
03/19/23
-
62
Fused amino pyridine as HSP90 inhibitors
Guris
03/19/23
-
478
Compounds and uses thereof
Foghorn Therapeutics
03/19/23
-
175
Proteasome activity enhancing compounds
Proteostasis Therapeutics
03/19/23
-
39
5-heteroaryl-1H-pyrazol-3-amine derivative
Sumitomo Pharma
03/19/23
-
158
Cannabinoid receptor type 2 (CB2) modulators and uses thereof
Teon Therapeutics
03/19/23
-
22
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals
03/19/23
-
4
Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex
Alternox Scientific
03/19/23
-
373
Isoquinolines as inhibitors of HPK1
Genentech
03/19/23
-
718
Ras inhibitors
Revolution Medicines
03/19/23
-
215
Bruton's tyrosine kinase inhibitors
Suzhou Baijibugong Pharmaceutical Technology
03/12/23
-
22
Phosphonate linkers and their use to facilitate cellular retention of compounds
Merck Sharp & Dohme
03/12/23
-
17
2-(substituted benzene matrix) aromatic formate FTO inhibitor, preparation method therefor, and applications thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
03/12/23
-
474
ACLY inhibitors and uses thereof
Nimbus Artemis
03/12/23
-
59
Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
The Usa, As Represented By The Secretary, Dhhs
03/12/23
-
656
PD-1/PD-L1 inhibitors
Gilead Sciences
03/12/23
-
98
Amide compounds as kinase inhibitors, compositions and methods of treatment
Translational Drug Development
03/12/23
-
581
Transglutaminase 2 (TG2) inhibitors
Sitari Pharma
03/06/23
-
109
Heterocyclic compounds as RET kinase inhibitors
Cancer Research Technology
03/06/23
-
137
Oxazino-quinazoline and oxazino-quinoline type compound, preparation method and uses thereof
Beijing Scitech-Mq Pharmaceuticals
03/06/23
-
23
Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections
Gilead Sciences
03/06/23
-
46
Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
Amgen
03/06/23
-
21
Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers
Jazz Pharmaceuticals Ireland
03/06/23
-
59
Neprilysin inhibitors
Theravance Biopharma R&D Ip
03/05/23
-
9
LSD1 inhibitors and medical uses thereof
Constellation Pharmaceuticals
03/05/23
-
523
Heterocyclic compounds and uses thereof
Millennium Pharmaceuticals
03/05/23
-
45
Kinase inhibitor compounds and compositions and methods of use
Icahn School of Medicine At Mount Sinai
03/05/23
-
13
Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1
Mangosuthu University of Technology
03/05/23
-
31
Therapeutic compounds and methods of use thereof
Ligature Therapeutics
03/05/23
-
238
Isoquinolin-3-yl carboxamides and preparation and use thereof
Biosplice Therapeutics
03/05/23
-
80
Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
Legochem Biosciences
03/05/23
-
822
HPK1 antagonists and uses thereof
Nimbus Saturn
03/05/23
-
6
Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases
Sarbonne Universite
02/26/23
-
25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease
Shy Therapeutics
02/26/23
-
5
Tetrahydroisoquinoline derivatives, preparation process and use thereof
Sichuan Kelun-Biotech Biopharmaceutical
02/26/23
-
108
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals
02/26/23
-
17
STK19 inhibitors for treatment of cancer
Trustees of Boston University
02/26/23
-
71
Substituted piperazines as selective HDAC1,2 inhibitors
Regenacy Pharmaceuticals
02/26/23
-
5
Quinoline compounds as IRAK inhibitors and uses thereof
Merck Patent
02/26/23
-
10
Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer
Janssen Pharmaceutica
02/26/23
-
47
BTK inhibitor compounds
Eli Lilly
02/26/23
-
6
IRAK degraders and uses thereof
Dana-Farber Cancer Institute
02/26/23
-
27
Methods and composition of 4-substituted benzoylpiperazine-1-substituted carbonyls as beta-catenin/B-cell lymphoma 9 inhibitors
Universisity of Utah Research Foundation
02/26/23
-
65
Compounds for the treatment of kinase-dependent disorders
Exelixis
02/26/23
-
51
Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
Children'S Hospital Medical Center
02/26/23
-
126
Pyrazolopyrimidine compounds and uses thereof
Incyte
02/26/23
-
1
Substituted piperidines as BTK inhibitors
Haisco Pharmaceuticals
02/26/23
-
5
Amide compound having bet proteolysis-inducing action and medicinal application thereof
Mitsubishi Tanabe Pharma
02/26/23
-
94
Therapeutic compounds and methods of use thereof
Agency For Science, Technology and Research (A*Star)
02/26/23
-
96
Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors
Aurigene Discovery Technologies
02/26/23
-
8
Synthesis of peptide borate ester compound and use thereof
Jiangsu Chia Tai Fenghai Pharmaceutical
02/26/23
-
42
Phenothiazine derivatives and uses thereof
Camp4 Therapeutics
02/26/23
-
46
Sting modulator compounds, and methods of making and using
Takeda Pharmaceutical
02/26/23
-
230
Compositions and methods for treating CNS disorders
Sage Therapeutics
02/26/23
-
39
Methods for treating depressive symptoms
Alkermes Pharma Ireland
02/20/23
-
198
MAP4K1 inhibitors
Blueprint Medicines
02/20/23
-
75
Quinazoline compounds, preparation method, use, and pharmaceutical composition thereof
Institute of Materia Medica, Chinese Academy of Medical Sciences
02/20/23
-
16
Analogs of dextromethorphan with balanced receptor activities
Center For Neurologic Study
02/20/23
-
26
Histone deacetylases (HDACs) inhibitors
Annji Pharmaceutical
02/20/23
-
11
Benzisoxazole derivative
Sumitomo Pharma
02/20/23
-
100
Isoindolines as HDAC inhibitors
Valo Health
02/20/23
-
85
Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
H. Lundbeck
02/20/23
-
155
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals
02/20/23
-
21
Heterocyclic compounds as immunomodulators
Incyte
02/20/23
-
287
Heterobicyclic amides as inhibitors of CD38
Ribon Therapeutics
02/20/23
-
10
Pyrrolo[1,2-b] pyridazine derivatives
Gilead Sciences
02/20/23
-
15
Dioxoloisoquinolinone derivatives and use thereof
Hanmi Pharmaceutical
02/20/23
-
16
Small molecule inhibition of transcription factor SALL4 and uses thereof
Dana-Farber Cancer Institute
02/17/23
-
291
Substituted heteroaromatic pyrazolo-pyridines and their use as GLUN2B receptor modulators
Janssen Pharmaceutica
02/17/23
-
93
Naphthyridinone derivatives and their use in the treatment of arrhythmia
Novartis
02/17/23
-
54
Bicyclic heterocycles as FGFR inhibitors
Incyte Holdings
02/17/23
-
3
Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitors
Genzyme
02/17/23
-
17
Ligands to cereblon (CRBN)
Dana-Farber Cancer Institute
02/17/23
-
59
Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof
Nurix Therapeutics
02/17/23
-
228
Compositions and methods for treating CNS disorders
Sage Therapeutics
02/17/23
-
382
Cyclic polypeptides for PCSK9 inhibition
Merck Sharp & Dohme
02/17/23
-
9
Use of known compounds as D-amino acid oxidase inhibitors
National Taiwan University
02/17/23
-
61
Use of aminomethylenecyclohexane-1,3-dione compound
Wigen Biomedicine Technology (Shanghai)
02/16/23
-
51
SHP2 phosphatase inhibitors and methods of use thereof
Relay Therapeutics
02/16/23
-
431
2-(morpholin-4-yl)-1,7-naphthyridines
Bayer Pharma Aktiengesellschaft
02/16/23
-
30
Alpha-5 beta-1 inhibitors
University of California
02/16/23
-
31
Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Bristol-Myers Squibb
02/16/23
-
123
Kinase inhibitors
University of Manchester
02/16/23
-
17
Protacs targeting coronavirus 3CL protease and preparation method and application thereof
Shaanxi Panlong Pharmaceutical
02/16/23
-
45
Analogs for the treatment of disease
Insilico Medicine Ip
02/16/23
-
63
Compositions and methods for treating infections
Vyera Pharmaceuticals
02/16/23
-
45
Analogs for the treatment of disease
Insilico Medicine Ip
02/16/23
-
31
Compounds
Inflazome
02/16/23
-
9
Imidazo[4,5-C]pyridine derived SSAO inhibitors
Proximagen
02/16/23
-
14
JAK kinase inhibitor and preparation method and use thereof
Shanghai Longwood Biopharmaceuticals
02/13/23
-
31
Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5)
Prelude Therapeutics
02/13/23
-
717
Heterocyclic compound as a protein kinase inhibitor
Hk Inno.N
02/13/23
-
310
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences
02/12/23
-
15
Pyrazole compounds as LSD1 inhibitors and applications thereof
Medshine Discovery
02/12/23
-
7
Metabolites of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 yl}-phenoxy)-propyl]-diethyl-amine
Vtv Therapeutics
02/12/23
-
10
Compounds for treating ILK-mediated diseases
The Cleveland Clinic Foundation
02/12/23
-
7
Alkyne substituted quinazoline compound and methods of use
Newgen Therapeutics
02/12/23
-
1076
Indole and azaindole inhibitors of pad enzymes
Bristol-Myers Squibb
02/12/23
-
2
Macrocycle and composition comprising thereof
Shenzhen Targetrx
02/05/23
-
11
Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
Kronos Bio
02/05/23
-
10
Radiolabeled pharmaceuticals and methods of making and using same
Yale University
02/05/23
-
9
Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof
Shaanxi Panlong Pharmaceutical
02/05/23
-
58
CDPK1 inhibitors, compositions, and methods related thereto
Vyera Pharmaceuticals
02/05/23
-
370
Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction
Ontario Institute For Cancer Research (Oicr)
02/05/23
-
15
MTOR inhibitor compounds
Galderma Research & Development
02/05/23
-
50
Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
Nikang Therapeutics
02/05/23
-
8
Inhibitors of DNMT1 as anticancer therapeutic agents
Victoria Link
02/05/23
-
59
Compounds useful in HIV therapy
Glaxosmithkline Intellectual Property Development
01/31/23
-
250
Anti-tumor effect potentiator using novel biphenyl compound
Taiho Pharmaceutical
01/28/23
-
50
Aminocyclobutanes as monoacylglycerol lipase modulators
Janssen Pharmaceutica
01/28/23
-
107
Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Takeda Pharmaceutical
01/28/23
-
1
Substituted diamino heterocyclic carboxamide compound and a composition containing the compound and use thereof
Shenzhen Targetrx
01/28/23
-
102
CRBN ligands and uses thereof
Kymera Therapeutics
01/28/23
-
139
Compounds and methods for the enhanced degradation of targeted proteins
Arvinas Operations
01/28/23
-
16
BRK inhibitory compound
Ono Pharmaceutical
01/28/23
-
62
Inhibitors of fibroblast activation protein
Praxis Biotech
01/21/23
-
159
Compounds and methods for treating oxalate-related diseases
Oxalurx
01/21/23
-
35
2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy
Thomas Helledays Stiftelse FÖR Medicinsk Forskning
01/21/23
-
30
Therapeutic compounds and methods of use thereof
Ligature Therapeutics
01/21/23
-
19
HDAC8 inhibitors for treating cancer
City of Hope
01/21/23
-
3
Aryl-piperidine derivatives
Artax Biopharma
01/21/23
-
3
Tetrahydroquinoline derivatives and a process of preparation thereof
King Abdulaziz University
01/21/23
-
81
SSAO inhibitor
Shandong Danhong Pharmaceutical
01/21/23
-
138
Dihydroorotate dehydrogenase inhibitors
Janssen Biotech
01/21/23
-
76
Azaspirocycles as monoacylglycerol lipase modulators
Janssen Pharmaceutica
01/21/23
-
196
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck
01/20/23
-
4
Therapeutic methods and combinations
Individual
01/20/23
-
45
Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
Janssen Sciences Ireland
01/20/23
-
66
N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
Nerviano Medical Sciences
01/20/23
-
150
ACLY inhibitors and uses thereof
Nimbus Artemis
01/20/23
-
120
Benzisoxazole sulfonamide derivatives
Pfizer
01/20/23
-
153
Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways
Neuropore Therapies
01/20/23
-
320
MTA-cooperative PRMT5 inhibitors
Mirati Therapeutics
01/20/23
-
54
Indazole compounds and uses thereof
Incyte
01/20/23
-
2
Thieno[3,2-d]pyrimidine derivative compound having inhibitory activity for protein kinase
Hanmi Pharm.
01/20/23
-
23
Cyclic dinucleotides as sting agonists
Janssen Biotech
01/20/23
-
7
Peptides for treatment of medical disorders
Humanwell Pharmaceutical Us
01/20/23
-
24
Cyclic peptide immunomodulators
Bristol-Myers Squibb
01/20/23
-
38
Dopamine D2 receptor ligands
The Broad Institute
01/17/23
-
26
Azaindolylpyridone and diazaindolylpyridone compounds
Sprint Bioscience
01/17/23
-
275
Tricyclic heterocycles as BET protein inhibitors
Incyte
01/17/23
-
152
Pyrimidine-fused cyclic compound, preparation method therefor and application thereof
Blueray Therapeutics (Shanghai)
01/17/23
-
82
Mu opioid receptor modulators
University of California
01/06/23
-
5
Synthesis of (+)-cannabinoids and their therapeutic effects
Symrise
01/06/23
-
2
Deuterated compounds as rock inhibitors
Fochon Pharmaceuticals
01/06/23
-
127
Compounds for treatment of PD-L1 diseases
Chemocentryx
01/06/23
-
140
Compounds for inhibiting TNIK and medical uses thereof
Korea Research Institute of Chemical Technology
01/06/23
-
35
N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators
Boehringer Ingelheim International
01/06/23
-
137
Compounds and methods useful in the treatment of a PRMT5-mediated disorder
Argonaut Therapeutics
01/06/23
-
121
Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors
Ksq Therapeutics
01/06/23
-
222
Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
Mirati Therapeutics
01/06/23
-
368
Amido spirocyclic amide and sulfonamide derivatives
Valo Health
01/06/23
-
70
Macrocyclic chlorine substituted indole derivatives
Bayer Aktiengesellschaft
12/30/22
-
486
Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
Chemocentryx
12/30/22
-
6
Method for treating inflammation
King Faisal University
12/30/22
-
5
Targeted drug rescue with novel compositions, combinations, and methods thereof
Exciva
12/30/22
-
222
2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor
Hutchison Medipharma
12/30/22
-
14
Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
The Johns Hopkins University
12/30/22
-
6
5-aminolevulinate synthase inhibitors and methods of use thereof
University of South Florida
12/30/22
-
71
Inhibitors of Rho associated coiled-coil containing protein kinase
Kadmon
12/30/22
-
24
Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
Bristol-Myers Squibb
12/30/22
-
154
Small molecule modulators of the BTB domain of Keap1
Medimmune
12/30/22
-
49
Heterocyclic RIP1 kinase inhibitors
Rigel Pharmaceuticals
12/30/22
-
38
EP4 antagonist
Ono Pharmaceutical
12/30/22
-
321
MTA-cooperative PRMT5 inhibitors
Mirati Therapeutics
12/30/22
-
4
Substituted piperidine compounds and their use
Eisai R&D Management
12/30/22
-
66
5-5 fused rings as C5a inhibitors
Chemocentryx
12/30/22
-
4
Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones as inhibitors of WEE-1 kinase
Newave Pharmaceutical
12/30/22
-
94
Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof
Beijing Scitech-Mq Pharmaceuticals
12/30/22
-
225
OX2R compounds
University of Texas System
12/30/22
-
172
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences
12/24/22
-
27
1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
Angelini Acraf
12/24/22
-
79
Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
Array Biopharma
12/24/22
-
95
Tricyclic compounds and their use as phosphodiesterase inhibitors
Pfizer
12/24/22
-
36
Pyrazolo[1,5-a]pyrazin-4-yl derivatives
Pfizer
12/24/22
-
111
Imidazopyrazinones as PDE1 inhibitors
H. Lundbeck
12/24/22
-
186
Pyrazolotriazolopyrimidine derivatives as A2A receptor antagonist
Beigene
12/24/22
-
35
1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and preparation method therefor and use thereof
Southern Medical University
12/24/22
-
1
Mcl-1 inhibitors and methods of use thereof
Astrazeneca
12/24/22
-
52
Acyclic antivirals
Janssen Pharmaceutica
12/24/22
-
14
Cyclic dinucleotides as sting agonists
Janssen Biotech
12/24/22
-
67
Inhibitors of blood coagulation factor XIII
Zedira
12/24/22
-
19
Sphingosine analogs and use thereof against bacterial lung infections
Yeda Research and Development
12/23/22
-
11
Compounds for treatment of hypoproliferative disorders
Lu License
12/23/22
-
27
Diacylglycerol acyl transferase 2 inhibitor
Pfizer
12/23/22
-
146
SSAO inhibitors and use thereof
Eccogene (Shanghai)
12/23/22
-
18
Quinazolinones that inhibit the formation of tau oligomers and their method of use
Oligomerix
12/23/22
-
93
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals
12/23/22
-
5
Docosahexaenoic acid endocannabinoid epoxide derivative compositions
University of Illinois
12/23/22
-
35
Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases
Beigene
12/23/22
-
279
Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
Incyte
12/23/22
-
51
3-substituted piperidine compounds for Cbl-b inhibition, and use thereof
Nurix Therapeutics
12/11/22
-
13
Heterocyclic compounds as immunomodulators
Incyte
12/11/22
-
31
Pyridazines
Boehringer Ingelheim International
12/11/22
-
48
Compound having ERK kinase inhibitory activity and use thereof
Shanghai Haihe Pharmaceutical
12/11/22
-
60
Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof
Shanghai Yingli Pharmaceutical
12/11/22
-
27
Tricyclic compounds
Jacobio Pharmaceuticals
12/11/22
-
187
Substituted lactams showing serotonin 5-HT receptor activity
Sumitomo Pharma
12/11/22
-
142
Pharmaceutical compounds
Otsuka Pharmaceutical
12/11/22
-
94
Heterocyclic inhibitors of PTPN11
Board of Regents, The University of Texas System
12/11/22
-
16
Modulators of the NMDA receptor
H. Lundbeck
12/11/22
-
21
Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
Enanta Pharmaceuticals
12/11/22
-
69
Compound functioning as bromodomain protein inhibitor, and composition
Betta Pharmaceuticals
12/11/22
-
10
Cyclic di-nucleotide compounds as sting agonists
Merck Sharp & Dohme
12/11/22
-
3
Combination of pure 5-HT6 receptor antagonists with acetylcholinesterase inhibitors
Suven Life Sciences
12/07/22
-
286
6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors
Novartis
12/07/22
-
20
Annulated glycosidase inhibitors
Asceneuron
12/07/22
-
229
TEAD inhibitors and uses thereof
Ikena Oncology
12/07/22
-
15
2-beta-naphthyl-acetic acid analogs as AKR1C3 inhibitors and methods of using same
The Trustees of The University of Pennsylvania
12/07/22
-
30
Antibacterial compounds
Infex Therapeutics
12/07/22
-
108
Heterocyclic compounds for the inhibition of PASK
Bioenergenix
12/07/22
-
74
Broad spectrum inhibitors of filoviruses
Microbiotix
12/07/22
-
3
Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
Pharmakea
12/07/22
-
227
Modulators of methyl modifying enzymes, compositions and uses thereof
Constellation Pharmaceuticals
12/07/22
-
72
Broad spectrum antiviral compositions and methods
Evrys Bio
12/07/22
-
71
Imidazopyridazine and imidazopyridine compounds and uses thereof
Incyte
12/07/22
-
5
Substituted pyrrolo[2,3-d]pyrimidines as JAK inhibitors
Vimalan Biosciences
12/07/22
-
160
N/O-linked Degrons and Degronimers for protein degradation
C4 Therapeutics
12/07/22
-
67
Pyrazine carbamates and their use as GluN2B receptor modulators
Janssen Pharmaceutica
12/07/22
-
48
Isothiazolo[5,4-D]pyrimidine compound as IRAK4 inhibitor
Chia Tai Tianqing Pharmaceutical Group
12/07/22
-
140
Biaryl derivative, preparation method thereof and pharmaceutical application thereof
Abbisko Therapeutics
12/07/22
-
36
Tri-substituted heteroaryl derivatives as Src homology-2 phosphatase inhibitors
Nikang Therapeutics
12/07/22
-
576
Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof
Sanford Burnham Prebys Medical Discovery Institute
12/04/22
-
44
Substituted propanamides as inhibitors of nucleases
Masarykova Univerzita
12/04/22
-
13
JAK inhibitors containing a 4-membered heterocyclic amide
Theravance Biopharma R&D Ip
12/04/22
-
1
Substituted pyrazolo[1,5-a]pyrimidines as tropomyosin receptor kinase inhibitors
Shenzhen Targetrx
12/04/22
-
16
Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
Eli Lilly
12/04/22
-
29
Tricyclic compounds useful to treat orthomyxovirus infections
Novartis
12/04/22
-
72
Substituted eneoxindoles and uses thereof
Gilead Sciences
12/04/22
-
452
KRas G12D inhibitors
Mirati Therapeutics
12/04/22
-
15
3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
Mindset Pharma
12/04/22
-
143
Receptor inhibitor, pharmaceutical composition comprising same, and use thereof
Beijing Tide Pharmaceutical
12/04/22
-
215
Cyclic di-nucleotide compounds as sting agonists
Merck Sharp & Dohme
12/04/22
-
12
Tricyclic amine compounds as CDK2 inhibitors
Incyte
11/20/22
-
4
(S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
Histogen
11/20/22
-
49
Macrocyclic chlorine substituted indole derivatives
Bayer Aktiengesellschaft
11/20/22
-
225
Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer
Cancer Research Technology
11/20/22
-
66
Galactoside inhibitor of galectins
Galecto Biotech
11/20/22
-
353
Tetrahydroquinoline derivatives as P2X7 receptor antagonists
Raqualia Pharma
11/19/22
-
46
Pyrimidine JAK inhibitors for the treatment of skin diseases
Theravance Biopharma R&D Ip
11/19/22
-
90
Compounds, salts thereof and methods for treatment of diseases
Acadia Pharmaceuticals
11/19/22
-
116
Anti-inflammatory compound, and preparation and use thereof
E-Nitiate Biopharmaceuticals (Hangzhou)
11/19/22
-
6
Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity
The Board of Trustees of The Leland Stanford Junior University
11/19/22
-
98
Pyrimidine TBK/IKKe inhibitor compounds and uses thereof
Merck Patent
11/19/22
-
30
Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof
Milstein Zhang & Wu
11/19/22
-
360
Aminoimidazopyridazines as kinase inhibitors
Bristol-Myers Squibb
11/19/22
-
32
Tricyclic amine compounds as CDK2 inhibitors
Incyte
11/19/22
-
22
Triazolo-azepine derivatives
Hoffmann-La Roche
11/19/22
-
5
Selective A2A receptor antagonist
Inxmed (Nanjing)
11/19/22
-
10
p38α mitogen-activated protein kinase inhibitors
Gen1E Lifesciences
11/19/22
-
32
Heterocyclylmethylidene derivatives and their use as modulators of mGluR5 receptors
Recordati Industria Chimica E Farmacentica
11/19/22
-
79
Substituted macrocyclic indole derivatives
Bayer Aktiengesellschaft
11/19/22
-
7
Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
Nanjing Zhengxiang Pharmaceuticals
11/19/22
-
118
Pharmaceutical compounds for treatment of medical disorders
Achillion Pharmaceuticals
11/19/22
-
10
Hetero ring-fused phenyl compounds for inhibiting TNIK and medical uses thereof
Korea Research Institute of Chemical Technology
11/19/22
-
33
Indoleamine-2,3-dioxygenase inhibitor, the preparative method and the use thereof
Hinova Pharmaceuticals
11/19/22
-
83
Compound exhibiting enteropeptidase inhibitory activity
Lg Chem
11/19/22
-
64
Cyclic compound having dopamine D3 receptor antagonistic effect
Shionogi
11/19/22
-
94
Spiroheptanyl hydantoins as rock inhibitors
Bristol-Myers Squibb
11/19/22
-
25
Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof
Shanghai Yingli Pharmaceutical
11/19/22
-
95
Inhibitors of cyclin-dependent kinases
Kinnate Biopharma
11/19/22
-
164
LSD1 inhibitor and preparation method and application thereof
Medshine Discovery
11/13/22
-
359
Heterocyclylamines as PI3K inhibitors
Incyte
11/13/22
-
56
ATR inhibitor and application thereof
Wuxi Biocity Biopharmaceutics
11/13/22
-
129
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System
11/13/22
-
165
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
11/13/22
-
70
PDE9 inhibitor and use thereof
Nanjing Transthera Biosciences
11/13/22
-
12
ASK1 inhibitor compounds and uses thereof
Seal Rock Therapeutics
11/13/22
-
17
Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
Genentech
11/13/22
-
312
Immunomodulator compounds
Chemocentryx
11/07/22
-
24
Prolyl hydroxylase inhibitors and methods of use
Akebia Therapeutics
11/07/22
-
8
Cycloalkyl-diamines for the treatment of inflammation
Medisynergics
11/07/22
-
84
Imidazo-pyridine compounds as PAD inhibitors
Jubilant Epipad
11/07/22
-
291
Dihydrooxadiazinones
Bayer Aktiengesellschaft
11/07/22
-
332
Indazoles and azaindazoles as LRRK2 inhibitors
Escape Bio
11/07/22
-
1
Substituted quinolines useful as kinase inhibitors
Teligene
11/07/22
-
124
Composition and methods for inhibiting mammalian sterile 20-like kinase 1
The Scripps Research Institute
11/07/22
-
40
IRAK4 inhibiting agents
Biogen Ma
11/07/22
-
70
Aryl cyclopropyl-amino-isoquinolinyl amide compounds
Aerie Pharmaceuticals
11/07/22
-
465
Imidazolyl pyrimidinylamine compounds as CDK2 inhibitors
Incyte
11/07/22
-
228
Substituted pyrrolopyridine-derivatives
Bayer Pharma Aktiengesellschaft
11/07/22
-
22
JAK inhibitor and use thereof
Zhuhai United Laboratories
11/07/22
-
84
Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) for the treatment of neurodegenerative diseases
The Johns Hopkins University
11/07/22
-
13
Kinase inhibitors
Insilico Medicine Ip
11/07/22
-
69
Bromodomain inhibitor compound and use thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
11/07/22
-
4
Psilocin derivatives as serotonergic psychedelic agents for the treatment of CNS disorders
Mindset Pharma
11/07/22
-
145
Dosage forms and regimens for amino acid compounds
Pliant Therapeutics
11/06/22
-
30
Treatment of tachycardia
Oslo University Hospital
11/06/22
-
150
Bicyclic compounds
Vivace Therapeutics
11/06/22
-
16
Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases
Nikang Therapeutics
11/06/22
-
22
4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors
Nerviano Medical Sciences
11/06/22
-
18
Compounds as neuronal histamine receptor-3 antagonists and uses thereof
Xwpharma
11/06/22
-
452
Aryl and heteroaryl substituted indole compounds
Bristol-Myers Squibb
11/06/22
-
26
DACOS type NNRTIS amino acid ester derivative, preparation method thereof, pharmaceutical composition, and application thereof
Yunnan University
11/06/22
-
67
Substituted pyrrolopyridines as JAK inhibitors
Aclaris Therapeutics
11/06/22
-
589
Bcl-2 inhibitors
Beigene
11/06/22
-
316
Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents
Novartis
11/06/22
-
208
Amide substituted indole compounds useful as TLR inhibitors
Bristol-Myers Squibb
11/06/22
-
39
Substituted imidazo[1,5-a]pyrazines as Bruton's tyrosine kinase inhibitors
TRANSTHERA SCIENCES (NANJING), INC.
11/06/22
-
67
Heterocyclic compounds as anti-viral agents
Enanta Pharmaceuticals
11/06/22
-
29
Arginase inhibitors and methods of use thereof
Astrazeneca
11/06/22
-
22
Tryptophan hydroxylase inhibitor and pharmaceutical composition including same
Gwangju Institute of Science and Technology
11/05/22
-
53
AMPK activators
Kallyope
11/05/22
-
97
Formulations of Tie-2 activators and methods of use thereof
Eyepoint Pharmaceuticals
10/30/22
-
379
P300/CBP hat inhibitors
Constellation Pharmaceuticals
10/30/22
-
103
Oxoacridinyl acetic acid derivatives and methods of use
Stingthera
10/30/22
-
136
Heterocyclic compounds as modulators of mGluR7
Pragma Therapeutics
10/30/22
-
37
Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors
Mission Therapeutics
10/30/22
-
78
Compounds for the treatment of BRAF-associated diseases and disorders
Array Biopharma
10/30/22
-
212
Inhibitors of protein kinases
Alexion Pharmaceuticals
10/30/22
-
55
Heterocyclic compound as JAK inhibitor, and salts and therapeutic use thereof
Suzhou Longbiotech Pharmaceuticals
10/30/22
-
149
Compounds and uses thereof
Foghorn Therapeutics
10/30/22
-
5
Compounds useful as immunomodulators
Bristol-Myers Squibb
10/30/22
-
19
Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
Auckland Uniservices
10/30/22
-
1022
Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
Nimbus Lakshmi
10/30/22
-
66
Heterocyclic compounds as immunomodulators
Incyte
10/30/22
-
16
Pyrazolopyridine compounds and uses thereof
Incyte
10/28/22
-
26
JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
Incyte
10/28/22
-
79
Tropomyosin-related kinase (TRK) inhibitors
Genzyme
10/28/22
-
6
Acetamide thienotriazolodiazepines and uses thereof
Dana-Farber Cancer Institute
10/28/22
-
13
Treatment of upper aerodigestive tract disorders and cough
Individual
10/28/22
-
80
CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
Amgen
10/28/22
-
208
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals
10/28/22
-
85
Inhibitors of RAF kinases
Kinnate Biopharma
10/28/22
-
121
Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
Achillion Pharmaceuticals
10/28/22
-
58
Antibacterial compounds
Forge Therapeutics
10/28/22
-
27
Heterocyclic compounds as immunomodulators
Incyte
10/28/22
-
3
Derivatives of an FGFR inhibitor
Incyte
10/28/22
-
13
Substituted piperidines as kinase inhibitors
Daewoong Pharmaceutical
10/28/22
-
114
Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors
Development Center For Biotechnology
10/28/22
-
36
Dioxinoquinoline compounds, preparation method and uses thereof
Beijing Scitech-Mq Pharmaceuticals
10/28/22
-
118
Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
Washington University
10/28/22
-
41
Small molecule activators of Parkin enzyme function
Mayo Foundation For Medical Education and Research
10/23/22
-
64
Dihydroquinolinones for medical treatment
C4 Therapeutics
10/23/22
-
11
Isoquinoline derivatives and use thereof
Purdue Pharma
10/23/22
-
22
1-Pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
Novartis
10/23/22
-
1
Biochemical binding of RET9 and VEGFR2 inhibitors
Kala Pharmaceuticals
10/23/22
-
153
Alcoxyamino derivatives for treating pain and pain related conditions
Esteve Pharmaceuticals
10/23/22
-
138
Heterocyclic compounds as LSD1 inhibitors
Incyte
10/23/22
-
8
[1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes
Eli Lilly
10/23/22
-
62
Macrocyclic indole derivatives
The Broad Institute
10/23/22
-
40
Pyrido[3,2-d]pyrimidine compounds as immunomodulators
Incyte
10/23/22
-
81
Pyrimidinones as PI3K inhibitors
Incyte Holdings
10/23/22
-
307
Heteroaryl inhibitors of PDE4
Tetra Discovery Partners
10/23/22
-
23
Cyclic dinucleotide compound and uses thereof
Shanghai Jemincare Pharmaceuticals
10/23/22
-
21
Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor
Chia Tai Tianqing Pharmaceutical Group
10/17/22
-
479
Benzodiazepine derivatives as RSV inhibitors
Enanta Pharmaceuticals
10/17/22
-
34
Amine compound for inhibiting SSAO/VAP-1 and use thereof
Sunshine Lake Pharma
10/17/22
-
23
1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
University of Illinois
10/17/22
-
45
Substituted heterocyclic derivatives as PI3K inhibitors
Incyte
10/17/22
-
15
Amino acid compounds with unbranched linkers and methods of use
Pliant Therapeutics
10/17/22
-
601
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
10/17/22
-
218
CDK2/4/6 inhibitors
Pfizer
10/17/22
-
2
Tricyclic compounds as Cyp1 inhibitors
The General Hospital
10/17/22
-
34
Compounds for targeting mutant huntingtin protein and uses thereof
Chdi Foundation
10/16/22
-
7
Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof
Beijing Innocare Pharma Tech
10/16/22
-
104
Compounds and methods for treating oxalate-related diseases
Oxalurx
10/16/22
-
66
Arginase inhibitors as therapeutics
Mars
10/16/22
-
267
1-cyano-pyrrolidine compounds as USP30 inhibitors
Mission Therapeutics
10/16/22
-
314
Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
Beijing Tide Pharmaceutical
10/16/22
-
215
Piperazine derivatives as MAGL inhibitors
Hoffmann-La Roche
10/16/22
-
159
Inhibitors of cyclin-dependent kinases
Kinnate Biopharma
10/16/22
-
47
Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors
Incyte
10/16/22
-
38
Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application
Guangzhou Maxinovel Pharmaceuticals
10/09/22
-
20
Heterocyclic compound as CSF-1R inhibitor and use thereof
Medshine Discovery
10/09/22
-
45
Heterocyclic compounds useful as aurora a selective inhibitors
Jacobio Pharmaceuticals
10/09/22
-
1
Diphenylaminopyrimidine compound for inhibiting kinase activity
Shenzhen Targetrx
10/09/22
-
19
Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
Incyte
10/09/22
-
120
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals
10/09/22
-
7
Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors
Union Therapeutics
10/09/22
-
209
2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors
Merck Sharp & Dohme
10/06/22
-
164
Heterocyclic prolinamide derivatives
Orion Ophthalmology
10/06/22
-
106
Galactoside inhibitor of galectins
Galecto Biotech
10/06/22
-
132
CD73 inhibitors
Oric Pharmaceuticals
10/06/22
-
41
Acetyl-CoA carboxylase modulators
Monsanto Technology
10/05/22
-
20
Inhibiting mutant IDH-1
Forma Therapeutics
10/05/22
-
34
Purine derivatives and the use thereof as medicament
Boehringer Ingelheim International
10/05/22
-
177
Serine/threonine kinase inhibitors
Genentech
10/05/22
-
19
Inhibitors of histone deacetylase
The Broad Institute
10/05/22
-
94
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals
10/05/22
-
56
Inhibitors of RAF kinases
Kinnate Biopharma
10/05/22
-
23
Compounds and methods for inhibiting CPY26 enzymes
Queens University At Kingston
09/25/22
-
229
Compounds
Tmem16A
09/25/22
-
54
Compounds that inhibit Mcl-1 protein
Amgen
09/25/22
-
17
P-phenylenediamine derivative as potassium channel regulator and preparation method and medical application thereof
Shanghai Zhimeng Biopharma
09/25/22
-
27
Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds
Eli Lilly
09/25/22
-
14
Substituted benzimidazoles, their preparation and their use as pharmaceuticals
Epigenetix
09/25/22
-
60
Heterocyclic inhibitors of tyrosine kinase
Board of Regents, The University of Texas System
09/25/22
-
185
Substituted cyclohexyl compounds as NOP inhibiiors
Dart Neuroscience
09/25/22
-
447
Pyridine compound substituted with azole
Taisho Pharmaceutical
09/25/22
-
79
FGFR inhibitor and application thereof
Betta Pharmaceuticals
09/25/22
-
10
Antimalarial compounds, process for preparation and their use for drug resistant malaria
Council of Scientific and Industrial Research
09/25/22
-
73
Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
Union Therapeutics
09/25/22
-
124
Imidazolidin-2-one compounds as PRMT5 modulators
Aurigene Discovery Technologies
09/25/22
-
365
Melt-extruded solid dispersions containing an apoptosis-inducing agent
Abbvie
09/25/22
-
10
Optically active azabicyclo ring derivative
Sumitomo Dainippon Pharma
09/25/22
-
7
Therapeutic compounds and uses thereof
Kala Pharmaceuticals
09/25/22
-
94
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals
09/25/22
-
32
3-arylindazoles as selective MEK4 inhibitors
Northwestern University
09/25/22
-
528
Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors
Biocryst Pharmaceuticals
09/25/22
-
47
Pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer
Pelemed
09/25/22
-
92
Cyano-substituted heterocycles with activity as inhibitors of USP30
Mission Therapeutics
09/25/22
-
598
GLS1 inhibitors for treating disease
Board of Regents, The University of Texas System
09/25/22
-
5
Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
Imara
09/25/22
-
62
Substituted pyrazoles as LRRK2 inhibitors
Oscotec
09/25/22
-
549
Compounds useful as inhibitors of ATR kinase
Vertex Pharmaceuticals
09/25/22
-
21
Heteroaryl plasma kallikrein inhibitors
Takeda Pharmaceutical
09/25/22
-
9
Compounds and methods for inhibiting CYP26 enzymes
Queens University At Kingston
09/19/22
-
102
Lysyl oxidase-like 2 inhibitors and uses thereof
Pharmakea
09/19/22
-
31
CRBN ligands and uses thereof
Kymera Therapeutics
09/19/22
-
29
Functionalized peptides as antiviral agents
Enanta Pharmaceuticals
09/19/22
-
12
Prodrugs of modulators of the NMDA receptor
H. Lundbeck
09/19/22
-
305
TGF-beta inhibitors
Syngene International
09/11/22
-
56
Compounds useful as RET inhibitors
Cancer Research Technology
09/11/22
-
122
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals
09/11/22
-
89
Nitrile-containing antiviral compounds
Pfizer
09/10/22
-
261
2,4-disubstituted pyrimidines useful as kinase inhibitors
Celgene Car
09/10/22
-
16
Substituted pyrimidines as CDK4/6 inhibitors
Beijing Xuanyi Pharmasciences
09/10/22
-
163
Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
Jubilant Epicore
09/10/22
-
347
HIV protease inhibitors
Gilead Sciences
09/10/22
-
210
Phenoxymethyl derivatives
Hoffmann-La Roche
09/10/22
-
198
1-cyano-pyrrolidine derivatives as DUB inhibitors
Mission Therapeutics
09/10/22
-
281
Pyridine and pyridimine compounds as PI3K-gamma inhibitors
Incyte
09/10/22
-
33
Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof
Xiamen University
09/10/22
-
324
Inhibitors of plasma kallikrein and uses thereof
Takeda Pharmaceutical
09/10/22
-
28
Autotaxin inhibitor compounds
Sabre Therapeutics
09/05/22
-
42
Benzamide compounds
Recurium Ip Holding
09/05/22
-
241
2-substituted pyrazole amino-4-substituted amino-5-pyrimidine formamide compound, composition, and application thereof
Beijing Scitech Mq Pharmaceuticals
09/05/22
-
2
Substituted pyrazolopyrimidines useful as kinases inhibitors
Teligene
09/05/22
-
128
Phenyl and pyridinyl substituted imidazoles as modulators of RORγT
Janssen Pharmaceutica
09/05/22
-
33
Apoptosis signal-regulating kinase 1 (ASK 1) inhibitor compounds
Pharmakea
09/05/22
-
69
Benzopyrazole compound used as RHO kinase inhibitor
Medshine Discovery
09/05/22
-
20
Quaternary lactam compound and pharmaceutical use thereof
Shanghai Meiyue Biotech Development
09/05/22
-
280
Inhibitors of fibroblast growth factor receptor kinases
Kinnate Biopharma
09/05/22
-
64
Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
Guangzhou Innocare Pharma Tech
09/05/22
-
152
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
09/05/22
-
9
KRAS mutant protein inhibitors
Jacobio Pharmaceuticals
09/05/22
-
43
PGDH inhibitors and methods of making and using
Myoforte Therapeutics
09/05/22
-
75
Aliphatic acid amide derivative
Sumitomo Dainippon Pharma
08/29/22
-
31
4H-pyrrolo[3,2-c]pyridin-4-one derivatives
Bayer Aktiengesellschaft
08/29/22
-
52
Imidazole and triazole containing bicyclic compounds as JAK inhibitors
Theravance Biopharma R&D Ip
08/29/22
-
33
Substituted piperidines as kinase inhibitors
Daewoong Pharmaceutical
08/29/22
-
55
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals
08/29/22
-
35
Glycoside derivatives and uses thereof
Novartis
08/29/22
-
34
Identification of stabilizers of multimeric proteins
Leland Stanford Junior University
08/28/22
-
34
Dopamine D3 receptor selective antagonists/partial agonists and uses thereof
The United States of America, As Represented By The Secretary, Department of Health and Human Services
08/28/22
-
28
Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors
Bayer Aktiengesellschaft
08/28/22
-
207
Compounds and methods for kinase modulation, and indications therefor
Plexxikon
08/28/22
-
11
hTRPV1 chemical agents
University of Pittsburgh
08/28/22
-
466
Heteroaryl Rheb inhibitors and uses thereof
Navitor Pharmaceuticals
08/28/22
-
266
Heterocyclic compounds as immunomodulators
Incyte
08/28/22
-
94
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals
08/21/22
-
42
MAGL inhibitors
H. Lundbeck
08/21/22
-
33
Inhibitors of lysine gingipain
Cortexyme
08/21/22
-
30
Substituted pyrazolo[3,4-d]pyrimidines as Wee1 inhibitors
Nuvation Bio
08/21/22
-
22
Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
Korea Institute of Science and Technology
08/21/22
-
12
CD73 inhibitors and therapeutic uses thereof
Jiangsu Hengrui Medicine
08/21/22
-
19
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals
08/15/22
-
68
Imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase
University of Alberta
08/15/22
-
32
Chemical compounds
Astrazeneca
08/15/22
-
26
CaMKII inhibitors and uses thereof
The Johns Hopkins University
08/15/22
-
134
Spiropyrrolidine derived antiviral agents
Enanta Pharmaceuticals
08/15/22
-
22
Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
Valo Health
08/15/22
-
18
Optically active crosslinked cyclic secondary amine derivative
Sumitomo Dainippon Pharma
08/15/22
-
203
CD73 inhibitors
Oric Pharmaceuticals
08/15/22
-
26
Combination therapy for treatment of hematological diseases
Incyte
08/14/22
-
67
Ketone inhibitors of lysine gingipain
Cortexyme
08/14/22
-
42
Benzamide compounds
Recurium Ip Holdings
08/07/22
-
147
Cyanopyrrolidines as dub inhibitors for the treatment of cancer
Mission Therapeutics
08/07/22
-
708
Substituted carboxamides as inhibitors of WDR5 protein-protein binding
Propellon Therapeutics
08/07/22
-
121
Pyridine quinoline compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
08/07/22
-
18
Tricyclic fused derivatives of 1-(cyclo)alkyl pyrtdin-2-one useful for the treatment of cancer
Jubilant Biosys
08/07/22
-
22
Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
Temple University
08/07/22
-
415
Inhibitors of Bruton's tyrosine kinase and methods of their use
Janssen Pharmaceutica
08/07/22
-
193
Substituted dihydroimidazopyridinediones as MKNK1 and MKNK2 inhibitors
Bayer Pharma Aktiengesellschaft
08/06/22
-
20
Inhibiting mutant isocitrate dehydrogenase 1 (mIDH-1)
Forma Therapeutics
08/06/22
-
83
Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors
Merck Sharp & Dohme
08/06/22
-
54
Treatment of GVHD
Kadmon
08/06/22
-
63
Pyrazole compound
Sumitomo Dainippon Pharma
08/06/22
-
6
Protease inhibitors
Medivir
08/06/22
-
177
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences
08/06/22
-
46
Heteroaryl[4,3-C]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
Jiangsu Hengrui Medicine
08/06/22
-
17
Ghrelin O-acyltransferase inhibitors
Glaxosmithkline Intellectual Property Development
08/06/22
-
19
Morpholine derivative
Hoffmann-La Roche
08/06/22
-
410
Azabenzimidazoles and their use as AMPA receptor modulators
Janssen Pharmaceutica
08/06/22
-
91
Imidazo[4,5-C]quinoline derivatives as LRRK2 inhibitors
Pfizer
08/06/22
-
61
9H-pyrrolo-dipyridine derivatives
Ucb Biopharma
08/06/22
-
173
9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use
Merck Sharp & Dohme
08/06/22
-
113
Hsp90 inhibitors and uses thereof
Trustees of Boston University
08/06/22
-
182
Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases
Rockefeller University
08/06/22
-
37
Thienodiazepine derivatives and application thereof
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
08/06/22
-
375
Macrocyclic flu endonuclease inhibitors
Janssen Biopharma
08/06/22
-
23
Inhibitors of KRAS G12C and methods of using the same
Amgen
08/01/22
-
78
4,6 dihydropyrrolo [3,4-C] pyrazole-5 (1H)-carbonitrile derivates for treating cancer
Mission Therapeutics
08/01/22
-
47
Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
Venenum Biodesign
08/01/22
-
25
Cyano thienotriazolodiazepines and uses thereof
Dana-Farber Cancer Institute
08/01/22
-
213
Tosylacetate based compounds and derivatives thereof as PHGDH inhibitors
Boehringer Ingelheim International
07/31/22
-
26
Treatment of hidradenitis suppurativa using JAK inhibitors
Incyte
07/31/22
-
52
Substituted quinazolines for inhibiting kinase activity
Neupharma
07/31/22
-
29
Heterocyclic compounds as adenosine antagonists
Nuvation Bio
07/31/22
-
22
Benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use
Oligomerix
07/31/22
-
475
Piperidine CXCR7 receptor modulators
Idorsia Pharmaceuticals
07/31/22
-
85
3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors
Incyte
07/31/22
-
176
Phenylacetamides as inhibitors of rock
Bristol-Myers Squibb
07/31/22
-
156
2-arylsulfonamido-N-arylacetamide derivatized STAT3 inhibitors
University of Hawaii
07/28/22
-
10
Chemical compounds
Glaxosmithkline Intellectual Property (No. 2)
07/24/22
-
47
Benzimidazole and indole compounds and uses thereof
Incyte
07/24/22
-
66
Five membered-aminoheterocycle and 5,6-or 6,6-membered bicyclic aminoheterocyclic inhibitors of rock for the treatment of heart failure
Bristol-Myers Squibb
07/24/22
-
83
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals
07/24/22
-
27
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D Ip
07/24/22
-
108
Heterocyclic compounds and uses thereof
Nuvation Bio
07/24/22
-
24
Substituted tetrahydropyran dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
Union Therapeutics
07/24/22
-
171
RAD51 inhibitors
Cyteir Therapeutics
07/21/22
-
1
Combination therapy involving diaryl macrocyclic compounds
Turning Point Therapeutics
07/21/22
-
256
Substituted piperidine compound and use thereof
Takeda Pharmaceutical
07/21/22
-
237
Heterocyclic inhibitors of MCT4
Vettore
07/21/22
-
184
Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
Reata Pharmaceuticals
07/21/22
-
37
Diarylhydantoin compounds and methods of use thereof
Nuvation Bio
07/21/22
-
18
Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
Hanmi Pharm.
07/21/22
-
3
Composition for inhibiting growth of SARS-CoV-2 and method of preparing the same
Medicare Pharmaceuticals
07/21/22
-
780
Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
Forma Therapeutics
07/21/22
-
82
Tricyclic CRBN ligands and uses thereof
Kymera Therapeutics
07/21/22
-
16
Substituted azetidine dihydrothienopyrimidines and their use as phosphodiesterase inhibitors
Union Therapeutics
07/21/22
-
390
Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
Incyte
07/16/22
-
369
Substituted piperazines as KRAS G12C inhibitors
Amgen
07/16/22
-
32
Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
Daegu-Gyeongbuk Medical Innovation Foundation
07/16/22
-
6
Pyrrolidine compounds
Eli Lilly
07/16/22
-
33
Macrocyclic fluorine substituted indole derivatives
The Broad Institute
07/16/22
-
1775
EIF4E-inhibiting compounds and methods
Effector Therapeutics
07/16/22
-
9
Enantiomers of substituted thiazoles as antiviral compounds
Innovative Molecules Gmbg
07/10/22
-
435
Compounds and compositions for the inhibition of NAMPT
Valo Health
07/10/22
-
41
Inhibitors of RET
Blueprint Medicines
07/10/22
-
51
Aromatic derivative, preparation method for same, and medical applications thereof
Bioardis
07/10/22
-
19
Compound as selective JAK inhibitor, and salt and therapeutic use thereof
Suzhou Longbiotech Pharmaceuticals
07/10/22
-
9
AMPK activators
Kallyope
07/10/22
-
229
Fused pyrimidine compounds as BRD4 and JAK2 dual inhibitors and methods for use thereof
Aptose Biosciences
07/10/22
-
61
Macrocyclic compounds that inhibit MCL-1 protein
Amgen
07/10/22
-
63
Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof
Royal Institution For The Advancement of Learning
07/10/22
-
28
Tricyclic compounds for use in treatment of proliferative disorders
Argonaut Therapeutics
07/05/22
-
171
Alpha-hydroxy phenylacetic acid pharmacophore or bioisostere Mcl-1 protein antagonists
Amgen
07/05/22
-
291
Colony stimulating factor-1 receptor (CSF-1R) inhibitors
Genzyme
07/05/22
-
55
MAPK inhibitors
Everbrilliant Pharma
07/04/22
-
34
Pharmaceutical composition for ANO1 antagonist with anticancer activity
Industry-Academic Cooperation Foundation Yonsei University
07/04/22
-
375
P300/CBP HAT inhibitors
Constellation Pharmaceuticals
07/04/22
-
32
Cyclopentane compounds
Dizal (Jiangsu) Pharmaceutical
07/04/22
-
16
Modulators of methyl modifying enzymes, compositions and uses thereof
Constellation Pharmaceuticals
07/04/22
-
17
Maslinic and oleanolic acids derivatives for treating SARS-CoV-2 infection
King Abdulaziz University
06/26/22
-
516
Triaryl compounds for treatment of PD-L1 diseases
Chemocentryx
06/26/22
-
48
Carbocyclic prolinamide derivatives
Orion Ophthalmology
06/26/22
-
1
Indazole compound for use in inhibiting kinase activity, composition and application thereof
Shenzhen Targetrx
06/26/22
-
14
Benzamide derivatives as PPAR-gamma modulators
Medibiofarma
06/26/22
-
1
Aminopyrimidine compound and composition comprising same and use thereof
Shenzhen Targetrx
06/26/22
-
331
Small molecule inhibitors of galectin-3
Bristol-Myers Squibb
06/26/22
-
19
Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof
Shanghai Ringene Biopharma
06/26/22
-
105
Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Array Biopharma
06/26/22
-
14
Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
Jubilant Biosys
06/26/22
-
3
Substituted 1,2,3,3a,4,5,7,9,13,13a-decahydropyrido[1′,2′:4,5]pyrazino[1,2-a]pyrrolo[1,2-c]pyrimidines having HIV integrase inhibitory activity
Shionogi
06/26/22
-
224
Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
Idorsia Pharmaceuticals
06/26/22
-
126
TRPV4 antagonists
Glaxosmithkline Intellectual Property (No. 2)
06/24/22
-
15
Aromatic compound, pharmaceutical composition and use thereof
Sichuan Kelun-Biotech Biopharmaceutical
06/24/22
-
51
Sulfoximine glycosidase inhibitors
Asceneuron
06/24/22
-
41
[1,6]naphthyridine compounds and derivatives as CDK8/CDK19 inhibitors
Boehringer Ingelheim International
06/24/22
-
53
Bicyclic heterocyclic derivatives
Merck Patent
06/24/22
-
587
Biaryl derivative as GPR120 agonist
Lg Chem.
06/24/22
-
48
Dihydropyrimidine compounds and uses thereof in medicine
Sunshine Lake Pharma
06/24/22
-
205
Imidazotriaines and imidazopyrimidines as kinase inhibitors
Incyte Holdings
06/24/22
-
73
19-NOR neuroactive steroids and methods of use thereof
Sage Therapeutics
06/24/22
-
45
Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
Children''S Hospital Medical Center
06/19/22
-
371
Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives
Pfizer
06/19/22
-
11
Fused imidazo-piperidine JAK inhibitors
Theravance Biopharma R&D Ip
06/19/22
-
9
1,8-naphthyridinone compounds and uses thereof
Nuvation Bio
06/19/22
-
72
Pyrazole derivative compound and use thereof
Hanmi Pharm.
06/19/22
-
49
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics
06/19/22
-
637
Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor
Corvus Pharmaceuticals
06/19/22
-
3
Triple combination of pure 5-HT6 receptor antagonists, acetylcholinesterase inhibitors and NMDA receptor antagonist
Suven Life Sciences
06/17/22
-
43
N2,N4-diphenylpyrimidine-2,4-diamine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of cancer
Korea Research Institute of Chemical Technology
06/17/22
-
71
3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators
Ludwig Institute For Cancer Research
06/17/22
-
22
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
Tes Pharma
06/17/22
-
409
Substituted bicyclic compounds as farnesoid X receptor modulators
Bristol-Myers Squibb
06/17/22
-
114
Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
University of Washington Through Its Center For Commercialization
06/13/22
-
4
Metalloenzyme inhibitor compounds
Mycovia Pharmaceuticals
06/13/22
-
69
Compounds and methods for inhibiting JAK
Dizal (Jiangsu) Pharmaceutical
06/13/22
-
157
Phenyl indole allosteric inhibitors of P97 ATPase
University of Pittsburgh
06/13/22
-
11
FXR (NR1H4) modulating compounds
Gilead Sciences
06/13/22
-
172
Therapeutic compounds and uses thereof
Genentech
06/13/22
-
508
Bicyclic fused pyridine compounds as inhibitors of TAM kinases
Array Biopharma
06/13/22
-
116
Cyclopropylamines as LSD1 inhibitors
Incyte
06/13/22
-
34
Quinazoline and indole compounds to treat medical disorders
Achillion Pharmaceuticals
06/13/22
-
288
PCSK9 inhibitors and methods of use thereof
Astrazeneca
06/13/22
-
3
Pyrimidine derivative having effect of inhibiting cancer cell growth and pharmaceutical composition containing same
Oncobix
06/13/22
-
63
Macrocyclic derivative of pyrazol[3,4-d]pyrimidin-3-one, pharmaceutical composition and use thereof
Shanghai De Novo Pharmatech
06/13/22
-
52
Tricyclic inhibitors of poly(ADP-ribose)polymerase
Rakovina Therapeutics
06/13/22
-
134
Compounds useful for treating gastrointestinal tract disorders
Ardelyx
06/10/22
-
56
Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
06/10/22
-
76
Pyrazolopyridine compounds and uses thereof
Incyte
06/10/22
-
86
(4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
Genentech
06/10/22
-
61
Sulfonimidoylpurinone compounds and methods of treatment using the same
Hoffmann-La Roche
06/10/22
-
12
2-phenyl-3,4-dihydropyrrolo[2,1-Ff] [1,2,4]triazinone derivatives as phosphodiesterase inhibitors and uses thereof
Topadur Pharma
06/10/22
-
2
Ethynyl derivatives
Hoffmann-La Roche
06/10/22
-
90
Spirocyclic ROR-gamma modulators
Escalier Biosciences
06/10/22
-
98
Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof
Ontario Institute For Cancer Research (Oicr)
06/10/22
-
174
Proteasome activity enhancing compounds
Proteostasis Therapeutics
06/10/22
-
4
Organosilicon carriers for use in treating infections and/or diseases caused by SARS viruses
Individual
06/09/22
-
21
Heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and/or 2(HDAC1-2)
Medibiofarma
06/09/22
-
1
Formulations of an AXL/MER inhibitor
Incyte
06/09/22
-
6
Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof
Landsteiner Genmed
06/09/22
-
95
Inhibitors of plasma kallikrein
Kalvista Pharmaceuticals
06/09/22
-
134
Isoxazole compounds as inhibitors of heat shock proteins
Cancer Research Technology
06/06/22
-
36
Substituted sulfoximine compounds
Cadila Healthcare
06/06/22
-
182
Substituted heterocyclic sulfonamide compounds useful as TRPA1 modulators
Genentech
06/06/22
-
3
Aminobenzimidazole derivatives, treatments, and methods of inhibiting histone deacetylase
Translational Drug Development
06/06/22
-
274
Combination of isoindolinone derivatives with SGI-110
Astex Therapeutics
06/06/22
-
99
Fused ring compounds
Genentech
06/06/22
-
197
KIF18A inhibitors
Amgen
06/06/22
-
8
Morpholine derivates as inhibitors of Vps34
Neuropore Therapies
06/06/22
-
6
Substituted pyrrolopyridines as ATR inhibitors
Bluevalley Pharmaceutical
06/06/22
-
116
Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
Mission Therapeutics
06/06/22
-
77
Protein kinase B inhibitors
Astrazeneca
06/06/22
-
78
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical
06/06/22
-
166
KDM1A inhibitors for the treatment of disease
Imago Biosciences
05/30/22
-
11
2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
Crystalgenomics
05/30/22
-
99
Purine inhibitors of human phosphatidylinositol 3-kinase delta
Merck Sharp & Dohme
05/30/22
-
108
Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
Incyte
05/29/22
-
38
Substituted tetrahydroquinolinone compounds as ROR gamma modulators
Aurigene Discovery Technologies
05/29/22
-
32
Selective androgen receptor degrader (SARD) ligands and methods of use thereof
University of Tennessee Research Foundation
05/29/22
-
128
Myocyte enhancer factor 2 (MEF2) modulators
Standard
05/29/22
-
244
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
05/29/22
-
812
Compounds that inhibits MCL-1 protein
Amgen
05/22/22
-
275
Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof
Whitehead Institute For Biomedical Research
05/22/22
-
10
Substituted pyridines as inhibitors of histone deacetylase
Alkermes
05/22/22
-
15
Bicyclic inhibitors of histone deacetylase
Alkermes
05/22/22
-
122
Tertiary alcohols as PI3K-γ inhibitors
Incyte
05/22/22
-
18
Heterocycles useful as anti-cancer agents
Hangzhou Innogate Pharma
05/22/22
-
23
Pyridylpyridone compounds
Sprint Bioscience
05/14/22
-
333
Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof
La Jolla Institute of Allergy & Immunology
05/14/22
-
137
Cyclin dependent kinase inhibitors
Pfizer
05/14/22
-
16
5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
Temple University
05/14/22
-
217
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
05/14/22
-
218
Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
Mirati Therapeutics
05/14/22
-
30
Pyrrole tricyclic compounds as A2A / A2B inhibitors
Incyte
05/14/22
-
93
Substituted n-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazoles as protein kinase C inhibitors
Pfizer
05/14/22
-
71
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics
05/14/22
-
25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
Shy Therapeutics
05/08/22
-
16
Phenylpyrazolylacetamide compounds and derivatives as CDK8/CDK19 inhibitors
Boehringer Ingelheim International
05/08/22
-
21
Linear glycosidase inhibitors
Asceneuron
05/08/22
-
88
Compositions for treating neurodegenerative diseases
Cognition Therapeutics
05/08/22
-
103
Histone demethylase inhibitors
Celgene Quanticel Research
05/08/22
-
17
Cannabinoid receptor modulators
Arena Pharmaceuticals
05/08/22
-
52
Indoleamine 2,3-dioxygenase inhibitor, method for preparation and use thereof
Nanjing Huawe Medicine Technology Group
05/08/22
-
42
MAGL inhibitors
H. Lundbeck
05/08/22
-
52
Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
Janssen Pharmaceutica
05/08/22
-
341
Compound, compositions, and methods
Denali Therapeutics
05/08/22
-
7
Substituted pyridine derivatives useful as C-FMS kinase inhibitors
Janssen Pharmaceutica
05/08/22
-
42
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
Incyte Holdings
05/08/22
-
49
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics
05/08/22
-
4
2,3-dihydrofuro[2,3-b]pyridine compounds
Eli Lilly
05/08/22
-
121
Pyridone derivatives having tetrahydropyranylmethyl groups
Daiichi Sankyo
05/03/22
-
109
Compounds useful as inhibitors of ALCAT 1
Perenna Pharmaceuticals
05/03/22
-
32
Compositions and methods for treating parasitic diseases
University of California
05/03/22
-
80
Ectonucleotidase inhibitors and methods of use thereof
Calithera Biosciences
05/03/22
-
376
Substituted indole Mcl-1 inhibitors
Vanderbilt University
05/03/22
-
41
Selective inhibitors of protein arginine methytransterase 5 (PRMT5)
Prelude Therapeutics
05/03/22
-
5
Nitrogenous tricyclic compounds and uses thereof in medicine
Sunshine Lake Pharma
05/03/22
-
53
Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors
Bayer Pharma Aktiengesellschaft
05/03/22
-
20
Pyridinamine-pyridone and pyrimidinamine- pyridone compounds
Sprint Bioscience
05/03/22
-
31
Prognostic biomarkers for TTK inhibitor chemotherapy
Netherlands Translational Research Center
05/03/22
-
595
Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GLUN2B receptor modulators
Janssen Pharmaceutica
05/02/22
-
20
1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
Incyte
05/02/22
-
204
Metallo-beta-lactamase inhibitors and methods of use thereof
Merck Sharp & Dohme
05/02/22
-
243
Triazolopyrimidine compounds and uses thereof
Novartis
05/02/22
-
27
HDAC6 inhibitors and imaging agents
The General Hospital
05/02/22
-
119
3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
Allergan
05/02/22
-
55
Indole derivatives and their use as protein kinase inhibitors
Respivert
05/02/22
-
1
Sulfinylpyridines and their use in the treatment of cancer
Oblique Therapeutics
05/02/22
-
96
Certain chemical entities, compositions, and methods
Neupharma
05/02/22
-
117
NLRP3 inflammasome inhibitors
Novartis
05/02/22
-
526
Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
Bayer Aktiengesellschaft
05/02/22
-
14
Personal care compositions comprising fatty acid amide derivatives
Conopco
04/29/22
-
100
Sulfonamides as modulators of sodium channels
Vertex Pharmaceuticals
04/29/22
-
247
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
04/29/22
-
37
Iridinesulfonamide compound and use method thereof
Chia Tai Tianqing Pharmaceutical Group
04/29/22
-
302
Substituted 6-azabenzimidazole compounds
Gilead Sciences
04/29/22
-
28
Anti-proliferative agents for treating PAH
Pfizer
04/29/22
-
13
Aza-indazole compounds for use in tendon and/or ligament injuries
Novartis
04/29/22
-
281
Kinase inhibitors and uses thereof
Denali Therapeutics
04/29/22
-
19
Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
The Broad Institute
04/29/22
-
573
Fused ring derivative having MGAT-2 inhibitory activity
Shionogi
04/25/22
-
56
Compounds targeting PRMT5
Aligos Therapeutics
04/25/22
-
113
Aminopyrimidinyl compounds
Pfizer
04/24/22
-
16
Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists
Glycomimetics.
04/24/22
-
13
Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
Bioaxone Biosciences
04/24/22
-
115
Heteroaryl inhibitors of PAD4
Padlock Therapeutics
04/24/22
-
92
N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
Kalvista Pharmaceuticals
04/24/22
-
8
Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy
The Johns Hopkins University
04/17/22
-
111
Alkyl substituted triazole compounds as agonists of the APJ Receptor
Amgen
04/17/22
-
44
Heterocyclic compounds for the inhibition of PASK
Bioenergenix
04/17/22
-
36
N-aryl oxamic acids
Purdue Research Foundation
04/17/22
-
43
Quinoline compounds as modulators of RAGE activity and uses thereof
TBA
04/17/22
-
246
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
04/17/22
-
4
Quinolone compounds as inhibitors of the BCL6 BTB domain protein-protein interaction and/or as BCL6 degraders
Ontario Institute For Cancer Research (Oicr)
04/17/22
-
6
Pyrazoloquinazolinone antitumor agents
Rockefeller University
04/17/22
-
68
Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors
Nuvation Bio
04/17/22
-
377
Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
Janssen Pharmaceutica
04/17/22
-
130
Pyrazolo[1,5-A][1,3,5]triazine and pyrazolo[1,5-A]pyrimidine derivatives as CDK inhibitors
Aurigene Discovery Technologies
04/10/22
-
212
Vasopressin receptor antagonists and products and methods related thereto
Blackthorn Therapeutics
04/10/22
-
6
Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors
Shenzhen Targetrx
04/10/22
-
35
Therapeutic heterocyclic compounds
Gilead Sciences
04/10/22
-
4
Crystalline forms of a phosphoinositide 3-kinase (PI3K) inhibitor
Incyte
04/10/22
-
562
Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors
Dart Neuroscience (Cayman)
04/10/22
-
32
Compound as ACC inhibitor and use thereof
Nanjing Sanhome Pharmaceutical
04/10/22
-
73
6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivative
Ayumi Pharmaceutical
04/10/22
-
95
Cyanoindoline derivatives as NIK inhibitors
Janssen Pharmaceutica
04/10/22
-
23
Somatostatin modulators and uses thereof
Crinetics Pharmaceuticals
04/10/22
-
8
Cannabinoid receptor antagonists/inverse agonists useful for treating disease conditions, including metabolic disorders and cancers
Jenrin Discovery
04/10/22
-
38
Purine inhibitors of human phosphatidylinositol 3-kinase delta
Merck Sharp & Dohme
04/10/22
-
145
Imidazopyrimidine derivatives
Gilead Sciences
04/10/22
-
88
6-heterocyclyl-4-morpholin-4-ylpyridine-2-one compounds useful for the treatment of cancer and diabetes
Sprint Bioscience
04/10/22
-
161
Compounds for the treatment of pain
TBA
04/10/22
-
40
Amino pyrimidine derivatives
Novartis
04/10/22
-
254
Substituted oxopyridine derivatives
Bayer Pharma Aktiengesellschaft
04/10/22
-
46
Anilinopyrimidines as haematopoietic progenitor kinase 1 (HPK1) inhibitors
Ariad Pharmaceuticals
04/10/22
-
59
Pyrazole derivatives as plasma kallikrein inhibitors
Kalvista Pharmaceuticals
04/10/22
-
183
Substituted amino acids as integrin inhibitors
Pliant Therapeutics
04/10/22
-
14
Azaspiro[4.5]decane derivatives and use thereof
Purdue Pharma
04/10/22
-
13
[1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives
Eli Lilly
04/10/22
-
49
Methods for modulating taste receptors
Mars
04/09/22
-
27
3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
Novartis
04/09/22
-
45
Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Bristol-Myers Squibb
04/09/22
-
164
Non-fused tricyclic compounds
Vivace Therapeutics
04/09/22
-
63
Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
Vertex Pharmaceuticals
04/09/22
-
59
Compositions and methods to modulate chloride ion channel activity
The Board of Trustees of The Leland Stanford Junior University
04/03/22
-
8
Adrenergic receptor modulating compounds and methods of using the same
The Board of Trustees of The Leland Stanford Junior University
04/03/22
-
73
4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
Takeda Pharmaceutical
04/03/22
-
187
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
04/03/22
-
7
Neprilysin inhibitors
Theravance Biopharma R&D Ip
04/03/22
-
89
Substituted heterocyclyl derivatives as CDK inhibitors
Aurigene Discovery Technologies
04/03/22
-
303
Isoquinolin-3-yl carboxamides and preparation and use thereof
Biosplice Therapeutics
04/03/22
-
124
Benzimidazole compounds and derivatives as EGFR inhibitors
Boehringer Ingelheim International
04/03/22
-
29
Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
Merck Sharp & Dohme
04/03/22
-
126
Substituted carboxamides as inhibitors of WDR5 protein-protein binding
Propellon Therapeutics
04/03/22
-
133
Heterocyclic compounds as kinase inhibitors
Nuvation Bio
04/03/22
-
17
Aniline-substituted 1,2-dihydropyrrol[3,4-C]pyridin/pyrimidin-3-one derivative and use thereof
Yangtze River Pharmaceutical Group
04/03/22
-
18
Compounds, compositions and methods
Denali Therapeutics
04/03/22
-
19
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
04/03/22
-
333
Benzenesulfonamide compouds and their use as therapeutic agents
Xenon Pharmaceuticals
04/03/22
-
5
Matriptase inhibitors and uses thereof
SociÉTÉ
03/30/22
-
42
Inhibitors of dihydroceramide desaturase for treating disease
Centaurus Therapeutics
03/27/22
-
8
Indane-amines as PD-L1 antagonists
Chemocentryx
03/27/22
-
239
Substituted N-arylethyl-2-arylquinoline-4-carboxamides and use thereof
Bayer Aktiengesellschaft
03/27/22
-
214
Heteroaromatic derivatives as NIK inhibitors
Janssen Pharmaceutica
03/27/22
-
71
3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
Board of Trustees of The Southern Illinois University
03/27/22
-
35
CXCR2 antagonist
Medshine Discovery
03/27/22
-
25
Fused ring derivative used as FGFR4 inhibitor
Jacobio Pharmaceuticals
03/27/22
-
38
Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors
Jiangsu Hansoh Pharmaceutical Group
03/27/22
-
7
Pyrrolopyrimidine and pyrrolopyridine derivatives
Galapagos
03/27/22
-
96
Pyrrolopyrimidine derivatives as TAM inhibitors
Incyte
03/27/22
-
77
Macrocycles as factor XIA inhibitors
Bristol-Myers Squibb
03/27/22
-
11
3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman)
03/27/22
-
118
JAK inhibitors
Vimalan Biosciences
03/27/22
-
10
Functionalized pyrano[2,3-D]pyrimidin-7-one derivatives and methods for their preparation and use
The Texas A&M University System
03/27/22
-
22
Thienopyrimidones
Boehringer Ingelheim International
03/27/22
-
42
Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
Boehringer Ingelheim International
03/27/22
-
13
Amino-triazolopyridine compounds and their use in treating cancer
Astrazeneca
03/27/22
-
55
Inhibitors of integrated stress response pathway
Praxis Biotech
03/27/22
-
20
4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament
Boehringer Ingelheim International
03/27/22
-
6
Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer
Oblique Therapeutics
03/27/22
-
125
Therapeutic compounds and uses thereof
Genentech
03/27/22
-
34
Compounds and their use for reducing uric acid levels
Acquist
03/27/22
-
67
Dynamin-1-like protein inhibitors
Mitobridge
03/27/22
-
95
Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
The Regents of The University of Michigan
03/27/22
-
66
Inhibitors of Plasma Kallikrein and uses thereof
Takeda Pharmaceutical
03/27/22
-
56
Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof
TBA
03/27/22
-
34
Fused pyrimidine derivatives as A2A / A2B inhibitors
Incyte
03/27/22
-
115
Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
Array Biopharma
03/27/22
-
135
Thienopyridine inhibitors of RIPK2
Celgene
03/27/22
-
173
ASK1 inhibiting agents
Biogen Ma
03/27/22
-
135
Bicyclic heteroaryl compounds and uses thereof
Revolution Medicines
03/27/22
-
48
Pyridinone derivatives and their use as selective ALK-2 inhibitors
Novartis
03/20/22
-
33
Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer
Oblique Therapeutics
03/20/22
-
15
Compounds and their use for reducing uric acid levels
Acquist
03/20/22
-
13
Heterocyclic derivatives as PI3K inhibitors
Incyte
03/20/22
-
186
2-quinolone derived inhibitors of BCL6
The Institute of Cancer Research: Royal Cancer Hospital
03/20/22
-
37
Cyclic substituted imidazo[4,5-c]quinoline derivatives
Pfizer
03/20/22
-
528
Purinones as ubiquitin-specific protease 1 inhibitors
Forma Therapeutics
03/20/22
-
6
Inhibiting the transient receptor potential al ion channel
Eli Lilly
03/20/22
-
113
Fused pyrazine derivatives as A2A / A2B inhibitors
Incyte
03/20/22
-
44
Inhibitors of NEK7 kinase
Halia Therapeutics
03/20/22
-
77
Indazolyl-spiro[2.2]pentane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
Merck Sharp & Dohme
03/20/22
-
97
Tricyclic fused thiophene derivatives as JAK inhibitors
Incyte
03/20/22
-
76
Sting agonists
Venenum Biodesign
03/20/22
-
35
Fused piperidinyl bicyclic and related compounds as modulators of C5A receptor
Inflarx
03/13/22
-
2
Crystal form of urate transporter 1 inhibitor and preparation method and use thereof
Tianjin Institute of Pharmaceutical Research
03/13/22
-
272
Substituted N-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
Bayer Aktiengesellschaft
03/13/22
-
46
MAP kinase modulators and uses thereof
Columbia University
03/13/22
-
66
Antagonists of the muscarinic acetylcholine receptor M4
Vanderbilt University
03/13/22
-
70
Substituted triazole derivatives and uses thereof
Bayer Pharma Aktiengesellschaft
03/13/22
-
251
Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
Sanofi
03/13/22
-
37
Pyrazole MAGL inhibitors
H. Lundbeck
03/13/22
-
38
Fused triazole agonists of the APJ receptor
Amgen
03/13/22
-
12
Substituted nucleosides, nucleotides and analogs thereof
Janssen Biopharma
03/13/22
-
157
Oxysterols and methods of use thereof
Sage Therapeutics
03/13/22
-
13
C7 substituted oxysterols and methods of use thereof
Sage Therapeutics
03/13/22
-
15
Thrombospondin 1-binding peptide
Daiichi Sankyo
03/13/22
-
33
Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors
UniversitÄT Duisburg-Essen
03/13/22
-
1
Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
Arena Pharmaceuticals
03/13/22
-
4
Amide derivatives as Nav1.7 and Nav1.8 blockers
Raqualia Pharma
03/13/22
-
129
Cyclopropylamines as LSD1 inhibitors
Incyte
03/13/22
-
57
Heterocycle comprising tyrosine kinase inhibitors
Principia Biopharma
03/13/22
-
71
4,6,7-trisubstituted 1,2-dihydropyrrolo[3,4-c]pyridin/pyrimidin-3-one derivatives and uses thereof
Shanghai Haiyan Pharmaceutical Technology
03/13/22
-
17
Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
Dana-Farber Cancer Institute
03/13/22
-
140
Pyrazolopyrimidine compounds and methods of use thereof
Genentech
03/13/22
-
30
Dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
Topadur Pharma
03/13/22
-
29
Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
Aurigene Discovery Technologies
03/12/22
-
8
Composition for inducing differentiation and protection of neural stem cells and method for inducing neuro-regeneration using the same composition
Genuv
03/12/22
-
5
Methods for treating GI tract disorders
Neurogastrx
03/12/22
-
17
Compositions and methods for treating CNS disorders
Sage Therapeutics
03/12/22
-
2
Compounds as neurokinin-1 receptor antagonists and uses thereof
Xwpharma
03/12/22
-
60
Dual MAGL and FAAH inhibitors
Abide Therapeutics
03/08/22
-
66
Pyridazinone compounds and their use as DAAO inhibitors
Takeda Pharmaceutical
03/08/22
-
17
Substituted 2,3-dihydro-1H-indene analogs and methods using same
Arbutus Biopharma
03/08/22
-
215
2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
Bayer Aktiengellschaft
03/08/22
-
78
Compounds
Mission Therapeutics
03/08/22
-
15
Calcium channel inhibitors
Cavion
03/08/22
-
95
Substituted benzamides as RIPK2 inhibitors
Boehringer Ingelheim International
03/08/22
-
715
2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
Ideaya Bioscience
03/08/22
-
38
Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
Incyte
03/08/22
-
308
Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein
Prelude Therapeutics
03/08/22
-
61
Benzimidazoles and indoles as taro inhibitors
Merck Sharp & Dohme
03/04/22
-
99
Oxazolidinones as taro inhibitors
Merck Sharp & Dohme
03/04/22
-
3
Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
Poxel
03/04/22
-
58
Compositions for APP-selective BACE inhibition and uses therefor
University of California
03/04/22
-
35
Inhibitors of cyclin-dependent kinases
Dana-Farber Cancer Institute
03/04/22
-
37
LDHA activity inhibitors
Arctic Pharma
03/04/22
-
51
Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
Stingray Therapeutics
03/04/22
-
179
Azalactam compounds as HPK1 inhibitors
Pfizer
03/04/22
-
187
Spirocycle compounds and methods of making and using same
H. Lundbeck
03/04/22
-
99
Dihydropyrimidine compounds and uses thereof in medicine
Sunshine Lake Pharma
03/04/22
-
13
Cyano substituted heteroarylpyrimidinone derivative, preparation method and use thereof
Zhejiang Hisun Pharmaceutical
03/04/22
-
21
Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor
Hangzhou Innogate Pharma
03/04/22
-
8
Inhibitors of bromodomain-containing protein 4 (BRD4)
Board of Regents, The University of Texas System
03/02/22
-
32
Tetrahydroisoquinolines and terahydronaphthyridines for the treatment of hepatitis B virus infection
Hoffmann-La Roche
02/26/22
-
7
Imidazolidine compounds
Eli Lilly
02/26/22
-
38
Disubstituted pyrazole compounds
Eli Lilly
02/26/22
-
50
Tri-substituted imidazoles for the inhibition of TGF beta and methods of treatment
Clavius Pharmaceuticals
02/26/22
-
24
Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof
Dynavax Technologies
02/26/22
-
33
Heterocyclic compounds as immunomodulators
Incyte
02/26/22
-
28
L,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-one analogs
Recurium Ip Holdings
02/26/22
-
34
2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof
TBA
02/26/22
-
101
Inhibitors of glucocorticoid receptor
Oric Pharmaceuticals
02/26/22
-
62
Neuroactive steroids, compositions, and uses thereof
Sage Therapeutics
02/26/22
-
635
Methods and compositions of inhibiting DCN1-UBC12 interaction
Memorial Sloan Kettering Cancer Center
02/26/22
-
3
Combination of pure 5-HT6 receptor antagonists with NMDA receptor antagonist
Suven Life Sciences
02/26/22
-
127
Phenylpyrrolidinone formyl peptide 2 receptor agonists
Bristol-Myers Squibb
02/26/22
-
37
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
Astrazeneca
02/26/22
-
4
Isoquinolin and naphthydrin compounds
Eli Lilly
02/26/22
-
39
Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
TBA
02/26/22
-
7
Pyrazolo-heteroaryl derivative, preparation method and medical use thereof
Jiangsu Hengrui Medicine
02/26/22
-
546
Compounds useful as inhibitors of ATR kinase
Vertex Pharmaceuticals
02/26/22
-
22
Selective estrogen receptor degraders
Eli Lilly
02/26/22
-
81
Pyrazolopyrimidine compounds and uses thereof
Incyte
02/22/22
-
12
Pyrimidine compounds and pyrimido indole compounds and methods of use
Duquesne University of The Holy Spirit
02/22/22
-
117
6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
University of Pittsburgh
02/22/22
-
39
Inhibitor of apoptosis protein (IAP) antagonists
Sanford Burnham Prebys Medical Discovery Institute
02/22/22
-
62
Methods of treating mental disorders
University of California
02/21/22
-
1227
6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
Shionogi
02/21/22
-
53
EPAC antagonists
Board of Regents, The University of Texas System
02/21/22
-
23
Autotaxin inhibitors
University of Tennessee Research Foundation
02/21/22
-
71
Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Bristol-Myers Squibb
02/21/22
-
17
Imidazopyrazine inhibitors of Bruton's tyrosine kinase
Acerta Pharma
02/21/22
-
43
Pyrimidine compounds as JAK kinase inhibitors
Theravance Biopharma R&D Ip
02/21/22
-
64
Amino pyrimidine compound for inhibiting protein tyrosine kinase activity
Shenzhen Targetrx
02/21/22
-
163
Compounds, compositions, and methods
Denali Therapeutics
02/21/22
-
250
Bicyclic compound and use thereof
Sk Biopharmaceuticals
02/21/22
-
27
Sultam compound and application method thereof
Chai Tai Tianqing Pharmaceutical Group
02/21/22
-
314
Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides
Pfizer
02/21/22
-
106
Substituted pyridines as TYK2 inhibitors
Esker Therapeutics
02/13/22
-
138
Pyrimidine derivative compound, optical isomer thereof, or pharmaceutically acceptable salt thereof, and composition for preventing or treating Tyro 3 related disease comprising same as active ingredient
Korea Research Institute of Chemical Technology
02/13/22
-
379
KRAS G12C inhibitors and methods of using the same
Amgen
02/13/22
-
15
Benzimidazole derivatives, preparation methods and uses thereof
Betta Pharmaceuticals
02/13/22
-
96
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
02/13/22
-
156
[9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
Neurocrine Biosciences
02/13/22
-
50
Inhibitors of hepatitis C virus replication
Merck Sharp & Dohme
02/13/22
-
843
4-azaindole compounds
Bristol-Myers Squibb
02/13/22
-
233
Substituted tricyclic compounds as FGFR inhibitors
Incyte
02/13/22
-
8
Pyrimidinones as factor XIA inhibitors
Bristol-Myers Squibb
02/13/22
-
10
Pyrrolo[1,2-b]pyridazine derivatives
Gilead Sciences
02/13/22
-
223
Macrocyclic compounds for treatment of medical disorders
Achillion Pharmaceuticals
02/13/22
-
26
JAK1 pathway inhibitors for the treatment of cytokine-related disorders
Incyte
02/13/22
-
47
4,5,6-trisubstituted indazole derivatives, and preparation method and pharmaceutical use thereof
TBA
02/13/22
-
14
Pyridazines
Boehringer Ingelheim International
02/13/22
-
20
Inhibitors of bruton's tyrosine kinase
Hoffmann-La Roche
02/13/22
-
13
4-pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament
Boehringer Ingelheim International
02/13/22
-
21
PTPN11 inhibitors
Navire Pharma
02/13/22
-
188
Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases
Array Biopharma
02/13/22
-
27
1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 inhibitors
H. Lundbeck
02/13/22
-
2
Salts of TAM inhibitors
Incyte
02/13/22
-
199
Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharp & Dohme
02/13/22
-
262
Apoptosis signal-regulating kinase inhibitors
Gilead Sciences
02/13/22
-
71
5-alkyl pyrrolidine orexin receptor agonists
Merck Sharp & Dohme
02/07/22
-
126
Inhibitors of RAF kinases
Kinnate Biopharma
02/07/22
-
4
Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
02/07/22
-
179
Heteroaryl compounds as BTK inhibitors and uses thereof
Merck Patent
02/07/22
-
103
Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders
1St Biotherapeutics
02/07/22
-
116
Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
Pharmaxis
02/07/22
-
40
Macrocyclic compounds as TRK kinase inhibitors and uses thereof
Angex Pharmaceutical
02/07/22
-
64
Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
Hoffmann-La Roche
02/07/22
-
149
Bicyclic ketone compounds and methods of use thereof
Genentech
02/07/22
-
26
PRMT5 inhibitors
Merck Sharp & Dohme
02/07/22
-
32
Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof
Chia Tai Tianqing Pharmaceutical Group
02/07/22
-
126
MK2 inhibitors and uses thereof
Celgene Car
02/07/22
-
113
Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders
Bayer Aktiengesellschaft
02/07/22
-
10
Anti-HIV compounds
Gilead Sciences
02/06/22
-
21
BRK inhibitory compound
Ono Pharmaceutical
02/06/22
-
183
Aryl-or heteroaryl-substituted benzene compounds
Epizyme
02/06/22
-
26
Substituted indoline derivatives as dengue viral replication inhibitors
Janssen Pharmaceuticals
02/06/22
-
165
Carbazole derivatives
Bristol-Myers Squibb
02/06/22
-
116
1-cyano-pyrrolidine compounds as USP30 inhibitors
Mission Therapeutics
02/06/22
-
18
Indoleamine-2,3-dioxygenase inhibitor and preparation method therefor
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
02/06/22
-
252
Pharmaceutical compounds
Almac Discovery
02/06/22
-
168
Heterocyclic compounds useful as Pim kinase inhibitors
Incyte
02/06/22
-
36
Compounds and methods of use
Medivation Technologies
02/06/22
-
49
Combination therapies using immuno-dash inhibitors and PGE2 antagonists
Tufts College
02/06/22
-
19
Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase
Merck Sharp & Dohme
02/06/22
-
47
Heterocyclic compounds and uses thereof
Celgene Car
02/06/22
-
56
Triazolopyridine inhibitors of myeloperoxidase
Bristol-Myers Squibb
02/02/22
-
96
1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte
02/02/22
-
25
MAGL inhibitors
H. Lundbeck
02/02/22
-
15
Small molecule inhibitors of the JAK family of kinases
Janssen Pharmaceutica
02/02/22
-
30
Substituted purines as TLR7 agonists
Primmune Therapeutics
02/02/22
-
129
CXCR7 antagonists
Chemocentryx
02/02/22
-
25
Compounds and compositions useful for treating disorders related to NTRK
Blueprint Medicines
02/02/22
-
376
Disubstituted octahydropyrrolo[3,4-C]pyrroles as orexin receptor modulators
Janssen Pharmaceutica
02/02/22
-
10
Compounds that participate in cooperative binding and uses thereof
Revolution Medicines
02/02/22
-
24
Macrocyclic immunomodulators
Chemocentryx
02/02/22
-
30
Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
University of South Carolina
02/02/22
-
60
Difluoroketamide derivatives as HtrA1 inhibitors
Hoffmann-La Roche
02/02/22
-
7
Hydantoins that modulate BACE-mediated app processing
Buck Institute For Research On Aging
01/30/22
-
6
Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
AchÉ
01/30/22
-
70
SHMT inhibitors and uses thereof
Raze Therapeutics
01/30/22
-
200
Isoxazolyl ether derivatives as GABAA α5 PAM
Hoffmann-La Roche
01/30/22
-
113
PI-kinase inhibitors with anti-infective activity
University of California
01/30/22
-
4
Alkoxy bis-heteroaryl derivatives as modulators of protein aggregation
Ucb Biopharma
01/30/22
-
46
Protein kinase inhibitors, preparation method and medical use thereof
Gan & Lee Pharmaceuticals
01/30/22
-
63
Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
Ardelyx
01/30/22
-
270
Tricyclic heterocycles as BET protein inhibitors
Incyte
01/30/22
-
40
Imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidine compound as protein kinase inhibitor
Shengke Pharmaceuticals (Jiangsu)
01/30/22
-
78
1-cyano-pyrrolidine derivatives as inhibitors of USP30
Mission Therapeutics
01/30/22
-
218
Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors
Mirati Therapeutics
01/30/22
-
107
Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
Jiangsu Hengrui Medicine
01/24/22
-
92
N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
Kalvista Pharmaceuticals
01/24/22
-
20
(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
Centrexion Therapeutics
01/24/22
-
27
Cyanopyrrolidine derivatives with activity as inhibitors of USP30
Mission Therapeutics
01/24/22
-
26
Salts and processes of preparing a PI3K inhibitor
Incyte
01/24/22
-
51
Substituted pyrrolo[2,1-f][1,2,4]triazines as kinase inhibitors
Daewoong Pharmaceutical
01/24/22
-
51
Pyrazolopyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating cancer, autoimmune disease and brain disease containing the same as an active ingredient
Korea Research Institute of Chemical Technology
01/24/22
-
21
Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
Pharmakea
01/23/22
-
122
Imidazopiperazine inhibitors of transcription activating proteins
Board of Regents, The University of Texas System
01/23/22
-
12
Substituted bicyclic compounds
Bristol-Myers Squibb
01/23/22
-
6
Ethynyl derivatives
Hoffmann-La Roche
01/23/22
-
31
Oxime ether compounds
Bristol-Myers Squibb
01/23/22
-
21
Isoquinoline-steroid conjugates and uses thereof
Aerie Pharmaceuticals
01/23/22
-
28
Imidazolyl tricyclic enones as antioxidant inflammation modulators
Reata Pharmaceuticals
01/23/22
-
70
Heterocyclic compounds useful as dual ATX/CA inhibitors
Hoffmann-La Roche
01/23/22
-
84
Methods to induce targeted protein degradation through bifunctional molecules
Dana-Farber Cancer Institute
01/23/22
-
7
Substituted cyanopyrrolidines with activity as DUB inhibitors
Mission Therapeutics
01/23/22
-
33
Benzofuran derivative, preparation method thereof and use thereof in medicine
Jiangsu Hengrui Medicine
01/23/22
-
9
Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases
Regents of The University of Colorado, A Body Corporate
01/23/22
-
7
ROR-gamma modulators and uses thereof
Piramal Enterprises
01/23/22
-
118
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
01/23/22
-
713
2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
Ideaya Biosciences
01/23/22
-
565
Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
Achillion Pharmaceuticals
01/23/22
-
354
Tetrahydroquinoline derivatives as P2X7 receptor antagonists
Raqualia Pharma
01/16/22
-
60
Triazolopyrazine
TBA
01/16/22
-
2
Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals
Bayer Animal Health
01/16/22
-
17
6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes
Sprint Bioscience
01/16/22
-
3
Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
Yeda Research and Development
01/16/22
-
32
Heteroaromatic compounds as Vanin inhibitors
Boehringer Ingelheim International
01/16/22
-
155
ROR γ modulators
Bristol-Myers Squibb
01/16/22
-
39
Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
01/16/22
-
69
Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof
TBA
01/16/22
-
13
Heteroaryl amides as inhibitors of protein aggregation
Ucb Biophama
01/16/22
-
158
5-membered and bicyclic heterocyclic amides as inhibitors of rock
Bristol-Myers Squibb
01/16/22
-
155
Quinolone derivatives as fibroblast growth factor receptor inhibitors
Principia Biopharma
01/16/22
-
819
Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists
Nimbus Saturn
01/16/22
-
51
Heterocyclic derivatives as PI3K inhibitors
Incyte
01/16/22
-
42
Selective inhibitors of protein arginine methlytransferase 5 (PRMT5)
Prelude Therapeutics
01/16/22
-
14
Amino-fluoropiperidine derivatives as kinase inhibitor
Daewoong Pharmaceutical
01/16/22
-
17
Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same
Duquesne University of The Holy Spirit
01/16/22
-
201
Ectonucleotidase inhibitors and methods of use thereof
Calithera Biosciences
01/16/22
-
229
COMPOUNDS
Enterprise Therapeutics
01/13/22
-
179
Inhibitors of cysteine proteases and methods of use thereof
Pardes Biosciences
01/13/22
-
105
Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
Pharmakea
01/09/22
-
101
Bicyclic amide compounds and methods of use thereof
Genentech
01/07/22
-
29
1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones
Addex Pharmaceuticals
01/07/22
-
201
Substituted 6-azabenzimidazole compounds
Gilead Sciences
01/07/22
-
21
Antibody drug conjugates of kinesin spindel protein (KSP) inhibitors with antiB7H3-antibodies
Bayer Pharma Aktiengesellschaft
01/07/22
-
275
Substituted pyrrolidines as G-protein coupled receptor 43 agonists
Epics Therapeutics
01/07/22
-
41
Inhibitors of RIP1 kinase and methods of use thereof
Genentech
01/07/22
-
215
Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Galapagos
01/07/22
-
223
Bicyclic sulfones and sulfoxides and methods of use thereof
Genentech
01/07/22
-
13
Pyrazole[1,5-a] pyrimidine derivatives as kinase JAK inhibitors
Celon Pharma
01/07/22
-
31
Small molecule inhibitors of Galectin-3
Bristol-Myers Squibb
01/07/22
-
198
Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
Sk Biopharmaceuticals
12/28/21
-
48
Sulfonamide compounds
Daiichi Sankyo
12/28/21
-
175
Glycosidase inhibitors
Asceneuron
12/28/21
-
19
Androgen receptor modulating compounds
Orion
12/28/21
-
146
2,2-difluorodioxolo A2A receptor antagonists
Merck Sharp & Dohme
12/28/21
-
26
Galactoside inhibitor of galectins
Galecto Biotech
12/28/21
-
41
Piperidines as covalent menin inhibitors
The Regents of The University of Michigan
12/27/21
-
26
Azetidine derivative, preparation method therefor, and use thereof
Sichuan Kelun-Biotech Biopharmaceutical
12/27/21
-
208
Piperidinyl-3-(aryloxy)propanamides and propanoates
Takeda Pharmaceutical
12/27/21
-
5
Alkylphenyl compounds
Bristol-Myers Squibb
12/27/21
-
148
Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
Board of Regents, The University of Texas System
12/27/21
-
35
Piperazine substituted azapine derivatives and uses thereof
Alairion
12/27/21
-
36
Hydroxamic acids comprising pyrazole moiety and uses thereof
Hawaii Biotech
12/27/21
-
127
Aminopyrazine derivatives as PI3K-γ inhibitors
Incyte
12/27/21
-
45
2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma
DompÉ
12/27/21
-
27
Piperazinyl norbenzomorphan compounds and methods for using the same
Board of Regents, The University of Texas System
12/27/21
-
12
Dihydropyrimidinyl benzazepine carboxamide compounds
Hoffmann-La Roche
12/27/21
-
70
Indolinones compounds and their use in the treatment of fibrotic diseases
Respivert
12/27/21
-
8
Substituted isoquionline derivatives as immunomudulators
Bristol-Myers Squibb
12/27/21
-
436
Heteroaryl-substituted triazoles as APJ receptor agonists
Amgen
12/27/21
-
33
Substituted piperidines for the treatment of cancer
Les Laboratoires Servier
12/27/21
-
39
Fused heterocyclic derivatives, their preparation methods thereof and medical uses thereof
Beijing Innocare Pharma Tech
12/27/21
-
30
Thiadiazole IRAK4 compounds
Gilead Sciences
12/27/21
-
159
Selective estrogen receptor down-regulators
Astrazeneca
12/27/21
-
729
2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
Ideaya Biosciences
12/27/21
-
198
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical
12/27/21
-
1145
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
12/27/21
-
271
1-cyano-pyrrolidine compounds as USP30 inhibitors
Mission Therapeutics
12/23/21
-
918
Cot modulators and methods of use thereof
Gilead Sciences
12/23/21
-
6
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
Incyte
12/20/21
-
15
Small molecule inhibitors of the JAK family of kinases
Janssen Pharmaceutica
12/20/21
-
211
Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same
Shionogi
12/20/21
-
57
Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof
Guangzhou Maxinovel Pharmaceuticals
12/20/21
-
55
Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides
Arvinas Operations
12/19/21
-
26
Diacylglycerol acyl transferase 2 inhibitor
Pfizer
12/19/21
-
329
Arylquinazolines
Merck Patent
12/19/21
-
101
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
12/19/21
-
13
Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK and SRPK
Dana-Farber Cancer Institute
12/19/21
-
478
3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
Merck Sharp & Dohme
12/19/21
-
135
Metalloenzyme inhibitor compounds
Phasebio Pharmaceuticals
12/14/21
-
14
Benzimidazole-proline derivatives
Idorsia Pharmaceuticals
12/14/21
-
11
TYK2 inhibitors, uses, and methods for production thereof
Nimbus Lakshmi
12/14/21
-
17
Pyridine derivative as ASK1 inhibitor and preparation method and use thereof
TBA
12/14/21
-
42
VMAT2 inhibitor compounds and compositions thereof
Neurocrine Biosciences
12/14/21
-
4
Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
Blueprint Medicines
12/14/21
-
32
Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
Principia Biopharma
12/14/21
-
11
Quinazoline compound for EGFR inhibition
Medshine Discovery
12/14/21
-
10
Methods of identifying SENP1 inhibitors
City of Hope
12/14/21
-
146
Ectonucleotidase inhibitors and methods of use thereof
Calithera Biosciences
12/06/21
-
11
Farnesoid X receptor modulators
Intercept Pharmaceuticals
12/06/21
-
5
Methods to determine KDM1A target engagement and chemoprobes useful therefor
Oryzon Genomics
12/06/21
-
551
Compounds of formulas (VII), (VIII), (IX), (XI), (XII), (XIII), and (XIV) as muscarinic receptor 4(M4) antagonists for treating neurological diseases
Neurocrine Biosciences
12/05/21
-
100
Carboxamide-pyrimidine derivatives as SHP2 antagonists
Merck Patent
12/05/21
-
65
Pyridinyl pyrazoles as modulators of RORγT
Janssen Pharmaceutica
12/05/21
-
67
Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase IDO inhibitors
Merck Sharp & Dohme
12/05/21
-
53
Poly-ADP ribose polymerase (PARP) inhibitors
Mitobridge
12/05/21
-
99
Apoptosis signal-regulating kinase inhibitors and uses thereof
Sichuan Haisco Pharmaceutical
12/05/21
-
16
Diacylglycerol acyl transferase 2 inhibitors
Pfizer
12/05/21
-
366
Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders
The Scripps Research Institute
12/05/21
-
390
Naphthyridines as inhibitors of HPK1
Genentech
12/05/21
-
825
Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
Nimbus Saturn
12/05/21
-
94
Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators
Genentech
12/05/21
-
17
Ethynyl derivatives
Hoffmann-La Roche
12/05/21
-
52
Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors
Nikang Therapeutics
12/05/21
-
145
Therapeutic inhibitory compounds
Attune Pharmaceuticals
11/29/21
-
131
Phosphatidylinositol 3-kinase inhibitors
Gilead Sciences
11/29/21
-
35
Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
Bristol-Myers Squibb
11/29/21
-
23
Indolizine derivatives and their application in medicine
Kind Pharmaceutical
11/29/21
-
812
Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonists
Nimbus Saturn
11/29/21
-
166
1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
Amgen
11/29/21
-
6
Cyclic dinucleotides as sting agonists
Janssen Biotech
11/29/21
-
207
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals
11/29/21
-
192
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck
11/29/21
-
34
Piperidinyl-propanone derivatives
Merck Patent
11/29/21
-
134
Heteroaryl inhibitors of PAD4
Padlock Therapeutics
11/29/21
-
36
Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors
Merck Sharp & Dohme
11/29/21
-
18
Second generation GRP94-selective inhibitors
University of Kansas
11/29/21
-
7
Tetrahydroquinoline-based bromodomain inhibitors
St. Jude Children'S Research Hospital
11/29/21
-
35
1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors
Merck Patent
11/29/21
-
12
Heterocyclic compounds as adenosine antagonists
Nuvation Bio
11/29/21
-
76
Tricyclic heterocyclic derivatives and uses thereof
Auckland Uniservices
11/29/21
-
97
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
11/29/21
-
7
Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer
Oblique Therapeutics
11/29/21
-
90
Therapeutic compounds and methods of use thereof
Genentech
11/29/21
-
36
Substituted pyrimidines as LRKK2 inhibitors
Denali Therapeutics
11/29/21
-
145
Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases
Board of Regents, The University of Texas System
11/29/21
-
822
Substituted isoindolin-1-ones and 2,3-dihydro-1h-pyrrolo[3,4-c]pyridin-1-ones as hpk1 antagonists
Nimbus Saturn
11/29/21
-
491
[1,2,4]Triazolo[4,3-a]quinoxaline derivative, method for preparing same, and pharmaceutical composition for preventing or treating BET protein-related diseases, containing same as active ingredient
Dong Wha Pharm.
11/29/21
-
60
Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
Merck Sharp & Dohme
11/29/21
-
205
4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
Array Biopharma
11/29/21
-
3
3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies
Ctxt
11/29/21
-
42
Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin
11/29/21
-
396
Therapeutic compounds
Celgene Quanticel Research
11/28/21
-
169
Biaryloxy derivatives as TTX-S blockers
Raqualia Pharma
11/28/21
-
115
Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
Amgen
11/28/21
-
44
Compounds and their use for reducing uric acid levels
Acquist
11/28/21
-
299
Amino-pyrrolopyrimidinone compounds and methods of use thereof
Arqule
11/28/21
-
27
Type of aryl benzofuran amidated derivative and medical use thereof
China Pharmaceutical University
11/28/21
-
150
Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof
Wigen Biomedicine Technology (Shanghai)
11/28/21
-
9
LSD1 inhibitors and medical uses thereof
Constellation Pharmaceuticals
11/22/21
-
79
Triazolopyrimidine, triazolopyridine compounds, and the composition thereof for treating PRC2-mediated diseases
Shanghai Institute of Material Medica, Chinese Academy of Sciences
11/22/21
-
36
2,6-disubstituted pyridine derivative
Sumitomo Dainippon Pharma
11/22/21
-
72
Heteroaromatic compounds and their use as dopamine D1 ligands
Pfizer
11/22/21
-
569
CDK2 inhibitors
Pfizer
11/22/21
-
68
Cyanopyrrolidine derivatives with activity as inhibitors of USP30
Mission Therapeutics
11/22/21
-
800
Pyridazinones as PARP7 inhibitors
Ribon Therapeutics
11/22/21
-
35
Factor XIIa inhibitors
Merck Sharp & Dohme
11/22/21
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
11/22/21
-
30
Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit MNK1 and MNK2
Effector Therapeutics
11/22/21
-
126
Pyrazolopyrimidine compounds and uses thereof
Incyte
11/22/21
-
78
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical
11/22/21
-
202
Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
Hoffmann-La Roche
11/22/21
-
155
Compounds and methods for modulating interleukin-2-inducible t-cell kinase
Corvus Pharmaceuticals
11/15/21
-
8
Compounds useful for inhibiting RORγt
Eli Lilly
11/15/21
-
25
C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
11/15/21
-
8
Cycloalkyl-diamines for the treatment of pain
Medisynergics
11/14/21
-
21
Piperidinone formyl peptide 2 receptor agonists
Bristol-Myers Squibb
11/14/21
-
85
Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
11/14/21
-
420
Quinazolinones as PARP14 inhibitors
Ribon Therapeutics
11/14/21
-
359
Pyridazine derivatives as RORc modulators
Genentech
11/14/21
-
59
Compounds and their uses as ACC inhibitors
Nanjing Ruijie Pharmatech
11/08/21
-
25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
Shy Therapeutics
11/08/21
-
15
1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
Astrazeneca
11/08/21
-
11
Compound useful for the treatment of degenerative and inflammatory diseases
Galapagos
11/08/21
-
22
Difluoroketamide derivatives as HTRA1 inhibitors
Hoffmann-La Roche
11/08/21
-
136
Pyrimidinone derivatives as SHP2 antagonists
Merck Patent
11/08/21
-
81
SSAO inhibitor
TBA
11/08/21
-
44
Histone demethylase inhibitors
Celgene Quanticel Research
11/08/21
-
10
Pyrimidine derivative, method for preparing same and use thereof in medicine
TBA
11/08/21
-
899
Benzolactam compounds as protein kinase inhibitors
Otsuka Pharmaceutical
11/08/21
-
92
N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
Kalvista Pharmaceuticals
11/08/21
-
16
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals
11/08/21
-
88
Alkyl pyrrolopyrimidine analogs and methods of making and using same
The University of North Carolina At Chapel Hill
11/08/21
-
13
Pyrimidine compounds and pyrimido indole compounds and methods of use
Duquesne University of The Holy Spirit
11/08/21
-
8
7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors
Eli Lilly
11/08/21
-
13
Disubstituted compounds for treatment of medical disorders
Achillion Pharmaceuticals
11/08/21
-
6
Aminopyrimidinecarboxamides as CXCR2 modulators
Syntrix Biosystems
11/08/21
-
108
EGFR proteolysis targeting chimeric molecules and associated methods of use
Arvinas Operations
11/04/21
-
15
Acetyl-CoA carboxylase modulators
Monsanto Technology
11/04/21
-
57
Inhibitors of protease-activated receptor-2
Heptares Therapeutics
11/04/21
-
218
PARG inhibitory compounds
Cancer Research Technology
11/04/21
-
116
Pyrrolidine derivative
Kissei Pharmaceutical
11/04/21
-
162
Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
The Institute of Cancer Research: Royal Cancer Hospital
11/04/21
-
92
Zaindole derivatives and their use as ERK kinase inhibitors
Agv Discovery
11/04/21
-
19
Substituted dihydrobenzofuran glycosidase inhibitors
Asceneuron
11/04/21
-
440
MCL-1 inhibitors
Gilead Sciences
11/01/21
-
23
Inhibitors of influenza virus replication and uses thereof
Sunshine Lake Pharma
11/01/21
-
136
Compounds
Astrazeneca
11/01/21
-
53
1,2,4-triazine-4-amine derivatives
Heptares Therapeutics
11/01/21
-
70
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
11/01/21
-
77
Bicyclic lactams and methods of use thereof
Genentech
11/01/21
-
37
Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof
Japan Tobacco
11/01/21
-
140
Substituted pyrimidines as cyclin-dependent kinase inhibitors
Shanghai Pharmaceuticals Holding
11/01/21
-
532
Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
Genentech
11/01/21
-
20
Potent and selective mu opioid receptor modulators
Virginia Commonwealth University
11/01/21
-
99
IRAK4 inhibitor and use thereof
Beijing Hanmi Pharmaceutical
11/01/21
-
204
Substituted n′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
Merck Sharp & Dohme
11/01/21
-
32
Alpha-D-galactoside inhibitors of galectins
Galecto Biotech
11/01/21
-
2
Immunomodulators
Bristol-Myers Squibb
11/01/21
-
55
Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
Pfizer
11/01/21
-
11
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
Bristol-Myers Squibb Companay
10/27/21
-
25
Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors
Dart Neuroscience
10/27/21
-
229
Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
Daewoong Pharmaceutical
10/27/21
-
1
Substituted thiohydantoin derivatives as androgen receptor antagonists
Janssen Pharmaceutica
10/27/21
-
18
6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
Purdue Research Foundation
10/26/21
-
329
PRMT5 inhibitors and uses thereof
Epizyme
10/26/21
-
95
Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof
Beijing Scitech-Mq Pharmaceuticals
10/26/21
-
113
Aminopyrimidinyl compounds
Pfizer
10/26/21
-
164
Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase
Bristol-Myers Squibb
10/26/21
-
8
FXR (NR1H4) modulating compounds
Gilead Sciences
10/26/21
-
19
Compound for inhibiting IDO, a manufacturing method and a use thereof
Shanghai Joyu Pharmatech
10/26/21
-
25
Benzothiophene estrogen receptor modulators
G1 Therapeutics
10/26/21
-
30
Therapeutic inhibitory compounds
Attune Pharmaceuticals
10/26/21
-
22
Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase
Board of Regents, The University of Texas System
10/26/21
-
85
Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Astex Therapeutics
10/26/21
-
5
Inhibitors of soluble adenylyl cyclase
Cornell University
10/26/21
-
61
1,3,4-thiadiazole compounds and their use in treating cancer
Cancer Research Technology
10/26/21
-
49
Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals
10/26/21
-
51
Substituted pyrrolopyridine JAK inhibitors and methods of making and using the same
Aclaris Therapeutics
10/26/21
-
236
Biaryl kinase inhibitors
Bristol-Myers Squibb
10/26/21
-
210
Imidazopyrrolopyridine as inhibitors of the JAK family of kinases
Janssen Pharmaceutica
10/26/21
-
146
Pharmaceutical compounds
Sentinel Oncology
10/20/21
-
28
Grp94 selective inhibitors and uses thereof
University of Kansas
10/20/21
-
225
Phenyl substituted pyrazoles as modulators of RORγt
Janssen Pharmaceutica
10/20/21
-
22
Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
Institute of Materia Medica, Chinese Academy of Medical Sciences
10/20/21
-
644
Substituted pyridines as inhibitors of DNMT1
Glaxosmithkline Intellectual Property Development
10/20/21
-
92
6-aminopyridin-3-yl pyrazoles as modulators of RORgT
Janssen Pharmaceutica
10/20/21
-
4
Imidazolyl kinase inhibitors and uses thereof
Dana-Farber Cancer Institute
10/20/21
-
135
4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors
TBA
10/20/21
-
27
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals
10/20/21
-
25
Bis-heteroaryl derivatives as modulators of protein aggregation
Ucb Biopharma
10/20/21
-
440
6-aminopyridin-3-yl thiazoles as modulators of RORγT
Janssen Pharmaceutica
10/20/21
-
134
Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
Merck Patent
10/20/21
-
71
Compounds and compositions for inhibiting the activity of SHP2
Novartis
10/20/21
-
16
Substituted fused pyrazole compounds and their use as LRRK2 inhibitors
Glaxosmithkline Intellectual Property Development
10/20/21
-
185
KDM5 inhibitors
Merck Sharp & Dohme
10/20/21
-
150
Pyridine derivative
Astellas Pharma
10/20/21
-
273
Pyrrolo[2,3-d]pyrimidine derivatives
Pfizer
10/09/21
-
13
Macrocyclic compounds as ROS1 kinase inhibitors
Array Biopharma
10/09/21
-
23
Therapeutic compounds and uses thereof
Kala Pharmaceuticals
10/09/21
-
22
Synergistic combination of immunologic inhibitors for the treatment of cancer
The University of Chicago
10/09/21
-
34
Alpha-truxillic acid derivatives and pharmaceutical compositions thereof
The Research Foundation For The State University of New York
10/09/21
-
90
USP30 inhibitors
Mitobridge
10/09/21
-
114
Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
1St Biotherapeutics
10/09/21
-
35
Biaryltriazole inhibitors of macrophage migration inhibitory factor
Yale University
10/09/21
-
29
Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
10/09/21
-
107
Cyclopropanamine compound and use thereof
Takeda Pharmaceutical
10/09/21
-
189
Pyrido five-element aromatic ring compound, preparation method therefor and use thereof
Shanghai Haihe Pharmaceutical
10/09/21
-
297
4,5-annulated 1,2,4-triazolones
Bayer Aktiengesellschaft
10/09/21
-
13
Substituted [1,2,4]triazolo[1,5-a]pyrazines as LSD1 inhibitors
Incyte
10/09/21
-
155
Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
Proximagen
10/09/21
-
45
Isoquinoline ether compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
10/09/21
-
91
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
10/09/21
-
35
Cyclopentane-based modulators of STING (stimulator of interferon genes)
Pfizer
10/09/21
-
119
Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
Celgene Quanticel Research
10/04/21
-
66
Farnesoid X receptor agonists and uses thereof
Metacrine
10/04/21
-
512
Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
The United States of America, As Represented By The Secretary, Department of Health and Human Services
10/04/21
-
66
JAK1 selective inhibitors
Astrazeneca
10/04/21
-
568
Substituted pyrazines as ATR kinase inhibitors
Vertex Pharmaceuticals
10/04/21
-
45
Oxazole derivatives for use in the treatment of cancer
Lifearc
10/04/21
-
63
(S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino) thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one as a phosphatidylinositol 3-kinase inhibitor
Astrazeneca
10/04/21
-
145
Inhibiting agents for Bruton's tyrosine kinase
Biogen Ma
10/04/21
-
66
Chemical compounds
Astrazeneca
10/04/21
-
80
Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
Legochem Biosciences
10/04/21
-
180
Pyrazolopyrimidine derivatives as kinase inhibitor
Daewoong Pharmaceutical
10/04/21
-
21
Modulators of the sigma-2 receptor and their method of use
Temple University
10/04/21
-
34
Quinazoline and indole compounds to treat medical disorders
Achillion Pharmaceuticals
10/04/21
-
3
PRMT5 inhibitors
Ctxt
10/04/21
-
261
Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
Theravance Biopharma R&D Ip
09/28/21
-
97
Methods of treating intraocular pressure with activators of Tie-2
Aerpio Pharmaceuticals
09/28/21
-
27
Azaindoles as inhibitors of HPK1
Genentech
09/28/21
-
556
Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
Array Biopharma
09/28/21
-
239
Heterocyclic compounds for the inhibition of pask
Bioenergenix
09/28/21
-
134
Substituted indole Mcl-1 inhibitors
Vanderbilt University
09/28/21
-
444
Pyrazole derivatives as MALT1 inhibitors
Janssen Pharmaceutica
09/28/21
-
90
BMP-signal-inhibiting compound
Riken
09/28/21
-
43
Sigma receptor binders
Board of Regents, The University of Texas System
09/28/21
-
15
Selective NR2B antagonists
Bristol-Myers Squibb
09/28/21
-
145
1 H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof
The Trustees of The University of Pennsylvania
09/28/21
-
12
JAK inhibitors containing a 4-membered heterocyclic amide
Theravance Biopharma R&D Ip
09/28/21
-
60
Compounds inhibiting leucine-rich repeat kinase enzyme activity
Merck Sharp & Dohme
09/28/21
-
108
Heterocyclic compounds as ret kinase inhibitors
Cancer Research Technology
09/28/21
-
22
Substituted heterocyclic inhibitors of PTPN11
Navire Pharma
09/28/21
-
11
Compounds and uses thereof
Kala Pharmaceuticals
09/28/21
-
75
1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one derivative as Wee1 inhibitor
Shijiazhuang Sagacity New Drug Development
09/28/21
-
6
Treatment and diagnosis of melanoma
Rockefeller University
09/26/21
-
3
Combinations comprising a pyrrolidine-2,5-dione IDO1 inhibitor and an anti-body
Pfizer
09/26/21
-
11
Tank-binding kinase-1 PROTACs and associated methods of use
Arvinas Operations
09/26/21
-
33
Nurr1:RXR activating compounds for simultaneous treatment of symptoms and pathology of Parkinson's disease
TBA
09/26/21
-
391
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals
09/26/21
-
4
Beta adrenergic agonist and methods of using the same
Curasen Therapeutics
09/26/21
-
88
1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
St. Jude Children''S Rsearch Hospital
09/26/21
-
135
Inhibitors of Hepatitis C virus polymerase
Cocrystal Pharma
09/26/21
-
449
Heteroaryl compounds and their use as therapeutic drugs
Dong-A Socio Holdings
09/26/21
-
87
Aminopyridine derivatives and their use as selective ALK-2 inhibitors
Novartis
09/26/21
-
72
Indole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharp & Dohme
09/26/21
-
18
Substituted oxazines as beta-secretase inhibitors
Amgen
09/26/21
-
23
Bicyclic pyridone lactams and methods of use thereof
Genentech
09/26/21
-
11
Dimethyl amino azetidine amides as JAK inhibitors
Theravance Biopharma R&D Ip
09/26/21
-
54
Bicyclic heterocycles as FGFR inhibitors
Incyte
09/26/21
-
12
PRMT5 inhibitors
Merck Sharp & Dohme
09/26/21
-
1
[1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
Janssen Pharmaceutica
09/26/21
-
26
Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same
Seoul National University Hospital
09/26/21
-
79
Heteroaryl SYK inhibitors
Boehringer Ingelheim International
09/26/21
-
38
Therapeutic compounds and methods of use thereof
Genentech
09/26/21
-
547
Inhibitors of KEAP1-Nrf2 protein-protein interaction
Janssen Pharmaceutica
09/26/21
-
25
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
Shy Therapeutics
09/20/21
-
3
Kinase inhibitors
Oxular Acquisitions
09/20/21
-
26
Benzyl phenyl ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
Institute of Materia Medica, Chinese Academy of Medical Sciences
09/20/21
-
88
Quinoline and isoquinoline derivatives for treating pain and pain related conditions
Esteve Pharmaceuticals
09/20/21
-
30
Methods for inhibiting fascin
Novita Pharmaceuticals
09/20/21
-
29
Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Ogeda
09/20/21
-
499
Bromodomain inhibitors
Celgene Quanticel Research
09/20/21
-
8
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals
09/20/21
-
214
Bruton's tyrosine kinase inhibitors
Suzhou Baijibugong Pharmaceutical Technology
09/12/21
-
61
Compounds and compositions for inhibiting the activity of SHP2
Novartis
09/12/21
-
236
Pyrazolopyridine compounds and uses thereof
Incyte
09/12/21
-
60
Substituted pyrazolo[3,4-d]pyrimidines as PDE9 inhibitors
Merck Sharp & Dohme
09/12/21
-
131
4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
Merck Sharp & Dohme
09/12/21
-
143
5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
Samumed
09/12/21
-
288
SHP2 phosphatase inhibitors and methods of use thereof
Relay Therapeutics
09/12/21
-
28
Aryl ethene derivative and pharmaceutical composition containing same as active ingredient
Daegu-Gyeongbuk Medical Innovation Foundation
09/12/21
-
87
Spirocyclic compounds
Recurium Ip Holdings
09/12/21
-
32
SHMT inhibitors
The Trustees of Princeton University
09/12/21
-
472
Inhibitors of Bruton's tyrosine kinase and method of their use
Janssen Pharmaceutica
09/12/21
-
26
Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
The Usa, As Represented By The Secretary, Department of Health and Human Services
09/06/21
-
7
Treatment of conditions associated with hyperinsulinaemia
Tensha Therapeutics
09/06/21
-
48
HSP90B N-terminal isoform-selective inhibitors
University of Kansas
09/06/21
-
69
Intermediate compound of novel tetrahydronaphthyl urea derivative
Mochida Pharmaceutical
09/06/21
-
48
Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
Merck Sharp & Dohme
09/06/21
-
248
Pyrazole MAGL inhibitors
Lundbeck La Jolla Research Center
09/06/21
-
44
Benzothiazole derivatives as DYRK1 inhibitors
Pharmasum Therapeutics
09/06/21
-
31
Cyano-subtituted heterocycles with activity as inhibitors of USP30
Mission Therapeutics
09/06/21
-
62
Inhibitors of RAF kinases
Kinnate Biopharma
09/06/21
-
45
CDK inhibitors
Gi Therapeutics
09/06/21
-
35
Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
Arena Pharmaceuticals
09/06/21
-
112
Oxadiazaspiro compounds for the treatment of drug abuse and addiction
Esteve Pharmaceuticals.
09/06/21
-
18
Azetidine derivatives
Vernalis (R&D)
09/02/21
-
68
N-(substituted-phenyl)-sulfonamide derivatives as kinase inhibitors
Nerviano Medical Sciences
09/02/21
-
51
Substituted tricyclic heterocyclic compounds and use thereof
Lifearc
09/02/21
-
9
Cannabidiol derivatives as inhibitors of the HIF prolyl hydroxylases activity
Emerald Health Pharmaceuticals
09/02/21
-
407
Immunomodulator compounds
Chemocentryx
09/02/21
-
18
Cyclohexene compounds and use thereof
Guangzhou Henovcom Bioscience
09/02/21
-
70
Thioacetate compounds, compositions and methods of use
Ardea Biosciences
09/02/21
-
56
Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
09/02/21
-
6
Fused imidazoles as mIDH1 inhibitors
Bayer Pharma Aktiengesellschaft
09/02/21
-
49
Thiazole derivative and applications
East China University of Science and Technology
09/02/21
-
8
Amide compounds for treatment of immune and inflammatory disorders
Achillion Pharmaceuticals
09/02/21
-
463
Compounds and uses thereof
Yumanity Therapeutics
09/02/21
-
1
Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Galapagos
09/02/21
-
37
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
Bristol-Myers Squibb
09/02/21
-
12
Imidazopyrazine compounds, preparation methods and uses thereof
Dongguan Zhenxing-Beite Medicine Technology
09/02/21
-
5
Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
Incyte Holdings
09/02/21
-
23
Hetero-halo inhibitors of histone deacetylase
Alkermes
09/02/21
-
80
Tricyclic ASK1 inhibitors
Terns
09/02/21
-
56
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
Boehringer Ingelheim International
09/02/21
-
3
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals
09/02/21
-
107
Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors
H. Lundbeck
08/30/21
-
67
Pyrimidine FGFR4 inhibitors
Eisai R&D Management
08/30/21
-
99
Benzene disulfonamide for the treatment of cancer
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften
08/30/21
-
59
Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
The United States of America, As Represented By The Secretary, Department of Health and Human Services
08/30/21
-
50
Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof
Alectos Therapeutics
08/30/21
-
14
Bis-heteroaryl derivatives as modulators of protein aggregation
Ucb Biopharma
08/30/21
-
16
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D Ip
08/30/21
-
110
Oxadiazolones as transient receptor potential channel inhibitors
Genentech
08/30/21
-
20
LRRK2 inhibitors and methods of making and using the same
Dana-Farber Cancer Institute
08/30/21
-
47
Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors
Hoffmann-La Roche
08/30/21
-
111
Substituted 4-phenylpiperidines, their preparation and use
Columbia University
08/30/21
-
219
Thienopyridine carboxamides as ubiquitin-specific protease inhibitors
Valo Early Discovery
08/30/21
-
20
Substituted piperazines as ROR-gamma modulators
Escalier Biosciences
08/22/21
-
111
Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors
H. Lundbeck
08/22/21
-
7
Kinase inhibitors for the treatment of disease
Dana Farber Cancer Institute
08/22/21
-
198
Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
Pfizer
08/22/21
-
103
Triazole phenyl compounds as agonists of the APJ receptor
Amgen
08/22/21
-
42
Compositions and methods for inhibiting kinases
Inhibikase Therapeutics
08/22/21
-
14
Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases
Centre National De La Recherche Scientifique
08/22/21
-
52
Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof
Jiangsu Hengrui Medicine
08/22/21
-
370
Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
Leo Pharma
08/22/21
-
65
Heterocyclic compounds as immunomodulators
Incyte
08/22/21
-
34
IRAK4 modulators
Genentech
08/16/21
-
71
IRAK4 modulators
Genentech
08/16/21
-
38
Pyrazine compounds and uses thereof
TBA
08/15/21
-
427
PD-1/PD-L1 inhibitors
Gilead Sciences
08/15/21
-
378
Piperidines as menin inhibitors
The Regents of The University of Michigan
08/15/21
-
4
3,4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof
Jiangsu Hengrui Medicine
08/15/21
-
110
Inhibiting agents for Bruton's tyrosine kinase
Biogen Ma
08/15/21
-
32
Benzothiazole compounds and uses thereof
Incyte
08/15/21
-
23
Phosphodiesterase inhibitors and uses thereof
Columbia University
08/15/21
-
33
Imidazo isoindole derivative, preparation method therefor and medical use thereof
Jiangsu Hengrui Medicine
08/15/21
-
124
Imidazopiperazinone inhibitors of transcription activating proteins
Board of Regents, The University of Texas System
08/15/21
-
19
Indolizine derivatives, composition and methods of use
Shanghai Fochon Pharmaceutical
08/14/21
-
49
Antitumor drug for intermittent administration of FGFR inhibitor
Taiho Pharmaceutical
08/14/21
-
35
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System
08/14/21
-
120
Modulators of P97 AAA ATPase activity
University of Pittsburgh
08/14/21
-
648
Heteroarylbenzimidazole compounds
Bayer Pharma Aktiengesellschaft
08/14/21
-
46
Substituted pyrazole derivatives as selective CDK12/13 inhibitors
Aurigene Discovery Technologies
08/14/21
-
161
Inhibitors of cyclin-dependent kinases
Kinnate Biopharma
08/14/21
-
165
Halo-substituted piperidines as orexin receptor modulators
Astrazeneca
08/14/21
-
3
Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics
King Abdulaziz University
08/14/21
-
51
Fused tricyclic ring derivatives as SRC homology-2 phosphatase inhibitors
Nikang Therapeutics
08/14/21
-
4
Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor
Nanomedsyn
08/14/21
-
102
PSMA imaging agents
Siemens Medical Solutions Usa
08/14/21
-
14
CGRP receptor antagonists
Heptares Therapeutics
08/09/21
-
78
Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
Auckland Uniservices
08/09/21
-
74
Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof
Jiangsu Hengrui Medicine
08/09/21
-
29
Dihydroxybenzamide compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof
Oncozen
08/09/21
-
268
Sulfonamide compound or salt thereof
Taiho Pharmaceutical
08/09/21
-
52
Tetrahydroindazoles and medical uses thereof
Genase Therapeutics
08/09/21
-
95
Inhibitors of TRPC6
Boehringer Ingelheim International
08/09/21
-
32
Condensed ring group azacyclobutyl triazole derivative, preparation method therefor and use thereof in medicine
Jiangsu Hengrui Medicine
08/09/21
-
217
Substituted benzoimidazoles and imidazo[4,5-c]pyridines for treating certain leukemias
Terns
08/09/21
-
17
Thiazine derivatives as β-secretase inhibitors and methods of use
Amgen
08/09/21
-
40
Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
Amgen
08/09/21
-
157
Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
Array Biopharma
08/09/21
-
69
PDE9 inhibitor and use thereof
Nanjing Transthera Biosciences
08/09/21
-
21
Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors
Valo Early Discovery
08/09/21
-
7
[1,3]thiazin-2-amine compound, application, and pharmaceutical composition
Tetranov Pharmaceutical
08/09/21
-
22
Alpha-D-galactoside inhibitors of galectins
Galecto Biotech
08/09/21
-
33
Pyrazole derivatives as MALT1 inhibitors
Janssen Pharmaceutica
08/08/21
-
812
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
08/01/21
-
6
Acetamide thienotriazolodiazepines and uses thereof
Dana-Farber Cancer Institute
08/01/21
-
22
Pharmaceutical compounds
Sareum
08/01/21
-
16
Phenylate derivative, preparation method therefor, and pharmaceutical composition and uses thereof
Institute of Materia Medica, Chinese Academy of Medical Sciences
08/01/21
-
27
KDM1A inhibitors for the treatment of disease
Imago Biosciences
08/01/21
-
61
Cannabinergic compounds and uses thereof
Northeastern University
08/01/21
-
48
Compounds useful as immunomodulators
Bristol-Myers Squibb
08/01/21
-
8
Tyrosine kinase inhibitor and application thereof
Lanova Medicines
08/01/21
-
19
Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
Ono Pharmaceutical
08/01/21
-
17
Bicyclic compounds as ATX inhibitors
Hoffmann-La Roche
08/01/21
-
3
Kinase inhibitors
Topivert Pharma
08/01/21
-
137
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
Boehringer Ingelheim International
08/01/21
-
10
Zwitterionic propargyl-linked antifolates useful for treating bacterial infections
University of Connecticut
07/26/21
-
25
Compounds and their use as BACE1 inhibitors
Allgenesis Biotherapeutics
07/26/21
-
18
Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
Hanmi Pharm.
07/26/21
-
825
Pyridazinones as PARP7 inhibitors
Ribon Therapeutics
07/26/21
-
40
Inhibitors of cyclin-dependent kinase 7 (CDK7)
Dana-Farber Cancer Institute
07/26/21
-
138
Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
Shionogi
07/26/21
-
4
Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions
Aristea Translational Medicine
07/25/21
-
23
Compounds and methods for inhibiting CYP26 enzymes
Queens University At Kingston
07/25/21
-
136
Substituted pyrrolizine compounds and uses thereof
Gilead Sciences
07/25/21
-
16
Neuroprotective agents for treatment of neurodegenerative diseases
Wayne State University
07/25/21
-
34
Pteridine dione monocarboxylate transporter inhibitors
The Scripps Research Institute
07/25/21
-
26
N4-hydroxycytidine and derivatives and anti-viral uses related thereto
Emory University
07/25/21
-
3
Highly active compounds against COVID-19
Atea Pharmaceuticals
07/25/21
-
2
Azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
Integrative Research Laboratories Sweden
07/25/21
-
3
Substituted pyrimidines for treating bacterial infections
Forge Therapeutics
07/25/21
-
9
Aminopyrazoles as selective janus kinase inhibitors
Intervet
07/25/21
-
174
Factor XIIa inhibitors
Merck Sharp & Dohme
07/25/21
-
151
Heteroaromatic compounds as BTK inhibitors
Boehringer Ingelheim International
07/25/21
-
34
Triazolopyridines
Hoffmann-La Roche
07/25/21
-
25
RIPK2 inhibitors and method of treating cancer with same
University Health Network
07/25/21
-
102
Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
Sumitomo Dainippon Pharma Oncology
07/25/21
-
90
Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
Boehringer Ingelheim International
07/25/21
-
22
Phosphonate linkers and their use to facilitate cellular retention of compounds
Merck Sharp & Dohme
07/25/21
-
30
Histone deacetylase inhibitors and uses thereof
Musc Foundation For Research Development
07/25/21
-
23
Trifluoromethylpropanamide derivatives as HTRA1 inhibitors
Hoffmann-La Roche
07/25/21
-
57
Heteroaromatic compounds as Vanin inhibitors
Boehringer Ingelheim International
07/18/21
-
75
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
07/18/21
-
3
Dab2 inhibitors for the prevention and treatment of cystic fibrosis
Trustees of Dartmouth College
07/18/21
-
17
Difluoroketamide derivatives as HtrA1 inhibitors
Hoffmann-La Roche
07/18/21
-
12
Opioid agonists and uses thereof
Nektar Therapeutics
07/18/21
-
7
Pet imaging agents
Novartis
07/18/21
-
15
Inhibitors of cyclin-dependent kinase 7 (CDK7)
Syros Pharmaceuticals
07/18/21
-
229
ATG7 inhibitors and the uses thereof
Millennium Pharmaceuticals
07/18/21
-
47
2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis
Agency For Science, Technology and Research
07/18/21
-
116
Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl
Hoffmann-La Roche
07/13/21
-
39
Biaryl urea derivative or salt thereof and preparation process and use for the same
Fudan University
07/13/21
-
377
Benzopyrazole compounds and analogues thereof
Biocryst Pharmaceuticals
07/12/21
-
118
Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas
Celgene Quanticel Research
07/12/21
-
140
Arf6 inhibitors and methods of synthesis and use thereof
Navigen
07/12/21
-
64
C3-carbon linked glutarimide degronimers for target protein degradation
C4 Therapeutics
07/12/21
-
31
Methods of treatment using pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds
Array Biopharma
07/12/21
-
227
Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2)
Northwestern University
07/12/21
-
185
Benzoimidazoles as prolyl hydroxylase inhibitors
Janssen Pharmaceutica
07/12/21
-
30
Matrix metalloproteinase (MMP) inhibitors and methods of use thereof
Foresee Pharmaceuticals
07/12/21
-
21
Benzoxazepin oxazolidinone compounds and methods of use
Genentech
07/12/21
-
3
Pyridine compound
Daiichi Sankyo
07/12/21
-
52
Imidazole and triazole containing bicyclic compounds as JAK inhibitors
Theravance Biopharma R&D Ip
07/12/21
-
12
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
07/12/21
-
7
Substituted bicyclic heterocyclic compounds
Bristol-Myers Squibb
07/12/21
-
92
Heterocyclic inhibitors of PTPN11
Board of Regents, The University of Texas System
07/12/21
-
43
Bicyclic amines as novel JAK kinase inhibitors
Leo Pharma
07/12/21
-
26
Diarylalkanes as potent inhibitors of binuclear enzymes
Unigen
07/11/21
-
98
Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof
University of Maryland, Baltimore
07/11/21
-
3
HDAC inhibitors for the treatment of diabetic peripheral neuropathy
Regenacy Pharmaceuticals
07/11/21
-
5
Oxazoline pseudodimers, pharmaceutical compositions and the use thereof
Purdue Pharma
07/11/21
-
112
Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases
Boehringer Ingelheim International
07/11/21
-
20
Hydantoin containing deoxyuridine triphosphatase inhibitors
CV6 Therapeutics (NI)
07/11/21
-
34
Inhibitors of phosphatidylinositol 3-kinase gamma
Astrazeneca
07/11/21
-
80
Pyrazolopyridine derivative having GLP-1 receptor agonist effect
Chugai Seiyaku Kabushiki Kaisha
07/11/21
-
6
Heterocyclic ring derivatives useful as SHP2 inhibitors
Jacobio Pharmaceuticals
07/11/21
-
3
Imidazopyrazine inhibitors of Bruton's tyrosine kinase
Acerta Pharma
07/11/21
-
111
Imidazopyrazinones as PDE1 inhibitors
H. Lundbeck
07/11/21
-
119
Triazolo-pyrimidine compounds and uses thereof
TBA
07/11/21
-
41
Tricyclic compounds useful to treat orthomyxovirus infections
Novartis
07/11/21
-
22
Modulators of the 5-hydroxytryptamine receptor 7 and their method of use
Temple University
07/11/21
-
53
Heterocyclic spiro compounds as MAGL inhibitors
Pfizer
07/11/21
-
107
Serine/threonine kinase inhibitors
Genentech
07/06/21
-
100
Imidazopyridines Syk inhibitors
Kronos Bio
07/06/21
-
271
Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors
Vanderbilt University
07/06/21
-
16
1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions
Sabila Biosciences
07/06/21
-
359
WDR5 inhibitors and modulators
Vanderbilt University
07/06/21
-
63
Fused amino pyridine as HSP90 inhibitors
Curis
07/06/21
-
13
Process for preparing JAK inhibitors and intermediates thereof
Theravance Biopharma R&D Ip
07/06/21
-
92
Pyridine derivative inhibiting RAF kinase and vascular endothelial growth factor receptor, method for preparing same, pharmaceutical composition containing same, and use thereof
Incheon University Industry Academic Cooperation Foundation
07/06/21
-
86
Heterocyclic compounds as RET kinase inhibitors
Cancer Research Technology
07/06/21
-
146
Pyrrolotriazine compounds as TAM inhibitors
Incyte
07/06/21
-
22
Thiazolyl-containing compounds for treating proliferative diseases
Dana-Farber Cancer Institute
07/06/21
-
57
Bicyclic heterocyclic derivatives
Merck Patent
06/30/21
-
50
Therapeutic agent for FGFR inhibitor-resistant cancer
Taiho Pharmaceutical
06/30/21
-
13
Inhibitors of integrin alpha 5 beta 1 and methods of use
University of California
06/30/21
-
11
Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
Mebias Discovery
06/30/21
-
12
Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
Valo Early Discovery
06/30/21
-
15
N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
Neomed Institute
06/30/21
-
58
Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
06/30/21
-
73
Acyl sulfonamide NaV1.7 inhibitors
Bristol-Myers Squibb
06/30/21
-
12
5 to 7 membered heterocyclic amides as JAK inhibitors
Theravance Biopharma R&D Ip
06/30/21
-
55
5-HT2C receptor agonists and compositions and methods of use
Arena Pharmaceuticals
06/30/21
-
47
N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
Ogeda
06/30/21
-
55
Substituted pyrrolizine compounds and uses thereof
Gilead Sciences
06/30/21
-
6
6-fluoro-2-methylbenzo[d]thiazol-5-yl compounds
Eli Lilly
06/30/21
-
22
N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
The Regents of The University of Michigan
06/29/21
-
108
Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
Incyte
06/28/21
-
7
Crystalline monomesylate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine
Kronos Bio
06/28/21
-
244
Substituted 2,4-diaminopyrimidines as kinase inhibitors
Celgene Car
06/28/21
-
51
2,4-pyrimidinediamine compounds and their uses
Rigel Pharmceuticals
06/28/21
-
7
Neprilysin inhibitors
Theravance Biopharma R&D Ip
06/28/21
-
155
Aryl sulfonohydrazides
Monash University
06/28/21
-
111
Substituted benzoimidazoles as modulators of ROR-γ
Vitae Pharmaceuticals
06/28/21
-
150
5-[3-[piperazin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating e.g. osteoarthritis
Galapagos
06/28/21
-
153
3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives
Gruenenthal
06/28/21
-
189
Benzimidazole derivatives as modulators of ROR-gamma
Vitae Pharmaceuticals
06/28/21
-
103
Thiophene, manufacturing method thereof, and pharmaceutical application of same
Cstone Pharmaceutical (Suzhou)
06/28/21
-
149
Benzylamino substituted pyridopyrimidinones and derivatives as SOS1 inhibitors
Boehringer Ingelheim International
06/28/21
-
9
Substituted dihydropyrazino[1 ′,2′:1,5]pyrrolo[2,3-d]pyrimidine-based antiproliferative agents
Gi Therapeutics
06/28/21
-
22
Pyrimido[5,4-B]indolizine or pyrimido[5,4-B]pyrrolizine compound, preparation method and use thereof
Shanghai Institute of Materia Medica, Chinese Acad
06/28/21
-
50
Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor
Chia Tai Tianqing Pharmaceutical Group
06/28/21
-
23
Compositions and methods for treating KIT- and PDGFRA-mediated diseases
Blueprint Medicines
06/28/21
-
27
Thienopyridines and benzothiophenes useful as IRAK4 inhibitors
Bristol-Myers Squibb
06/28/21
-
5
Pyridyl-triazabicycles
Hoffmann-La Roche
06/28/21
-
82
Pyrimidinones as PI3K inhibitors
Incyte
06/28/21
-
2
Crystal of DPP-IV long-acting inhibitor and salt
Chia Tai Tianqing Pharmaceutical Group
06/21/21
-
1
Processes for preparing ATR inhibitors
Vertex Pharmaceuticals
06/21/21
-
30
ErbB receptor inhibitors
TBA
06/21/21
-
74
Substituted aminoquinazoline compounds as A2A antagonist
Merck Sharp & Dohme
06/21/21
-
35
Pyrazolo[1,5-a]pyrazin-4-yl derivatives
Pfizer
06/21/21
-
12
Pyrazolopyrimidine derivatives as NIK inhibitors
Janssen Pharmaceutica
06/21/21
-
63
KV1.3 inhibitors and their medical application
4Sc
06/21/21
-
789
Inhibitors of Bruton's tyrosine kinase and methods of their use
Janssen Pharmaceutica
06/21/21
-
703
Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
Achillion Pharmaceuticals
06/21/21
-
797
Compounds that inhibit Mcl-1 protein
Amgen
06/20/21
-
10
Isoidide derivatives and methods of making and using same
Rutgers, The State University of New Jersey
06/14/21
-
107
Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
Incyte
06/13/21
-
31
1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors
Respivert
06/13/21
-
17
Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
Pfizer
06/13/21
-
90
RIP1 inhibitory compounds and methods for making and using the same
Rigel Pharmaceuticals
06/13/21
-
4
Method for preparing 2-hydroxyl-4-(2, 3-disubstituted benzyloxy)-5-substituted benzaldehyde derivative
Institute of Materia Medica, Chinese Academy of Medical Sciences
06/13/21
-
140
Bruton's tyrosine kinase inhibitors
Pfizer
06/13/21
-
215
2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
Bayer Aktiengesellschaft
06/13/21
-
325
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals
06/13/21
-
192
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck
06/11/21
-
51
Selective androgen receptor degrader (SARD) ligands and methods of use thereof
University of Tennessee Research Foundation
06/11/21
-
59
Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2-negative allosteric modulators, compositions, and their use
Merck Sharp & Dohme
06/11/21
-
191
Immunomodulator compounds and methods of use
Incyte
06/11/21
-
28
Protease inhibitors having enhanced features
Nektar Therapeutics
06/11/21
-
42
HDAC inhibitor compounds and methods of treatment
University of Florida Research Foundation
06/11/21
-
101
Compounds for treatment of immune inflammatory disorders
Achillion Pharmaceuticals
06/11/21
-
260
WDR5-MLL1 inhibitors and modulators
Vanderbilt University
06/11/21
-
16
Heterocyclic compounds as kinase inhibitors
Translational Drug Development
06/11/21
-
17
Pyrrolidinone compounds
Eli Lilly
06/11/21
-
161
Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
The Institute of Cancer Research: Royal Cancer Hospital
06/11/21
-
156
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals
06/11/21
-
104
Bromodomain inhibitors
Celgene Quanticel Research
06/11/21
-
124
Compositions useful for treating disorders related to kit
Blueprint Medicines
06/11/21
-
200
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical
06/11/21
-
382
3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
GrüNenthal
06/11/21
-
289
3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
GrÜNenthal
06/11/21
-
42
Spiro-cyclic amine derivatives as S1P modulators
Abbvie
06/11/21
-
51
Dihydrochromene derivatives
Sumitomo Dainippon Pharma
06/11/21
-
97
Heterocyclic compounds and uses thereof
Nuvation Bio
06/11/21
-
22
Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor
TBA
06/01/21
-
155
5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors
Leo Pharma
06/01/21
-
179
Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
Allergan
06/01/21
-
7
Conjugate comprising a neurotensin receptor ligand and use thereof
3B Pharmaceuticals
06/01/21
-
20
Arylpropionyl-triketone antibacterial agents
TBA
06/01/21
-
20
4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors
Nerviano Medical Sciences
06/01/21
-
41
Imidazole derivatives as formyl peptide receptor modulators
Allergan
06/01/21
-
11
Oxoalkyl-substituted phenyltriazole derivatives and uses thereof
Bayer Pharma Aktiengesellschaft
06/01/21
-
7
Tetrahydrothiophene-based GABA aminotransferase inactivators and analogs thereof for treating neurological disorders
Northwestern University
06/01/21
-
38
2,6-disubstituted pyridine derivative
Sumitomo Dainippon Pharma
06/01/21
-
94
Inhibitors of TRPC6
Boehringer Ingelheim International
06/01/21
-
105
Carboxamide compounds and uses thereof
Incyte
06/01/21
-
6
Substituted pyridine derivatives useful as C-FMS kinase inhibitors
Janssen Pharmaceutica
06/01/21
-
62
Indole derivative used as CRTH2 inhibitor
Chia Tai Tianqing Pharmaceutical Group
06/01/21
-
36
Thyroid hormone receptor beta agonist compounds
Terns
06/01/21
-
266
Heterocyclic compounds as immunomodulators
Incyte
06/01/21
-
122
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System
06/01/21
-
32
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System
06/01/21
-
7
Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
Aclaris Therapeutics
06/01/21
-
25
Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
06/01/21
-
40
Beta-lactamase inhibitor compounds
Entasis Therapeutics
06/01/21
-
138
Heterocyclic compounds as LSD1 inhibitors
Incyte
06/01/21
-
219
CDK2/4/6 inhibitors
Pfizer
06/01/21
-
123
Nitrogen-containing heterocyclic amide compound and pharmaceutical use thereof
Japan Tobacco
06/01/21
-
85
Substituted pyrrolo[2,3-d]pyridazin-4-ones and pyrazolo[3,4-d]pyridazin-4-ones as protein kinase inhibitors
Shanghai Fochon Pharmaceutical
06/01/21
-
32
Bicyclic compounds as ATX inhibitors
Hoffmann-La Roche
06/01/21
-
912
Inhibitors of Bruton's tyrosine kinase and method of their use
Janssen Pharmaceutica
06/01/21
-
12
Hybrid galactoside inhibitor of galectins
TBA
06/01/21
-
9
Methotrexate adjuvants to reduce toxicity and methods for using the same
Tosk
06/01/21
-
7
Quinoline analogs as phosphatidylinositol 3-kinase inhibitors
Hangzhou Zhengxiang Pharmaceuticals
05/14/21
-
19
Glutamine transport inhibitors and methods for treating cancer
Vanderbilt University
05/14/21
-
73
3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
GrÜNenthal
05/14/21
-
4
Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators
Arena Pharmaceuticals
05/14/21
-
45
Heterocyclic glutaminase inhibitors
Calithera Biosciences
05/14/21
-
22
Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs
Bayer Pharma Aktiengesellschaft
05/14/21
-
59
Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof
Shanghai Haiyan Pharmaceutical Technology
05/14/21
-
3
Amino pyrimidine ssao inhibitors
Eli Lilly
05/14/21
-
34
8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
Gruenenthal
05/14/21
-
2
1,8-naphthyridinone compounds and uses thereof
Nuvation Bio
05/14/21
-
502
GCN2 inhibitors and uses thereof
Merck Patent
05/14/21
-
144
Amino acid compounds and methods of use
Pliant Therapeutics
05/14/21
-
4
Heterocyclic compounds as immunomodulators
Incyte
05/14/21
-
123
Bruton's tyrosine kinase inhibitors
Zibo Biopolar Changsheng Pharmaceutical
05/14/21
-
15
Bicyclic inhibitors of histone deacetylase
Rodin Therapeutics
05/14/21
-
336
Hormone receptor modulators for treating metabolic conditions and disorders
Ardelyx
05/14/21
-
217
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
05/14/21
-
59
Oxoisoquinoline derivatives
Carna Biosciences
05/14/21
-
126
Compound used as Bruton's tyrosine kinase inhibitor and preparation method and application thereof
Chengdu Brilliant Pharmaceutical
05/14/21
-
361
Bicyclic-fused heteroaryl or aryl compounds
Pfizer
05/14/21
-
310
Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors
Leo Pharma
05/14/21
-
84
Bicyclic heterocyclic compound
Mitsubishi Tanabe Pharma
05/14/21
-
15
Substituted nucleosides, nucleotides and analogs thereof
Janssen Biopharma
05/14/21
-
555
Compounds useful as inhibitors of ATR kinase
Vertex Pharmaceuticals
05/11/21
-
90
Cannabinoid receptor mediating iminopyrazole compounds
The United States of America, As Represented By The Secretary, Department of Health and Human Services
05/09/21
-
105
Thiazolidinedione derivative and use thereof
Industry-Academic Cooperation Foundation Chosun University
05/09/21
-
9
Benzopiperdine derivatives and their use in the treatment of cancer and hemoglobinopathies
Ctxt
05/09/21
-
56
ASK1 inhibitor and preparation method and use thereof
Fuijan Cosunter Pharmaceutical
05/09/21
-
40
Inhibitors of cyclin-dependent kinase 7 (CDK7)
Dana-Farber Cancer Institute
05/09/21
-
18
Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
Pfizer
05/09/21
-
253
Spiro-fused cyclic ureas as inhibitors of rock
Bristol-Myers Squibb
05/09/21
-
2
Octahydropyrrolopyrroles their preparation and use
Columbia University
05/09/21
-
78
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical
05/09/21
-
3
Bicyclic compounds as ATX inhibitors
Hoffmann-La Roche
05/09/21
-
23
Prodrugs of pyridone amides useful as modulators of sodium channels
Vertex Pharmaceuticals
05/09/21
-
4
3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
05/03/21
-
108
N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
Kalvista Pharmaceuticals
05/03/21
-
6
Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
AchÉ
05/03/21
-
108
Heterocyclic compounds for the inhibition of PASK
Bioenergenix
05/03/21
-
137
Therapeutic inhibitory compounds
Attune Pharmaceuticals
05/03/21
-
10
Azetidinyloxyphenylpyrrolidine compounds
Eli Lilly
05/03/21
-
163
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
05/03/21
-
93
1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte
05/03/21
-
260
Spirocycle compounds and methods of making and using same
Lundbeck La Jolla Research Center
05/03/21
-
2
2,6-diamino pyridine compounds
Eli Lilly
05/03/21
-
7
Mu opioid receptor modulators
University of California
05/02/21
-
3
Macrocycle and composition comprising thereof
Shenzhen Targetrx
05/02/21
-
352
Heteroaryl compounds useful as inhibitors of SUMO activating enzyme
Millennium Pharmaceuticals
05/02/21
-
151
Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators
Merck Sharp & Dohme
05/02/21
-
25
Compositions and methods for treating disorders of circadian and diurnal rhythms using prokineticin 2 agonists and antagonists
University of California
05/02/21
-
287
Substituted pyrrolidines as G-protein coupled receptor 43 agonists
Epics Therapeutics
05/02/21
-
43
Trk-inhibiting compound
Ono Pharmaceutical
04/26/21
-
19
Substituted benzamides and methods of use thereof
Genentech
04/26/21
-
106
Morphinan derivatives for the treatment of neuropathic pain
Nektar Therapeutics
04/26/21
-
33
Sulfonylcycloalkyl carboxamide compounds
Genentech
04/26/21
-
83
2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
Array Biopharma
04/26/21
-
9
Aminopyrazoles as janus kinase inhibitors
Merck Sharp & Dohme
04/26/21
-
137
Cyclin dependent kinase inhibitors
Pfizer
04/26/21
-
242
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck
04/26/21
-
13
Aza-indazole compounds for use in tendon and/or ligament injuries
Novartis
04/26/21
-
155
Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors
Proximagen
04/26/21
-
96
Wee-1 inhibiting pyrazolopyrimidinone compounds
Almac Discovery
04/26/21
-
243
Piperidine derivatives as inhibitors of ubiquitin specific protease 7
Almac Discovery
04/26/21
-
54
Indazole compounds and uses thereof
Incyte
04/25/21
-
432
2-(morpholin-4-yl)-1,7-naphthyridines
Bayer Pharma Aktiengesellschaft
04/25/21
-
1204
6-membered heterocyclic derivatives and pharmaceutical composition comprising the same
Shionogi
04/25/21
-
191
Heteroaryl compounds and uses thereof
Celgene Car
04/25/21
-
352
HIV protease inhibitors
Gilead Sciences
04/25/21
-
8
FXR (NR1H4) modulating compounds
Gilead Sciences
04/25/21
-
71
Substituted piperazines as selective HDAC1,2 inhibitors
Regenacy Pharmaceuticals
04/25/21
-
24
Materials and method for inhibiting replication protein A and uses thereof
Indiana University Research and Technology
04/25/21
-
22
1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
Novartis
04/25/21
-
123
Composition and methods for inhibiting mammalian sterile 20-like kinase 1
The Scripps Research Institute
04/25/21
-
3
Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making
Pharmakea
04/25/21
-
39
2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
Blueprint Medicines
04/25/21
-
381
PD-1/PD-L1 inhibitors
Gilead Sciences
04/25/21
-
105
Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
Array Biopharma
04/25/21
-
343
ULK1 inhibitors and methods using same
Salk Institute For Biological Studies
04/25/21
-
106
Galactoside inhibitor of galectins
Galecto Biotech
04/25/21
-
20
Indazole containing macrocycles and therapeutic uses thereof
Samumed
04/19/21
-
43
Compounds that are ERK inhibitors
Merck Sharp & Dohme
04/19/21
-
15
Thienopyrimidine derivative and use thereof in medicine
Sunshine Lake Pharma
04/19/21
-
220
Neprilysin inhibitors
Theravance Biopharma R&D Ip
04/19/21
-
20
Carboxamide derivatives useful as rsk inhibitors
Phoenix Molecular Designs
04/18/21
-
7
Therapeutic compounds and uses thereof
Kala Pharmaceuticals
04/18/21
-
232
Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors
Array Biopharma
04/18/21
-
32
Certain chemical entities, compositions, and methods
Neupharma
04/18/21
-
46
Glucosylceramide synthase inhibitors for the treatment of diseases
TBA
04/18/21
-
138
Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
Synchronicity Pharma
04/18/21
-
33
Benzofuran derivative, preparation method thereof and use thereof in medicine
Jiangsu Hengrui Medicine
04/18/21
-
2
Pharmaceutical uses of pyridine carboxamide derivatives
Jiangsu Hengrui Medicine
04/18/21
-
24
Mammalian and bacterial nitric oxide synthase inhibitors
Northwestern University
04/18/21
-
26
CaMKII inhibitors and uses thereof
The Johns Hopkins University
04/18/21
-
106
2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors
Almirall
04/18/21
-
77
2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders
Bayer Pharma Aktiengesellschaft
04/18/21
-
138
CXCR4 inhibitors and uses thereof
X4 Pharmaceuticals
04/18/21
-
6
Adenosine A3 receptor modulators
Palobiofarma
04/13/21
-
66
6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
Samumed
04/13/21
-
420
Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
Lycera
04/13/21
-
2
Pyridine derivatives and their use in the treatment of cancer and hemoglobinopathies
Ctxt
04/13/21
-
8
1,3,5-triazine derivative and method of using same
Chia Tai Tianqing Pharmaceutical Group
04/13/21
-
16
Indazole compounds and uses thereof
Incyte
04/13/21
-
19
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals
04/13/21
-
57
Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
Merck Patent
04/13/21
-
190
Condensed lactam derivative
Sumitomo Dainippon Pharma
04/13/21
-
18
Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents
Zenji Research Laboratories
04/13/21
-
96
Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
Board of Regents, The University of Texas System
04/13/21
-
40
Neprilysin inhibitors
Theravance Biopharma R&D Ip
04/12/21
-
5
PPARG modulators for the treatment of osteoporosis
The Scripps Research Institute
04/12/21
-
28
Signaling-biased mu opioid receptor agonists
The Scripps Research Institute
04/11/21
-
14
Substituted aminopyrimidine compounds and methods of use
Sunshine Lake Pharma
04/11/21
-
75
4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
Eastern Virginia Medical School
04/11/21
-
27
Dopamine D2 receptor ligands
The Broad Institute
04/11/21
-
38
Morphan and morphinan analogues, and methods of use
Alkermes Pharma Ireland
04/11/21
-
152
Nitrogen-containing heteroaryl compound and pharmaceutical use thereof
Japan Tobacco
04/11/21
-
20
Aryldiazepine derivatives as RSV inhibitors
Enanta Pharmaceuticals
04/11/21
-
20
C-glucoside derivative containing fused phenyl ring or pharmaceutically acceptable salt thereof, process for preparing same, and pharmaceutical composition comprising same
Je Ii Pharmaceutical
04/11/21
-
15
Compounds and their use for reducing uric acid levels
Acquist
04/11/21
-
148
Spirocyclic containing compounds and pharmaceutical uses thereof
Gb005
04/11/21
-
46
Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists
King''S College London
04/11/21
-
62
Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
Xenon Pharmaceuticals
04/11/21
-
25
Iso-citrate dehydrogenase (IDH) inhibitor
Shanghai Meton Pharmaceutical
04/11/21
-
12
Heterocyclic compounds as FGFR inhibitors
Guangzhou Innocare Pharma Tech
04/11/21
-
6
6-fluoro 2-methylbenzo[d]thiazol-5-yl compounds
Eli Lilly
04/11/21
-
96
Benzimidazole derivatives: preparation and pharmaceutical applications
Mei Pharma
04/04/21
-
315
Triazole furan compounds as agonists of the APJ receptor
Amgen
04/04/21
-
37
Methods for treating depressive symptoms
Alkermes Pharma Ireland
04/04/21
-
35
Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy
The Johns Hopkins University
04/04/21
-
97
Amide compounds as kinase inhibitors, compositions and methods of treatment
Translation Drug Development
04/04/21
-
158
Pyridone amides as modulators of sodium channels
Vertex Pharmaceuticals
04/04/21
-
42
1,3-diaza-spiro-[3.4]-octane derivatives
GrÜNenthal
04/04/21
-
11
Isoquinoline derivatives and use thereof
Purdue Pharma
04/04/21
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
04/04/21
-
204
Imidazotriaines and imidazopyrimidines as kinase inhibitors
Incyte Holdings
04/04/21
-
4
Bicyclic compounds as dual ATX/CA inhibitors
Hoffmann-La Roche
04/04/21
-
508
Pyrazolopyrimidinone compounds and uses thereof
Aduro Biotech
04/04/21
-
118
Tertiary alcohols as PI3K-γ inhibitors
Incyte
04/04/21
-
64
6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
Pfizer
04/04/21
-
29
Cyclic di-nucleotide compounds as STING agonists
Merck Sharp & Dohme
04/04/21
-
33
Apoptosis signal-regulating kinase inhibitors
Gilead Sciences
04/04/21
-
242
Biphenyl compound or salt thereof
Taiho Pharmaceutical
03/30/21
-
380
Amido spirocyclic amide and sulfonamide derivatives
Forma Tm
03/28/21
-
5
1,1 ′-sulfanediyl-di-beta-D-galactopyranosides as inhibitors of galectins
Galecto Biotech
03/28/21
-
10
D-3-phosphoglycerate dehydrogenase allosteric inhibitor and use thereof
Peking University
03/28/21
-
51
Cyanoindazole compounds and uses thereof
Incyte
03/28/21
-
4
Cyclodextrin-panobinostat adduct
Midatech
03/28/21
-
204
Heterocyclic compounds and uses thereof
Incyte
03/28/21
-
6
Protease inhibitors
Medivir
03/28/21
-
173
Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors
Bristol-Myers Squibb
03/28/21
-
230
Biaryl kinase inhibitors
Bristol-Myers Squibb
03/28/21
-
2
Diaminopyrimidine benzenesulfone derivatives and uses thereof
Dana-Farber Cancer Institute
03/27/21
-
49
Compounds for modulating aquaporins
Apoglyx
03/27/21
-
72
Indole derivatives and use thereof
Purdue Pharma
03/27/21
-
95
Bicyclic heteroaryl substituted compounds
Bristol-Myers Squibb
03/27/21
-
140
Compounds and methods for the enhanced degradation of targeted proteins
Arvinas Operations
03/27/21
-
311
Inhibitors of plasma kallikrein and uses thereof
Shire Human Genetic Therapies
03/27/21
-
31
Substituted imidazo[1,2-A]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof
Jn Therapeutics
03/27/21
-
841
4-Azaindole compounds
Bristol-Myers Squibb
03/27/21
-
199
4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors
Array Biopharma
03/27/21
-
28
Fused pyrimidine derivatives
Hoffmann-La Roche
03/27/21
-
34
2-aminoquinazoline derivatives as P70S6 kinase inhibitors
Sentinel Oncology
03/27/21
-
63
5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
Bayer Pharma Aktiengesellschaft
03/21/21
-
12
Alkynyl dihydroquinoline sulfonamide compounds
Amgen
03/21/21
-
59
Treatment of infectious diseases with glucose uptake inhibitors
Kadmon
03/21/21
-
29
Amino, amido and heterocyclic compounds as modulators of RAGE activity and uses thereof
The Research Foundation For The State University of New York
03/21/21
-
6
Catecholamine prodrugs for use in the treatment of Parkinson's disease
H. Lundbeck
03/21/21
-
66
Ketone inhibitors of lysine gingipain
Cortexyme
03/21/21
-
25
Tetrahydronaphthalene derivative
Ono Pharmaceutical
03/21/21
-
130
Aliphatic prolinamide derivatives
Orion Ophthalmology
03/21/21
-
9
Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
Wisconsin Alumni Research Foundation
03/21/21
-
51
Benzo[b]thiophene compounds as STING agonists
Merck Sharp & Dohme
03/21/21
-
106
Pyridinylmethyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors
Boehringer Ingelheim International
03/21/21
-
17
Compounds as neuronal histamine receptor-3 antagonists and uses thereof
Xw Laboratories
03/21/21
-
12
Benzimidazole derivatives as EP4 ligands
Bayer Pharma Aktiengesellschaft
03/21/21
-
427
Bridged bicyclic compounds as farnesoid X receptor modulators
Bristol-Myers Squibb
03/21/21
-
17
Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof
University Health Network
03/21/21
-
31
Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
Bristol-Myers Squibb
03/21/21
-
116
Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
Pharmaxis
03/21/21
-
44
Indole and azaindole haloallylamine derivative inhibitors of lysyl oxidases and uses thereof
Pharmaxis
03/21/21
-
115
Cyclopropylamines as LSD1 inhibitors
Incyte
03/21/21
-
29
Pyrimidinone and its derivatives inhibiting factor XIa
Ono Pharmaceutical
03/21/21
-
137
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
Boehringer Ingelheim International
03/21/21
-
86
Chemical compounds
Astrazeneca
03/21/21
-
207
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals
03/21/21
-
28
Selective Bruton's tyrosine kinase inhibitor and use thereof
Hangzhou Hertz Pharmaceutical
03/15/21
-
49
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics
03/15/21
-
783
Tricyclic sulfones as RORγ modulators
Bristol-Myers Squibb
03/15/21
-
87
MALT1 inhibitors and uses thereof
Cornell University
03/15/21
-
16
Agent for treating synucleinopathy
Tohoku University
03/14/21
-
2
Compounds as rearranged during transfection (RET) inhibitors
Glaxosmithkline Intellectual Property Development
03/14/21
-
203
Substituted carbonucleoside derivatives useful as anticancer agents
Pfizer
03/14/21
-
1072
Biaryl amide compounds as kinase inhibitors
Novartis
03/14/21
-
28
Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
Metabasis Therapeutics
03/14/21
-
10
Substituted bicyclic compounds
Bristol-Myers Squibb
03/14/21
-
294
Pyrimidine derivative
Aska Pharmaceutical
03/14/21
-
59
STK4 inhibitors for treatment of hematologic malignancies
Dana-Farber Cancer Institute
03/14/21
-
88
Aminopyridine derivatives and their use as selective ALK-2 inhibitors
Novartis
03/14/21
-
656
PD-1/PD-L1 inhibitors
Gilead Sciences
03/14/21
-
150
Oxadiazole transient receptor potential channel inhibitors
Genentech
03/14/21
-
275
Oxadiazole transient receptor potential channel inhibitors
Genentech
03/14/21
-
129
Cyclopropylamines as LSD1 inhibitors
Incyte
03/11/21
-
11
Antidiabetic bicyclic compounds
Merch Sharp & Dohne Corp. Rahway
03/11/21
-
3
Quinazolines as potassium ion channel inhibitors
Bristol-Myers Squibb
03/11/21
-
94
GLP-1 receptor agonists and uses thereof
Pfizer
03/11/21
-
58
Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof
Washington University
03/11/21
-
182
Kappa opioid receptor antagonists and products and methods related thereto
Blackthorn Therapeutics
03/11/21
-
34
Inhibitors of lysine gingipain
Cortexyme
03/11/21
-
14
Small-molecule HSP90 inhibitors
Sloan-Kettering Institute For Cancer Research
03/11/21
-
118
Imidazolepyridine compounds and uses thereof
Novartis
03/11/21
-
53
Macrocyclic MCL-1 inhibitors and methods of use
Abbvie
03/11/21
-
17
3′ end caps, 5′ end caps and combinations thereof for therapeutic RNA
Novartis
03/11/21
-
169
Somatostatin receptor subtype 4 (SSTR4) agonists
Centrexion Therapeutics
03/10/21
-
37
Treatment of B-cell malignancies by a combination JAK and PI3K inhibitors
Incyte
03/10/21
-
109
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals
03/10/21
-
127
Phenylpyrrolidinone formyl peptide 2 receptor agonists
Bristol-Myers Squibb
03/10/21
-
196
Indole derivatives and their use in neurodegenerative diseases
Merck Patent
03/10/21
-
178
Carbazole derivatives
Bristol-Myers Squibb
03/10/21
-
10
KCNQ2-5 channel activator
Ono Pharmaceutical
03/10/21
-
190
Bicyclic quinazolinone derivatives
Hoffmann-La Roche
03/10/21
-
15
MU opioid receptor modulators
University of California
03/08/21
-
21
Degradation of tripartite motif-containing protein 24 (TRIM24) by conjugation of TRIM24 inhibitors with E3 ligase ligand and methods of use
Dana-Farber Cancer Institute
03/08/21
-
445
MCL-1 inhibitors
Gilead Sciences
03/08/21
-
14
Substituted benzimidazoles, their preparation and their use as pharmaceuticals
Neomed Institute
03/08/21
-
16
Covalent inhibitors of PAD4
Padlock Therapeutics
03/08/21
-
289
P2X7 modulators
Janssen Pharmaceutica
03/08/21
-
7
Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof
Leo Pharma
03/08/21
-
337
Substituted purine derivative
Sumitomo Dainippon Pharma
03/08/21
-
1
Salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Galapagos
03/08/21
-
57
Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
Boehringer Ingelheim International
03/02/21
-
388
Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
Incyte Holdings
03/02/21
-
40
Pyrimidine derivative and use thereof
Hubei Bio-Pharmaceutical Industrial Technological Institute
03/02/21
-
43
Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same
Industrial Technology Research Institute
03/02/21
-
125
Therapeutic compounds and uses thereof
Genentech
03/02/21
-
36
Rho kinase inhibitors
Kadmon
03/02/21
-
69
Compounds
Exonate
03/02/21
-
23
Mutant IDH1 inhibitors
Eli Lilly
03/02/21
-
152
Amino acid compounds and methods of use
Pliant Therapeutics
03/02/21
-
64
Kinase inhibitor, and preparing method and pharmaceutical use thereof
Gan & Lee Pharmaceuticals
03/02/21
-
44
CDK inhibitors
G1 Therapeutics
03/02/21
-
23
Somatostatin modulators and uses thereof
Crinetics Pharmaceuticals
03/02/21
-
308
Amido-benzyl sulfone and sulfoxide derivates
TBA
03/02/21
-
647
Methods, compositions, and uses of novel Fyn kinase inhibitors
Pathways Neuro Pharma
02/22/21
-
13
Macrocylic compounds as ROS1 kinase inhibitors
Array Biopharma
02/22/21
-
15
Prodrug amino acid derivative
Taisho Pharmaceutical
02/22/21
-
69
Pyrrolidine derivatives
Hoffmann-La Roche
02/22/21
-
269
1-cyano-pyrrolidine compounds as USP30 inhibitors
Mission Therapeutics
02/22/21
-
246
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
02/22/21
-
43
N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof
Northeastern University
02/22/21
-
124
Quinoxaline compounds as type III receptor tyrosine kinase inhibitors
Development Center For Biotechnology
02/22/21
-
233
Triazole pyridyl compounds as agonists of the APJ receptor
Amgen
02/22/21
-
127
Substituted indazole compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
02/22/21
-
149
1,2-substituted cyclopentanes as orexin receptor antagonists
Takeda Pharmaceutical
02/22/21
-
39
Substituted-3H-imidazo [4,5-c] pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics
Stingray Therapeutics
02/22/21
-
18
Tricyclic fused derivatives of 1-(cyclo)alkyl pyridin-2-one useful for the treatment of cancer
Jubilant Biosys
02/22/21
-
14
Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors
Jubilant Biosys
02/22/21
-
89
OXA-Diazaspiro compounds having activity against pain
Esteve Pharmaceuticals
02/22/21
-
23
Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections
Gilead Sciences
02/22/21
-
25
C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
02/22/21
-
206
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals
02/22/21
-
71
FGFR3 fusion gene and pharmaceutical drug targeting same
Chugai Seiyaku Kabushiki Kaisha
02/22/21
-
63
Piperazine-substituted benzothiophenes for treatment of mental disorders
Otsuka Pharmaceutical
02/22/21
-
242
5-substituted indazole-3-carboxamides and preparation and use thereof
Samumed
02/21/21
-
10
Isoxazole carboxamides as irreversible SMYD inhibitors
Epizyme
02/21/21
-
37
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides dipeptidyl peptidase 1 inhibitors
Astrazeneca
02/21/21
-
115
Benzothiazol compounds and methods using the same for treating neurodegenerative disorders
1St Biotherapeutics
02/21/21
-
72
Pyridyl benzothiophenes as kinase inhibitors
Allergan
02/21/21
-
39
Substituted N-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and N-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives P2X7 receptor antagonists
Axxam
02/21/21
-
306
Bicyclic derivatives
Hoffmann-La Roche
02/21/21
-
30
Heterocyclic compounds as immunomodulators
Incyte
02/21/21
-
36
Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO
Peking University
02/21/21
-
48
Fused pyrimidine derivatives
Hoffmann-La Roche
02/21/21
-
104
Imidazopyridazine compounds
Pfizer
02/21/21
-
43
Condensed [1,4] diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
Hoffmann-La Roche
02/21/21
-
104
Boronic acid derivatives
Merck Patent
02/21/21
-
4
LXR agonists and uses thereof
Rgenix
02/21/21
-
80
Tricyclic compounds as anticancer agents
Bristol-Myers Squibb
02/16/21
-
3
Heterocyclic compounds for the treatment of disease
Oppilan Pharma
02/16/21
-
67
5-5 fused rings as C5a inhibitors
Chemocentryx
02/16/21
-
29
Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Ogeda
02/16/21
-
42
Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin
02/16/21
-
17
(S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using
Iowa State University Research Foundation
02/15/21
-
4
Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
02/15/21
-
56
Modulators of calcium release-activated calcium channel
Rhizen Pharmaceuticals
02/15/21
-
135
Pyridine sulfonamides
Amgen
02/15/21
-
100
(Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use
Bayer Pharma Aktiengesellschaft
02/15/21
-
21
Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
Yeda Research and Development
02/15/21
-
62
Glucocorticoid receptor agonist and immunoconjugates thereof
Abbvie
02/15/21
-
9
Curcumin analogues as zinc chelators and their uses
The Research Foundation of State University of New York
02/15/21
-
147
Cyanopyrrolidines as dub inhibitors for the treatment of cancer
Mission Therapeutics
02/15/21
-
55
Indole derivatives and their use as protein kinase inhibitors
Respivert
02/15/21
-
68
Tetrahydronaphthyl urea derivative
Mochida Pharmaceutical
02/15/21
-
100
Compound having mutant IDH inhibitory activity, preparation method and use thereof
Shanghai Haihe Pharmaceutical
02/15/21
-
68
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
02/15/21
-
45
Heterocyclic derivatives and their use in the treatment of neurological disorders
Novartis
02/15/21
-
23
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
02/15/21
-
841
Pyridyl substituted indole compounds
Bristol-Myers Squibb
02/08/21
-
89
Amino compounds for treatment of medical disorders
Achillion Pharmaceuticals
02/07/21
-
27
Benzimidazole derivatives as PI3 kinase inhibitors
Glaxosmithkline
02/07/21
-
90
Guanidine derivative and medical use thereof
Toray Industries
02/07/21
-
60
ABHD6 and dual ABHD6/MGL inhibitors and their uses
Makscientific
02/07/21
-
83
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals
02/07/21
-
137
Substituted pyrimidines as cyclin-dependent kinase inhibitors
Shanghai Pharmaceuticals Holding
02/07/21
-
124
Bruton's tyrosine kinase inhibitors
Zibo Biopolar Changsheng Pharmaceutical
02/07/21
-
78
PDE4 inhibitor
Shijiazhuang Sagacity New Drug Development
02/07/21
-
90
ASK1 isoindolin-1-one inhibitors and methods of use thereof
Hepatikos Therapeutics
02/01/21
-
69
Compounds and methods for inhibiting JAK
Dizal (Jiangsu) Pharmaceutical
02/01/21
-
10
Pyrimidine derivative, method for preparing same and use thereof in medicine
Zhejiang Hisun Pharmaceutical
02/01/21
-
145
Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors
Mission Therapeutics
02/01/21
-
73
Protein kinase B inhibitors
Astrazeneca
02/01/21
-
17
Method for preparing pyrrolo[3,2-D]pyrimidine compound, and intermediates thereof
Chia Tai Tianqing Pharmaceutical Group
02/01/21
-
7
Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
Hoffmann-La Roche
02/01/21
-
31
Tricyclic rho kinase inhibitors
Bristol-Myers Squibb
02/01/21
-
21
Selective estrogen receptor degraders
Eli Lilly
02/01/21
-
143
6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed
01/31/21
-
52
Substituted quinazolines for inhibiting kinase activity
Neupharma
01/31/21
-
127
Bicyclic hydroxamic acids useful as inhibitors of mammalian histone deacetylase activity
Kancera
01/31/21
-
14
Antiproliferative pyrimidine-based compounds
G1 Therapeutics
01/31/21
-
342
Heterocyclylamines as PI3K inhibitors
Incyte
01/25/21
-
3
Heterocyclic degronimers for target protein degradation
C4 Therapeutics
01/25/21
-
33
Biaryl urea derivative or salt thereof and preparation process and use for the same
Fudan University
01/25/21
-
50
Substituted pyrimidines for preventing or treating cancer and inflammatory diseases
Korea Research Institute of Chemical Technology
01/25/21
-
40
Diphenylaminopyrimidine and triazine compound, and pharmaceutical composition and use thereof
Arromax Pharmatech
01/25/21
-
14
EZH2 inhibitor and use thereof
Tarapeutics Science
01/25/21
-
14
Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies
Galderma Research & Development
01/25/21
-
46
Tetrahydroisoquinoline derived PRMT5-inhibitors
Ctxt
01/25/21
-
601
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
01/25/21
-
42
Bicyclic compounds as dual ATX/CA inhibitors
Hoffmann-La Roche
01/25/21
-
333
Pyrimido-pyridazinone compounds and methods of use thereof
Asan Biosciences
01/25/21
-
47
Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors
Merck Sharp & Dohme
01/25/21
-
312
Immunomodulator compounds
Chemocentryx
01/18/21
-
172
Alkoxy compounds for disease treatment
Acucela
01/18/21
-
85
Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
Boehringer Ingelheim International
01/18/21
-
20
Inhibitors of bruton's tyrosine kinase
Hoffmann-La Roche
01/18/21
-
615
Heterocycle derivatives having TrkA inhibitory activity
Shionogi
01/18/21
-
68
Compounds
Mission Therapeutics
01/18/21
-
158
Imidazopyridines and imidazopyrazines as LSD1 inhibitors
Incyte
01/18/21
-
19
Epoxyketone compounds for enzyme inhibition
Centrax International
01/18/21
-
205
Therapeutically active compositions and their methods of use
Agios Pharmaceuticals
01/18/21
-
113
Diazaspirocycloalkane and azaspirocycloalkane
Hoffmann-La Roche
01/12/21
-
115
Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases
University of Washington
01/10/21
-
168
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
01/10/21
-
130
Melanocortin receptor-specific peptides
Palatin Technologies
01/10/21
-
248
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
01/10/21
-
16
Methods to treat lymphoplasmacytic lymphoma
Dana-Farber Cancer Institute
01/10/21
-
72
Pyridyl benzothiophenes as kinase inhibitors
Allergan
01/10/21
-
107
Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
Jinagsu Hengrui Medicine
01/10/21
-
130
Bromodomain inhibitors
Abbvie
01/10/21
-
14
Pyrazolopyrimidone derivatives and methods of use thereof
Shanghai Hengrui Pharmaceutical
01/10/21
-
1023
CARM1 inhibitors and uses thereof
Epizyme
01/10/21
-
150
6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed
12/21/20
-
11
Enhancer of zeste homolog 2 inhibitors
Glaxosmithkline Intellectual Property (No. 2)
12/21/20
-
19
C5-C6-oxacyclic fused iminothiadiazine dioxide compounds bearing an ether linker as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
12/21/20
-
240
Compounds, compositions and methods
Denali Therapeutics
12/21/20
-
54
Substituted cyclopropanes as PDE-10 inhibitors
Sunovion Pharamaceuticals
12/21/20
-
1
Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds
Suzhou Zelgen Biopharmaceuticals
12/20/20
-
17
Compounds as neuronal histamine receptor-3 antagonists and uses thereof
Xw Laboratories
12/20/20
-
161
Spiroindolinones as DDR1 inhibitors
Hoffmann-La Roche
12/20/20
-
27
5-aromatic alkynyl substituted benzamide compound and preparation method, pharmaceutical composition, and use thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
12/20/20
-
249
Substituted pyrido[2,3-d]pyrimidines as inhibitors of protein kinases
Celgene Car
12/20/20
-
262
Heteroaryl substituted aminopyridine compounds
Bristol-Myers Squibb
12/20/20
-
29
Tricyclic heterocycles as BET protein inhibitors
Incyte
12/20/20
-
18
Diaryl macrocycles as modulators of protein kinases
Turning Point Therapeutics
12/20/20
-
37
Macrocycles as PDE1 inhibitors
H. Lundbeck
12/20/20
-
43
6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
University of Pittsburgh
12/20/20
-
68
Heterocyclic compounds as immunomodulators
Incyte
12/20/20
-
20
3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2, 7-dione compounds for the treatment and prophylaxis of virus infection
Hoffmann-La Roche
12/20/20
-
12
2-amino-6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
H. Lundbeck
12/20/20
-
3
Compounds useful for inhibiting ROR-gamma-t
Eli Lilly
12/20/20
-
65
Arginase inhibitors as therapeutics
Mars
12/20/20
-
171
Compounds for the treatment of pain
Alkermes
12/20/20
-
111
Substituted 5-cyanoindole compounds and uses thereof
Novartis
12/20/20
-
222
Indole carboxamide compounds
Bristol-Myers Squibb
12/20/20
-
11
2,3-dihydro-isoindole-1-one derivative as BTK kinase suppressant, and pharmaceutical composition including same
Crystalgenomics
12/20/20
-
15
Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
12/14/20
-
35
Bicyclic proline compounds
Genentech
12/14/20
-
8
Methods to treat lymphoplasmacytic lymphoma
Dana-Farber Cancer Institute
12/14/20
-
39
Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
12/14/20
-
5
Methods and compositions for cell-proliferation-related disorders
Agios Pharmaceuticals
12/13/20
-
26
Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
The Usa, As Represented By The Secretary, Department of Health and Human Services
12/13/20
-
8
Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes
Jenrin Discovery
12/13/20
-
594
Substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GluN2B receptor modulators
Janssen Pharmaceutica
12/13/20
-
397
Therapeutic compounds
Celgene Quanticel Research
12/13/20
-
4
Pyrrolopyrimidine comprising cyclopentyl substituent
Centaurus Biopharma
12/13/20
-
42
Compounds for cancer chemotherapeutic sensitization
Regents of The University of Minnesota
12/13/20
-
259
2,4-disubstituted pyrimidines useful as kinase inhibitors
Celgene Car
12/13/20
-
76
Aza-heteroaryl compounds as PI3K-gamma inhibitors
Incyte
12/13/20
-
325
Aryl ethers and uses thereof
Peloton Therapeutics
12/13/20
-
191
Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof
Sanford Burnham Prebys Medical Discovery Institute
12/13/20
-
258
Somatostatin modulators and uses thereof
Crinetics Pharmaceuticals
12/13/20
-
6
Certain chemical entities, compositions, and methods
Neupharma
12/08/20
-
14
Cardiac glycoside analogs and their use in methods for inhibition of viral infection
The John Hopkins University
12/07/20
-
18
1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
Universitat De Barcelona
12/07/20
-
97
Isoindoline compositions and methods for treating neurodegenerative disease
Cognition Therapeutics
12/07/20
-
212
Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators
Janssen Pharmaceutica
12/07/20
-
15
Dopamine D1 receptor positive allosteric modulators
Eli Lilly
12/07/20
-
95
Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer
Loxo Oncology
12/07/20
-
26
Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof
Guangzhou Maxinovel Pharmaceuticals
12/07/20
-
69
Imidazopyridazine compounds and their use
Hutchison Medipharma
12/07/20
-
29
Cyanopyrrolidine derivatives as inhibitors for DUBs
Mission Therapeutics
12/07/20
-
7
TRPV4 antagonists
Glaxosmithkline Intellectual Property Development
12/07/20
-
56
1,3-dihydroxy-phenyl derivatives useful as immunomodulators
Bristol-Meyers Squibb
12/07/20
-
24
Heterocyclic compounds used as FGFR inhibitors
Nanjing Innocare Pharma Tech
12/07/20
-
161
Compounds, compositions, and methods
Denali Therapautics
12/07/20
-
63
Chemical compounds
Astrazeneca
12/07/20
-
159
Selective estrogen receptor down-regulators
Astrazeneca
12/07/20
-
60
Method of treatment using substituted imidazo[1,2b]pyridazine compounds
Array Biopharma
12/07/20
-
438
Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions
Esteve Pharmaceuticals
12/07/20
-
138
Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharp & Dohme
11/30/20
-
22
Compounds and compositions as protein kinase inhibitors
Array Biopharma
11/30/20
-
13
Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors
Vtv Therapeutics
11/30/20
-
7
Substituted (4'-hydroxyphenyl)cyclohexane compounds and uses thereof as selective agonists of the estrogen receptor beta isoform
Marquette University
11/30/20
-
53
1,4-dicarbonyl-piperidyl derivatives
Merck Patent
11/30/20
-
40
Isoquinolones as BTK inhibitors
Boehringer Ingelheim International
11/30/20
-
114
Substituted dihydroisoquinolinone compounds
Pfizer
11/30/20
-
51
Pharmacokinetically improved compounds
Surface Logix
11/30/20
-
16
(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
Centrexion Therapeutics
11/30/20
-
42
Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
Prelude Therapeutics
11/30/20
-
7
Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof
Chia Tai Tianqing Pharmaceutical Group
11/30/20
-
8
Imidazooxazole derivative having antitumor effect, and pharmaceutical composition including same
Korea Institute of Science and Technology
11/30/20
-
42
Substituted imidazo[1,2-a]pyridines as PDE-10 inhibitors
Sunovion Pharmaceuticals
11/30/20
-
149
Ectonucleotidase inhibitors and methods of use thereof
Calithera Biosciences
11/30/20
-
61
A3 adenosine receptor agonists
The United States of America, As Represented By The Secretary, Department of Health and Human Services
11/29/20
-
1143
TYK2 inhibitors and uses thereof
Nimbus Lakshimi
11/29/20
-
356
Bruton's tyrosine kinase inhibitors
Sunesis Pharmaceuticals
11/29/20
-
37
Macrocyclic inhibitors of myeloperoxidase
Bristol-Myers Squibb
11/29/20
-
56
Triazole DAGLα inhibitors
The Scripps Research Institute
11/29/20
-
12
Ingenol analogs, pharmaceutical compositions and methods of use thereof
Glaxosmithkline Intellectual Property Development
11/29/20
-
12
Quinolone-3-diarylethers
Oregon Health & Science University
11/29/20
-
211
Small molecule agonists of neurotensin receptor 1
Sanford Burnham Prebys Medical Discovery Institute
11/29/20
-
18
Carboxylic acid URAT1 inhibitor containing diarylmethane structure, preparation method and use thereof
Tianjin Institute of Pharmaceutical Research
11/29/20
-
22
4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
Heptares Therapeutics
11/29/20
-
41
Inhibitors of RET
Blueprint Medicines
11/29/20
-
51
Heterocyclic sulfonamide derivative and medicine containing same
Ea Pharma
11/29/20
-
58
Benzimidazole compounds and use thereof for treating Alzheimer's Disease or Huntington's Disease
National Health Research Institutes
11/29/20
-
10
Heteroaryl substituted benzoic acids as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
11/29/20
-
11
3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman)
11/29/20
-
12
SHMT inhibitors
The Trustees of Princeton University
11/29/20
-
69
Use of physiological cooling active ingredients, and agents containing such active ingredients
Symrise
11/29/20
-
174
Substituted 3,6-diazabicyclo[3.2.0]heptanes
Indivior
11/29/20
-
8
Indane-amines as PD-L1 antagonists
Chemocentryx
11/29/20
-
27
SHP2 inhibitors and uses thereof
Synblia Therapeutics
11/22/20
-
5
Organic compounds
Intra-Cellular Therapies
11/22/20
-
23
Pyrrolopyrimidine compound
Centaurus Biophrama
11/22/20
-
73
4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
Takeda Pharmaceutical
11/22/20
-
14
HYPDH inhibitors and methods of use for the treatment of kidney stones
Wake Forest University Health Sciences
11/22/20
-
100
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
11/22/20
-
63
Compounds for treating disorders sensitive to serotoninergic regulation controlled by the 5-HT1A receptors
Neurolixis
11/22/20
-
16
Prolyl hydroxylase inhibitors
Aerpio Therapeutics
11/22/20
-
14
Carboxylic acid compounds
Sumitomo Dainippon Pharma
11/22/20
-
222
Cycloalkylamines as monoamine reuptake inhibitors
Sunovion Pharamceuticals
11/22/20
-
41
Piperidine derivatives for use in the treatment or prevention of psychiatric and neurological conditions
Takeda Pharmaceutical
11/22/20
-
177
Triazolones and tetrazolones as inhibitors of ROCK
Bristol-Myers Squibb
11/22/20
-
1
Crystalline FGFR4 inhibitor compound and uses thereof
Eisai R&D Management
11/22/20
-
15
Cancer therapeutics
University of Virginia Patent Foundation
11/22/20
-
427
Quinazolinones as PARP14 inhibitors
Ribon Therapeutics
11/22/20
-
22
Benzimidazoles derivatives as Tec kinases family inhibitors
Gb005
11/22/20
-
57
Indazole compounds as FGFR kinase inhibitor, preparation and use thereof
Shanghai Haihe Pharmaceutical
11/22/20
-
162
IRAK4 inhibitor and use thereof
Beijing Hanmi Pharmaceutical
11/22/20
-
9
Nitrogen-containing tricyclic compounds and uses thereof in medicine
North & South Brother Pharmacy Investment
11/22/20
-
206
Substituted quinoxalines as PDE-10 inhibitors
Sunovion Pharmaceuticals
11/22/20
-
508
IRAK4 inhibiting agents
Biogen Ma
11/21/20
-
221
NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
Ogeda
11/20/20
-
3
Tetrahydroisoquinolines as PRMT5 inhibitors
Ctxt
11/20/20
-
159
Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators
Novartis
11/20/20
-
803
Pyridazinones as PARP7 inhibitors
Ribon Therapeutics
11/20/20
-
21
Kinase inhibitors and their use in cancer therapy
Technische UniversitÄT Dortmund
11/20/20
-
11
2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
Genentech
11/20/20
-
8
JAK inhibitors containing a 4-membered heterocyclic amide
Theravance Biopharma R&D Ip
11/20/20
-
5
Prodrugs of imidazotriazine compounds as CK2 inhibitors
Bristol-Myers Squibb
11/20/20
-
20
Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes
Boehringer Ingelheim International
11/20/20
-
43
Ether compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
11/20/20
-
107
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
Boehringer Ingelheim International
11/20/20
-
58
Fused tricyclic compounds as Raf kinase inhibitors
Beigene
11/20/20
-
36
Sodium channel modulators
The Florey Institute
11/20/20
-
28
Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
Saint Louis University
11/20/20
-
87
Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists
Boehringer Ingelheim International
11/20/20
-
37
Cot modulators and methods of use thereof
Gilead Sciences
11/20/20
-
27
5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (No. 5)
11/20/20
-
6
Bis-pyridazine compounds and their use in treating cancer
Cancer Research Technology
11/20/20
-
153
Arylamide derivatives having multimodal activity against pain
Esteve Pharmaceuticals
11/20/20
-
33
Dopamine D3 receptor antagonists having a morpholine moiety
Indivior
11/20/20
-
980
Substituted piperidine compounds
Epizyme
11/20/20
-
556
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Eli Lilly
11/13/20
-
9
Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics
Galderma Research & Development
11/13/20
-
302
Isoquinolin-3-YL carboxamides and preparation and use thereof
Samumed
11/13/20
-
37
Piperazinyl methanone NAAA inhibitors
University of California
11/13/20
-
71
TrkA kinase inhibitors, compositions and methods thereof
Merck Sharp & Dohme
11/13/20
-
122
Glycosidase inhibitors
Asceneuron
11/13/20
-
119
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
Incyte
11/13/20
-
100
Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use
Abbvie
11/13/20
-
66
Pyrimidine FGFR4 inhibitors
Eisai R&D Management
11/09/20
-
188
Methods using HDAC11 inhibitors
Forma Therapeutics
11/09/20
-
208
Compounds as indoleamine 2,3-dioxygenase inhibitors
Merck Sharp & Dohme
11/09/20
-
61
Substituted amino triazoles useful as human chitinase inhibitors
Oncoarendi Therapeutics
11/09/20
-
3
4-(biphen-3-yl)-1H-pyrazolo[3,4-c]pyridazine derivatives of formula (I) as GABA receptor modulators for use in the treatment of epilepsy and pain
Pfizer
11/09/20
-
46
5H-pyrrolo[2,3-D]pyrimidin-6(7H)-one derivative
Taiho Pahrmaceutical
11/09/20
-
153
4,5-substituted picolinamide and picolinonitrile metabotropic glutamate receptor 2 negative allosteric modulators
Vanderbilt University
11/09/20
-
39
Quinolone derivatives as FGFR inhibitors
Principia Biopharma
11/09/20
-
130
Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
Astex Therapeutics
11/07/20
-
163
Modulators of sphingosine phosphate receptors
The Scripps Research Institute
11/07/20
-
34
Acetyl-CoA carboxylase modulators
Monsanto Technology
11/07/20
-
119
Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas
Celgene Quanticel Research
11/07/20
-
8
KSR antagonists
Icahn School of Medicine At Mount Sinai
11/07/20
-
25
Benzamide derivative
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
11/07/20
-
49
Acyl sulfonamide NaV1.7 inhibitors
Bristol-Myers Squibb
11/07/20
-
62
Inhibitors of protease-activated receptor-2
Heptares Therapeutics
11/07/20
-
87
1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
St. Jude Children''S Research Hospital
11/07/20
-
182
Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors
Forma Therapeutics
11/07/20
-
114
5-[3-[piperzin-1-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS 4 and 5 inhibitors for treating E.G. osteoarthritis
Galapagos
11/07/20
-
107
Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Takeda Pharmaceutical
11/02/20
-
235
Isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed
11/02/20
-
489
Metallo-beta-lactamase inhibitors
Merck Sharp & Dohme
11/02/20
-
150
Heteroaryl substituted pyridyl compounds useful as kinase modulators
Bristol-Myers Squibb
11/02/20
-
76
Derivatives and methods of treating hepatitis B infections
Novira Therapeutics
11/02/20
-
878
4-azaindole compounds
Bristol-Myers Squibb
11/02/20
-
1
Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
Fedora Pharmaceuticals
11/02/20
-
117
Purine inhibitors of human phosphatidylinositol 3-kinase delta
Merck Sharp & Dohme
11/02/20
-
11
Compounds and uses thereof
Kala Pharmaceuticals
11/02/20
-
9
5-HT2CR agonist analogs
University of Texas
11/02/20
-
12
Tetrahydroisoquinolin-1-one derivative or salt thereof
Seldar Pharma
11/02/20
-
213
Inhibitors of protein kinases
Portola Pharmaceuticals
11/02/20
-
376
Substituted indole Mcl-1 inhibitors
Vanderbilt University
11/02/20
-
6
Treatment and diagnosis of melanoma
Rockefeller University
11/01/20
-
6
Organic compounds
Intra-Cellular Therapies
11/01/20
-
75
Inhibitor of lysine specific demethylase-1
Celgene Quanticel Research
11/01/20
-
5
Macrocycle and composition comprising thereof
Shenzhen Targetrx
11/01/20
-
73
Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
Ardelyx
11/01/20
-
118
Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
Celgene Quanticel Research
11/01/20
-
13
Beta-lactamase inhibitors, formulations, and uses thereof
University of South Florida
11/01/20
-
4
Derivatives of sobetirome
Oregon Health & Science University
11/01/20
-
38
3-indol substituted derivatives, pharmaceutical compositions and methods for use
Pfizer
11/01/20
-
141
Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
University of Washington Through Its Center For
11/01/20
-
96
Certain chemical entities, compositions, and methods
Neupharma
11/01/20
-
35
Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
University of Pittsburgh
11/01/20
-
201
Thiazolidinone compounds and use thereof
National Health Research Institute
11/01/20
-
30
5-hydroxytryptamine receptor 7 activity modulators and their method of use
Temple University
11/01/20
-
331
Biaryl kinase inhibitors
Bristol-Myers Squibb
11/01/20
-
58
Spirocyclic compounds
Recurium Ip Holdings
10/25/20
-
57
Bicyclic heterocyclic derivatives
Merck Patent
10/25/20
-
214
Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Galapagos
10/25/20
-
16
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D Ip
10/25/20
-
98
Fused heteroaryl derivatives as orexin receptor antagonists
Merck, Sharp & Dohme
10/25/20
-
40
Benzimidazole derivates useful as inhibitors of mammalian histone deacetylase activity
Kancera
10/24/20
-
47
Oligomer-opioid agonist conjugates
Inheris Pharmaceuticals
10/24/20
-
31
Cyclopropylamines as LSD1 inhibitors
Incyte
10/24/20
-
22
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
Tes Pharma
10/24/20
-
11
Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
Forma Therapeutics
10/24/20
-
7
Flavanone derivatives, and preparation method and use thereof
Xuanwu Hospital of Capital Medical University
10/24/20
-
32
Piperidine compounds as PCSK9 inhibitors
Shenzhen Salubris Pharm
10/24/20
-
38
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
10/24/20
-
6
Sulfamide and sulfamate inhibitors of hHint1
Regents of The University of Minnesota
10/24/20
-
41
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
Incyte
10/24/20
-
246
Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators
Janssen Pharmaceutica
10/24/20
-
5
PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
H. Lundbeck
10/24/20
-
11
2′-chloro nucleoside analogs for HCV infection
Idenix Pharmaceuticals
10/24/20
-
9
LSD1 inhibitors and medical uses thereof
Constellation Pharmaceuticals
10/19/20
-
107
Thiazolecarboxamides and pyridinecarboxamide compounds useful as PIM kinase inhibitors
Incyte Holdings
10/19/20
-
15
Pyridazinone macrocycles as IRAK inhibitors and uses thereof
Merck Patent
10/19/20
-
106
Serine/threonine kinase inhibitors
Genentech
10/19/20
-
165
KDM1A inhibitors for the treatment of disease
Imago Biosciences
10/19/20
-
11
Fused imidazo-piperidine JAK inhibitors
Theravance Biopharma R&D Ip
10/19/20
-
89
Pyrrolopyrimidine derivatives as TAM inhibitors
Incyte
10/19/20
-
3
3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies
Ctxt
10/19/20
-
696
Heterocyclic compounds and uses thereof
Plexxikon
10/19/20
-
73
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
Bristol-Myers Squibb
10/18/20
-
1156
TYK2 inhibitors and uses thereof
Nimbus Lakshimi
10/18/20
-
190
1 H-pyrazolo[4,3-B]pyridines as PDE1 inhibitors
H. Lundbeck
10/18/20
-
303
Isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed
10/12/20
-
13
Inhibitors of cellular necrosis and related methods
President and Fellows of Harvard College
10/12/20
-
51
Benzimidazole-linked indole compound acting as novel divalent IAP antagonist
Medshine Discovery
10/12/20
-
514
6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1H)-one as APJ agonists
Bristol-Myers Squibb
10/12/20
-
117
Indazole compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
10/12/20
-
20
Morpholine derivative
Hoffmann-La Roche
10/12/20
-
121
Tricyclic compounds as inhibitors of mutant IDH enzymes
Merck Sharp & Dohme
10/12/20
-
303
Bicyclic compound and use thereof for inhibiting SUV39H2
Oncotherapy Science
10/12/20
-
30
Covalent small molecule DCN1 inhibitors and therapeutic methods using the same
The Regents of The University of Michigan
10/12/20
-
283
Substituted benzamides
Hoffmann-La Roche
10/12/20
-
5
Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
Northwestern University
10/12/20
-
36
Compounds and methods of use
Medivation Technologies
10/12/20
-
16
Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals
Neomed Institute
10/12/20
-
26
Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
Boehringer Ingelheim International
10/12/20
-
68
Substituted nitrogen containing compounds
Bristol-Myers Squibb
10/12/20
-
15
Selective NR2B antagonists
Bristol-Myers Squibb
10/12/20
-
37
Lactam compound derivative and application thereof
Nhwa Pharma.
10/12/20
-
37
Substituted bicyclic fused ring compounds as indoleamine-2,3-dioxygenase inhibitors
Iomet Pharma
10/12/20
-
33
WDR5 inhibitors and modulators
Vanderbilt University
10/12/20
-
66
Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors
Beigene
10/12/20
-
12
Fused heterocyclic ring compounds and method of treating retinal disease using same
The Industry & Academic Cooperation In Chungnam National University (IAC)
10/12/20
-
11
Quinazoline derivatives substituted by aniline, preparation method and use thereof
Xuanzhu Pharma
10/02/20
-
14
Compounds for the treatment of addiction
Amygdala Neurosciences
10/02/20
-
256
Substituted piperidine compound and use thereof
Takeda Pharmaceutical
10/02/20
-
218
PARG inhibitory compounds
Cancer Research Technology
10/02/20
-
193
Methods using HDAC11 inhibitors
Forma Therapeutics
10/02/20
-
13
Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
Forma Therapeutics
10/02/20
-
59
Spirocyclic compounds
Recurium Ip Holdings
10/02/20
-
118
Tetrahydroisoquinoline derived PRMT5-inhibitors
Ctxt
10/02/20
-
31
Nitrogen-containing tricyclic derivatives having HIV replication inhibitory activity
Shionogi
10/02/20
-
404
Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines and substituted imidazo[1,2-b]pyridazines as PI3K-gamma inhibitors
Incyte
09/26/20
-
7
Enhancer of Zeste Homolog 2 inhibitors
Glaxosmithkline
09/25/20
-
576
Substituted pyrazin-2-amines as inhibitors of ATR kinase
Vertex Pharmaceuticals
09/25/20
-
155
Compounds that inhibit MPS1 kinase
Cancer Research Technology
09/25/20
-
66
Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
Boehringer Ingelheim International
09/25/20
-
32
Six-membered ring benzo derivatives as DPP-4 inhibitor and use thereof
East China University of Science and Technology
09/25/20
-
29
Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
Incyte
09/25/20
-
31
Broad-spectrum non-covalent coronavirus protease inhibitors
Purdue Research Foundation
09/25/20
-
955
[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
Bristol-Myers Squibb
09/24/20
-
202
Mixed lineage kinase inhibitors for HIV/AIDS therapies
The University of Rochester
09/20/20
-
42
Pyrimidine compounds as JAK kinase inhibitors
Theravance Biopharma R&D Ip
09/20/20
-
15
Small molecule inhibitors of the JAK family of kinases
Janssen Pharmaceutica
09/20/20
-
13
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
Bristol-Myers Squibb
09/20/20
-
77
Macrocycles as factor XIa inhibitors
Bristol-Myers Squibb
09/20/20
-
25
Positive allosteric modulators of the GLP-1 receptor
Vanderbilt University
09/20/20
-
124
Pyrazolopyridinamines as MKNK1 and MKNK2 inhibitors
Bayer Pharma Aktiengesellschaft
09/20/20
-
12
IBAT inhibitors for the treatment of liver diseases
Albireo
09/20/20
-
6
Aminopyridinecarboxamides as CXCR2 modulators
Syntrix Biosystems
09/20/20
-
37
Substituted indazole derivatives active as kinase inhibitiors
Nerviano Medical Sciences
09/20/20
-
9
2-cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives
Algiax Pharmaceuticals
09/14/20
-
7
Factor XIa inhibitors
Merck Sharp & Dohme
09/14/20
-
389
1,3-thiazol-2-yl substituted benzamides
Bayer Aktiengesellschaft
09/14/20
-
86
1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte
09/14/20
-
80
Ectonucleotidase inhibitors and methods of use thereof
Calithera Biosciences
09/14/20
-
5
Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
Incyte Incorporation
09/14/20
-
277
Tricyclic heterocycles as BET protein inhibitors
Incyte Holdings
09/09/20
-
234
Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
Enanta Pharmaceuticals
09/08/20
-
66
Pyridazinone compounds and their use as DAAO inhibitors
Takeda Pharmaceutical
09/08/20
-
113
Aminopyrimidinyl compounds
Pfizer
09/08/20
-
10
Multi-tyrosine kinase inhibitors derivatives and methods of use
Ontogenesis
09/08/20
-
29
Compound having HSP90 inhibitory activity or pharmaceutically acceptable salt thereof, and medical use thereof
Industry Academic Cooperation Foundation Keimyung University
09/08/20
-
76
1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
Chong Kun Dang Pharmaceutical
09/08/20
-
11
Process of making somatostatin modulators
Crinetics Pharmaceuticals
09/08/20
-
184
Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same
Je Il Pharmaceutical
09/08/20
-
49
2,4-disubstituted pyrimidines as CDK inhibitors
Shanghai Xunhe Pharmaceutical Technology
09/08/20
-
3
Amino pyrimidine SSAO inhibitors
Eli Lilly
09/08/20
-
120
Benzenesulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (RORγ(T))
Galderma Research & Development
09/07/20
-
10
Substituted pyrrolo[2,3-b]pyridines as inhibitors of cellular necroptosis
Institut National De La Sante Et De La Recherche Medicale (Inserm)
09/07/20
-
11
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
Bristol_Myers Squibb
09/07/20
-
15
[1,2,3]triazolo[4,5-d]pyrimidine derivatives
Hoffmann-La Roche
09/07/20
-
38
[1,2,3]triazolo[4,5-D]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
Hoffmann-La Roche
09/07/20
-
7
[1,2,3]triazolo[4,5-D]pyrimidine derivatives
Hoffmann-La Roche
09/07/20
-
328
Sulfonyl amide derivatives for the treatment of abnormal cell growth
Pfizer
08/31/20
-
6
PET Imaging agents
Novartis
08/31/20
-
190
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
08/31/20
-
54
Bicyclic heterocycles as FGFR inhibitors
Incyte Holdings
08/31/20
-
7
[1,2,3]triazolo[4,5-D]pyrimidine derivatives
Hoffmann-La Roche
08/31/20
-
168
Heterocyclic compounds useful as Pim kinase inhibitors
Incyte
08/30/20
-
815
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
08/24/20
-
2
Methods for treating pulmonary hypertension
Reviva Pharmaceuticals
08/24/20
-
21
1-sulfonamido-4-aryloxy compounds, and preparation method and medicinal application thereof
China Pharmaceutical University
08/24/20
-
182
Benzimidazol-2-amines as mIDH1 inhibitors
Bayer Pharma Aktiengesellschaft
08/24/20
-
273
Tricyclic heterocycles as bet protein inhibitors
Incyte
08/24/20
-
124
Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors
Novartis
08/24/20
-
145
Pyrrolotriazine compounds as TAM inhibitors
Incyte
08/24/20
-
509
Tricyclic compounds as inhibitors of mutant IDH enzymes
Merck Sharp & Dohme
08/24/20
-
104
Substituted indoles as modulators of ROR-gamma
Vitae Pharmaceuticals
08/24/20
-
115
Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases
University of Washington
08/24/20
-
21
Inhibitors of the IRE-1/XBP-1 pathway and methods of using thereof
H. Lee Moffitt Cancer Center and Research Institute
08/24/20
-
55
1,3,4-thiadiazole compounds and their use in treating cancer
Astrazeneca
08/24/20
-
118
Aminopyridazinone compounds as protein kinase inhibitors
Jiangsu Hengrui Medicine
08/24/20
-
298
Human plasma kallikrein inhibitors
Biocryst Pharmaceuticals
08/24/20
-
80
Pyrazolo[3,4-d]pyrimidine compound or salt thereof
Taiho Pharmaceutical
08/24/20
-
348
Heterocyclylamines as PI3K inhibitors
Incyte Holdings
08/24/20
-
15
BCL-2 inhibitors
Newave Pharmaceutical
08/24/20
-
60
Negative allosteric modulators of metabotropic glutamate receptor 3
Vanderbilt University
08/24/20
-
539
Purinones as ubiquitin-specific protease 1 inhibitors
Forma Therapeutics
08/24/20
-
19
Azepine derivatives as 5-HT7 receptor modulators
Korea Institute of Science and Technology
08/24/20
-
31
Pharmaceutical composition comprising pyridone derivatives
Sk Biopharmaceuticals
08/24/20
-
18
Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors
University of Illinois
08/24/20
-
40
Amino pyrimidine derivatives
Novartis
08/24/20
-
239
Therapeutic compounds and methods of use thereof
Genentech
08/24/20
-
912
Benzolactam compounds as protein kinase inhibitors
Otsuka Pharmaceutical
08/24/20
-
128
γ-diketones as Wnt/β-catenin signaling pathway activators
Samumed
08/24/20
-
86
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
08/24/20
-
137
Imidazolonylquinolines and the use thereof as ATM kinase inhibitors
Merck Patent
08/24/20
-
154
Imidazo[4,5-C]pyridine and pyrrolo[2,3-C]pyridine derivatives as SSAO inhibitors
Proximagen
08/19/20
-
155
Imidazo[4,5-C]pyridine and pyrrolo[2,3-C]pyridine derivatives as SSAO inhibitors
Proximagen
08/19/20
-
5
6,7-cyclicmorphinan derivatives and use thereof
Purdue Pharma
08/17/20
-
169
Triaza-spirodecanones as DDR1 inhibitors
Hoffmann-La Roche
08/17/20
-
214
Tricyclic PI3K inhibitor compounds and methods of use
Genentech
08/17/20
-
43
Substituted tetrahydrocarbazole and carbazole carboxamide compounds
Bristol-Myers Squibb
08/17/20
-
27
Substituted spirocycles
Boehringer Ingelheim International
08/17/20
-
104
Methyl- and trifluromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
Pfizer
08/17/20
-
52
Piperidinyl derivatives
Merck Patent
08/17/20
-
15
HDAC inhibitors
Biomarin Pharmaceutical
08/17/20
-
480
3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones
Bayer Pharma Aktiengesellschaft
08/17/20
-
46
4H-pyrrolo[3,2-C]pyridin-4-one derivatives
Bayer Pharma Aktiengesellschaft
08/17/20
-
62
Fused amino pyridine as HSP90 inhibitors
Curis
08/17/20
-
69
Pyrrole heteroaryl ring derivative and method of use thereof
Jiangsu Hengrui Medicine
08/17/20
-
231
Soluble guanylate cyclase stimulators
Merck Sharp & Dohme
08/17/20
-
6
Heterocyclylmethyl-thienouracile as antagonists of the adenosine-A2B-receptor
Bayer Pharma Aktiengesellschaft
08/17/20
-
82
Pyrimidinones as PI3K inhibitors
Incyte
08/17/20
-
117
Substituted nucleoside derivatives useful as anticancer agents
Pfizer
08/17/20
-
93
Difluoroketamide derivatives
Hoffmann-La Roche
08/17/20
-
13
Inhibitors of fatty acid amide hydrolase (FAAH) enzyme with improved oral bioavailability and their use as medicaments
University of California
08/16/20
-
10
Kinase inhibitors
Topivert Pharma
08/16/20
-
268
Tricyclic sulfones as ROR gamma modulators
Bristol-Myers Squibb
08/16/20
-
9
[4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof
Santen Pharmaceutical
08/16/20
-
14
Non-aromatic difluoro analogues of resorcylic acid lactones
University of North Carolina At Greensboro
08/16/20
-
47
Heterocyclic compounds and uses thereof
Celgene Car
08/16/20
-
179
Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
Allergan
08/16/20
-
13
Bipyrazole derivatives as JAK inhibitors
Incyte
08/16/20
-
47
2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
Bayer Pharma Aktiegesellschaft
08/16/20
-
33
Oxazole orexin receptor antagonists
Merck Sharp & Dohme
08/16/20
-
57
2,4-disubstituted phenylene-1,5-diamine derivatives and applications thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom
Shanghai Haiyan Pharmaceutical Technology
08/16/20
-
235
Pyrazolopyridine compounds and uses thereof
Incyte
08/16/20
-
22
Pyrrolopyrimidine derivatives as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman)
08/12/20
-
9
Sulfur-containing compounds targeting vesicular acetylcholine transporter
Washington University
08/12/20
-
252
Substituted oxopyridine derivatives
Bayer Pharma Aktiengesellschaft
08/12/20
-
3
Tetrahydroisoquinolines as PRMT5 inhibitors
Ctxt
08/12/20
-
7
Quinoxaline derivatives useful as FGFR kinase modulators
Astex Therapeutics
08/12/20
-
47
Substituted morpholine derivatives having activity against pain
Esteve Pharmaceuticals
08/12/20
-
74
Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
Rodin Therapeutics
08/12/20
-
20
Pyrrolo[2,3-d]pyrimidine compound or salt thereof
Taiho Pharmaceutical
08/12/20
-
99
Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
Board of Regents, The University of Texas System
08/12/20
-
97
Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer
Janssen Pharmaceutica
08/02/20
-
136
Isoxazole compounds as inhibitors of heat shock proteins
The Institute of Cancer Research
08/02/20
-
295
Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
Merck Patent
08/02/20
-
16
Substituted oxopyridine derivatives
Bayer Pharma Aktiengesellschaft
08/02/20
-
27
5-hydroxyalkylbenzimidazoles as mIDH1 inhibitors
Bayer Pharma Aktiengesellschaft
08/02/20
-
111
Cyclopropanamine compound and use thereof
Takeda Pharmaceutical
08/02/20
-
48
Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same
Bayer Pharma Aktiengesellschaft
08/02/20
-
23
Gelatinase inhibitors and use thereof
Iproteos
08/02/20
-
27
Dimeric compounds
Hoffmann-La Roche
07/27/20
-
23
Therapeutic compounds and uses thereof
Kala Pharmaceuticals
07/27/20
-
7
Heteroaryldiazepine derivatives as RSV inhibitors
Enanta Pharmaceuticals
07/27/20
-
40
Tetrahydronaphthalene estrogen receptor modulators and uses thereof
Genentech
07/27/20
-
68
Tetrahydronaphthyl urea derivative
Mochida Pharmaceutical
07/27/20
-
21
PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
Mitobridge
07/27/20
-
15
Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
Boehringer Ingelheim International
07/27/20
-
139
Compounds for inflammation and immune-related uses
Prcl Research
07/27/20
-
66
Tricyclic compounds as inhibitors of mutant IDH enzymes
Merck Sharp & Dohme
07/27/20
-
27
Compounds I
Benevolentai Cambridge
07/27/20
-
57
N2-phenyl-pyrido[3,4-D]pyrimidine-2, 8-diamine derivatives and their use as Mps1 inhibitors
Cancer Research Technology
07/27/20
-
153
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals
07/27/20
-
23
Janus kinase inhibitors and uses thereof
Purdue Research Foundation
07/27/20
-
41
(Hetero)aryl imidazoles/pyrazoles for treatment of neurological disorders
Hoffmann-La Roche
07/27/20
-
49
TGF beta receptor antagonists
Bristol-Myer Squibb
07/27/20
-
96
Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer
Loxo Oncology
07/27/20
-
64
Kv1.3 inhibitors and their medical applications
4Sc
07/27/20
-
9
Composition for suppressing neuraminidase activity comprising geranylated flavonoid derived from Paulownia tomentosa as active ingredient
Industry-Academic Cooperation Foundation Gyeongsang National University
07/27/20
-
2
Tetrahydropyridopyrazine modulators of GPR6
Takeda Pharmaceutical
07/27/20
-
417
6-(5-hydroxy-1H-pyrazol-1-yl)nicotinamide inhibitors of PHD
Takeda Pharmaceutical
07/27/20
-
9
Triazolopyridine inhibitors of myeloperoxidase
Bristol-Myers Squibb
07/27/20
-
23
Compounds as inhibitors of DNA methyltransferases
FundaciÓN Para La InvestigaciÓN MÉDica Aplicada
07/27/20
-
34
Compounds and compositions as toll-like receptor 7 agonists
Novartis
07/27/20
-
111
Substituted 4-phenylpiperidines, their preparation and use
Columbia University
07/27/20
-
7
Compositions and methods for treating neoplasia, inflammatory disease and other disorders
Dana-Farber Cancer Institute
07/27/20
-
13
Amino-triazolopyridine compounds and their use in treating cancer
Astrazeneca
07/27/20
-
330
PRMT5 inhibitors and uses therof
Epizyme
07/20/20
-
72
Kinase inhibitors
Topivert Pharma
07/20/20
-
119
Heterocyclic inhibitors of ATR kinase
Board of Regents, The University of Texas System
07/20/20
-
547
Compounds useful as inhibitors of ATR kinase
Vertex Pharmaceuticals
07/20/20
-
103
Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
Tolero Pharmaceuticals
07/20/20
-
11
Heterocyclic compounds as kinase inhibitors
Translational Drug Development
07/20/20
-
25
Macrocyclic immunomodulators
Chemocentryx
07/20/20
-
23
Morphinan derivative and medical usage thereof
University of Tsukuba
07/13/20
-
91
Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
Lycera
07/13/20
-
419
Tricyclic compounds and compositions as kinase inhibitors
Novartis
07/13/20
-
63
Macrocyclic LRRK2 kinase inhibitors
Oncodesign
07/13/20
-
25
Treatment of inflammatory disorders in non-human mammals
University of California
07/13/20
-
23
Indazole and indole derivatives as inhibitors of retinoic acid related orphan receptor gamma (ROR gamma) for the treatment of immune-related diseases
Orca Pharmaceuticals
07/13/20
-
19
Azetidine derivatives
Vernalis (R&D)
07/13/20
-
237
Carbazole-containing sulfonamides as cryptochrome modulators
Synchronicity
07/13/20
-
323
3-amino-pyridines as GPBAR1 agonists
Hoffmann-La Roche
07/13/20
-
56
Substituted piperazines as selective HDAC1,2 inhibitors
Regenacy Pharmaceuticals
07/13/20
-
35
Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof
Pfizer
07/13/20
-
7
Tricyclic compound and JAK inhibitor
Nissan Chemical
07/13/20
-
35
Compounds as diacylglycerol acyltransferase inhibitors
Glaxosmithkline
07/13/20
-
17
Substituted-6,8-dioxabicyclo[3.2.1]octane-2,3-diol compounds as targeting agents of ASGPR
Pfizer
07/06/20
-
104
Farnesoid X receptor agonists and uses thereof
Metacrine
07/06/20
-
5
Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP)
Bsim Therapeutics
07/06/20
-
490
AMPK-activating heterocyclic compounds and methods for using the same
Rigel Pharmaceuticals
07/06/20
-
55
Potent soluble epdxide hydrolase inhibitors
Eicosis
07/06/20
-
20
Indolin-2-one derivatives
Hoffmann-La Roche
07/06/20
-
628
Substituted 4-azaindoles and their use as GluN2B receptor modulators
Janssen Pharmaceutica
07/06/20
-
142
Pyrrolopyrimidine compounds and uses thereof
Hutchison Medipharma
07/06/20
-
163
Sulfonamide compounds and uses as TNAP inhibitors
Sanford-Burnham Prebys Medical Discovery Institute
07/06/20
-
5
Phenyl-cyanoquinolinone PDE9 inhibitors
Merck Sharp & Dohme
07/06/20
-
5
Oxy-cyanoquinolinone PDE9 inhibitors
Merck, Sharp & Dohme
07/06/20
-
25
Benzazepine dicarboxamide compounds with tertiary amide function
Hoffmann-La Roche
07/06/20
-
47
N-Methylbenzimidazoles as mIDH1 inhibitors
Bayer Pharma Aktiengesellschaft
07/06/20
-
7
Cyclobutyl-imidazolidinone compounds
Eli Lilly
07/06/20
-
40
Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
University of Texas
07/06/20
-
9
Aryl acylsulfonamides as BLT1 antagonists
Merck Sharp & Dohme
07/06/20
-
58
Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors
Axovant Sciences
07/06/20
-
28
Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors
Elanco Tiergesundheit
07/06/20
-
25
Compounds and compositions useful for treating disorders related to NTRK
Blueprint Medicines
07/06/20
-
96
Tricyclic fused thiophene derivatives as JAK inhibitors
Incyte Holdings
07/06/20
-
82
Heterocyclic compounds and methods of their use
Novartis
07/06/20
-
20
Alkylated imino sugars exhibiting glucosidase inhibition and their method of use
TBA
06/29/20
-
6
Substituted quinolinones as PDE9 inhibitors
Merck Sharp & Dohme
06/29/20
-
300
Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6H)-ones
Dart Neuroscience (Cayman)
06/29/20
-
2
Pyridinecarboxamide derivatives, preparation method thereof and pharmaceutical uses thereof
Jiangsu Hengrui Medicine
06/29/20
-
92
N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
Kalvista Pharmaceuticals
06/29/20
-
1
Modulation of N-acylethanolamine-hydrolysing acid amidase (NAAA) for disease treatment
Fondazione Istituto Italiano Di Tecnologia
06/29/20
-
41
Heteroaromatic compounds as Vanin inhibitors
Boehringer Ingleheim International
06/29/20
-
19
D-amino acid oxidase inhibitors and therapeutic uses thereof
SyneuRx International (Taiwan)
06/21/20
-
79
Histone demethylase inhibitors
Celgene Quanticel Research
06/21/20
-
95
4-cyano-benzyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors
Boehringer Ingelheim International
06/21/20
-
14
Substituted 1H-indole-2-carboxamide compounds as indoleamine-2,3-dioxygenase inhibitors
Merck Sharp & Dohme
06/21/20
-
46
Aryl acylsulfonamides as BLT1 antagonists
Merk Sharp & Dohme
06/21/20
-
3
Inhibitors of ACK1/TNK2 tyrosine kinase
H. Lee Moffitt Cancer Center and Research Institute
06/21/20
-
250
4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists
Bristol-Myers Squibb
06/21/20
-
18
Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
Ono Pharmaceutical
06/21/20
-
11
TYK2 inhibitors, uses, and methods for production thereof
Nimbus Lakshmi
06/21/20
-
8
Pyrimidinones as factor XIa inhibitors
Bristol-Myers Squibb
06/21/20
-
23
Fused pyrazole derivatives, preparation method thereof, and use thereof in treatment of cancers, inflammation and immune diseases
Beijing Innocare Pharma Tech
06/21/20
-
25
Treatment of neurodegenerative diseases through inhibition of HSP90
Sloan-Kettering Institute For Cancer Research
06/21/20
-
26
Salts and processes of preparing a PI3K inhibitor
Incyte
06/21/20
-
341
TGFβ receptor antagonist
Bristol-Myers Squibb
06/21/20
-
935
Pyrrolo[1,2-b]pyridazine derivatives
Gilead Sciences
06/21/20
-
64
N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2
Novartis
06/21/20
-
174
Glycosidase inhibitors
Asceneuron
06/21/20
-
201
Metalloenzyme inhibitor compounds
Selenity Therapeutics (Bermuda)
06/21/20
-
10
Acceleration of diabetic wound healing
University of Notre Dame Du Lac
06/21/20
-
286
Substituted pyrrolidines as G-protein coupled receptor 43 agonists
Epics Therapeutics
06/21/20
-
66
Triazolyl pyrimidinone compounds as PDE2 inhibitors
Merck Sharp & Dohme
06/21/20
-
201
Kinase inhibitors and method of treating cancer
University Health Network
06/21/20
-
16
Bruton's tyrosine kinase inhibitors
Zibo Biopolar Changsheng Pharmaceutical
06/21/20
-
5
Xanthine derivative
Jiangsu Tasly Diyi Pharmaceutical
06/21/20
-
13
Heterocycles useful as IDO and TDO inhibitors
Hangzhou Innogate Pharma
06/21/20
-
263
Somatostatin modulators and uses thereof
Crinetics Pharmaceuticals
06/12/20
-
11
2-oxo-1,2-dihydropyridine-3-carboxamide compounds and their use as inhibitors of PDK1
International Society For Drug Development
06/12/20
-
212
Factor IXa inhibitors
Merck Sharp & Dohme
06/12/20
-
233
Biaryl kinase inhibitors
Bristol-Myers Squibb
06/12/20
-
10
Compounds and uses thereof
Kala Pharmaceuticals
06/12/20
-
158
Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
Array Biopharma
06/12/20
-
268
1-cyano-pyrrolidine compounds as USP30 inhibitors
Missions Therapeutics
06/09/20
-
35
Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
06/09/20
-
267
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
Boehringer Ingelheim International
06/09/20
-
7
Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
Gilead Sciences
06/08/20
-
1
Inhibitor of the mutated isocitrate dehydrogenase IDH1 R132H
Bayer Pharma Aktiengesellschaft
06/08/20
-
595
GLS1 inhibitors for treating disease
The University of Texas System
06/08/20
-
13
Pyrazolopyrimidone or Pyrrolotriazone derivatives, method of preparing same, and pharmaceutical applications thereof
Shanghai Hengrui Pharmaceutical
06/08/20
-
14
Substituted pyridazines for the treatment of pain
Inhibitaxin
06/01/20
-
15
1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
Astrazeneca
06/01/20
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
06/01/20
-
11
Fused imidazole compounds
Ono Pharmaceutical
06/01/20
-
276
Substituted pyrrolidines as G-protein coupled receptor 43 agonists
Ogeda
06/01/20
-
42
Benzimidazole derivatives as bromodomain inhibitors
Gilead Sciences
06/01/20
-
18
Benzoxazinone amides as mineralocorticoid receptor modulators
Astrazeneca
06/01/20
-
68
Piperidine isoxazole and isothiazole orexin receptor antagonists
Merck Sharp & Dohme
06/01/20
-
67
BMP inhibitors and methods of use thereof
The Brigham and Women'S Hospital
06/01/20
-
38
4-piperidinyl compounds for use as tankyrase inhibitors
Novartis
06/01/20
-
123
Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof
Beijing Tide Pharmaceutical
05/31/20
-
11
FXR (NR1H4) modulating compounds
Gilead Sciences
05/31/20
-
27
C5-C6-carbocyclic fused iminothiadiazine dioxides as BACE inhibitors, compositions, and their use
TBA
05/31/20
-
280
Pyrazolopyrimidine inhibitors of IRAK4 activity
Merck Sharp & Dohme
05/31/20
-
162
Pyrrolotriazine inhibitors of IRAK4 activity
Merck Sharp & Dohme
05/31/20
-
107
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals
05/31/20
-
361
Bicyclic-fused heteroaryl or aryl compounds
Pfizer
05/31/20
-
52
Heterocyclic inhibitors of monocarboxylate transporter
The Scripps Research Institute
05/31/20
-
70
Heterocyclic compounds as inhibitors of platelet aggregation
Universite De Montreal
05/31/20
-
61
Neuroactive steroids, compositions, and uses thereof
Sage Therapeutics
05/31/20
-
9
Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases
Hanmi Pharm.
05/31/20
-
41
Cyclic compounds useful as modulators of TNF α
Bristol-Myers Squibb
05/31/20
-
59
Chromane, isochromane and dihydroisobenzofuran derivatives as mGluR2—negative allosteric modulators, compositions, and their use
TBA
05/31/20
-
94
Non-aromatic heterocyclic derivative having MGAT2 inhibitory activity
Shionogi
05/31/20
-
23
Sulfonyl piperidine derivatives and their use for treating prokineticin mediated gastrointestinal disorders
Takeda Pharmaceutical
05/31/20
-
86
Inhibitors of hepatitis C virus
Gilead Pharmasset
05/31/20
-
53
Phenyl-(aza)cycloalkyl carboxylic acid GPR120 modulators
Bristol=Myers Squibb
05/31/20
-
12
Benzimidazole derivatives, preparation method therefor, and applications thereof
TBA
05/31/20
-
510
Inhibitors of beta-secretase
Vitae Pharmaceuticals
05/31/20
-
35
Biaryltriazole inhibitors of macrophage migration inhibitory factor
Yale University
05/31/20
-
108
Pyrazole, triazole and tetrazole orexin receptor antagonists
Merck Sharp & Dohme
05/26/20
-
147
Pharmaceutical compounds
Cascadian Therapeutics
05/26/20
-
21
Cyclohexyl pyridine derivative
Kissei Pharmaceutical
05/26/20
-
3
Preparation method for aromatic heterocyclic compound used as selective JAK3 and/or JAK1 kinase inhibitor and application of aromatic heterocyclic compound
Shenzhen Chipscreen Biosciences
05/26/20
-
149
1,2-substituted cyclopentanes as orexin receptor antagonists
Takeda Pharmaceutical
05/26/20
-
13
Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
Allergan
05/26/20
-
120
Ethyldiamine orexin receptor antagonists
Merck Sharp & Dohme
05/26/20
-
99
Compounds and compositions as inhibitors of MEK
Novartis
05/26/20
-
60
Method of treatment using substituted imidazo[1,2b]pyridazine compounds
Array Biopharma
05/26/20
-
111
Ethynyl derivatives
Hoffmann-La Roche
05/26/20
-
4
Histone deacetylase inhibitors and methods for use thereof
Reaction Biology
05/26/20
-
9
C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof
Youngene Therapeutics
05/26/20
-
48
Combination treatment comprising administration of 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahydropyridines
H. Lundbeck
05/18/20
-
40
Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity
University of North Carolina At Chapel Hill
05/18/20
-
40
Inhibitors of RPN11
California Institute of Technology
05/18/20
-
213
Quinazolinone and isoquinolinone derivative
Chugai Seiyaku Kabushiki Kaisha
05/18/20
-
76
Pyrrolidinone derivatives as MetAP-2 inhibitors
Merck Patent
05/18/20
-
80
Pyridine derivatives
Astellas Pharma
05/18/20
-
135
Carboxamide derivatives and use thereof
Purdue Pharma
05/18/20
-
78
2,3-dihydrobenzofuran-5YL compounds as DYRK kinase inhibitors
4Sc
05/18/20
-
200
Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators
Beigene
05/18/20
-
105
Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Array Biopharma
05/18/20
-
24
Bicyclic fused pyrimidine compounds as TAM inhibitors
Incyte
05/18/20
-
135
Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors
Ctxt
05/18/20
-
111
P2X7 Modulators
Janssen Pharmaceutica
05/11/20
-
217
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
05/11/20
-
143
Pyrazole compounds and methods of making and using same
Abide Therapeutics
05/11/20
-
64
6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
Pfizer
05/11/20
-
34
Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof
Enanta Pharmaceuticals
05/11/20
-
24
Prolyl hydroxylase inhibitors and methods of use
Akebia Therapeutics
05/11/20
-
135
Substituted pyrrolizine compounds and uses thereof
Gilead Sciences
05/11/20
-
69
Substituted pyrrolidines as mGluR5 antagonists
Hua Medicine (Shanghai)
05/11/20
-
61
Substituted [1,2,4]triazolo[4,3-a]pyrazines as BRD4 inhibitors
Boehringer Ingelheim International
05/11/20
-
118
Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
Celgene
05/11/20
-
43
(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
Oryzon Genomics
05/11/20
-
22
Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
Bristol-Myers Squibb
05/11/20
-
3
Urea derivatives and uses thereof
Kala Pharmaceuticals
05/11/20
-
387
Piperidin-4-yl azetidine derivatives as JAK1 inhibitors
Incyte Holdings
05/11/20
-
8
Combination Alzheimer therapy using anti-N3pGlu Abeta antibodies + a BACE inhibitor
Eli Lilly
05/11/20
-
21
Pyrazines as modulators of GPR6
Takeda Pharmaceutical
05/11/20
-
14
Triazine carboxamides as sodium channel blockers
Purdue Pharma
05/11/20
-
150
Pyridone derivative, pharmaceutical containing the same and methods of use thereof
Kaken Pharmaceutical
05/11/20
-
27
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
Dana-Farber Cancer Institute
05/11/20
-
13
Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
Effector Therapeutics
05/11/20
-
142
Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
Incyte
05/11/20
-
46
N-benzoate group substituted benzopyrroline-2-one derivative and use thereof
Beijing Hanmi Pharmaceutical
05/10/20
-
21
Compounds and methods for inhibiting Cif virulence factor
Dartmouth College
05/10/20
-
13
Preparation and use of 7a-heterocycle substituted-6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists
TBA
05/10/20
-
61
Inhibitors of ADAMTS4 or ADAMTS5 for use in preventing or treating cardiac remodeling and chronic heart failure
Universitetet I Oslo
05/10/20
-
196
Indole derivatives and their use in neurodegenerative diseases
Merck Patent
05/10/20
-
24
Imidazol- or 1,2,4-triazol-derivatives and their use
Universite De Lille 2 Droit Et Sante
05/10/20
-
227
Quinazoline and quinoline compounds and uses thereof
Millennium Pharmaceuticals
05/10/20
-
6
Pyrazolylaminobenzimidazole derivatives as JAK inhibitors
Eli Lilly
05/10/20
-
13
Substituted piperidinyl tetrahydroquinolines
Bayer Pharma Aktiengesellschaft
05/10/20
-
114
Triazoles as NR2B receptor inhibitors
Janssen Pharmaceuticals
05/10/20
-
638
Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors
Array Biopharma
05/10/20
-
19
Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof
Beijing Tide Pharmaceutical
05/10/20
-
365
Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders
The Scripps Research Institute
05/10/20
-
11
10-substituted morphinan hydantoins
Purdue Pharma
05/07/20
-
10
2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof
Georgetown University
05/05/20
-
32
1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as P38 MAP knase inhibitors
Respivert
05/05/20
-
43
Trk-inhibiting compound
Ono Pharmaceutical
05/05/20
-
16
H3 antagonists containing phenoxypiperidine core structure
Richter Gedeon
05/05/20
-
129
Cyclopropylamines as LSD1 inhibitors
Incyte
05/05/20
-
149
Heteroarylamide inhibitors of TBK1
Takeda Pharmaceutical
05/05/20
-
8
Heterocyclic modulators of lipid synthesis for use against cancer and viral infections
3-V Biosciences
05/05/20
-
138
Compositions useful for treating disorders related to kit
Blueprint Medicines
05/05/20
-
33
Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
Principia Biopharma
05/05/20
-
54
Substituted [1,2,4]triazolo[1,5-a]pyrazines as phosphodiesterase inhibitors
Sunovion Pharmaceuticals
05/05/20
-
47
N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
Ogeda
04/30/20
-
13
7-beta-alkyl analogs of orvinols
Purdue Pharma
04/30/20
-
5
Primary amines and derivitves thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
04/25/20
-
8
Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes
Jenrin Discovery
04/25/20
-
24
5,5-bicyclic oxazole orexin receptor antagonists
Merck Sharp & Dohme
04/25/20
-
31
Pharmaceutical composition comprising pyridone derivatives
Sk Biopharmaceuticals
04/25/20
-
239
Substituted 2,4-diaminopyrimidines as kinase inhibitors
Celgene Car
04/25/20
-
41
Pharmaceutical composition for treating FLT3 mutation-positive cancer, mutant FLT3 inhibitor and uses thereof
Fujifilm
04/25/20
-
33
Inhibitors of lysine gingipain
Cortexyme
04/25/20
-
73
Trifluoromethylpropanamide derivatives
Hoffmann-La Roche
04/18/20
-
73
IRE-1α inhibitors
Fosun Orinove Pharmatech
04/18/20
-
296
Serotonin receptor modulators
Janssen Pharmaceutica
04/18/20
-
74
Substituted benzo[d][1,2,3]triazines as p70S6K inhibitors
Merck Patent
04/18/20
-
124
GDF-8 inhibitors
Rigel Pharmaceuticals
04/18/20
-
116
Triazoles as NR2B receptor inhibitors
Janssen Pharmaceuticals
04/18/20
-
29
3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors
Janssen Pharmaceutica
04/18/20
-
10
Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
Newlink Genetics
04/18/20
-
146
Pyrrolotriazine compounds as tam inhibitors
Incyte
04/18/20
-
673
Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
Epizyme
04/15/20
-
34
Pyridinyl and fused pyridinyl triazolone derivatives
Takeda Pharmaceutical
04/15/20
-
16
Therapeutic compounds and compositions, and methods of use thereof
Genentech
04/15/20
-
18
Apoptosis signal-regulating kinase inhibitors
Gilead Sciences
04/15/20
-
14
Proton pump inhibitors
Takeda Pharmaceutical
04/15/20
-
3
Fucosidase inhibitors
Horizon Orphan
04/15/20
-
238
Therapeutic compounds and uses thereof
Genentech
04/15/20
-
163
Heterocyclic compounds as inhibitors of Vanin-1 enzyme
Pfizer
04/15/20
-
74
Muscarinic M1 receptor positive allosteric modulators
Suven Life Sciences
04/15/20
-
10
Heterocyclic compounds and methods for their use
Novartis
04/15/20
-
40
1H-pyrrol-3-amines
Bayer Pharma Aktiengesellschaft
04/15/20
-
22
Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs
Bayer Pharma Aktiengesellschaft
04/15/20
-
23
1-sulfonyl piperidine derivatives as modulators of prokineticin receptors
Takeda Pharmaceutical
04/15/20
-
80
Aromatic heterocyclic compound
Mitsubishi Tanabe Pharma
04/15/20
-
310
Therapeutic inhibitory compounds
Lifesci Pharmaceuticals
04/15/20
-
267
Heterocyclic compounds as immunomodulators
Incyte
04/15/20
-
43
Piperidine oxadiazole and thiadiazole orexin receptor antagonists
Merck Sharp & Dohme
04/15/20
-
15
Inhibitors of cyclin-dependent kinase 7 (CDK7)
Syros Pharmaceuticals
04/15/20
-
60
Tricyclic heterocyclic compounds useful as inhibitors of TNF
Bristol-Myers Squibb
04/15/20
-
18
Preparation and use of kinase inhibitor
Changzhou Longthera Pharmaceuticals
04/15/20
-
121
Pyridine derivatives
Hoffmann-La Roche
04/15/20
-
170
Compounds and compositions for inhibiting the activity of SHP2
Novartis
04/15/20
-
28
Thienopyranones as kinase and epigenetic inhibitors
Signal Rx Pharmaceuticals
04/15/20
-
3
Inhibitors of PTP4A3 for the treatment of cancer
University of Virginia Patent Foundation
04/15/20
-
167
Oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
Boehringer Ingelheim International
04/15/20
-
18
Methods of use of cyclopamine analogs
Infinity Pharmaceuticals
04/15/20
-
17
β- and γ-diketones and γ-hydroxyketones as Wnt/β-catenin signaling pathway activators
Samumed
04/15/20
-
36
Aromatic heterocyclic derivatives and pharmaceutical applications thereof
Sunshine Lake Pharma
04/10/20
-
3
Benzomorphan analogs and use thereof
Purdue Pharma
04/10/20
-
10
Benzimidazole derivatives and use thereof
Purdue Pharma
04/10/20
-
4
Dual inhibitor compounds for use in the treatment of neurodegenerative disorders and alzheimer''s disease
Fondazione Istituto Itaiano Di Tecnologia
04/10/20
-
2
Arylpiperazine derivatives and methods of utilizing same
Reviva Pharmaceuticals
04/10/20
-
44
Factor XIa inhibitors
Merck Sharp & Dohme
04/10/20
-
31
2-pyridyloxy-3-ester-4-ether orexin receptor antagonists
Merck Sharp & Dohme
04/10/20
-
63
Heteroaromatic compounds as BTK inhibitors
Boehringer Ingelheim International
04/10/20
-
11
Compounds for the inhibition of cyclophilins and uses thereof
Merck Patent
04/10/20
-
80
Pyrimidinones as PI3K inhibitors
Incyte Holdings
04/10/20
-
10
Pyrrolopyrimidine derivatives as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman)
04/06/20
-
9
Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
Wisconsin Alumni Research Foundation
04/06/20
-
122
Compounds useful as CCR9 modulators
Norgine
04/06/20
-
8
P2X4 receptor antagonist
Nippon Chemiphar
04/06/20
-
50
3-(4-(benzyloxy)phenyl)hex-4-ynoic acid derivative, method of preparing same and pharmaceutical composition for preventing and treating metabolic disease including same as effective ingredient
Hyundai Pharm
04/06/20
-
53
Factor IXa inhibitors
Merck Sharp & Dohme
04/06/20
-
190
Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof
Sanford-Burnham Medical Research Institute
04/06/20
-
6
N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders
Ogeda
04/06/20
-
130
Urea and amide derivatives of aminoalkylpiperazines and use thereof
Southern Research Institute
04/06/20
-
166
Inhibitors of IRAK4 activity
Merck Sharp & Dohme
04/06/20
-
12
Use of small molecule inhibitors targeting EYA tyrosine phosphatase
Cincinnati Childrens Hospital Medical Center
03/30/20
-
45
Pyrrolopyrimidine compounds used as TLR7 agonist
Chia Tai Tianqing Pharmaceutical Group
03/30/20
-
15
Sulfonamide compounds for inhibition of metastatic tumor growth
Welichem Biotech
03/30/20
-
220
N-arylmethyl sulfonamide negative modulators of NR2A
Luc Therapeutics
03/30/20
-
18
Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase
University of Washington Through Its Center For Commercialization
03/30/20
-
13
Radiolabeled compounds
Takeda Pharmaceutical
03/30/20
-
117
N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof
Northeastern University
03/30/20
-
26
Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
Genentech
03/30/20
-
43
Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators
Laboratorios Del Dr. Esteve
03/30/20
-
40
Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof
Taiho Pharmaceutical
03/30/20
-
1
Morphinan derivative
University of Tsukuba
03/30/20
-
139
Therapeutic inhibitory compounds
Lifesci Pharmaceuticals
03/26/20
-
33
Piperazine derivative
Astellas Pharma
03/26/20
-
15
Kinase inhibitors
Topivert Pharma
03/26/20
-
31
Imidazole derivative having JNK inhibitory activity and use thereof
Samjin Pharmaceutical
03/26/20
-
62
Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
Guangzhou Innocare Pharma Tech
03/26/20
-
63
Heteroaromatic derivatives and their use as pharmaceuticals
Mutabilis
03/26/20
-
180
Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors
Bristol-Myers Squibb
03/26/20
-
365
Inhibitors of ERK and methods of use
Kura Oncology
03/26/20
-
25
Compositions and methods of modulating 15-PGDH activity
University of Kentucky Research Foundation
03/26/20
-
61
Histone deacetylase inhibitors
Biomarin Pharmaceutical
03/26/20
-
33
Phosphonate compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
03/26/20
-
53
Thiazolidinones as cellular anandamide uptake inhibitors and their use in the treatment of psychiatric or neurological disorders and inflammation, in particular neuroinflammation
Universitat Bern
03/25/20
-
61
Cyclopropylamines as LSD1 inhibitors
Incyte
03/25/20
-
14
CGRP receptor antagonists
Heptares Therapeutics
03/25/20
-
18
Tyrosine kinase inhibitor and uses thereof
Xuanzhu Pharma
03/25/20
-
43
Trk-inhibiting compound
Ono Pharmaceutical
03/25/20
-
118
Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
Zhejiang Dtrm Biopharma
03/25/20
-
53
Tetrahydropyridopyrimidine compound or salt thereof
Taiho Pharmaceutical
03/25/20
-
40
Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy
Sanford Burnham Prebys Medical Discovery Institute
03/25/20
-
87
Therapeutic compounds and uses thereof
Genentech
03/25/20
-
41
Imidazole derivatives as formyl peptide receptor modulators
Allergan
03/25/20
-
306
Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ]
Phenex Pharmaceuticals
03/25/20
-
54
1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions therefor for inhibiting the activity of SHP2
Novartis
03/25/20
-
153
Compounds and methods for kinase modulation, and indications therefor
Plexxikon
03/25/20
-
21
Selective histone deactylase 6 inhibitors
H. Lee Moffitt Cancer Center and Research Institute
03/23/20
-
4
Compounds for the treatment of cancer and inflammatory diseases
TBA
03/23/20
-
103
5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum
University of Washington Through Its Center For Commercialization
03/23/20
-
139
Benzimidazol-2-amines as mIDH1 inhibitors
Bayer Pharma Aktiengesellschaft
03/23/20
-
59
6-amino-5,6,7,8-tetrahydronaphthalen-2-yl or 3-aminochroman-7-yl derivatives
Hoffmann-La Roche
03/23/20
-
184
Bromodomain inhibitors
Abbvie
03/23/20
-
423
Geminally substituted cyanoethylpyrazolo pyridones as Janus kinase inhibitors
Merck Sharp & Dohme
03/23/20
-
75
N-(2-cyano heterocyclyl) pyrazolo pyridones as janus kinase inhibitors
Merck Sharp & Dohme
03/23/20
-
88
1H-pyrrolo[2,3,c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
Incyte
03/23/20
-
44
CDK inhibitors
Gi Therapeutics
03/23/20
-
61
Substituted nicotinamide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
Beijing Innocare Pharma Tech
03/18/20
-
28
Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors
Iteos Therapeutics
03/16/20
-
25
Inhibitors of beta-secretase
Vitae Pharmaceuticals
03/16/20
-
35
Mammalian and bacterial nitric oxide synthase inhibitors
Northwestern University
03/16/20
-
13
Heterocyclic vinyl autotaxin inhibitor compounds
Pharmakea
03/16/20
-
346
Benzimidazol-2-amines as MIDH1 inhibitors
Bayer Pharma Aktiengesellschaft
03/16/20
-
63
Styryl quinazoline derivatives as pharmaceutically active agents
Vichem Chemie Kutató
03/16/20
-
23
Tertiary amines for use in the treatment of cardiac disorders
Universitetet I Oslo
03/16/20
-
3
Selective matrix metalloproteinase inhibitors
University of Notre Dame Du Lac
03/16/20
-
236
Isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed
03/16/20
-
147
8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives
Idorsia Pharmaceuticals
03/16/20
-
219
Dihydropyridone P1 as factor XIa inhibitors
Bristol-Myers Squibb
03/16/20
-
116
Aminopyridazinone compounds as protein kinase inhibitors
Jiangsu Hengrui Medicine
03/16/20
-
305
Indazolecarboxamides, processes for their preparation, pharmaceutical preparations comprising them and their use for producing medicaments
Bayer Pharma Aktiengesellschaft
03/16/20
-
17
Inhibitors of IRAK4 activity
Merck Sharp & Dohme
03/12/20
-
43
(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
Oryzon Genomics
03/12/20
-
5
Cannabinoid receptor modulators
Arena Pharmaceuticals
03/12/20
-
167
Inhibiting neurotransmitter reuptake
Mayo Foundation
03/12/20
-
61
Substituted amino triazoles useful as human chitinase inhibitors
Oncoarendi Therapeutics
03/12/20
-
8
Factor XIa inhibitors
Merck Sharp & Dohme
03/12/20
-
205
Imidazotriazines and imidazopyrimidines as kinase inhibitors
Incyte
03/12/20
-
109
Bicyclic azaheterocyclobenzylamines as PI3K inhibitors
Incyte Holdings
03/12/20
-
138
Heterocyclic compounds as LSD1 inhibitors
Incyte
03/12/20
-
103
Oxazole compound and pharmaceutical composition
Otsuka Pharmaceutical
03/12/20
-
2
Compounds as rearranged during transfection (RET) inhibitors
Glaxosmithkline
03/10/20
-
47
Oxazoline and isoxazoline derivatives as CRAC modulators
Lupin
03/10/20
-
36
TGF beta receptor antagonists
Bristol-Myers Squibb
03/10/20
-
273
Inhibitors of the kynurenine pathway
Curadev Pharma
03/10/20
-
80
Positive allosteric modulators of human melanocortin-4 receptor
Vanderbilt University
03/10/20
-
27
Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators
Suven Life Sciences
03/10/20
-
150
4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity
Virostatics
03/10/20
-
57
1, 3, 4-thiadiazole compounds and their use in treating cancer
Astrazeneca
03/10/20
-
129
Quinolone derivatives as fibroblast growth factor receptor inhibitors
Principia Biopharma
03/10/20
-
15
Small molecule inhibitors of the JAK family of kinases
Janssen Pharmaceutica
03/10/20
-
21
Compounds
University Court of The University of Edinburgh
03/10/20
-
398
Heteroaryl substituted aminopyridine compounds
Bristol-Myers Squibb
03/10/20
-
11
3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman)
03/10/20
-
135
Substituted boronic acids and boronate esters as immunoproteasome inhibitors
Merck Patent
03/10/20
-
3
Phenyl c-glucoside derivative containing deoxyglucose structure, preparation method and use thereof
Tianjin Institute of Pharmaceutical Research
03/10/20
-
116
Cyclopropanecarboxylic acid GPR120 modulators
Bristol-Myers Squibb
03/02/20
-
33
1,3,4-thiadiazole compounds and their use in treating cancer
Astrazeneca
03/02/20
-
667
Heterocyclic inhibitors of glutaminase
Calithera Biosciences
03/02/20
-
34
Hydrazine compound as blood coagulation factor Xa inhibitor
North China Pharmaceutical
03/02/20
-
81
6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists
Merck Sharp & Dohme
03/02/20
-
9
Therapeutic pyrazolyl thienopyridines
Fbm Therapeutics
03/02/20
-
13
Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
Karus Therapeutics
03/02/20
-
25
Substituted heteroaryl compounds and methods of use
Calitor Sciences
03/02/20
-
34
C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof
Merck Patent
03/02/20
-
22
Naphthyridine compounds, medical combinations and use thereof
Nanjing Natinefy Pharmatech
03/02/20
-
66
Pyridazinone compounds and their use as DAAO inhibitors
Takeda Pharmaceutical
02/29/20
-
260
Compounds
Takeda Pharmaceutical
02/29/20
-
66
3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
Samumed
02/27/20
-
70
3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof
Samumed
02/27/20
-
30
Compounds for treatment of fibrosis diseases
Curegenix
02/27/20
-
197
Pyrimidinone amide compounds as PDE2 inhibitors
Merck Sharp & Dohme
02/27/20
-
35
Morphan and morphinan analogues, and methods of use
Alkermes Pharma Ireland
02/27/20
-
51
Substituted pyrimidines containing acidic groups as TLR7 modulators
Apros Therapeutics
02/27/20
-
37
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
Astrazeneca
02/27/20
-
304
Isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed
02/27/20
-
4
Imidazolyl kinase inhibitors and uses thereof
Dana-Farber Cancer Institute
02/27/20
-
3
Amino pyrimidine SSAO inhibitors
Eli Lilly
02/27/20
-
126
Substituted indazole compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
02/27/20
-
14
Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies
Galderma Research & Development
02/27/20
-
39
Inhibitors of human 12/15-lipoxygenase
The Children'S Hospital
02/27/20
-
129
CXCR7 antagonists
Chemocentryx
02/27/20
-
22
Bicyclic heterocyclic compounds as PDE2 inhibitors
Merck Sharp & Dohme
02/27/20
-
303
TGF-β inhibitors
Rigel Pharmaceuticals
02/27/20
-
64
Heterocyclic derivatives as modulators of kinase activity
Merck Patent
02/27/20
-
698
Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
Achillion Pharmaceuticals
02/27/20
-
261
Substituted piperidine compound and use thereof
Takeda Pharmaceutical
02/27/20
-
125
2-(1H-indazol-3-yl)-3H-imidazo[4,5-B]pyridine and therapeutic uses thereof
Samumed
02/24/20
-
39
Purine derivatives for the treatment of viral infections
Janssen Ireland
02/24/20
-
98
Heterocyclic inhibitors of PTPN11
The University of Texas System
02/24/20
-
69
Heterocyclic kinase inhibitors
Abbvie
02/24/20
-
7
Syk inhibitors
Gilead Sciences
02/24/20
-
166
Compounds, compositions, and methods
Denali Therapeutics
02/24/20
-
5
Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
The Council of Scientific & Industrial Research
02/24/20
-
14
Benzimidazole derivatives as RLK and ITK inhibitors
Principia Biopharma
02/24/20
-
2
FXR (NR1H4) modulating compounds
Gilead Sciences
02/24/20
-
112
Use of pyrazolopyrimidine derivatives for the treatment of PI3K-delta related disorders
Incyte
02/24/20
-
101
Inhibitors of IRAK4 activity
Merck Sharp & Dohme
02/24/20
-
36
Identification of stabilizers of multimeric proteins
The Board of Trustees of The Leland Stanford Junior University
02/21/20
-
11
Tricyclic analogues, preparation method and uses thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
02/21/20
-
15
Combination therapy with glutaminase inhibitors
Calithera Biosciences
02/21/20
-
172
Serine/threonine kinase inhibitors
Genentech
02/21/20
-
213
Pyridazine derivatives as RORc modulators
Genentech
02/21/20
-
219
Therapeutic compounds and uses thereof
Genentech
02/21/20
-
183
Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors
Forma Tm2
02/21/20
-
26
Phthalazinone compounds and methods for the treatment of cystic fibrosis
Flatley Discovery Lab
02/21/20
-
16
Pyrazolopyridone compounds and uses thereof
Incyte
02/21/20
-
40
Pyridopyrimidinones and methods of use thereof
Genentech
02/21/20
-
2
Salt of fused pyrimidine compound and crystal thereof
Taiho Pharmaceutical
02/21/20
-
475
Inhibitors of glucocorticoid receptor translocation
Sanford Burnham Prebys Medical Discovery Institute
02/20/20
-
14
Piperidinone carboxamide azaindane CGRP receptor antagonists
Merck Sharp & Dohme
02/20/20
-
180
NHE3-binding compounds and methods for inhibiting phosphate transport
Ardelyx
02/20/20
-
8
Pteridines as FGFR inhibitors
Astex Therapeutics
02/20/20
-
83
NRF2 regulators
Glaxosmithkline
02/20/20
-
5
Metabolites of N-{4-([6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Exelixis
02/20/20
-
39
Subunit selective NMDA receptor potentiators for the treatment of neurological conditions
Emory University
02/20/20
-
163
Histone demethylase inhibitors
Celgene Quantscel Research
02/20/20
-
389
Substituted 6,5-fused bicyclic heteroaryl compounds
Epizyme
02/20/20
-
21
Pyrazines as modulators of GPR6
Takeda Pharmaceutical
02/20/20
-
15
Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof
Piramal Enterprises
02/20/20
-
26
Compounds that are S1P modulating agents and/or ATX modulating agents
Biogen Ma
02/20/20
-
173
Substituted hexahydropyrrolo[3,4-b]pyrroles and hexahydrocyclopenta[c]pyrroles as dopamine receptor modulators
Indivior
02/20/20
-
804
Tricyclic sulfones as RORγ modulators
Bristol-Myers Squibb
02/20/20
-
23
Benzazepine sulfonamide compounds
Hoffmann-La Roche
02/16/20
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
02/16/20
-
3
Compounds I
Proximagen
02/16/20
-
52
Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
Incyte
02/16/20
-
168
Imidazopyrrolidine derivatives and their use in the treatment of disease
Novartis
02/16/20
-
15
2,4-disubstituted 7H-pyrrolo[2,3-d]pyrimidine derivative, preparation method and medicinal use thereof
Shanghai Haiyan Pharmaceutical Technology
02/16/20
-
130
Aldosterone synthase inhibitors
Boehringer Ingelheim International
02/16/20
-
169
Urea derivatives useful as kinase inhibitors
Respivert
02/16/20
-
451
5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis
Galapagos
02/10/20
-
401
Phthalazinones and isoquinolinones as rock inhibitors
Bristol-Myers Squibb
02/10/20
-
34
Inhibitors of bruton's tyrosine kinase
Centaurus Biopharma
02/10/20
-
13
Bipyrazole derivatives as JAK inhibitors
Incyte
02/10/20
-
33
Inhibition of MCL-1 and/or BFL-1/A1
Dana-Farber Cancer Institute
02/10/20
-
53
Tetracyclic autotaxin inhibitors
Pharmakea
02/10/20
-
53
Inhibitors of IRAK4 activity
Merck Sharp & Dohme
02/10/20
-
13
Branched 3-phenylpropionic acid derivatives and their use
Bayer Intellectual Property
02/07/20
-
4
Psychotropic agents and uses thereof
Lb Pharmaceuticals
02/07/20
-
258
Tank-binding kinase inhibitor compounds
Gilead Sciences
02/07/20
-
26
Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof
Guangzhou Maxinovel Pharmaceuticals
02/07/20
-
109
Bicyclic azaheterocyclobenzylamines as PI3K inhibitors
Incyte
02/07/20
-
11
2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
Gilead Sciences
02/07/20
-
106
Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
Incyte
02/07/20
-
71
6-membered cyclic amines or lactames substituted with urea and phenyl
GrÜNenthal
02/07/20
-
168
Carbazole derivatives
Bristol-Myers Squibb
02/07/20
-
70
Thioacetate compounds, compositions and methods of use
Ardea Biosciences
02/07/20
-
118
Carboxy substituted (hetero) aromatic ring derivatives and preparation method and uses thereof
Sunshine Lake Pharma
02/07/20
-
134
Bruton's tyrosine kinase inhibitors
Pfizer
02/07/20
-
144
Therapeutic inhibitory compounds
Lifesci Pharmaceuticals
02/07/20
-
932
Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer
Epizyme
02/07/20
-
22
2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof
Merck Patent
02/07/20
-
29
Inhibitor of FLT3 kinase and use thereof
Hefei Institutes of Physical Science, Chinese Academy of Sciences
02/07/20
-
27
3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof
St. Chuan University
02/07/20
-
18
EZH2 inhibitors
Mirati Therapeutics
02/07/20
-
187
Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases
Bayer Intellectual Property
02/07/20
-
343
ULK1 inhibitors and methods using same
Salk Institute
02/07/20
-
26
Bacterial topoisomerase I inhibitors with antibacterial activity
The Florida International University Board of Trustees
02/07/20
-
64
Bile acid analogs as FXR/TGR5 agonists and methods of use thereof
Enanta Pharmaceuticals
02/07/20
-
14
Substituted oxopyridine derivatives and use thereof as factor XIa/plasma
Bayer Pharma Aktiengesellschaft
02/04/20
-
2
Pyridone derivatives as rearranged during transfection (RET) kinase inhibitors
Glaxosmithkline
02/04/20
-
155
Compounds and their use as BACE inhibitors
Astrazeneca
02/04/20
-
111
Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
Incyte
02/04/20
-
218
Indole carboxamide compounds
Bristol-Myers Squibb
02/04/20
-
168
Heterocyclic compounds useful as pim kinase inhibitors
Incyte
02/04/20
-
30
Methyl oxazole orexin receptor antagonists
Merck Sharp & Dohme
02/04/20
-
109
Cyclopropanamine compound and use thereof
Takeda Pharmaceutical
02/04/20
-
35
N-(hetero)aryl-substituted heteroyclic derivatives useful for the treatment of diseases or conditions related to the central nervous system
Chronos Therapeutics
02/04/20
-
104
Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
Pfizer
02/04/20
-
79
Pyrazolo[3,4-d]pyrimidine compound or salt thereof
Taiho Pharmaceutical
02/04/20
-
30
Naphthylamide compound, preparation method and use thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
01/30/20
-
11
Use of benzimidazole-proline derivatives
Idorsia Pharmaceuticals
01/30/20
-
156
Pyrazolo[1,5-a]pyridine derivatives and methods of their use
Ignyta
01/30/20
-
78
Heteroaryl Syk inhibitors
Boehringer Ingelheim International
01/30/20
-
113
TrKA kinase inhibitors, compositions and methods thereof
Merck Sharp & Dohme
01/30/20
-
404
Tricyclic pyrido-carboxamide derivatives as rock inhibitors
Bristol-Myers Squibb
01/30/20
-
198
Kinase inhibitors and method of treating cancer
University Health Network
01/27/20
-
65
Aryl ethers and uses thereof
Peloton Therapeutics
01/27/20
-
154
Histone demethylase inhibitors
Celgene Quanticel Research
01/27/20
-
8
Methods to treat lymphoplasmacytic lymphoma
Dana-Farber Cancer Institute
01/27/20
-
45
Apoptosis signal-regulating kinase inhibitors
Gilead Sciences
01/27/20
-
132
Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof
Agency For Science, Technology and Research
01/27/20
-
88
Tricyclic fused thiophene derivatives as JAK inhibitors
Incyte
01/27/20
-
84
Spirocyclic derivatives
Chronos Therapeutics
01/27/20
-
48
Histone deacetylase inhibitors
Biomarin Pharmaceutical
01/27/20
-
57
Fused tricyclic compounds as Raf kinase inhibitors
Beigene
01/21/20
-
65
Aryl ethers and uses thereof
Peloton Therapeutics
01/21/20
-
31
N-pyrrolidinyl,N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
Array Biopharma
01/21/20
-
106
Histone demethylase inhibitors
Celgene Quanticel Research
01/21/20
-
101
Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
Novartis
01/21/20
-
46
TrkA kinase inhibitors, compositions and methods thereof
Merck Sharp & Dohme
01/21/20
-
365
Substituted prolines/piperidines as orexin receptor antagonists
Eolas Therapeutics
01/21/20
-
243
Compounds, compositions and methods
Denali Therapeutics
01/21/20
-
13
Polysubstituted pyridine compound, preparation method, use and pharmaceutical composition
Peking University Founder Group
01/21/20
-
168
Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
Exonhit Therapeutics
01/21/20
-
7
Quinoxaline derivatives useful as FGFR kinase modulators
Astex Therapeutics
01/21/20
-
31
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
01/21/20
-
234
Biaryl kinase inhibitors
Bristol-Myers Squibb
01/21/20
-
4
Pyridone-sulfone morphinan analogs as opioid receptor ligands
Purdue Pharma
01/21/20
-
46
Macrocyclic compounds as TRK kinase inhibitors
Array Biopharma
01/21/20
-
5
Assays for screening for or identifying an agent or molecule that can block or inhibit AVB3 integrin from forming a complex with KRAS
University of California
01/21/20
-
135
4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors
Janssen Pharmaceutica
01/21/20
-
32
1,2-dithiolane and dithiol compounds useful in treating mutant EGFR-mediated diseases and conditions
Sabila Biosciences
01/21/20
-
330
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals
01/21/20
-
509
IRAK4 inhibiting agents
Biogen Ma
01/21/20
-
28
Indazole and azaindazole Btk inhibitors
Merck Sharp & Dohme
01/21/20
-
88
Chemokine receptor modulators and uses thereof
Flx Bio
01/21/20
-
18
Diaryl macrocycles as modulators of protein kinases
Tp Therapeutics
01/21/20
-
57
Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors
Boehringer Ingelheim International
01/21/20
-
232
Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors
Array Biopharm
01/21/20
-
186
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
01/21/20
-
227
N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators
Novartis
01/21/20
-
51
Inhibiting G protein coupled receptor 6 kinase polypeptides
Mayo Foundation
01/21/20
-
53
Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
01/21/20
-
85
Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
Forma Tm2
01/21/20
-
9
Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors
Palobiofarma
01/21/20
-
41
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Enanta Pharmaceuticals
01/21/20
-
609
Tank-binding kinase inhibitor compounds
Gilead Sciences
01/21/20
-
357
Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C
Boehringer Ingelheim International
12/30/19
-
48
Benzothiazole and benzothiophene compounds
Universite De Montreal
12/30/19
-
32
1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl) oxy) napththalen-1-yl) ureas as p38 MAP kinase inhibitors
Respivert
12/30/19
-
49
C5-C6-fused tricyclic iminothiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
TBA
12/30/19
-
141
N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of NR2B
Cadent Therapeutics
12/30/19
-
53
Heteroaryl orexin receptor antagonists
Merck Sharp & Dohme
12/30/19
-
22
Benzoazepine derivatives
Viiv Healthcare
12/30/19
-
620
2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG
Cancer Research Technology
12/30/19
-
58
Therapeutic compounds and uses thereof
Genetech
12/30/19
-
243
Sulfonamide compounds as voltage-gated sodium channel modulators
Lupin
12/30/19
-
190
Dopamine D3 receptor antagonists
Indivior
12/30/19
-
169
Triaza-spirodecanones as DDR1 inhibitors
Hoffmann-La Roche
12/30/19
-
25
RIPK2 inhibitors and method of treating cancer with same
University Health Network
12/30/19
-
86
Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors
Dart Neuroscience (Cayman)
12/30/19
-
132
4-imidazopyridazin-1-yl-benzamides as BTK inhibitors
Merck Sharp & Dohme
12/30/19
-
75
Positive allosteric modulators of the muscarinic acetylcholine receptor M4
Vanderbilt University
12/30/19
-
1057
Biaryl amide compounds as kinase inhibitors
Novartis
12/30/19
-
76
Triterpenoids with HIV maturation inhibitory activity
Viiv Healthcare UK (No. 4)
12/30/19
-
12
Liver X receptor (LXR) modulators
Ralexar Therapeutics
12/30/19
-
16
3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
Parion Sciences
12/30/19
-
240
Triazole compounds as T-type calcium channel blockers
Idorsia Pharmaceuticals
12/30/19
-
248
Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
Amgen
12/30/19
-
22
4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators
Heptares Therapeutics
12/30/19
-
337
Heterocyclic modulators of lipid synthesis and combinations thereof
3-V Biosciences
12/27/19
-
45
Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
University of California
12/27/19
-
75
Small molecule NF-κB inhibitors
Immunetarget
12/27/19
-
24
Selective histone deactylase 6 inhibitors
H. Lee Moffitt Cancer Center and Research Institute
12/27/19
-
287
3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones
Bayer Pharma Aktiengesellschaft
12/27/19
-
6
Ghrelin 0-acyl transferase inhibitors
Eli Lilly
12/27/19
-
46
Glucosylceramide synthase inhibitors for the treatment of diseases
Biomarin Pharmaceutical
12/27/19
-
13
Cystathionine-gamma-lyase (CSE) inhibitors
Sova Pharmaceuticals
12/27/19
-
11
Inhibitors of metallo-beta-lactamase (MBL) comprising a zinc chelating moiety
Universitetet | Oslo
12/27/19
-
130
Compounds useful for treating disorders related to RET
Blueprint Medicines
12/27/19
-
369
Metallo-beta-lactamase inhibitors
Merck Sharp & Dohme
12/27/19
-
4
T-type calcium channel modulator and uses thereof
Uti Limited Partnership
12/27/19
-
8
Estrogen receptor modulators and uses thereof
Genentech
12/27/19
-
16
Pyrazole orexin receptor antagonists
Merck Sharp & Dohme
12/27/19
-
136
Substituted benzenesulfonamides as sodium channel blockers
Daewoong Pharmaceutical
12/27/19
-
26
Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors
Bristol-Myers Squibb
12/27/19
-
145
Inhibiting agents for bruton's tyrosine kinase
Biogen Ma
12/27/19
-
99
Heteroaryl compounds for kinase inhibition
Ariad Pharmaceuticals
12/27/19
-
109
Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
12/27/19
-
104
Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use therof
Pfizer
12/27/19
-
129
Phosphatidylinositol 3-kinase inhibitors
Gilead Sciences
12/27/19
-
650
Compounds and methods for kinase modulation, and indications therefor
Plexxikon
12/27/19
-
28
Tricyclic heterocycles as bet protein inhibitors
Incyte
12/27/19
-
49
Compounds for use as GPR120 agonists
Piramal Enterprises
12/27/19
-
6
Enantiomers of the 1′,6′-isomer of neplanocin A
Auburn University
12/27/19
-
39
Methods for treating depressive symptoms
Alkermes Pharma Ireland
12/27/19
-
159
Compounds and their use as BACE inhibitors
Astrazeneca
12/27/19
-
158
LSD1 inhibitors
Mirati Therapeutics
12/27/19
-
57
9-membered fused ring derivative
Shionogi
12/27/19
-
75
Substituted pyrido[3,4-d]pyrimidines and pyrido[4,3-d]pyrimidines as p70S6K inhibitors
Merck Patent
12/27/19
-
642
Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators
Janssen Pharmaceutica
12/27/19
-
25
TRPV1 vanilloid receptor antagonists with a bicyclic portion
TBA
12/27/19
-
8
Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use
Oryzon Genomics
12/27/19
-
243
Substituted spirocyclic inhibitors of autotaxin
X-Rx
12/27/19
-
47
Fused bicyclic compounds for the treatment of disease
Akarna Therapeutics
12/27/19
-
217
CDK2/4/6 inhibitors
Pfizer
12/27/19
-
76
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical
12/27/19
-
157
IDO inhibitors
Newlink Genetics
12/27/19
-
292
Compounds useful as immunomodulators
Bristol-Myers Squibb
12/19/19
-
43
P2X4 receptor antagonist
Nippon Chemiphar
12/19/19
-
307
Methods of treatment using pyridinonyl PDK1 inhibitors
Sunesis Pharmaceuticals
12/19/19
-
774
Triazolopyridine compounds, compositions and methods of use thereof
Genentech
12/19/19
-
47
Heterocycles as modulators of kinase activity
Merck Patent
12/12/19
-
72
Pyridyl benzothiophenes as kinase inhibitors
Allergan
12/12/19
-
185
Serine/threonine kinase inhibitors
Genentech
12/10/19
-
92
C-linked heterocycloaklyl substituted pyrimidines and their uses
Genentech
12/10/19
-
214
Inhibitors of protein kinases
Portola Pharmaceuticals
12/10/19
-
51
Diazine-fused amidines as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
12/10/19
-
19
Heteroaromatic compounds and their use as dopamine D1 ligands
Pfizer
12/10/19
-
110
Thiazolopyrrolidine inhibitors of ROR- γ
Vitae Pharmaceuticals
12/10/19
-
7
Indolyl-containing RORγt inhibitors
Orca Pharmaceuticals
12/03/19
-
58
Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
The United States of America, As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institutes of Health
12/03/19
-
7
Hydrophobically tagged janus kinase inhibitors and uses thereof
Dana-Farber Cancer Institute
12/03/19
-
83
TrkA kinase inhibitors, compositions and methods thereof
Merck Sharp & Dohme
12/03/19
-
13
Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
Novartis
12/03/19
-
13
Tetrahydrocarboline derivative
Ono Pharmaceutical
12/03/19
-
20
Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
Purdue Pharma
12/03/19
-
393
Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
Bristol-Myers Squibb
12/03/19
-
11
Treatment of respiratory disorders using ROR-gamma inhibitors
Glenmark Pharmaceuticals
11/21/19
-
340
Aminoquinazoline and pyridopyrimidine derivatives
Genentech
11/21/19
-
124
Inhibitor compounds of phosphodiesterase type 10A
Abbvie Deutschland
11/21/19
-
38
Carboxylic acid compound, method for preparation thereof, and use thereof
Inventisbio Shanghai
11/21/19
-
57
Substituted tropane derivatives
Toa Eiyo
11/21/19
-
106
2-(hetero)aryl-benzimidazole and imidazopyridine derivatives as inhibitors of asparagime emethyl transferase
Cancer Therapeutics Crc
11/21/19
-
68
Pyrazolonaphthyridinone derivatives as MetAP2 inhibitors (methionine aminopeptidase type-2)
Sanofi
11/21/19
-
39
Heteroaromatic compounds and their use as dopamine D1 ligands
Pfizer
11/21/19
-
42
Substituted pyrazolo[1,5-a]pyridines as PDE-10 inhibitors
Sunovion Pharmaceuticals
11/21/19
-
27
SHP2 inhibitors and methods of treating autoimmune and/or glomerulonephritis-associated diseases using SHP2 inhibitors
Indiana University Research and Technology
11/14/19
-
10
Pyrazolopyridyl compounds as aldosterone synthase inhibitors
Merck Sharp & Dohme
11/14/19
-
62
Isoindoline inhibitors of ROR-gamma
Vitae Pharmaceuticals
11/14/19
-
485
Intermediates for preparing triazole agonists of the APJ receptor
Amgen
11/14/19
-
151
Cycloalkane derivatives
Daiichi Sankyo
11/14/19
-
47
Substituted 2-azabicycles and their use as orexin receptor modulators
TBA
11/14/19
-
5
1,4-benzodiazepone-2,5-diones and related compounds with therapeutic properties
The Regents of The University of Michigan
11/14/19
-
122
Autotaxin inhibitor compounds
Pharmakea
11/14/19
-
375
Compounds useful as immunomodulators
Bristol-Myers Squibb
11/14/19
-
21
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
11/14/19
-
13
Tricyclic heterocycles as BET protein inhibitors
Incyte
11/14/19
-
43
Substituted tetrahydrocarbazole and carbazole carboxamide compounds
Bristol-Myers Squibb
11/14/19
-
207
Therapeutically active compositions and their methods of use
Agios Pharmaceuticals
11/14/19
-
32
Substituted quinazolin-4-one derivatives
Novartis
10/31/19
-
121
Morpholin-pyridine derivatives
Hoffmann-La Roche
10/31/19
-
10
Heterocyclic compounds and uses thereof
Incyte
10/31/19
-
18
N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a] pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders
Oged
10/31/19
-
14
Piperidinone carboxamide azaindane CGRP receptor antagonists
Merck Sharp & Dohme
10/28/19
-
13
Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
Vtv Therapeutics
10/28/19
-
125
Benzylamine derivatives
Kalvista Pharmceuticals
10/28/19
-
12
Indazoles and use thereof
Purdue Pharma
10/28/19
-
129
Pyridazine compounds as JAK inhibitors
Portola Pharmaceuticals
10/28/19
-
109
Substituted pyrrolo[2,3-b]pyrazines and substituted pyrazolo[3,4-b]pyridines as ITK and JAK kinase inhibitors
Arrien Pharmaceuticals
10/28/19
-
41
BTK inhibitors
Merck Sharp & Dohme
10/28/19
-
209
Substituted quinolines as PDE-10 inhibitors
Sunovion Pharmaceuticals
10/28/19
-
29
Tricyclic heterocycles as bet protein inhibitors
Incyte
10/28/19
-
491
Metallo-beta-lactamase inhibitors
Merck Sharp & Dohme
10/27/19
-
64
Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
10/27/19
-
159
Chemical compounds
Astrazeneca
10/27/19
-
22
N-(phenylsulfonyl)benzamides and related compounds as BCL-2 inhibitors
The Regents of The University of Michigan
10/27/19
-
42
Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1
Vanderbilt University
10/27/19
-
248
Inhibiting the transient receptor potential A1 ion channel
Hydra Biosciences
10/27/19
-
82
Purine inhibitors of human phosphatidylinositol 3-kinase delta
Merck Sharp & Dohme
10/27/19
-
19
3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman)
10/27/19
-
44
Pyridine compounds
Daiichi Sankyo
10/27/19
-
147
Phosphatidylinositol 3-kinase inhibitors
Gilead Sciences
10/27/19
-
25
Pyridinecarboxamides as CXCR2 modulators
Syntrix Biosystems
10/27/19
-
64
Oxazole orexin receptor antagonists
Merck Sharp & Dohme
10/24/19
-
224
Biphenyl derivatives and methods for preparing same
Dong-A St
10/22/19
-
10
Benzimidazole derivatives and use thereof
Purdue Pharma
10/22/19
-
166
Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharpe & Dohme
10/22/19
-
47
Substituted pyrazino[2,2-a]isoquinoline derivatives
Hoffmann-La Roche
10/22/19
-
69
Kinase inhibitors and methods of use
Intellikine
10/22/19
-
88
Substituted pyrazolopyrimidines and method of use
Abbvie Deutschland
10/22/19
-
92
Alkyne compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
10/22/19
-
9
Compounds and methods for inhibiting production of trimethylamine
The Procter & Gamble
10/20/19
-
11
Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
University of Chicago
10/20/19
-
10
Pharmaceutical formulations comprising CCR3 antagonists
Alkahest
10/20/19
-
107
Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
Incyte
10/20/19
-
370
Solid dispersions containing an apoptosis-inducing agent
Abbvie
10/20/19
-
56
(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
Oryzon Genomics
10/20/19
-
11
Amantadine nitrate compounds with neural protective effect, and preparation and medical use thereof
TBA
10/20/19
-
238
Heterocyclic inhibitors of MCT4
Vettore
10/20/19
-
137
Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
Reset Therapeutics
10/20/19
-
18
Amino-substituted heterocyclic derivatives as sodium channel inhibitors
Almirall
10/20/19
-
3
Quinazolines as potassium ion channel inhibitors
Bristol-Myers Squibb
10/20/19
-
227
Factor XIA inhibitors
Merck Sharp & Dohme
10/20/19
-
9
Substituted pyrazoles as inhibitors of fibroblast growth factor receptor
Zhejiang Hisun Pharmaceutical
10/20/19
-
14
5-(N-fused tricyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (NO.5)
10/20/19
-
6
Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
10/20/19
-
327
Phosphatidylinositol 3-kinase inhibitors
Gilead Sciences
10/20/19
-
19
2-heteroaryl carboxamides
Bayer Intellectual Property
10/20/19
-
65
Triazolopyridine inhibitors of myeloperoxidase
Bristol-Myers Squibb
10/20/19
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
10/20/19
-
57
Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same
Max-DelbrÜCk-Centrum FÜR Molekulare Medizin
10/20/19
-
7
N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders
Ogeda
10/20/19
-
44
Substituted 2-phenyl (AZA)benzofuran compounds for the treatment of hepatitis C
Bristol-Myers Squibb
10/20/19
-
16
Hydroxmethyl piperidine orexin receptor antagonists
Merck Sharp & Dohme
10/20/19
-
76
Amlexanox analogs
The Regents of The University of Michigan
10/20/19
-
774
Bicyclic heteroaryl amine compounds
Bristol-Myers Squibb
10/20/19
-
154
Imidazopyridazine and imidazothiadiazole compounds
Universite De Montreal
10/20/19
-
18
Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders
Bayer Pharma Aktiengesellschaft
10/20/19
-
174
Btk inhibitors
Merck Sharp & Dohme
10/20/19
-
9
Compounds, compositions and methods useful for cholesterol mobilization
Cerenis Therapeutics Holding
10/20/19
-
97
Compositions and methods for treating ocular diseases
Aerpio Therapeutics
10/20/19
-
288
Inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (NO.5)
10/20/19
-
118
Substituted pyrazole compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
10/20/19
-
411
Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
Lycera
10/20/19
-
6
Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (NO.5)
10/20/19
-
4
Metalloenzyme inhibitor compounds
Mycovia Pharmaceuticals
10/20/19
-
94
Inhibitors of plasma kallikrein
Kalvista Pharmaceuticals
10/20/19
-
507
Triazole agonists of the APJ receptor
Amgen
10/20/19
-
88
Method of treating conditions with kinase inhibitors
Allergan
10/20/19
-
13
Inhibitors of fatty acid amide hydrolase (FAAH) enzyme with improved oral bioavailability and their use as medicaments
University of California
10/20/19
-
94
Dihydropyridinone MGAT2 inhibitors
Bristol-Myers Squibb
10/20/19
-
143
Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders
Bayer Pharma Aktiengesellschaft
10/20/19
-
92
Inhibitors of lysine methyl transferase
Bristol-Myers Squibb
10/20/19
-
32
Protein kinase inhibitors
Pharmascience
10/20/19
-
85
Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
Incyte
10/20/19
-
33
Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof
Merck Patent
10/14/19
-
24
Protein kinase inhibitor containing pyrrolopyridazine derivative
The Asan Foundation
10/14/19
-
126
Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors
Novartis
10/14/19
-
227
TrkA kinase inhibitors, compositions and methods thereof
Merck Sharp & Dohme
10/14/19
-
255
Compounds, compositions and methods
Denali Therapeutics
10/14/19
-
12
Selective glycosidase inhibitors and uses thereof
Alectos Therapeutics
10/14/19
-
165
Substituted pyrrolo[2,3-b]pyridines as MLK inhibitors
The University of Rochester
10/13/19
-
7
Liver X receptor modulators
Vitae Pharamceuticals
10/13/19
-
23
Chemically modified quinoline and quinolone derivatives useful as CB-1 inverse agonists
Janssen Pharmaceutica
10/13/19
-
689
Pyrimidone carboxamide compounds as PDE2 inhibitors
Merck Sharp & Dohme
10/13/19
-
76
Complement pathway modulators and uses thereof
Novartis
10/13/19
-
7
Rho kinase inhibitors
Kadmon
10/13/19
-
92
Azabenzimidazole compounds
Pfizer
10/13/19
-
91
Quinolone derivatives as fibroblast growth factor receptor inhibitors
Principia Biopharma
10/13/19
-
30
Factor IXa inhibitors
Merck Sharp & Dohme
10/07/19
-
25
Factor XIa inhibitors
Merck Sharp & Dohme
10/07/19
-
422
Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
Merck Sharp & Dohme
10/07/19
-
7
Compounds inhibiting leucine-rich repeat kinase enzyme activity
Merck Sharp & Dohme
10/07/19
-
1
Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds
Suzhou Zelgen Biopharmaceuticals
10/07/19
-
248
Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them
Les Laboratoires Servier
10/07/19
-
24
Aminoester derivatives
Chiesi Farmaceutici
10/07/19
-
31
Oxazolidine-based compound and selective androgen receptor agonist comprising same
Dong-A St
10/07/19
-
34
Pyridinyl and fused pyridinyl triazolone derivatives
Takeda Pharmaceutical
10/01/19
-
32
Quinoline derivatives as PDE10A enzyme inhibitors
H. Lundbeck
10/01/19
-
129
Pyrimidine compounds as mTOR and PI3K inhibitors
Development Center For Biotechnology
10/01/19
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
10/01/19
-
62
Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof
The United States of America, As Represented By The Secretary, Department of Health and Human Services
10/01/19
-
44
2-aryl selenazole compound and pharmaceutical composition thereof
Jiangsu Atom Bioscience and Pharmaceutical
10/01/19
-
215
Indole carboxamide compounds
Bristol-Myers Squibb
10/01/19
-
107
Pyridineamine compounds useful as Pim kinase inhibitors
Incyte
10/01/19
-
20
Inhibitors of bruton's tyrosine kinase
Hoffmann-La Roche
10/01/19
-
43
5-hydroxytryptamine receptor 7 activity modulators and their method of use
Temple University
10/01/19
-
24
C-6 spirocarbocyclic iminothiadiazine dioxides as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
10/01/19
-
77
Macrocycles as factor XIa inhibitors
Bristol-Myers Squibb
10/01/19
-
64
Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
Hoffmann-La Roche
10/01/19
-
23
Imidazopyridazine derivatives as modulators of the GABAA receptor activity
Pfizer
10/01/19
-
9
3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5H)-yl) derivatives II
GrÜNenthal
10/01/19
-
476
Heteroaryls and uses thereof
Millennium Pharmaceuticals
10/01/19
-
219
Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Galapagos
09/24/19
-
9
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
Gilead Sciences
09/23/19
-
35
Pyrrolopyrimidine compounds for the treatment of cancer
University of North Carolina At Chapel Hill
09/23/19
-
15
Protein kinase inhibitors
Pharmascience
09/23/19
-
59
Method of treatment using substituted imidazo[1,2b]pyridazine compounds
Array Biopharma
09/23/19
-
11
Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
Biomarin Pharmaceutical
09/23/19
-
93
Isoindoline compositions and methods for treating neurodegenerative disease
Cognition Therapeutics
09/23/19
-
31
Glucocerebrosidase modulators and uses thereof
Alectos Therapeutics
09/23/19
-
18
S-substituted quinazolines and their therapeutic applications for the treatment of diseases mediated by PDE7
Consejo Superior De Investigaciones Cientificas
09/23/19
-
344
ERK inhibitors and uses thereof
Celgene Car
09/23/19
-
23
Dihydroquinoline pyrazolyl compounds
Hoffmann-La Roche
09/23/19
-
275
Substituted quinazolines as receptor-type kinase inhibitors
Symphony Evolution
09/23/19
-
173
Inhibitors of Jun N-terminal kinase
Imago Pharmaceuticals
09/23/19
-
36
Piperazine derivatives for treating disorders
The University of Nottingham
09/23/19
-
1352
Pyrrolo [2,3-B] pyridine CDK9 kinase inhibitors
Abbvie
09/23/19
-
44
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals
09/23/19
-
124
Selective inhibitors of Tec and Src protein kinase families
Pharmascience
09/23/19
-
31
Imidazole-derived modulators of the glucocorticoid receptor
Bristol-Myers Squibb
09/23/19
-
60
Method of treatment using substituted imidazo[1,2b]pyridazine compounds
Array Biopharma
09/23/19
-
232
Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors
Array Biopharma
09/23/19
-
122
Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
Millennium Pharmaceuticals
09/23/19
-
33
Compounds as diacylglycerol acyltransferase inhibitors
Glaxosmithkline
09/23/19
-
42
Pyridopyrimidine or pyrimidopyrimidine compound, prepration method, pharmaceutical composition, and use thereof
Shandong Luoxin Pharmaceutical Group Stock
09/23/19
-
167
Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
09/23/19
-
61
Kinase inhibitors
Respivert
09/23/19
-
322
Compounds useful for the treatment of degenerative and inflammatory diseases
Galapagos
09/21/19
-
311
Therapeutic compounds and uses thereof
Genentech
09/21/19
-
93
Isoindoline compositions and methods for treating neurodegenerative disease
Cognition Therapeutics
09/21/19
-
119
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
09/21/19
-
19
Eis inhibitors
University of Kentucky Research Foundation
09/21/19
-
25
Benzothiophene estrogen receptor modulators
G1 Therapeutics
09/21/19
-
23
1-sulfonyl piperidine derivatives as modulators of prokineticin receptors
Takeda Pharmaceutical
09/21/19
-
246
GLP-1 receptor agonists and uses thereof
Pfizer
09/21/19
-
62
Substituted amino triazoles useful as human chitinase inhibitors
Oncoarendi Therapeutics
09/21/19
-
21
Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
Bristol-Myers Squibb
09/21/19
-
7
Heterocyclic inhibitors of the sodium channel
TBA
09/21/19
-
83
2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
Array Biopharma
09/21/19
-
1
Processes for preparing ATR inhibitors
Vertex Pharmaceuticals
09/21/19
-
11
Fused imidazo-piperidine JAK inhibitors
Theravance Biopharma R&D Ip
09/21/19
-
30
Methods for inhibiting fascin
Cornell University
09/21/19
-
3
ACC inhibitors and uses thereof
Gilead Apollo
09/21/19
-
35
Tertiary alcohol imidazopyrazine BTK inhibitors
Merck Sharp & Dohme
09/21/19
-
97
Condensed tricyclic compounds as protein kinase inhibitors
F.S.P. Cnio
09/21/19
-
10
Inhibitors of HIF prolyl hydroxylase
Merck Sharp & Dohme
09/21/19
-
36
Inhibitors of the renal outer medullary potassium channel
Wuxi Apptec (Shanghai)
09/21/19
-
68
Imidazopyridazine compounds and their use
Hutchison Medipharma
09/21/19
-
46
Macrocycles as factor XIa inhibitors
Bristol-Myers Squibb
09/21/19
-
187
Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases
Allergan
09/21/19
-
133
Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
Enanta Pharmaceuticals
09/21/19
-
20
Somatostatin receptor subtype 4 (SSTR4) agonists
Centrexion Therapeutics
09/09/19
-
21
1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
Incyte Holdings
09/09/19
-
45
Compounds as rearranged during transfection (RET) inhibitors
Glaxosmithkline
09/09/19
-
55
Diacylglycerol acyltransferase 2 inhibitors
Pfizer
09/09/19
-
91
Compositions and methods of modulating short-chain dehydrogenase activity
Case Western Reserve University
09/09/19
-
12
Substituted tropolone derivatives and methods of use
University of Connecticut
09/09/19
-
118
Kinase inhibitors
Respivert
09/09/19
-
41
Piperidine derivatives as HDAC1/2 inhibitors
Regenacy Pharmaceuticals
09/09/19
-
4
Lysine demethylase inhibitors for diseases and disorders associated with Flaviviridae
Oryzon Genomics
09/09/19
-
98
Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
Janssen Pharmaceutica
09/09/19
-
113
Piperidine and azepine derivatives as prokineticin receptor modulators
Takeda Pharmaceutical
09/09/19
-
25
Inhibitor compounds of phosphodiesterase type 10A
Abbvie
09/09/19
-
17
Kinase inhibitors
Respivert
09/09/19
-
72
Enhancer of zeste homolog 2 inhibitors
Glaxosmithkline
09/09/19
-
85
Pyridinyloxy- and phenyloxy-pyrazolyl compounds
Hoffmann-La Roche
09/09/19
-
25
Substituted cyclopentanes, tetrahydrofuranes and pyrrolidines as orexin receptor antagonists
Takeda Pharmaceutical
09/09/19
-
287
Heteroaryl compounds as IRAK inhibitors and uses thereof
Merck Patent
09/09/19
-
194
Heterocyclic kinase inhibitors
Intellikine
09/09/19
-
356
Bruton's tyrosine kinase inhibitors
Sunesis Pharmaceuticals
09/09/19
-
106
2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives
Hoffmann-La Roche
09/09/19
-
19
Compositions and methods of modulating 15-PGDH activity
Case Western Reserve University
09/09/19
-
130
MK2 inhibitors and uses thereof
Celgene Car
09/09/19
-
10
Methods of identifying SENP1 inhibitors
City of Hope
09/09/19
-
81
MCT4 inhibitors for treating disease
Vettore
09/02/19
-
120
Therapeutic compounds and uses thereof
Genentech
09/02/19
-
361
Therapeutic compounds
Celgene Quanticel Research
09/02/19
-
2
Inhibitors of leukotriene A4 hydrolase
Celtaxsys
09/02/19
-
39
2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
Blueprint Medicines
09/02/19
-
62
Heterocyclic compounds and methods of use thereof
The United States of America, As Represented By The Secretary, Department of Health and Human Services
09/02/19
-
88
CXCR7 receptor modulators
Idorsia Pharmaceuticals
09/02/19
-
393
1,3-thiazol-2-yl substituted benzamides
Bayer Aktiengesellschaft
09/02/19
-
153
Benzimidazole derivatives as selective proteine kinase inhibitors
Ab Science
09/02/19
-
19
Oxazolidin-2-one-pyrimidine derivatives and the use thereof as phosphatidylinositol-3-kinase inhibitors
Novartis
09/02/19
-
49
Heteroaryls and uses thereof
Millennium Pharmaceuticals
09/02/19
-
26
N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors
Redx Pharma
09/02/19
-
115
3-(1H-benzo[D]imidazol-2-yl)-1H-pyrazolo[3,4-C]pyridine and therapeutic uses thereof
Samumed
09/02/19
-
200
Therapeutic compounds and uses thereof
Genentech
09/02/19
-
388
Substituted polycyclic carbamoyl pyridone derivative prodrug
Shionogi
09/02/19
-
145
Histone demethylase inhibitors
Celgene Quanticel Research
09/02/19
-
46
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
Boehringer Ingelheim International
09/02/19
-
43
Fused-ring compounds, pharmaceutical composition and uses thereof
Shanghai De Novo Pharmatech
09/02/19
-
120
Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
Millennium Pharmaceuticals
09/02/19
-
28
Heteroaryl substituted aminopyridine compounds
Bristol-Myers Squibb
09/02/19
-
34
Dihydroxy aromatic heterocyclic compound
Takeda Pharmaceutical
09/02/19
-
18
Macrocyclic benzofuran compounds for the treatment of hepatitis C
Bristol-Myers Squibb
09/02/19
-
127
Polycyclic pyridone derivative having integrase inhibitory activity
Shionogi
09/02/19
-
15
3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
Idenix Pharmaceuticals
09/02/19
-
16
β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
Atea Pharmaceuticals
09/02/19
-
20
Hydroxy-ethylene derivatives for the treatment of arthrosis
Merck Patent
09/02/19
-
107
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
08/20/19
-
80
Substituted quinolines as modulators of sodium channels
Vertex Pharmaceuticals
08/20/19
-
10
Protein tyrosine kinase modulators and methods of use
Betta Pharmaceuticals
08/19/19
-
356
Indazole ureas and method of use
Abbvie
08/19/19
-
40
Factor Xla inhibitors
Merck Sharp & Dohme
08/19/19
-
19
Aminoimidazopyridazines
Bayer Pharma Aktiengesellschaft
08/19/19
-
9
Pyranochromenyl phenol derivative, and pharmaceutical composition for treating metabolic syndrome or inflammatory disease
Glaceum
08/19/19
-
22
Kinase inhibitors
Respivert
08/19/19
-
66
IAP antagonists
Bristol-Myers Squibb
08/19/19
-
255
Carbamate benzoxazine propionic acids and acid derivatives for modulation of RORgamma activity and the treatment of disease
Lycera
08/18/19
-
232
Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors
Array Biopharma
08/17/19
-
24
Quinoline derivatives and their applications
Shenyang Pharmaceutical University
08/17/19
-
18
2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition
Northwestern University
08/17/19
-
33
Amino-substituted imidazopyridazines
Bayer Intellectual Property
08/13/19
-
306
PRMT5 inhibitors and uses thereof
Epizyme
08/13/19
-
111
Substituted 4-phenylpiperidines, their preparation and use
Columbia University
08/13/19
-
90
Tricyclic fused thiophene derivatives as JAK inhibitors
Incyte Holdings
08/13/19
-
185
Furo-3-carboxamide derivatives and methods of use
Abbvie
08/13/19
-
73
Isoindolone derivatives
Abbvie
08/12/19
-
206
Thienomethylpiperazine derivatives as inhibitors of soluble epoxide hydrolase
Sanofi
08/12/19
-
366
Bicyclic sulfonamide compounds as sodium channel inhibitors
Amgen
08/12/19
-
158
Pyrazole derivative
Mochida Pharmaceutical
08/12/19
-
269
Tricyclic heterocycles as bet protein inhibitors
Incyte
08/12/19
-
41
2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
Merck Sharp & Dohme
08/11/19
-
109
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals
08/11/19
-
119
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
08/11/19
-
8
Pyrazolylbenzo[d]imidazole derivatives
Celon Pharma
08/11/19
-
14
Kinase inhibitors based upon N-alkyl pyrazoles
Topivert Pharma
08/06/19
-
33
Substituted oxazole- and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands II
Medifron Dbt
08/06/19
-
20
Substituted tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors
Phoenix Molecular Design
08/06/19
-
253
Compounds and methods for kinase modulation, and indications therefor
Plexxikon
08/06/19
-
156
Indazole compounds useful as ketohexokinase inhibitors
Janssen Pharmaceutica
08/06/19
-
51
N-substituted benzamides and methods of use thereof
Genentech
08/06/19
-
28
N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides
Pfizer
08/06/19
-
293
Carbocyclic sulfone RORγ modulators
Bristol-Myers Squibb
08/05/19
-
119
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
08/05/19
-
17
Phenoxyalkylamine compound
Osaka University
08/02/19
-
308
Therapeutic compounds and uses thereof
Genentech
07/30/19
-
37
Pyridine compounds as sodium channel blockers
Purdue Pharma
07/29/19
-
136
Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
University of Washington Through Its Center For Commercialization
07/29/19
-
23
Heteroaryl compounds and uses thereof
Celgene Car
07/29/19
-
15
Therapeutic agent for pain
Astellas Pharma
07/29/19
-
74
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
07/29/19
-
173
Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
Les Laboratoires Servier
07/29/19
-
14
3-ester-4 substituted orexin receptor antagonists
Merck Sharp & Dohme
07/29/19
-
19
Substituted benzylpyrazoles
Bayer Pharma Aktiengesellschaft
07/29/19
-
113
Phosphatidylinositol 3-kinase inhibitors
Gilead Sciences
07/29/19
-
193
PRMT5 inhibitors and uses thereof
Epizyme
07/29/19
-
39
Substituted oxopyridine derivatives
Bayer Pharma Aktiengesellschaft
07/29/19
-
442
Tricyclic piperidine compounds
Actelion Pharmaceuticals
07/29/19
-
43
Trk-inhibiting compound
Ono Pharmaceutical
07/26/19
-
262
Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
Novartis
07/26/19
-
201
Autotaxin inhibitors
Novartis
07/26/19
-
65
IDO inhibitors
Bristol-Myers Squibb
07/26/19
-
95
Benzimidazole derivatives: preparation and pharmaceutical applications
Mei Pharma
07/22/19
-
102
Styrenyl derivative compounds for treating ophthalmic diseases and disorders
Acucela
07/22/19
-
362
Quinolinyl modulators of RORγt
Janssen Pharmaceutica
07/22/19
-
18
Lysine specific demethylase-1 inhibitors and their use
Oryzon Genomics
07/22/19
-
350
Therapeutic compounds and compositions
Agios Pharmaceuticals
07/22/19
-
17
Glucosylceramide synthase inhibitors and therapeutic methods using the same
The Regents of The University of Michigan
07/22/19
-
67
Aryl substituted indoles and the use thereof
Purdue Pharma
07/22/19
-
71
Naphthyridine derivative compounds
Astex Therapeutics
07/22/19
-
27
Heterocyclic GSK-3 allosteric modulators
Consejo Superior de Investigaciones Cientificas (CSIC)
07/22/19
-
15
Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities
Almirall
07/22/19
-
44
1-(cycloalkyl-carbonyl)proline derivative
Sumitomo Dainippon Pharma
07/22/19
-
159
Pyridone amides as modulators of sodium channels
Vertex Pharmaceuticals
07/22/19
-
7
Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer
Amgen
07/22/19
-
35
3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use
Iteos Therapeutics
07/22/19
-
11
2,3-dihydro-isoindole-1-on derivative as BTK kinase suppressant, and pharmaceutical composition including same
Crystalgenomics
07/22/19
-
21
Histone demethylase inhibitors
Celgene Quanticel Research
07/22/19
-
20
Triazolopyridines and triazolopyrazines as LSD1 inhibitors
Incyte
07/22/19
-
132
4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
Merck Sharp & Dohme
07/22/19
-
116
Compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
07/22/19
-
153
Pyrimidine derivatives
Pfizer
07/22/19
-
47
Macrocyclic compounds as Trk kinase inhibitors
Array Biopharma
07/11/19
-
14
Pyridazinones as DAAO enzyme inhibitors
Takeda Pharmaceutical
07/11/19
-
21
Selective histone deactylase 6 inhibitors
H. Lee Moffitt Cancer Center and Research Institute
07/11/19
-
4
Kinase inhibitors
Respivert
07/11/19
-
148
Substituted uracils and use thereof
Bayer Pharma Aktiengesellschaft
07/11/19
-
11
TRPA1 antagonists
Abbvie
07/11/19
-
477
Heteroaryls and uses thereof
Millennium Pharmaceuticals
07/11/19
-
6
Ethynyl derivatives
Hoffmann-La Roche
07/11/19
-
138
Aryl sultam derivatives as RORc modulators
Genentech
07/11/19
-
115
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
07/11/19
-
224
Cyclopropanamine compound and use thereof
Takeda Pharmaceutical
07/11/19
-
10
4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-A]pyrazine derivatives as inhibitors of beta-secretase (BACE)
Janssen Pharmaceutica
07/11/19
-
58
Heterocyclic compounds and uses thereof
Infinity Pharmaceuticals
07/11/19
-
90
Kallikrein 7 inhibitors
Sixera Pharma
07/05/19
-
286
Pyrazolopyrimidine compounds for the treatment of cancer
University of North Carolina At Chapel Hill
07/05/19
-
114
2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
Pfizer
07/05/19
-
20
Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi
Piramal Imaging
07/05/19
-
126
4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
07/05/19
-
47
Indoline compounds as aldosterone synthase inhibitors
Merck Sharp & Dohme
07/05/19
-
169
Uracil derivatives as AXL and c-MET kinase inhibitors
Ignyta
07/05/19
-
59
2-pyridyloxy-4-ether orexin receptor antagonists
Merck Sharp & Dohme
07/05/19
-
22
Pyrimidines and use thereof
Purdue Pharma
07/05/19
-
62
Aldosterone synthase inhibitors
Boehringer Ingelheim International
07/05/19
-
274
PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
Epizyme
07/05/19
-
32
Amidoimidazopyridazines as MKNK-1 kinase inhibitors
Bayer Pharma Aktiengesellschaft
07/05/19
-
45
Compounds that are ERK inhibitors
Merck Sharp & Dohme
07/05/19
-
198
Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
Sk Biopharmaceuticals
07/05/19
-
89
Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
Incyte
07/05/19
-
23
Heterocyclic compounds and their use as dopamine D1 ligands
Pfizer
07/05/19
-
140
Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof
Shanghai Yingli Pharmaceutical
07/05/19
-
44
Iminothiadiazepane dioxide compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
07/05/19
-
885
Flap modulators
Janssen Pharmaceutica
07/05/19
-
18
Bicyclic heterocycles as bet protein inhibitors
Incyte
07/01/19
-
17
NMDA receptor modulators and uses related thereto
Emory University
07/01/19
-
17
Small molecule activators of NRF2 pathway
The General Hospital
07/01/19
-
111
Pyrrolotriazine kinase inhibitors
Bristol-Myers Squibb
07/01/19
-
24
Compounds
Astex Therapeutics
07/01/19
-
7
Antagonists of prostaglandin EP3 receptor
Pfizer
07/01/19
-
21
Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions
University of Utah Research Foundation
07/01/19
-
16
Inhibitors of lysine methyl transferase
Bristol-Myers Squibb
07/01/19
-
18
Phenyl and benzodioxinyl substituted indazoles derivatives
Astrazeneca
07/01/19
-
93
Histone demethylase inhibitors
Celgene Quantical Research
07/01/19
-
8
Substituted benzamide derivatives as in vitro MAO-B inhibitors
Ntz Lab
07/01/19
-
10
Bicyclic inhibitors
Kalvista Pharmaceuticals
07/01/19
-
379
Tetrahydro-pyrimidoazepines as modulators of TRPV1
Janssen Pharmaceutica
07/01/19
-
318
Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors
Bristol-Myers Squibb
07/01/19
-
36
Compounds as diacylglycerol acyltransferase inhibitors
Glaxosmithkline
07/01/19
-
9
Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease
University of Kansas
07/01/19
-
7
Selected macrolides with PDE4-inhibiting activity
Basilea Pharmaceutica
07/01/19
-
33
Substituted aminoimidazopyridazines
Bayer Intellectual Property
06/26/19
-
43
Ether compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
06/24/19
-
67
Pyrimidine FGFR4 inhibitors
Eisai R&D Management
06/23/19
-
11
Quinazoline derivatives substituted by aniline, preparation method and use thereof
Xuanzhu Pharma
06/23/19
-
377
RAF kinase modulator compounds and methods of use thereof
Ambit Biosciences
06/23/19
-
326
Heterocyclylamines as PI3K inhibitors
Incyte Holdings
06/23/19
-
370
Purine inhibitors of human phosphatidylinositol 3-kinase delta
Merck Sharp & Dohme
06/23/19
-
21
2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors
Northwestern University
06/23/19
-
8
N-(pyrid-4-yl)amides and N-(pyrimidin-4-yl)amides and their pharmaceutical and cosmetic use
Galderma Research & Development
06/23/19
-
555
Aminotriazine derivative and pharmaceutical composition comprising the same
Shionogi
06/23/19
-
38
Cinnoline derivatives useful as CB-1 receptor inverse agonists
Janssen Pharmaceutica
06/23/19
-
72
Kinase inhibitors
Respivert
06/23/19
-
237
Heterocyclic derivative and pharmaceutical drug
Nippon Shinyaku
06/23/19
-
29
PRMT5 inhibitors and uses thereof
Epizyme
06/23/19
-
990
Benzimidazole-proline derivatives
Idorsia Pharmaceuticals
06/23/19
-
33
Pyridinone and pyrimidinone derivatives as factor Xia
Ono Pharmaceutical
06/23/19
-
30
Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H4 receptor
Janssen Pharmaceutica
06/23/19
-
39
C2-carbocyclic iminothiazine dioxides as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
06/23/19
-
23
Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]OXAZEPINES and methods for treating viral infections
Gilead Sciences
06/23/19
-
353
FLAP modulators
Janssen Pharmaceutica
06/23/19
-
326
Arylquinazolines
Merck Patent
06/23/19
-
26
Process for the synthesis of a phosphoinositide 3-kinase inhibitor
Incyte
06/23/19
-
16
Carbamate, ester, and ketone compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
06/23/19
-
87
Carbazole compounds useful as bromodomain inhibitors
Bristol-Myers Squibb
06/16/19
-
233
TYK2 inhibitors and uses thereof
Nimbus Lakshmi
06/16/19
-
119
Tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis B virus infection
Hoffmann-La Roche
06/16/19
-
6
JAK inhibitors containing a 4-membered heterocyclic amide
Theravance Biopharma R&D Ip
06/16/19
-
1
MCL-1 inhibitors and methods of use thereof
Astrazeneca
06/16/19
-
57
Inhibitors of the fibroblast growth factor receptor
Blueprint Medicines
06/16/19
-
174
Compounds antagonizing A3 adenosine receptor, method for preparing them, and medical-use thereof
Handok
06/16/19
-
10
Chemical compounds
Glaxosmithkline
06/14/19
-
127
4-heteroaryl substituted benzoic acid compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
06/14/19
-
11
Quinazoline derivative, preparation method therefor, and pharmaceutical composition and application thereof
Arromax Pharmatech
06/14/19
-
102
Spirocyclic EBI2 modulators
Sanford Burnham Prebys Medical Discovery Institute
06/14/19
-
86
Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of STAT protein
The Governing Council of The University of Toronto
06/14/19
-
24
1-alkyl-6-oxo-1,6-dihydropyridin-3-yl compounds and use as SGRM modulators
Astrazeneca
06/14/19
-
9
Inhibitors of BCR-ABL mutants and use thereof
The Regents of The University of Michigan
06/14/19
-
41
Benzimidazole-2-piperazine heterocyclic compound, pharmaceutical composition containing the same, preparation method and use thereof
Shanghai Huilun Life Science & Technology
06/14/19
-
6
bis-Pyridazine compounds and their use in treating cancer
Astrazeneca
06/14/19
-
4
Substituted quinazoline compounds and preparation and uses thereof
Sunshine Lake Pharma
06/14/19
-
3
Tetrahydropyranyl benzamide derivatives
Eli Lilly
06/14/19
-
32
1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as P38 MAP knase inhibitors
Respivert
06/12/19
-
7
Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
06/12/19
-
99
Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disorders
The University of Mississippi
06/12/19
-
44
Cystathionine-γ-lyase (CSE) inhibitors
Sova Pharmaceuticals
06/12/19
-
12
Use of small molecule inhibitors targeting EYA tyrosine phosphatase
Cincinnati Childrens Hospital Medical Center
06/12/19
-
146
Compounds as tyrosine kinase modulators
Allergan
06/12/19
-
31
Hydroxy-substituted orexin receptor antagonists
Merck Sharp & Dohme
06/12/19
-
16
Substituted 4,5,6,7-tetrahydropyrazolo[4,3-c]pyridines as factor XIa inhibitors
Bristol-Myers Squibb
06/12/19
-
17
Cytochrome P450 inhibitors and their method of use
Cortendo AB (PUBL)
06/12/19
-
20
Quinazoline derivative and preparation method therefor
Chia Tai Tianqing Pharmaceutical Group
06/12/19
-
338
Heterocyclic derivative having PGD2 receptor antagonist activity
Shionogi
06/12/19
-
31
RORγ modulators
Bristol-Myers Squibb
06/12/19
-
296
Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors
Merck Sharp & Dohme
06/12/19
-
15
7-azaindole derivatives
Merck Patent
06/12/19
-
292
Tricyclic compounds as anticancer agents
Bristol-Myers Squibb
06/12/19
-
89
3-oxo-tetrahydro-furo[3,2-B]pyrrol-4(5H)-yl) derivatives I
Grunenthal
06/12/19
-
201
Biaryl acetamide compounds and methods of use thereof
Ambit Biosciences
06/12/19
-
3
Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone
Deuterx
06/12/19
-
5
Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
Dartmouth College
06/12/19
-
9
[4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1H-quinoxalin-7-yl)phenoxy]ethyloxy compound or salt thereof
Santen Pharmaceutical
06/12/19
-
45
CDK inhibitors
G1 Therapeutics
06/12/19
-
15
Conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as anti-tumor agents
Duquesne University of The Holy Spirit
06/12/19
-
343
Substituted pyrimidine compounds
Gruenenthal
06/12/19
-
91
Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine
Nektar Therapeutics
06/12/19
-
98
GPR40 agonists in anti-diabetic drug combinations
Janssen Pharmaceutica
06/12/19
-
38
Carboxamide derivatives
Novartis
06/12/19
-
49
N-substituted-5-substituted phthalamic acids as sortilin inhibitors
H. Lundbeck
06/12/19
-
32
Heteroaryl-pyrimidinone compounds as PDE2 inhibitors
Merck Sharp & Dohme
06/12/19
-
26
Substituted acethydrazide derivative, preparation method and use thereof
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
06/12/19
-
176
Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
Vitae Pharmaceuticals
06/04/19
-
28
2 amino-3,4-dihydrcquinazoline derivatives and the use thereof as cathepsin D inhibitors
Merck Patent
06/04/19
-
17
Glycine transporter-1 inhibitors
Amgen
06/04/19
-
6
γ-aminobutyric acid (GABA) analogues for the treatment of pain and other disorders
Novassay
06/04/19
-
9
Inhibitors of bruton's tyrosine kinase
Hoffmann-La Roche
06/04/19
-
492
AMPK-activating heterocyclic compounds and methods for using the same
Rigel Pharmaceuticals
06/04/19
-
53
Aromatic heterocyclic compounds and their application in pharmaceuticals
Sunshine Lake Pharma
06/04/19
-
573
2-Acylamidomethyl and sulfonylamidomethyl benzoxazine carbamates for inhibition of RORgamma activity and the treatment of disease
Lycera
06/04/19
-
18
5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile and therapeutic uses thereof
Cancer Research Technology
06/04/19
-
292
Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use
Merck Sharp & Dohme
06/04/19
-
308
Biaryl acyl-sulfonamide compounds as sodium channel inhibitors
Amgen
06/04/19
-
28
Substituted triazolopyridines and their use as TTK inhibitors
Bayer Pharma Aktiengesellschaft
06/04/19
-
21
Sphingosine 1-phosphate receptor antagonists
Arroyo Biosciences
06/04/19
-
224
Pyrimidine PDE10 inhibitors
Merck Sharp & Dohme
06/04/19
-
16
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals
06/04/19
-
33
Compounds useful as inhibitors of ATR kinase
Vertex Pharmaceuticals
06/04/19
-
40
3-aminocycloalkyl compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
06/04/19
-
56
BET protein-inhibiting 5-aryltriazoleazepines
Bayer Pharma Aktiengesellschaft
06/04/19
-
119
Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
Millennium Pharmaceuticals
06/04/19
-
113
Aminopyrimidinyl compounds
Pfizer
06/04/19
-
4
Factor XIa inhibitors
Merck Sharp & Dohme
06/04/19
-
22
Substituted 1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazines and methods for treating viral infections
Gilead Sciences
06/04/19
-
96
Tricyclic pyrido-carboxamide derivatives as rock inhibitors
Bristol-Myers Squibb
06/04/19
-
67
5-oxa-2-azabicyclo[2.2.2]OCTAN-4-yl and 5-oxa-2-azabicyclo[2.2.1]heptan-4-yl derivatives
Hoffmann-La Roche
06/04/19
-
33
Phosphonate compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
06/04/19
-
66
Cyclopropanecarboxylic acid derivative
Daiichi Sankyo
06/03/19
-
393
Phenyl and pyridinyl substituted piperidines and piperazines as inhibitors of IDH1 mutants and their use in treating cancer
Agios Pharmaceuticals
06/03/19
-
240
Aminopyrimidine derivatives for use as modulators of kinase activity
Merck Patent
06/03/19
-
295
Benzodioxane inhibitors of leukotriene production for combination therapy
Boehringer Ingelheim International
06/03/19
-
209
Sulfur derivatives as chemokine receptor modulators
Allergan
06/03/19
-
21
3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purpose
Sanwa Kagaku Kenkyusho
06/03/19
-
26
Acetylcholinesterase inhibitors and promnesiant serotonin 5-HT4 receptor agonists, their methods of preparation and the pharmaceutical compositions containing the same
Universite De Caen
06/03/19
-
307
RORγ modulators
Bristol-Myers Squibb
06/03/19
-
40
Substituted tricyclic heterocyclic compounds
Bristol-Myers Squibb
05/29/19
-
538
Purinones as ubiquitin-specific protease 1 inhibitors
Forma Therapeutics
05/29/19
-
207
4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors
Array Biopharma
05/29/19
-
15
Tetrahydrocarboline derivative
Ono Pharmaceutical
05/29/19
-
43
Heteroaryl compounds as 5-HT4 receptor ligands
Suven Life Sciences
05/29/19
-
55
Aminoester derivatives
Chiesi Farmaceutici
05/29/19
-
292
Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use
Merck Sharp & Dohme
05/29/19
-
23
Phenyl-dihydropyridine derivatives as inhibitors of aldosterone synthase
Hoffmann-La Roche
05/29/19
-
32
Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors
Hoffmann-La Roche
05/29/19
-
21
Heterocyclic sulfone RORγ modulators
Bristol-Myers Squibb
05/29/19
-
389
Substituted 6,5-fused bicyclic heteroaryl compounds
Epizyme
05/29/19
-
20
Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof
Shanghai Hengrui Pharmaceutical
05/29/19
-
28
Btk inhibitors
Merck Sharp & Dohme
05/29/19
-
34
Purinone compounds as kinase inhibitors
Pharmacyclics
05/29/19
-
33
Heterocyclic compounds as inhibitors of class I PI3KS
TBA
05/29/19
-
45
Substituted pyrrolopyrimidines as HDM2 inhibitors
Merck Sharp & Dohme
05/29/19
-
378
Substituted 7-azabicycles and their use as orexin receptor modulators
Janssen Pharmaceutica
05/29/19
-
10
Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
Leo Pharma
05/29/19
-
181
Non-nucleoside reverse transcriptase inhibitors
Merck Sharp & Dohme
05/26/19
-
21
Derivatives and methods of treating hepatitis B infections
Novira Therapeutics
05/26/19
-
189
Therapeutic compounds, compositions and methods of use thereof
Genentech
05/26/19
-
114
Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
Hoffmann-La Roche
05/26/19
-
171
Alkoxy compounds for disease treatment
Acucela
05/25/19
-
32
PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
Mitobridge
05/25/19
-
103
Pharmacologically active compounds
Cancer Research Technology
05/25/19
-
55
Diacylglycerol acyltransferase 2 inhibitors
Pfizer
05/25/19
-
11
Pharmaceutical compositions and methods of use of 4-pregenen-11β-17-21-triol-3,20-dione derivatives
Allergan
05/25/19
-
27
Imaging histone deacetylases with a radiotracer using positron emission tomography
The General Hospital
05/25/19
-
5
Organic compounds
Intra-Cellular Therapies
05/25/19
-
73
Substituted N,2-diarylquinoline-4-carboxamides and the use thereof as anti-inflammatory agents
Bayer Pharma Aktiengesellschaft
05/25/19
-
192
Heteroaryl compounds and uses thereof
Celgene Car
05/25/19
-
8
Metabolism probes for therapy and diagnosis
Vanderbilt University
05/25/19
-
7
Tetrahydrothiophene-based GABA aminotransferase inactivators
Northwestern University
05/25/19
-
191
SGC stimulators
Ironwood Pharmaceuticals
05/25/19
-
162
Substituted pyridines as inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (NO.5)
05/25/19
-
86
Factor IXa inhibitors
Merck Sharp & Dohme
05/25/19
-
139
Inhibiting agents for Bruton's tyrosine kinase
Biogen Ma
05/25/19
-
100
Compounds and compositions as inhibitors of MEK
Novartis
05/20/19
-
19
Multitarget FAAH and COX inhibitors and therapeutical uses thereof
Fondazione Istituto Italiano Di Tecnologia
05/20/19
-
57
Benzenesulfonamide compounds and their use as therapeutic agents
Xenon Pharmaceuticals
05/20/19
-
29
Pharmaceutically active pyrazine derivatives
Sentinel Oncology
05/20/19
-
80
Autotaxin inhibitors
Novartis
05/20/19
-
77
Oxoazetidine derivatives, process for the preparation thereof and use thereof in human medicine and in cosmetics
Galderma Research & Development
05/20/19
-
149
Compounds useful as inhibitors of ATR kinase
Vertex Pharmaceuticals
05/20/19
-
63
Fused amino pyridine as HSP90 inhibitors
Curis
05/20/19
-
10
Pyridone or pyrimidone derivative, preparation method therefor and application thereof
Sichuan Haisco Pharmaceutical
05/16/19
-
22
Heterocyclic-imidazole compounds, pharmaceutical compositions thereof, preparation method therefor and use thereof
Shanghai Huilun Life Science & Technology
05/16/19
-
59
5H-pyrido[3,2-B]indole compounds as anticancer agents
Bristol-Myers Squibb
05/16/19
-
716
Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
Array Biopharma
05/16/19
-
716
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
05/16/19
-
116
Cyclopropylamines as LSD1 inhibitors
Incyte
05/16/19
-
135
6-morpholinyl-2-pyrazolyl-9H-purine derivatives and their use as PI3K inhibitors
Daiichi Sankyo
05/16/19
-
205
Dihydropyrazolopyrimidinone compounds as PDE2 inhibitors
Merck Sharp & Dohme
05/16/19
-
110
Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof
Taiho Pharmaceutical
05/16/19
-
62
Fused pyridines as kinase inhibitors
Bristol-Myers Squibb
05/16/19
-
36
Compounds as diacylglycerol acyltransferase inhibitors
Glaxosmithkline
05/16/19
-
74
2-aryl- and 2-arylalkyl-benzimidazoles as mIDH1 inhibitors
Bayer Pharma Aktiengesellschaft
05/16/19
-
28
Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
Universite De Lille 2 Droit Et Sante
05/16/19
-
103
Histone demethylase inhibitors
Celgene Quanticel Research
05/16/19
-
10
Isoxazole carboxamides as irreversible SMYD inhibitors
Epizyme
05/16/19
-
42
Spiro-cyclic amine derivatives as S1P modulators
Abbvie
05/16/19
-
132
Melanocortin receptor-specific peptides
Palatin Technologies
05/16/19
-
121
Therapeutic compounds and uses thereof
Genentech
05/16/19
-
384
sGC stimulators
Ironwood Pharmaceuticals
05/16/19
-
200
Autotaxin inhibitors
Novartis
05/16/19
-
64
Pyrazole compound
Sumitomo Dainippon Pharma
05/16/19
-
17
Tricyclic compounds and uses thereof in medicine
Sunshine Lake Pharma
05/16/19
-
4
Inhibitors of RET
Blueprint Medicines
05/16/19
-
36
Rho kinase inhibitors
Kadmon
05/16/19
-
143
Substituted oxopyridine derivatives and use thereof cardiovascular disorders
Bayer Pharma Aktiengesellschaft
05/16/19
-
407
1,3-thiazol-2-yl substituted benzamides
Bayer Aktiengesellschaft
05/16/19
-
300
Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors
Axovant Sciences
05/16/19
-
21
Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers
Redx Pharma
05/16/19
-
78
Aryl and heteroaryl-fused tetrahydro-1,4-oxazepine amides as somatostatin receptor subtype 4 (SSTR4) agonists
Boehringer Ingelheim International
05/16/19
-
16
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D Ip
05/16/19
-
335
Pyrimido-pyridazinone compounds and methods of use thereof
Asana Biosciences
05/16/19
-
45
Triazolo[4,5-D]pyrimidines
Hoffmann-La Roche
05/16/19
-
49
Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors
Astrazeneca
05/16/19
-
258
Substituted 2-azabicycles and their use as orexin receptor modulators
Janssen Pharmaceutica
05/16/19
-
14
Oxathiolane carboxylic acids and derivatives for the treatment and prophylaxis of virus infection
Hoffmann-La Roche
05/16/19
-
12
Nuclear receptor binding agents
Gtx
05/15/19
-
28
Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
Signal Pharmaceuticals
05/15/19
-
8
Aniline derivatives, their preparation and their therapeutic application
Sanofi
05/15/19
-
61
Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
Forma Therapeutics
05/15/19
-
12
IDO inhibitors
Bristol-Myers Squibb
05/15/19
-
22
Heteroaryl compounds as sodium channel blockers
Purdue Pharma
05/15/19
-
15
2-pyridylamino-4-nitrile-piperidinyl orexin receptor antagonists
Merck Sharp & Dohme
05/15/19
-
14
Substituted piperidinyltetrahydroquinolines
Bayer Pharma Aktiengesellschaft
05/15/19
-
21
Substituted bipiperidinyl derivatives
Bayer Pharma Aktiengesellschaft
05/15/19
-
20
Inhibitors of bruton's tyrosine kinase
F. Hoffmann-La Roche
05/15/19
-
6
Substituted 6,5-fused bicyclic heteroaryl compounds
Epizyme
05/15/19
-
3
Amino-pyrimidine-containing spleen tyrosine kinase (Syk) inhibitors
Merck Sharp & Dohme
05/15/19
-
207
Compounds and methods for kinase modulation, and indications therefor
Plexxikon
05/15/19
-
156
Dihydropyrrolopyridine inhibitors of ROR-gamma
Vitae Pharmaceuticals
05/15/19
-
32
Pyrido[2,3-d]pyrimidin-4-one compounds as tankyrase inhibitors
Eli Lilly
05/15/19
-
369
Inhibitors of ERK and methods of use
Kura Oncology
05/15/19
-
24
Heterocyclic compounds and methods for their use
Novartis
05/15/19
-
15
Compounds and methods for inhibition of AP endonuclease-1/redox factor-1 (HAPE1) activity
University of Pittsburgh
05/15/19
-
277
Tricyclic heterocycles as BET protein inhibitors
Incyte
05/15/19
-
83
Heterocyclic compounds and methods of their use
Novartis
05/15/19
-
15
Pyridazinone macrocycles as IRAK inhibitors and uses thereof
Merck Patent
05/15/19
-
27
Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease
Novartis
05/15/19
-
52
Substituted quinazolines for inhibiting kinase activity
Neupharma
05/15/19
-
18
Aminoindazole derivatives as sodium channel inhibitors
Almirall
05/15/19
-
5
N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine
Glucox Biotech
05/15/19
-
17
URAT1 inhibitor
Nippon Chemiphar
05/15/19
-
589
Sulfone amide linked benzothiazole inhibitors of endothelial lipase
Bristol-Myers Squibb
05/15/19
-
6
Pyridine compounds used as PI3 kinase inhibitors
Teligene
05/15/19
-
32
Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
Pfizer
05/15/19
-
18
Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
Pfizer
05/15/19
-
98
Heterocyclic compounds, process for preparation of the same and use thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
05/15/19
-
27
Benzimidazole derivatives as kinase inhibitors
Selvita
05/15/19
-
46
Substituted heterocyclic derivative, preparation method and use thereof
Xiamen University
05/15/19
-
411
1,3-thiazol-2-yl substituted benzamides
Beyer Aktiengesellschaft
05/15/19
-
36
Thioether-piperidinyl orexin receptor antagonists
Merck Sharp & Dohme
05/10/19
-
150
4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity
Virostatics
05/08/19
-
44
Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases
Abbvie Deutschland
05/08/19
-
88
Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase
North Carolina Central University
05/08/19
-
13
Pyridin-4-yl derivatives
Actelion Pharmaceuticals
05/08/19
-
315
Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides
Pfizer
05/08/19
-
45
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
05/08/19
-
34
Inhibitors of bruton's tyrosine kinase
Hoffmann-La Roche
05/08/19
-
11
Substituted pyridinone compounds as MEK inhibitors
Cmg Pharmaceutical
05/08/19
-
60
Antibacterial cyclopental[C]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones
Janssen Ireland
05/08/19
-
86
Compounds and methods for kinase modulation, and indications therefor
Plexxikon
05/08/19
-
96
N-substituted pyrazolo [3,4-D] pyrimidine ketone compound, and preparation process and use thereof
Sun Yat-Sen University
05/08/19
-
72
Triazolo compounds
Hoffmann-La Roche
05/08/19
-
10
Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
Newlink Genetics
05/08/19
-
68
Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors
Beigene
05/08/19
-
8
Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments
Laboratories Del Dr. Esteve
05/08/19
-
216
Macrocyclic compounds as IRAK4 inhibitors for the treatment of inflammatory diseases
Biogen Ma
05/08/19
-
15
1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
Astrazeneca
05/07/19
-
77
Rho kinase inhibitors and methods of use
H. Lee Moffitt Cancer Center and Research Institute
05/07/19
-
48
Alkynyl indazole derivative and use thereof
Senju Pharmaceutical
05/07/19
-
42
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
Incyte
04/30/19
-
14
Inhibitors of CYP17A1
University of Kansas
04/30/19
-
59
Permeable glycosidase inhibitors and uses thereof
Alectos Therapeutics
04/30/19
-
259
Substituted 2-azabicycles and their use as orexin receptor modulators
Janssen Pharmaceutica
04/30/19
-
157
Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof
Bayer Pharma Aktiengesellschaft
04/30/19
-
11
Insulin sensitisers and methods of treatment
Naia Metabolic
04/30/19
-
79
Piperidine derivatives
Hoffmann-La Roche
04/30/19
-
814
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
04/30/19
-
556
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
04/30/19
-
122
2,4-diaminopyrimidine derivatives as histamine H4 modulators
Janssen Pharmaceutica
04/30/19
-
95
Combination pharmaceutical compositions and uses thereof
Intellikine
04/30/19
-
330
Arylquinazolines
Merck Patent
04/30/19
-
389
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals
04/30/19
-
15
Compounds for the treatment and prevention of retroviral infections
Kflp Biotech
04/29/19
-
12
Compounds for the treatment of addiction
Gilead Sciences
04/29/19
-
10
Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof
President and Fellows of Harvard College
04/29/19
-
93
Histone demethylase inhibitors
Celgene Quanticel Research
04/29/19
-
151
Pyridine compounds and the uses thereof
Purdue Pharma
04/29/19
-
177
Antiproliferative benzo [B] azepin-2-ones
Hoffmann-La Roche
04/29/19
-
39
1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders
Laboratorios Del Dr. Esteve
04/29/19
-
8
Oxazolidinone and imidazolidinone compounds
Hoffmann-La Roche
04/29/19
-
34
1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
Angelini Acraf
04/29/19
-
192
Substituted piperidine compounds and their use as orexin receptor modulators
Janssen Pharmaceutica
04/29/19
-
145
Therapeutic inhibitory compounds
Lifesci Pharmaceuticals
04/29/19
-
3
Substituted pyridine derivatives useful as C-FMS kinase inhibitors
Janssen Pharmaceutica
04/29/19
-
397
Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
Amgen
04/29/19
-
129
Substituted 2-azabicycles and their use as orexin receptor modulators
Janssen Pharmaceutica
04/29/19
-
79
Tropomyosin-related kinase (TRK) inhibitors
Genzyme
04/29/19
-
232
Substituted tricyclic compounds as FGFR inhibitors
Incyte Holdings
04/29/19
-
95
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
04/24/19
-
198
Alkynyl alcohols and methods of use
Genentech
04/24/19
-
15
5-aryl-1-imino-1-oxo-[1,2,4]thiadiazines
Hoffmann-La Roche
04/24/19
-
118
2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
Pfizer
04/24/19
-
21
Benzyl-1H-pyrazolo[3,4-b]pyridines and use thereof
Bayer Pharma Aktiengesellschaft
04/24/19
-
20
Macrocyclic compounds for inhibition of inhibitors of apoptosis
Ensemble Therapeutics
04/24/19
-
9
PAR4 agonist peptides
Bristol-Myers Squibb
04/24/19
-
151
Substituted triazoles useful as Axl inhibitors
Rigel Pharmaceuticals
04/24/19
-
78
Tropomyosin-related kinase (Trk) inhibitors
Genzyme
04/24/19
-
228
Substituted bicyclic compounds
Bristol-Myers Squibb
04/24/19
-
4
Psychotrophic agents and uses thereof
Lb Pharmaceuticals
04/24/19
-
9
2-oxo-3,4-dihydroquinolin-6-yl sulphonamide CPDS and their use as plant growth regulators
University of California
04/24/19
-
5
Substituted pyrimidines useful as EGFR-T790M kinase inhibitors
Jiangsu Medolution
04/24/19
-
127
Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
Northwestern University
04/24/19
-
107
Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Takeda Pharmaceutical
04/24/19
-
69
Compounds and methods for inhibiting JAK
Dizal (Jiangsu) Pharmaceutical
04/24/19
-
305
Compounds and compositions as RAF kinase inhibitors
Novartis
04/24/19
-
47
Substituted oxopyridine derivatives
Bayer Pharma Aktiengesellschaft
04/24/19
-
119
Substituted thiazole or oxazole P2X7 receptor antagonists
Axxam
04/24/19
-
5
1-(5-tert-butyl-2-aryl-pyrazol-3-yl)-3-[2-fluoro-4-[(3-oxo-4H-pyrido [2, 3-B]pyrazin- 8-yl)oxy]phenyl]urea derivatives as RAF inhibitors for the treatment of cancer
Cancer Research Technology
04/24/19
-
16
Small-molecule HSP90 inhibitors
Memorial Sloan-Kettering Cancer Center
04/24/19
-
37
Benzodiazepines as bromodomain inhibitors
Catalyst Therapeutics
04/24/19
-
76
[8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
Bayer Pharma Aktiengesellschaft
04/24/19
-
67
Sulfoximine substituted quinazolines for pharmaceutical compositions
Evotec International
04/24/19
-
111
1-(3-aminopropyl) substituted cyclic amine compounds, preparation method therefor, and pharmaceutical compositions and uses thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
04/24/19
-
25
Selective caspase inhibitors and uses thereof
Genesis Technologies
04/24/19
-
13
Substituted aminobutyric derivatives as neprilysin inhibitors
Novartis
04/23/19
-
42
Benzene or thiophene derivative and use thereof as VAP-1 inhibitor
R-Tech Ueno
04/23/19
-
26
1,2- bis-sulfonamide derivatives as chemokine receptor modulators
Allergan
04/23/19
-
27
Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors
Iteos Therapeutics
04/23/19
-
113
Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
Les Laboratoires Servier
04/23/19
-
43
IAP antagonists
Bristol-Myers Squibb
04/23/19
-
99
Highly selective sigma receptor radioligands
The University of Mississippi
04/23/19
-
12
Nuclear receptor binding agents
Gtx
04/23/19
-
2
Arylpiperazine derivatives and methods of utilizing same
Reviva Pharmaceuticals
04/23/19
-
7
Sydnonimines-specific dopamine reuptake inhibitors and their use in treating dopamine related disorders
Caliper Life Sciences
04/23/19
-
27
Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
Albany Molecular Research
04/23/19
-
251
Bicyclic thiophenylamide compounds
Hoffmann-La Roche
04/23/19
-
116
P2X7 modulators
Janssen Pharmaceutica
04/23/19
-
465
5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof
Genentech
04/23/19
-
80
Imidazopyridazines as Akt kinase inhibitors
Bayer Intellectual Property
04/23/19
-
9
CGRP receptor antagonists
Heptares Therapeutics
04/11/19
-
10
Compounds and methods for the treatment of cancer
University of Illinois
04/11/19
-
127
Nitrogen-containing saturated heterocyclic compound
Mitsubishi Tanabe Pharma
04/10/19
-
5
Ribonucleotide reductase inhibitors and methods of use
City of Hope
04/10/19
-
27
N-aralkylcarbonyl-piperazine and -homopiperazine compounds and personal care compositions comprising the same
Conopco
04/10/19
-
38
Amidoethyl azole orexin receptor antagonists
Merck Sharp & Dohme
04/10/19
-
27
Pyrazolyl-substituted heteroaryls and their use as medicaments
Boehringer Ingelheim International
04/10/19
-
12
Indazoles and use thereof
Purdue Pharma
04/10/19
-
233
Biaryl kinase inhibitors
Bristol-Myers Squibb
04/10/19
-
7
2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
Tiumbio
04/10/19
-
111
Therapeutic compounds and uses thereof
Genentech
04/10/19
-
66
Carboxamide inhibitors of IRAK4 activity
Merck Sharp & Dohme
04/10/19
-
197
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical
04/10/19
-
91
Fused azaheterocyclic compounds and their use as AMPA receptor modulators
Janssen Pharmaceutica
04/10/19
-
8
Substituted amino six-membered saturated heteroalicycles as long-acting DPP-IV inhibitors
Centaurus Biopharma
04/10/19
-
6
Screening method
Iomet Pharma
04/10/19
-
169
Somatostatin receptor subtype 4 (SSTR4) agonists
Centrexion Therapeutics
04/10/19
-
352
Inhibitors of Bruton's tyrosine kinase
Pharmacyclics
04/09/19
-
70
Inhibitors of glutaminyl cyclase
Probiodrug
04/09/19
-
17
Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof
Shanghai Yingli Pharmaceutical
04/09/19
-
65
Compounds and uses
Astrazeneca
04/09/19
-
20
Androgen receptor modulating compounds
Orion
04/09/19
-
18
Substituted aminopyrimidine compounds and methods of use
Calitor Sciences
04/09/19
-
150
Heteroaryl substituted pyridyl compounds useful as kinase modulators
Bristol-Myers Squibb
04/09/19
-
49
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
Boehringer Ingelheim International
04/09/19
-
92
Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease
Lycera
04/09/19
-
88
ASK1 inhibitor compounds and uses thereof
Seal Rock Therapeutics
04/09/19
-
29
PRMT5 inhibitors and uses thereof
Epizyme
04/09/19
-
3
1,4-pyridone bicycic heteroaryl compounds
Epizyme
04/09/19
-
224
Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor
Amgen
04/09/19
-
86
Trifluoromethyl alcohols as modulators of RORγt
Janssen Pharmaceutica
04/09/19
-
38
Histone deacetylase inhibitors and their use in therapy
Karus Therapeutics
04/09/19
-
70
Substituted benzene compounds
Epizyme
04/09/19
-
286
P2X7 modulators
Janssen Pharmaceutica
04/09/19
-
62
P2X7 modulators
Janssen Pharmaceutica
04/09/19
-
45
Therapeutic compounds and uses thereof
Genentech
04/09/19
-
10
TC-PTP inhibitors as APC activators for immunotherapy
TBA
04/09/19
-
185
Aryl- or heteroaryl-substituted benzene compounds
Epizyme
04/09/19
-
20
Antitumor compound targeting IDH2 mutation and method of use thereof
Chia Tai Tianqing Pharmaceutical Group
04/09/19
-
103
Pyrazoles
Janssen Pharmaceuticals
04/09/19
-
94
Heteroarylcarboxylic acid ester derivative
Ea Pharma
04/08/19
-
790
Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie
04/08/19
-
77
Substituted pyridines as sodium channel blockers
Purdue Pharma
04/08/19
-
54
Methods for treating depressive symptoms
Alkermes Pharma Ireland
04/08/19
-
47
Ring-contracted morphinans and the use thereof
Purdue Pharma
04/08/19
-
102
Pyrimidines as sodium channel blockers
TBA
04/08/19
-
10
Bicyclo[3.2.1]octyl amide derivatives and uses of same
H. Lundbeck
04/08/19
-
11
Mono-fluoro beta-secretase inhibitors
Astrazeneca
04/03/19
-
335
Pyridine CDK9 kinase inhibitors
Abbvie
04/03/19
-
10
Inhibitors
Probiodrug
04/03/19
-
13
Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
Allergan
04/03/19
-
37
Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
Shionogi
04/03/19
-
161
Diazepinone derivatives
Novartis
04/03/19
-
175
Benzamide-containing compounds and their use in the treatment of pain
H. Lundbeck
04/03/19
-
400
Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity
University of North Carolina At Chapel Hill
04/03/19
-
344
Bridged bicyclic kallikrein inhibitors
Global Blood Therapeutics
03/31/19
-
7
Isoxazole derivatives as FXR agonists and methods of use thereof
Elmore Patent Law Group
03/31/19
-
72
Chemical compounds
Astrazeneca
03/31/19
-
3
OCT3 activity inhibitor containing imidazopyridine derivative as active component, and OCT3 detection agent
Shin Nippon Biomedical Laboratories
03/31/19
-
6
Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof
Shenyang Sunshine Pharmaceutical
03/31/19
-
701
Alkylene derivatives
Shionogi
03/31/19
-
15
6,7-dihydropyrido[2,1-A]phthalazin-2-ones for the treatment and prophylaxis of hepatitis B virus infection
Hoffmann-La Roche
03/31/19
-
13
Carboxylic acid compounds
Sumitomo Dainippon Pharma
03/31/19
-
31
Compounds for the treatment of hepatitis C
Bristol-Myers Squibb
03/31/19
-
41
Pyrrolidine orexin receptor antagonists
Merck Sharp & Dohme
03/31/19
-
112
Pyrazolopyridine derivatives and their use in therapy
TBA
03/30/19
-
14
Fused triazole derivatives as phosphodiesterase 10A inhibitors
Celon Pharma
03/30/19
-
20
Triazolopyridines and triazolopyrazines as LSD1 inhibitors
Incyte
03/30/19
-
28
Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (NO.5)
03/30/19
-
78
Methods of treating fibrosis, cancer and vascular injuries
Ewha University—Industry Collaboration Foundation
03/30/19
-
71
Factor XIa inhibitors
Merck Sharp & Dohme
03/30/19
-
26
Pyrrolobenzodiazepines and conjugates thereof
Mersana Therapeutics
03/30/19
-
28
Immunomodulators
Bristol-Myers Squibb
03/30/19
-
407
Piperazine derivatives as liver X receptor modulators
Vitae Pharmaceuticals
03/30/19
-
5
Hydroxy-substituted amino and ammonium derivatives and their medical use
Gri Bio
03/30/19
-
1
Methods for treating cancer
Epizyme
03/30/19
-
8
Isoxazole analogs as FXR agonists and methods of use thereof
Enanta Pharmaceuticals
03/30/19
-
256
Nrf2 regulators
Glaxosmithkline
03/30/19
-
812
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
03/30/19
-
35
Pyrazolo[1,5-A]PYRAZIN-4-YL derivatives
Pfizer
03/30/19
-
520
Quinoxaline compounds and uses thereof
Millennium Pharmaceuticals
03/30/19
-
70
Chemical compounds
Astrazeneca
03/29/19
-
174
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
03/29/19
-
231
Substituted tricyclic compounds as FGFR inhibitors
Incyte
03/29/19
-
36
Bicyclic heteroaryl derivatives as CFTR potentiators
Cystic Fibrosis Foundation Therapeutics
03/29/19
-
41
Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)
Janssen Ireland
03/29/19
-
152
Tricyclic DLK inhibitors and uses thereof
Genentech
03/29/19
-
43
Vasopressin-2 receptor agonists
Ferring
03/29/19
-
65
Indanyloxydihydrobenzofuranylacetic acids
Boehringer Ingelheim International
03/29/19
-
37
Substituted indazole derivatives active as kinase inhibitiors
Nerviano Medical Sciences
03/29/19
-
7
2-oxothiazole compounds and method of using same for chronic inflammatory disorders
Avexxin
03/29/19
-
26
Benzonapthyridine compositions and uses thereof
Glaxosmithkline
03/29/19
-
48
Drugs for treating respiratory diseases
Daiichi Sankyo
03/29/19
-
79
Benzazepine dicarboxamide compounds
Hoffmann-La Roche
03/29/19
-
24
Prolyl hydroxylase inhibitors and methods of use
Akebia Therapeutics
03/29/19
-
17
SMYD2 inhibitors
Abbvie
03/29/19
-
129
Urea and amide derivatives of aminoalkylpiperazines and use thereof
Southern Research Institute
03/29/19
-
19
Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
Janssen Pharmaceutica
03/29/19
-
46
Substituted heteroaryl compounds and methods of use thereof
Sunshine Lake Pharma
03/29/19
-
44
Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
Merck Sharp & Dohme
03/29/19
-
41
Antibacterial piperidinyl substituted 3,4-dihydro-1H-[1,8]naphthyridinones
Janssen Ireland
03/29/19
-
64
Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them
Sanofi
03/29/19
-
73
Substituted benzimidazole-type piperidine compounds and uses thereof
Purdue Pharma
03/29/19
-
260
Compounds as modulators of RORγ
Boehringer Ingelheim International
03/29/19
-
83
Substituted benzothienyl-pyrrolotriazines and uses thereof in the treatment cancer
Bayer Intellectual Property
03/29/19
-
103
Imidazopyridazine compounds
Pfizer
03/29/19
-
421
Substituted 4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazine derivatives as casein kinase 1 D/E inhibitors
Bristol-Myers Squibb
03/29/19
-
4
Organic compounds
Intra-Cellular Therapies
03/29/19
-
4
Compounds useful for inhibiting ROR-gamma-t
Eli Lilly
03/29/19
-
18
Substituted bicyclic heteroaryl compounds
Bristol-Myers Squibb
03/29/19
-
158
Inhibitors of IRAK4 activity
Merck Sharp & Dohme
03/29/19
-
65
Amino compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
03/29/19
-
14
Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof
Purdue Pharma
03/29/19
-
46
1-cyclohexyl-2-phenylaminobenzimidazoles as mIDH1 inhibitors for the treatment of tumors
Bayer Pharma Aktiengesellschaft
03/29/19
-
116
Kinase inhibitors and methods of use thereof
The Broad Institute
03/29/19
-
557
Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors
Array Biopharma
03/29/19
-
6
Antibody-drug conjugates and immunotoxins
Oncomatryx Biopharma
03/29/19
-
9
Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
The University of Pittsburgh—Of The Commonwealth System of Higher Education
03/29/19
-
111
Aminoquinazoline compounds as A2A antagonist
Merck Sharp & Dohme
03/29/19
-
120
Substituted benzamides as RIPK2 inhibitors
Boehringer Ingelheim International
03/29/19
-
35
Benzimidazol-2-amines as MIDH1 inhibitors
Bayer Pharma Aktiengesellschaft
03/29/19
-
4
Isoxazole derivatives as FXR agonists and methods of use therof
Enanta Pharmaceuticals
03/29/19
-
149
Heteroaromatic compounds as BTK inhibitors
Boehringer Ingelheim International
03/29/19
-
123
Autotaxin inhibitors
Cancer Research Technology
03/29/19
-
33
Factor xia-inhibiting pyridobenzazepine and pyridobenzazocine derivatives
Bayer Pharma Aktiengesellschaft
03/29/19
-
2
Crystal of 5-hydroxy-4-(trifluoromethyl)pyrazolopyridine derivative
Daiichi Sankyo
03/29/19
-
97
Substituted benzamides as RIPK2 inhibitors
Boehringer Ingelheim International
03/29/19
-
9
Chemical compounds
Astrazeneca
03/28/19
-
70
Amido thiadiazole derivatives as NADPH oxidase inhibitors
Genkyotex Suisse
03/28/19
-
4
Compounds for treatment of cystic fibrosis
Abbvie S.á.R.L.
03/28/19
-
253
Compounds
Bayer Pharma Aktiengesellschaft
03/28/19
-
64
Neprilysin inhibitors
Theravance Biopharma R&D Ip
03/28/19
-
33
Benzofurans substituted with primary benzamide as HCV inhibitors
Bristol-Myers Squibb
03/28/19
-
97
Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
Janssen Pharmaceutica
03/28/19
-
9
[7,6]-fused bicyclic antidiabetic compounds
Merck Sharp & Dohme
03/28/19
-
34
Anti-alphavbeta1 integrin compounds and methods
University of California
03/28/19
-
405
Axl inhibitors
Pfizer
03/15/19
-
22
Compounds and compositions as protein kinase inhibitors
Array Biopharma
03/15/19
-
23
Compounds and compositions as protein kinase inhibitors
Array Biopharma
03/15/19
-
97
Triazolo[4,5-D]pyrimidine derivatives
Hoffmann-La Roche
03/15/19
-
20
Heterocyclylalkyne derivatives and their use as modulators of mGluR5 receptors
Recordati Ireland
03/15/19
-
125
Substituted imidazoles as PDE10A inhibitors
H. Lundbeck
03/14/19
-
214
Aminoquinazoline and pyridopyrimidine derivatives
Genentech
03/14/19
-
144
Cyclic amines
H. Lundbeck
03/14/19
-
165
Neprilysin inhibitors
Theravence Biopharma R&D Ip
03/14/19
-
29
5-HT3 receptor antagonists
Takeda Pharmaceutical
03/12/19
-
27
Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (NO.5)
03/12/19
-
26
Crystalline forms of a PI3K inhibitor
Incyte
03/12/19
-
83
Imide and acylurea derivatives as modulators of the glucocorticoid receptor
Bristol-Myers Squibb
03/12/19
-
14
Indole substituted pyrrolopyrimidinyl inhibitors of Uba6
Millennium Pharmaceuticals
03/12/19
-
406
Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer
Amgen
03/12/19
-
326
Tricyclic compounds as anticancer agents
Bristol-Myers Squibb
03/11/19
-
53
Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
Effector Therapeutics
03/11/19
-
7
Inhibitors of protein methyltransferase DOT1L and methods of use thereof
Epizyme
03/11/19
-
13
Pyridine and pyrazine derivative for the treatment of CF
Novartis
03/11/19
-
62
Substituted N-bicyclo-2-aryl-quinolin-4-carboxamides and use thereof
Bayer Pharma Aktiengesellschaft
03/11/19
-
20
Immune system modulators
Janus Biotherapeutics
03/11/19
-
14
Targeted therapeutics
Madrigal Pharmaceuticals
03/11/19
-
7
Isoindolinone derivatives useful as antiviral agents
Viiv Healthcare
03/11/19
-
210
Small molecule agonists of neurotensin receptor 1
Sanford Burnham Prebys Medical Discovery Institute
03/11/19
-
548
Kappa opioid ligands
The Scripps Research Institute
03/11/19
-
48
PRMT5 inhibitors and uses thereof
Epizyme
03/11/19
-
3
Nonanoic and decanoic acid derivatives and uses thereof
Scifluor Life Sciences
03/11/19
-
459
Piperidinylpyrazolopyrimidinones and their use
Bayer Pharma Aktiengesellschaft
03/11/19
-
47
Neprilysin inhibitors
Theravance Biopharma R&D Ip
03/11/19
-
20
Factor XIa inhibitors
Merck Sharp & Dohme
03/11/19
-
49
Therapeutic agent for FGFR inhibitor-resistant cancer
Taiho Pharmaceutical
03/11/19
-
7
Bromodomain inhibitors
Tensha Therapeutics
03/11/19
-
18
1- [1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
Universitat De Barcelona
03/11/19
-
10
Kinase inhibitors
Topivert Pharma
03/11/19
-
45
Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
03/11/19
-
97
Benzofuran compounds for the treatment of hepatitis C
Bristol-Myers Squibb
03/11/19
-
450
Heteroaryl compounds and their use as therapeutic drugs
Dong-A Socio Holdings
03/11/19
-
58
N-(heteroaryl)-sulfonamide derivatives useful as S100-inhibitors
Active Biotech
03/11/19
-
13
Substituted [1,2,4]triazolo[1,5-a]pyridines and substituted [1,2,4]triazolo[1,5-a]pyrazines as LSD1 inhibitors
Incyte
03/11/19
-
47
Chemical compounds
Astrazeneca
03/11/19
-
10
Benzofurans substituted with bicyclic secondary benzamide as HCV inhibitors
Bristol-Myers Squibb
03/11/19
-
30
Rho kinase inhibitors
Kadmon
03/11/19
-
2
Compounds as rearranged during transfection (RET) inhibitors
Glaxosmithkline
03/10/19
-
32
Inhibitors of SYK
Hoffmann-La Roche
03/04/19
-
248
Lactams as inhibitors of rock
Bristol-Myers Squibb
03/04/19
-
397
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
Novartis
03/04/19
-
20
Benzoxazepin oxazolidinone compounds and methods of use
Genentech
03/04/19
-
20
(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
Centrexion Therapeutics
03/04/19
-
247
Indazolyl thiadiazolamines and related compounds for inhibition of Rho-associated protein kinase and the treatment of disease
Lycera
03/04/19
-
363
P2X7 modulators and methods of use
Janssen Pharmaceutica
03/04/19
-
103
Tied-back benzamide derivatives as potent rock inhibitors
Bristol-Myers Squibb
03/04/19
-
115
Histone demethylase inhibitors
Celgene Quanticel Research
03/04/19
-
555
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
03/04/19
-
37
Heterocyclic compounds useful as inhibitors of TNF
Bristol-Myers Squibb
03/04/19
-
116
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
Incyte
03/04/19
-
28
Heterocyclic GSK-3 allosteric modulators
Consejo Superior de Investigaciones Cientificas (CSIC)
03/02/19
-
19
Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
Ono Pharmaceutical
03/02/19
-
121
Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
Bristol-Myers Squibb
03/02/19
-
11
1-(dimethylamino)ethyl-substituted 6H-benzo[C]chromen-6-ones against senile dementia
Nobel IlaÇ
03/02/19
-
17
Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie Deutschland
03/02/19
-
35
Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie Deutschland
03/02/19
-
51
Inhibitors of IRAK4 activity
Merck Sharp & Dohme
03/02/19
-
78
Aza-heteroaryl compounds as PI3K-gamma inhibitors
Incyte
03/02/19
-
25
2-pyridyloxy-3-ester-4-nitrile orexin receptor antagonists
Merck Sharp & Dohme
03/02/19
-
110
Substituted tricyclic heterocycles as histamine 4 receptor inhibitors
C&C Research Laboratories
03/02/19
-
449
Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
Janssen Pharmaceutica
03/02/19
-
4
Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
Acea Biosciences
03/02/19
-
27
Imidazole derivatives
Hoffmann-La Roche
03/02/19
-
6
Pyrrolopyrimidine compounds and uses thereof
Hutchinson Medipharma
03/02/19
-
14
Antivirals against molluscum contagiosum virus
University of Pennsylvania
03/02/19
-
315
Isoindoline derivatives for use in the treatment of a viral infection
Viiv Healthcare
03/02/19
-
13
Substituted indazoles for treating tendon and/or ligament injuries
Novartis
03/02/19
-
75
Substituted cyanoguanidines as oral anti-virals
Abbvie
03/02/19
-
19
Inhibitor of bruton's tyrosine kinase
Centaurus Biopharma
03/02/19
-
226
Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
Novartis
03/02/19
-
416
Nuclear receptor modulators
Abbvie
02/24/19
-
68
Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (NO.5)
02/24/19
-
47
Quinazoline heterocyclic compound as EGFR kinase inhibitor and preparation and application thereof
Beijing Scitech-Mq Pharmaceuticals
02/24/19
-
59
Substituted isoxazoles for treating cancer
Epizyme
02/24/19
-
9
Eckol derivatives, methods of synthesis and uses thereof
Phloronol
02/24/19
-
12
Benzimidazole derivatives as antihistamine agents
Faes Farma
02/24/19
-
237
Isoquinolin-3-yl carboxamides and preparation and use thereof
Samumed
02/24/19
-
216
Histone demethylase inhibitors
Celgene Quanticel Research
02/24/19
-
45
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
02/24/19
-
6
Aza-phenalene-3-ketone derivative, preparation method thereof, and its application as PARP inhibitor
Suzhou Kangrun Pharmaceuticals
02/24/19
-
43
Compounds inhibiting eukaryotic elongation factor 2 kinase activity
Longevica Pharmaceuticals
02/24/19
-
70
Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
Janssen Pharmaceutica
02/24/19
-
6
Preparation method for benzoxazoleoxazine ketone compound and intermediate and crystal form thereof
North China Pharmaceutical New Drug R&D
02/24/19
-
43
Substituted tetrahydrocarbazole and carbazole carboxamide compounds
Bristol-Myers Squibb
02/24/19
-
22
HCV polymerase inhibitors
Medivir
02/24/19
-
243
Triazolopyrimidine compounds and uses thereof
Novartis
02/21/19
-
72
N2-(2-methoxyphenyl)pyrimidine derivative, method for preparing same, and pharmaceutical composition for cancer prevention or treatment containing same as active ingredient
Korea Research Institute of Chemical Technology
02/21/19
-
13
Carboxymethyl piperidine derivative
Kissei Pharmaceutical
02/21/19
-
10
[5,6]—fused bicyclic antidiabetic compounds
Merck Sharp & Dohme
02/21/19
-
36
3-aryl-2H-pyrazolo[4,3-b]pyridine compounds and their use as AMPA receptor modulators
Janssen Pharmaceutica
02/21/19
-
30
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
02/21/19
-
7
Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
Abbvie Deutschland
02/21/19
-
27
JAK kinase inhibitor compounds for treatment of respiratory disease
Theravance Biopharma R&D Ip
02/21/19
-
14
Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof
Shenyang Sunshine Pharmaceutical
02/21/19
-
198
Imidazopyrimidine and imidazotriazine derivative, and pharmaceutical composition comprising the same
Sk Biopharmaceuticals
02/21/19
-
364
Fused heterocyclic compounds as CaM kinase inhibitors
Gilead Sciences
02/21/19
-
6
Organic compounds
Intra-Cellular Therapies
02/21/19
-
300
Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones
Dart Neuroscience (Cayman)
02/21/19
-
473
Inhibitors of syk and JAK protein kinases
Portola Pharmaceuticals
02/19/19
-
4
Radiolabeled compounds and their use as radiotracers for quantitative imaging of phosphodiesterase (PDE10A) in mammals
Takeda Pharmaceutical
02/19/19
-
56
C6-spiro iminothiadiazine dioxides as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
02/19/19
-
10
Substituted sulfonamide compounds
Hoffmann-La Roche
02/19/19
-
21
Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases
Galderma Research & Development
02/19/19
-
52
Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
Incyte
02/19/19
-
37
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
02/19/19
-
84
Fused pyrimidine compound or salt thereof
Taiho Pharmaceutical
02/19/19
-
13
Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
Karus Therapeutics
02/19/19
-
21
Compounds
Proximagen
02/19/19
-
295
Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
Merck Patent
02/19/19
-
101
(Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use
Bayer Pharma Aktiengesellschaft
02/18/19
-
3
Substituted benzene compounds
Epizyme
02/18/19
-
5
Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
Zhejiang Dtrm Biopharma
02/18/19
-
66
Arginase inhibitors as therapeutics
Mars
02/18/19
-
176
Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof
Sanford-Burnham Medical Research Institute
02/18/19
-
53
Condensed ring derivative, and preparation method, intermediate, pharmaceutical composition and use thereof
Shanghai Yingli Pharmaceutical
02/18/19
-
83
Amide derivatives as lysophosphatidic acid receptor antagonists
Takeda Pharmaceutical
02/18/19
-
217
Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds
Dart Neuroscience (Cayman)
01/23/19
-
37
2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection
Hoffmann-La Roche
01/23/19
-
13
Tetracyclic pyridone compounds as antivirals
Novartis
01/23/19
-
58
Factor XIa inhibitors
Merck Sharp & Dohme
01/23/19
-
11
IBAT inhibitors for the treatment of liver diseases
TBA
01/23/19
-
119
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
01/23/19
-
29
Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
Genentech
01/23/19
-
151
Inhibitors of leukotriene production
Boehringer Ingelheim International
01/23/19
-
88
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
01/23/19
-
5
Coumarin compounds as receptor modulators with therapeutic utility
Allergan
01/23/19
-
92
Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
Theravance Respiratory
01/23/19
-
89
Treatment of dry eye
Principia Biopharma
01/23/19
-
73
Benzimidazole derivatives as ITK inhibitors
Principia Biopharma
01/23/19
-
6
Bifunctional compounds and use for reducing uric acid levels
Acquist
01/22/19
-
56
MAGL inhibitors
Abide Therapeutics
01/22/19
-
292
1-pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and compositions thereof for inhibiting the activity of SHP2
Novartis
01/22/19
-
23
Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors
Bristol-Myers Squibb
01/22/19
-
5
Ghrelin O-acyl transferase inhibitors
Eli Lilly
01/22/19
-
76
Heteroaromatic compounds and their use as dopamine D1 ligands
Pfizer
01/22/19
-
14
Bifunctional compounds and use for reducing uric acid levels
Acquist
01/22/19
-
220
Sulfoximine substituted quinazolines for pharmaceutical compositions
Evotec Internatonal
01/22/19
-
89
Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof
Novartis
01/22/19
-
72
Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease
The University of Texas System
01/22/19
-
87
Piperidine derivative and preparation method and pharmaceutical use thereof
Jiangsu Hengrui Medicine
01/18/19
-
7
Necrosis inhibitors
National Institute of Biological Sciences, Beijing
01/18/19
-
167
Spiro-thiazolones
Hoffmann-La Roche
01/18/19
-
14
Piperidine compound or salt thereof
Taiho Pharmaceutical
01/18/19
-
133
Phosphatidylinositol 3-kinase inhibitors
Gilead Sciences
01/18/19
-
340
Heterocyclylamines as PI3K inhibitors
Incyte Holdings
01/18/19
-
147
Quinolone derivatives as fibroblast growth factor receptor inhibitors
Principia Biopharma
01/17/19
-
25
Substituted nicotinamide derivatives as kinase inhibitors
Allergan
01/17/19
-
22
Pyrrolopyrimidine derivatives as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman)
01/17/19
-
19
Azabicyclo derivatives, process for preparation thereof and medical use thereof
Shanghai Haiyan Pharmaceutical Technology
01/17/19
-
135
Metalloenzyme inhibitor compounds
Viamet Pharmaceuticals (Bermuda)
01/17/19
-
20
Pyrimidinone compounds and their use
Takeda Pharmaceutical
01/17/19
-
5
Aglaroxin C and derivatives as HCV entry inhibitors
Sri International
01/17/19
-
64
Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
Vtv Therapeutics
01/17/19
-
124
Tricyclic compounds as inhibitors of mutant IDH enzymes
Merck Sharp & Dohme
01/17/19
-
158
Pyridone amides as modulators of sodium channels
Vertex Pharmaceuticals
01/17/19
-
18
Agents for use in the treatment of cardiovascular and inflammatory diseases structurally based on 4(1 H)-quinolone
Ucl Business
01/17/19
-
49
Quinazolines as biogenic amine transport modulators
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health
01/17/19
-
32
Benzofurans substituted with secondary benzamide as HCV inhibitors
Bristol-Myers Squibb
01/17/19
-
160
Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor
Japan Tobacco
01/17/19
-
30
Compound as WNT signaling inhibitor, composition, and use thereof
Curegenix
01/17/19
-
122
Fused bicylic pyridine compounds and their use as AMPA receptor modulators
Janssen Pharmaceutica
01/17/19
-
91
Imidazopyridazine derivatives as PI3KB inhibitors
Janssen Pharmaceutica
01/17/19
-
192
Benzamide imidazopyrazine Btk inhibitors
Merck Sharp & Dohme
01/17/19
-
8
Cannabinoid receptor antagonists/inverse agonists useful for treating metabolic disorders, including obesity and diabetes
Jenrin Discovery
01/14/19
-
98
Bicyclo [2.2.1] acid GPR120 modulators
Bristol-Myers Squibb
01/14/19
-
103
5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum
University of Washington Through Its Center For Commercialization
01/14/19
-
168
Pyrazolopyridines and pyrazolopyrimidines
Pfizer
01/14/19
-
19
Imidazopyridyl compounds as aldosterone synthase inhibitors
Merck Sharp & Dohme
01/14/19
-
94
Substituted pyrrolo[3,4-c]pyrazoles as PKC kinase inhibitors
Pfizer
01/14/19
-
113
Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
Bristol-Myers Squibb
01/14/19
-
5
Methods of using phthalazinone ketone derivatives
Jiangsu Hansoh Pharmaceutical
01/14/19
-
105
Cyclic peptides and use as medicines
Novartis
01/14/19
-
356
Quinazolinedione derivative
Chugai Seiyaku Kabushiki Kaisha
01/14/19
-
17
Pyridazinone-amides derivatives
Merck Patent
01/14/19
-
3
Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
01/14/19
-
7
Triazolopyridyl compounds as aldosterone synthase inhibitors
Merck Sharp & Dohme
01/14/19
-
60
Pyrazolo[3,4-d]pyrimidine compounds, their preparation and use as sigma ligands
Laboratorios Del Dr. Esteve
01/14/19
-
354
Primary carboxamides as BTK inhibitors
Abbvie
01/14/19
-
19
Substituted tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-α]pyrazine-2-carboxamides as RSK inhibitors
Phoenix Molecular Designs
01/13/19
-
5
Substituted N-(pyrrolidine-3-yl)-7H-pyrrolo[2,3-D]pyrimidine-4-amine as janus kinase inhibitor
Yang Ji Chemical
01/13/19
-
12
Opioid agonists and uses thereof
Nektar Therapeutics
01/12/19
-
23
Heteroaryl compounds and uses thereof
Celgene Car
01/12/19
-
94
Factor XIa inhibitors
Merck Sharp & Dohme
01/12/19
-
35
Diamide macrocycles that are FXIa inhibitors
Bristol-Myers Squibb
01/12/19
-
49
Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof
Jiangsu Hengrui Medicine
01/12/19
-
115
Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors
Bristol-Myers Squibb
01/11/19
-
28
Bicyclic pyridine compound
Astellas Pharma
01/11/19
-
494
Bromodomain inhibitors
Celgene Quanticel Research
01/11/19
-
54
Tricyclic spiro compound
Ono Pharmaceutical
01/11/19
-
13
Substituted oxopyridine derivatives
Bayer Pharma Aktiengesellschaft
01/11/19
-
140
Substituted pyrido[3,4-b]pyrazines as GPR6 modulators
Takeda Pharmaceutical
01/11/19
-
104
Imidazopyridazine compounds
Pfizer
01/11/19
-
23
Heteroaromatic compounds and their use as dopamine D1 ligands
Pfizer
01/11/19
-
33
SHMT inhibitors
The Trustees of Princeton University
01/11/19
-
26
Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
Incyte
01/11/19
-
38
Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
Allergan
01/11/19
-
85
Thiazoles as modulators of RORγt
Janssen Pharmaceutica
01/11/19
-
243
Aminopyrimidine derivatives for use as modulators of kinase activity
Merck Patent
01/11/19
-
31
Glucocerebrosidase modulators and uses thereof
Alectos Therapeutics
01/11/19
-
150
Heteroaryl substituted pyridyl compounds useful as kinase modulators
Bristol-Myers Squibb
01/10/19
-
39
G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
The Regents of The University of Michigan
01/10/19
-
715
Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors
Array Biopharma
01/10/19
-
66
Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
Boehringer Ingelheim International
01/10/19
-
59
Aryl-cyanoguanidine compounds
Bayer Pharma Aktiengesellschaft
01/06/19
-
119
Inhibitors of lysine specific demethylase-1
Celgene Quanticel Research
01/06/19
-
312
Therapeutic inhibitory compounds
Lifesci Pharmaceuticals
01/06/19
-
131
Substituted azetidine derivatives
Hoffmann-La Roche
01/06/19
-
74
Fumagillol heterocyclic compounds and methods of making and using same
Zafgen
01/06/19
-
117
Substituted cinnolines as inhibitors of LRRK2 kinase activity
Imago Pharmaceuticals
01/05/19
-
112
Cyclic sulfone and sulfoximine analogs and uses thereof
Peloton Therapeutics
01/05/19
-
4
Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
Acetylon Pharmaceuticals
01/05/19
-
353
Fused pyrroledicarboxamides and their use as pharmaceuticals
Sanofi
01/05/19
-
4
Azaspiro[4.5] decane derivatives and use thereof
Purdue Pharma
01/05/19
-
303
TGF-beta inhibitors
Rigel Pharmaceuticals
01/05/19
-
18
Bromodomain-inhibiting compounds and pharmaceutical composition comprising same for preventing or treating a cancer
Kainos Medicine
01/05/19
-
837
FLAP modulators
Janssen Pharmaceutica
01/05/19
-
265
Spirocycle compounds and methods of making and using same
Abide Therapeutics
12/31/18
-
47
Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
Ogeda
12/31/18
-
17
Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists
Rugen Holdings (Cayman)
12/31/18
-
233
Soluble guanylate cyclase stimulators
Merck Sharp & Dohme
12/31/18
-
55
Peptide macrocycles against acinetobacter baumannii
Hoffmann-La Roche
12/31/18
-
14
Modulators of ATP-binding cassette transporters
Vertex Pharmaceuticals
12/31/18
-
243
Pyrrolidine amide compounds as histone demethylase inhibitors
Genentech
12/31/18
-
168
Pyrazolopyridines and pyrazolopyrimidines
Pfizer
12/31/18
-
76
Aza-heteroaryl compounds as PI3K-gamma inhibitors
Incyte
12/31/18
-
105
Pyrrolo[2,3-C]pyridines as imaging agents for neurofibrilary tangles
Merck Sharp & Dohme
12/31/18
-
66
Cyclobutane containing carboxylic acid GPR120 modulators
Bristol-Myers Squibb
12/31/18
-
14
Branched 3-phenylpropionic acid derivatives and their use
Bayer Pharma Aktiengesellschaft
12/31/18
-
18
Carbazole and tetrahydrocarbazole compounds useful as inhibitors of BTK
Bristol-Myers Squibb
12/31/18
-
774
Heterocyclic compounds useful as PDK1 inhibitors
Sunesis Pharmaceuticals
12/31/18
-
390
Therapeutically active compounds and their methods of use
Agios Pharmaceuticals
12/30/18
-
68
Disubstituted 1, 2, 4-triazine compound
Mitsubishi Tanabe Pharma
12/30/18
-
36
Compounds and methods of use
Medivation Technologies
12/30/18
-
85
Piperidin-1-yl and azepin-1-yl carboxylates as muscarinic M4 receptor agonists
Heptares Therapeutics
12/30/18
-
190
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
H. Lundbeck
12/25/18
-
21
1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
Incyte Holdings
12/25/18
-
22
Synergistic combination of immunologic inhibitors for the treatment of cancer
The University of Chicago
12/25/18
-
273
Inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (NO.5)
12/25/18
-
11
Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
Revivia Pharmaceuticals
12/25/18
-
108
Heterocyclic kinase inhibitors
Bristol-Myers Squibb
12/25/18
-
17
Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists
Saint Louis University
12/25/18
-
9
Quinazoline scaffold based compounds, pharmaceutical compositions and methods of use thereof
Technion Research & Development Foundation
12/25/18
-
71
Resorcinol derivative as HSP90 inhibitor
Chia Tai Tianqing Pharmaceutical Group
12/25/18
-
47
Heterocyclic derivatives and their use in the treatment of neurological disorders
Novartis
12/25/18
-
61
Fused amino pyridine as HSP90 inhibitors
Curis
12/25/18
-
61
Spirodiamine derivatives as aldosterone synthase inhibitors
Hoffmann-La Roche
12/25/18
-
18
Guanine analogs as telomerase substrates and telomere length affectors
Geron
12/25/18
-
37
Substituted indazole derivatives active as kinase inhibitiors
Nerviano Medical Sciences
12/25/18
-
42
Pyrimidine compounds as JAK kinase inhibitors
Theravance Biopharma R&D Ip
12/25/18
-
57
1,3,4-thiadiazole compounds and their use in treating cancer
Astrazeneca
12/22/18
-
17
1,3,4-thiadiazole compounds and their use in treating cancer
Astrazeneca
12/22/18
-
54
Bicyclic heterocycles as FGFR inhibitors
Incyte Holdings
12/22/18
-
167
Isoxazole derivative as mutant isocitrate dehydrogenase 1 inhibitor
Daiichi Sankyo
12/22/18
-
115
Pyrrolopyridazine inhibitors of IRAK4 activity
Merck Sharp & Dohme
12/22/18
-
109
Thienopyrazine inhibitors of IRAK4 activity
Merck Sharp & Dohme
12/22/18
-
17
Substituted imidazo[1,5-a]pyrazines as Btk inhibitors
Merck Sharp & Dohme
12/22/18
-
20
3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection
Hoffmann-La Roche
12/22/18
-
105
1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
Samumed
12/21/18
-
17
Phosphonate compounds
University of California
12/21/18
-
98
N-substituted benzamides and methods of use thereof
Genentech
12/21/18
-
15
Pyridone FabI inhibitors and uses thereof
The Research Foundation For The State University of New York
12/21/18
-
85
Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists
Boehringer Ingelheim International
12/21/18
-
55
Histone demethylase inhibitors
Celgene Quanticel Research
12/21/18
-
640
Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators
Janssen Pharmaceutica
12/21/18
-
7
Substituted pyridine derivatives useful as c-fms kinase inhibitors
Janssen Pharmaceutica
12/21/18
-
13
Diacylglycerol acyl transferase 2 inhibitors
Pfizer
12/21/18
-
3
N-sulfonyl homoserine lactone derivatives, preparation method and use thereof
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
12/21/18
-
14
Substituted oxopyridine derivatives
Bayer Pharma Aktiengesellschaft
12/21/18
-
29
Iminothiadiazine dioxides bearing an amine-linked substituent as BACE inhibitors, compositions, and their use
TBA
12/21/18
-
262
Tank-binding kinase inhibitor compounds
Gilead Sciences
12/21/18
-
109
Tetrahydronaphthyridine derivatives as mGluR2-negative allosteric modulators, compositions, and their use
TBA
12/21/18
-
103
4-azaindole derivatives
Eisai R&D Management
12/21/18
-
7
Spiro-isoquinoline-3,4′-piperidine compounds having activity against pain
Esteve Pharmaceuticals
12/21/18
-
111
Substituted 4-phenylpiperidines, their preparation and use
Columbia University
12/21/18
-
62
Ethyl N-boc piperidinyl pyrazolo pyridones as Janus kinase inhibitors
Merck Sharp & Dohme
12/21/18
-
279
Crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
Theravance Biopharma R&D Ip
12/21/18
-
27
Kinase inhibitors
Respivert
12/21/18
-
611
Tank-binding kinase inhibitor compounds
Gilead Sciences
12/21/18
-
189
Bicyclic or tricyclic heterocyclic compound
Mitsubishi Tanabe Pharma
12/12/18
-
128
Pyrrolopyrrolone derivatives and their use as BET inhibitors
Novartis
12/12/18
-
95
Indole carboxamide derivatives as P2X7 receptor antagonists
Actelion Pharmaceuticals
12/12/18
-
469
Substituted imidazoles as casein kinase 1 D/E inhibitors
Bristol-Myers Squibb
12/12/18
-
467
Substituted pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidines and JAK inhibitors comprising the same
Nissan Chemical Industries
12/12/18
-
214
Substituted imidazo[1,2-b]pyrazoles as bruton'S tyrosine kinase modulators
Beigene
12/12/18
-
45
Piperidinyloxy lactone orexin receptor antagonists
Merck Sharp & Dohme
12/12/18
-
78
Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
Merck Sharp & Dohme
12/12/18
-
137
TRPV1 antagonists including dihydroxy substituent and uses thereof
Purdue Pharma
12/12/18
-
14
2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase
Northwestern University
12/12/18
-
27
Substituted spirocycles
Boehringer Ingelheim International
12/12/18
-
45
Pyridine compounds
Daiichi Sankyo
12/12/18
-
314
ERK inhibitors
Merck Sharp & Dohme
12/12/18
-
277
Acylguanidines for treating osteoarthritis
Merck Patent
12/12/18
-
1
Salt of monocyclic pyridine derivative and crystal thereof
Eisai R&D Management
12/12/18
-
4
Purinone derivative
Ono Pharmaceutical
12/12/18
-
137
Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
Novartis
12/11/18
-
18
2-amino-5,5-difluoro-6-(fluoromethyl)-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
H. Lundbeck
12/11/18
-
3
Imidazo[1,2-α]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
12/11/18
-
582
Methods of treating heart failure
Amgen
12/11/18
-
144
Antidiabetic compounds
Merck Sharp & Dohme
12/11/18
-
35
LSD1 inhibitors
Mirati Therapeutics
12/11/18
-
44
Histone demethylase inhibitors
Celgene Quanticel Research
12/11/18
-
9
Protein tyrosine kinase modulators and methods of use
Betta Pharmaceuticals
12/11/18
-
21
2-amino-3,5-difluoro-3,6-dimethyl-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treating alzheimer's disease
H. Lundbeck
12/11/18
-
37
Cot modulators and methods of use thereof
Gilead Sciences
12/11/18
-
174
Acyclic cyanoethylpyrazolo pyridones as janus kinase inhibitors
Merck Sharp & Dohme
12/11/18
-
28
Compounds
Elanco Tiergesundheit
12/11/18
-
296
3-substituted 2-amino-indole derivatives
Takeda Pharmaceutical
12/11/18
-
148
Pyridine derivative
Astellas Pharma
12/11/18
-
13
Compounds for use in methods for treating diseases or conditions mediated by protein disulfide isomerase
Beth Israel Deaconess Medical Center
12/11/18
-
41
Macrocyclic pyridazinone derivatives
Merck Patent
12/11/18
-
74
Compounds and compositions for treating HIV with derivatives of Betulin
Glaxosmithkline
12/11/18
-
42
Quinolinone compound and use thereof
Sunshine Lake Pharma
12/11/18
-
554
Aminotriazine derivative and pharmaceutical composition comprising the same
Shionogi
12/11/18
-
9
Isoquinoline derivatives as MGAT2 inhibitors
Merck Sharp & Dohme
12/11/18
-
88
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
12/11/18
-
17
Imidazo[1,2-A]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication
Viiv Healthcare UK (NO.5)
12/11/18
-
353
Substituted thiazoles as HIV integrase inhibitors
Japan Tobacco
12/11/18
-
31
Chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Ogeda
12/11/18
-
239
Heterocyclic compounds as PI3K-γ inhibitors
Incyte
12/11/18
-
43
Compounds that are ERK inhibitors
Merck Sharp & Dohme
12/11/18
-
210
Tricyclic PI3K inhibitor compounds and methods of use
Genentech
12/11/18
-
20
Substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
Hoffmann-La Roche
12/11/18
-
952
[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
Bristol-Myers Squibb
12/11/18
-
629
N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals
Sanofi
12/10/18
-
97
Imidazolin-5-one derivative useful as FASN inhibitors for the treatment of cancer
Janssen Pharmaceutica
12/10/18
-
86
Substituted aza-bicyclic imidazole derivatives useful TRPM8 receptor modulators
Janssen Pharmaceutica
11/29/18
-
48
Macrocyclic compounds as Trk kinase inhibitors
Array Biopharma
11/29/18
-
483
BTK Inhibitors
Merck Sharp & Dohme
11/29/18
-
20
Selective glycosidase inhibitors and uses thereof
Alectos Therapeutics
11/29/18
-
431
2-(morpholin-4-yl)-1,7-naphthyridines
Bayer Pharma Aktiengesellschaft
11/29/18
-
91
Keto-imidazopyridine derivatives as RORc modulators
Genentech
11/29/18
-
95
Substituted triazolopyridines and methods of use thereof
Genentech
11/29/18
-
123
Substituted thiazole or oxazole P2X7 receptor antagonists
Axxam
11/28/18
-
111
Cyclopropanamine compound and use thereof
Takeda Pharmaceutical
11/28/18
-
181
Non-nucleoside reverse transcriptase inhibitors
Merck Sharp & Dohme
11/28/18
-
2236
Triazine derivative and pharmaceutical composition having an analgesic activity comprising the same
Shionogi
11/27/18
-
99
Isoxazoline hydroxamic acid derivatives as LpxC inhibitors
Novartis
11/27/18
-
136
Isoxazole compounds as inhibitors of heat shock proteins
The Institute of Cancer Research
11/27/18
-
111
Chromenone derivatives
Astrazeneca
11/27/18
-
373
Unsaturated nitrogen heterocyclic compounds useful as PDE10 inhibitors
Amgen
11/27/18
-
140
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
11/27/18
-
82
Bisarylsulfonamides useful in the treatment of inflammation and cancer
Kancera
11/27/18
-
48
Aniline derivative, pharmaceutical composition containing same, and use thereof
Kissei Pharmaceutical
11/16/18
-
6
Substituted pyridines as sodium channel blockers
TBA
11/16/18
-
9
Poly (ADP-ribose) polymerase inhibitor
Chengdu Diao Pharmaceutical Group
11/16/18
-
356
Methods for treating pulmonary emphysema using substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
Boehringer Ingelheim International
11/15/18
-
30
Compounds for treatment of cancer
Curegenix
11/15/18
-
55
Compositions, methods, and systems for the synthesis and use of imaging agents
Lantheus Medical Imaging
11/15/18
-
217
Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof
Sanofi
11/15/18
-
7
Heterocyclic compounds and methods of their use
Novartis
11/15/18
-
38
Substituted piperazine compounds and methods of use thereof
Sunshine Lake Pharma
11/15/18
-
33
Carbazole carboxamide compounds
Bristol-Myers Squibb
11/15/18
-
20
Quinazoline derivatives, compositions thereof, and use as pharmaceuticals
Shanghai Fochon Pharmaceutical
11/15/18
-
69
Compounds and methods for inhibiting JAK
Astrazeneca
11/15/18
-
110
Cyclopropanamine compound and use thereof
Takeda Pharmaceutical
11/15/18
-
7
Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists
Bayer Intellectual Property
11/15/18
-
33
Substituted pyrido[4,3-d]pyrimidines as Wee-1 inhibitors
Almac Discovery
11/15/18
-
147
Multiple kinase pathway inhibitors
Tolero Pharmaceuticals
11/15/18
-
33
Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease
Novartis
11/15/18
-
7
Cyclic sulfonamides as sodium channel blockers
Purdue Pharma
11/15/18
-
46
Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3)
Bayer Pharma Aktiengesellschaft
11/15/18
-
14
Spirocyclic CETP inhibitors
Merck Sharp & Dohme
11/15/18
-
5
Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
Zhejiang Dtrm Biopharma
11/15/18
-
133
Plasminogen activator inhibitor-1 inhibitors and methods of use thereof
University of Michigan
11/15/18
-
77
Benzoisothiazole compounds and methods of treating schizophrenia
Shanghai Institute of Pharmaceutical Industry
11/08/18
-
73
4-oxo-3,4-dihydro-1,2,3-benzotriazine modulators of GPR139
Takeda Pharmaceutical
11/08/18
-
59
Inhibitors of bruton's tyrosine kinase
F. Hoffmann-La Roche
11/08/18
-
51
Azapeptides as CD36 binding compounds
Valorisation-Recherche, Limited Partnership
11/07/18
-
114
Heterocyclic derivates
Kalvista Pharmaceuticals
11/07/18
-
24
Compounds and methods for skin repair
Allergan
11/07/18
-
526
Substituted benzamides and methods of use thereof
Genentech
11/07/18
-
825
Metallo-beta-lactamase inhibitors
Merck Sharp & Dohme
11/05/18
-
36
Aryl amide-based kinase inhibitors
Bristol-Myers Squibb
11/05/18
-
48
Urea derivatives and their use as fatty-acid binding protein (FABP) inhibitors
Hoffmann-La Roche
11/05/18
-
131
Pyrrolopyrimidine nucleosides and analogs thereof
Chimerix
11/05/18
-
34
Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors
Incyte
11/01/18
-
23
Flouro-naphthyl derivatives
Hoffmann-La Roche
10/31/18
-
8
Arylcyclopropylamine based demethylase inhibitors of LSD1 and their medical use
Oryzon Genomics
10/31/18
-
143
Benzimidazole derivatives as EP4 antagonists
Bayer Pharma Aktiengesellschaft
10/31/18
-
139
Substituted pyrido[3,4-b]pyrazines as GPR6 modulators
Takeda Pharmaceutical
10/31/18
-
187
Bicyclic heterocycles as FGFR4 inhibitors
Incyte
10/31/18
-
45
Sulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
Hoffmann-La Roche
10/31/18
-
40
Tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis B virus infection
Hoffmann-La Roche
10/30/18
-
56
P2X7 modulators
Janssen Pharmaceutica
10/30/18
-
125
Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
Janssen Pharmaceutica
10/30/18
-
93
Pyrrolopyrimidine derivatives as TAM inhibitors
Incyte
10/30/18
-
17
Azabenzimidazole derivatives
Boehringer Ingelheim International
10/30/18
-
3
Kappa opioid receptor compounds
Medisynergies
10/30/18
-
16
Therapeutic hydroxyquinolones
Rutgers, The State University of New Jersey
10/30/18
-
11
Sulfonamide retinoic acid receptor-related orphan receptor modulators and uses thereof
Innov17
10/30/18
-
19
Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists
Merck Sharp & Dohme
10/30/18
-
91
Pyrazolyl-ureas as kinase inhibitors
Respivert
10/30/18
-
73
Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders
Bristol-Myers Squibb
10/30/18
-
13
Spiropyrrolidines as MDM2 inhibitors
Hudson Biopharma
10/30/18
-
25
Thienopyrimidine compounds
Hoffmann-La Roche
10/30/18
-
4
Selective glycosidase inhibitors and uses thereof
Alectos Therapeutics
10/30/18
-
15
S1P receptors modulators and their use thereof
Akaal Pharma
10/30/18
-
352
Heterocyclylamines as PI3K inhibitors
Incyte Holdings
10/30/18
-
123
Cyclohexyl sulfone RORγ modulators
Bristol-Myers Squibb
10/30/18
-
21
Cyclohexyl pyridine derivative
Kissei Pharmaceutical
10/30/18
-
12
ROR modulators and their uses
Innov17
10/30/18
-
7
Process for making isoquinoline compounds
Fibrogen
10/30/18
-
89
Substituted spiropiperidinyl compounds useful as GPR120 agonists
Merck Sharp & Dohme
10/30/18
-
22
Inhibitors of α-amino-β-carboxymuconic acid semialdehyde decarboxylase
Tes Pharma
10/30/18
-
298
Sulfoximine substituted quinazolines for pharmaceutical compositions
Evotec International
10/30/18
-
11
Heterocyclic compounds and methods for their use
Novartis
10/30/18
-
50
2-acylaminothiazoles for the treatment of cancer
UniversitÁ
10/30/18
-
41
Substituted 2-aminopyridine protein kinase inhibitor
Chia Tai Tianqing Pharmaceutical Group
10/30/18
-
151
Substituted pyrrolo[3,4-d]pyrimidines as kinase inhibitors
Novartis
10/19/18
-
434
Heterocyclic ring and carbocyclic derivative
Shionogi
10/19/18
-
247
Tetrahydro-benzodiazepinones
Hoffmann-La Roche
10/18/18
-
10
Androgen receptor antagonists
University of California
10/18/18
-
22
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
10/18/18
-
88
Carbazole compounds useful as bromodomain inhibitors
Bristol-Myers Squibb
10/18/18
-
22
Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitors
Ab Science
10/18/18
-
111
Cyclopropanamine compound and use thereof
Takeda Pharmaceutical
10/18/18
-
107
Pyrimidine-2,4-diamine derivative and anticancer pharmaceutical composition comprising same as effective ingredient
Korea Research Institute of Chemical Technology
10/18/18
-
101
Substituted triazolopyridines
Bayer Intellectual Property
10/17/18
-
26
Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
University of Utah Research Foundation
10/17/18
-
168
Amino-dihydrothiazine and amino-dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
Amgen
10/17/18
-
245
6-substituted phenoxychroman carboxylic acid derivatives
Array Biopharma
10/17/18
-
5
Metalloenzyme inhibitor compounds
Viamet Pharmaceuticals
10/17/18
-
29
N-cyanomethylamides as inhibitors of janus kinase
Cadila Healthcare
10/17/18
-
60
N-alkylated indole and indazole compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
10/17/18
-
158
Imidazopyridines and imidazopyrazines as LSD1 inhibitors
Incyte
10/17/18
-
7
C17-aryl substituted betulinic acid analogs
Viiv Healthcare UK (NO.5)
10/17/18
-
328
Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B
Cadent Therapeutics
10/17/18
-
46
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and thier use as pharmaceutical compositions
Boehringer Ingelheim International
10/10/18
-
12
2-amino-6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
H. Lundbeck
10/10/18
-
11
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
10/10/18
-
21
(R)-2-methyl-piperazine derivatives as CXCR3 receptor modulators
Idorsia Pharmaceuticals
10/10/18
-
37
Imidazolone derivatives, pharmaceutical compositions and uses thereof
Beijing Forelandpharma
10/10/18
-
102
Substituted imidazo[1,2-B]pyridazines as protein kinase inhibitors
Tolero Pharmaceuticals
10/10/18
-
30
Aminoquinazoline derivatives and their salts and methods of use thereof
Sunshine Lake Pharma
10/05/18
-
37
Guanidine compound
Astellas Pharma
10/03/18
-
3
Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy
Donesta Bioscience
10/03/18
-
23
PPAR-sparing compounds for the treatment of metabolic diseases
Metabolic Solutions Development
10/03/18
-
91
Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
Janssen Pharmaceutica
10/02/18
-
216
Substituted pyridobenzodiazepinone-derivatives and use thereof
Bayer Pharma Aktiengesellschaft
10/02/18
-
105
Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Array Biopharma
10/02/18
-
90
C5-C6-oxacyclic fused iminopyrimidinone compounds as bace inhibitors, compositions, and their use
Merck Sharp & Dohme
10/02/18
-
313
Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
Bristol-Myers Squibb
10/02/18
-
11
Substituted pyrazolopyrimidinylamino-indazoles
Bayer Pharma Aktiengesellschaft
09/30/18
-
1155
2,6,7,8 substituted purines as HDM2 inhibitors
Merck Sharp & Dohme
09/26/18
-
4
Enhancer of zeste homolog 2 inhibitors
Glaxosmithkline
09/26/18
-
3
Substituted-1H-benzo[d]imidazole series compounds as lysine-specific demethylase 1 (LSD1) inhibitors
University of Utah Research Foundation
09/26/18
-
115
2-pyridyloxy-3-substituted-4-nitrile orexin receptor antagonists
Merck Sharp & Dohme
09/18/18
-
427
Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators
Bristol-Myers Squibb
09/18/18
-
52
Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5
Vanderbilt University
09/18/18
-
23
Tertiary amines for use in the treatment of cardiac disorders
Universitetet I Oslo
09/18/18
-
71
PDE9 inhibitors with imidazo triazinone backbone
TBA
09/18/18
-
15
Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity
Shionogi
09/07/18
-
26
Kinase modulating compounds, compositions containing the same and use thereof
Centaurus Biopharma
09/07/18
-
39
Tetrazole derivatives and their use as potassium channel modulators
Saniona
09/07/18
-
10
2-pyridyloxy-4-ester orexin receptor antagonists
Merck Sharp & Dohme
09/07/18
-
7
Inhibitors of bruton's tyrosine kinase
Hoffmann-La Roche
09/07/18
-
38
6-arylamino pyridone carboxamide as MEK inhibitors
Centaurus Biopharma
08/28/18
-
28
ERK inhibitors
Merck Sharp & Dohme
08/28/18
-
5
Complement pathway modulators and uses thereof
Novartis
08/28/18
-
76
HSPC-sparing treatments for RB-positive abnormal cellular proliferation
Gi Therapeutics
08/25/18
-
2
Dihydropyrido pyrimidine compounds as autotaxin inhibitors
Eli Lilly
08/25/18
-
272
Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
Novartis
08/24/18
-
110
(1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases
Boehringer Ingelheim International
08/24/18
-
14
Substituted 1,7-naphthyridines as dopamine D1 ligands
Pfizer
08/16/18
-
79
Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof
Jiangsu Hengrui Medicine
08/16/18
-
267
7-hydroxy-indolinyl antagonists of P2Y1 receptor
Bristol-Myers Squibb
08/16/18
-
19
15-aryl prostaglandins as EP4 agonists, and methods of use thereof
Allergan
08/16/18
-
56
P2X7 modulators
Janssen Pharmaceutica
08/16/18
-
174
Azole derivative
Taisho Pharmaceutical
08/07/18
-
3
Compounds useful for producing an optically active diazabicyclooctane compound
Meiji Seika Pharma
08/07/18
-
166
Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of metabotropic glutamate receptor 3
Vanderbilt University
08/07/18
-
105
Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
Array Biopharma
08/07/18
-
4
Pharmacologically active compounds
The University of Liverpool
08/07/18
-
2
Pyrimido-diazepinone compounds and methods of treating disorders
Dana-Farber Cancer Institute
08/07/18
-
32
Toll-like receptor 2-agonistic lipopeptides, and method of making the same
University of Kansas
08/07/18
-
29
5-HT3 receptor antagonists
Takeda Pharmaceutical
08/07/18
-
12
Heteroaryl compounds and methods of use thereof
Sunovion Pharmaceuticals
08/07/18
-
84
Fused tricyclic amide compounds as multiple kinase inhibitors
Beigene
08/07/18
-
2
Modified biotin, mutant streptavidin, and use thereof
Savid Therapeutics
08/07/18
-
14
Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
Sanofi
08/07/18
-
64
Fused thiazin-3-ones as KCA3.1 inhibitors
Boehringer Ingelheim International
08/07/18
-
19
Benzimidazole tetrahydrofuran derivatives
Merck Sharp & Dohme
08/07/18
-
27
Substituted spirocycles
Boehringer Ingelheim International
08/07/18
-
58
Pyrrolidino heterocycles
Hoffmann-La Roche
08/07/18
-
101
Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors
Beigene
07/07/18
-
208
Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Galapagos
07/07/18
-
48
Serine/threonine kinase inhibitors
Array Biopharma
07/07/18
-
24
Muscarinic agonists
Acadia Pharmaceuticals
07/07/18
-
116
Cyclopropylamines as LSD1 inhibitors
Incyte
07/07/18
-
45
Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
Hoffmann-La Roche
07/07/18
-
188
Inhibitors of PI3K-delta and methods of their use and manufacture
Exelixis
07/07/18
-
34
Pteridine ketone derivative and applications thereof as EGFR, BLK, and FLT3 inhibitor
East China University of Science and Technology
07/07/18
-
200
Small molecule myristate inhibitors of Bcr-abl and methods of use
Dana-Farber Cancer Institute
07/07/18
-
33
Cannabinoid-2 agonists
Allergan
07/07/18
-
21
Fused heterocyclic derivatives as S1P modulators
Abbvie
07/07/18
-
65
Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors
Arrien Pharmaceuticals
05/19/18
-
110
Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors
H. Lundbeck
05/19/18
-
182
MNK inhibitors and methods related thereto
Effector Therapeutics
05/19/18
-
84
4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group
Bayer Intellectual Property
05/19/18
-
32
Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl-[1,2,4]triazolo-[4,3-A]]quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological of metabolic disorders
Janssen Pharmaceutica
05/19/18
-
13
Cyclosporin analogues for preventing or treating hepatitis C infection
Enanta Pharmaceuticals
05/19/18
-
57
(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
Oryzon Genomics
05/19/18
-
170
1,3-diaminocyclopentane carboxamide derivatives
Merck Patent
05/19/18
-
121
Benzylamine derivatives
Kalvista Pharmaceuticals
05/19/18
-
5
5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group
Bayer Pharma Aktiengesellschaft
05/19/18
-
273
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
Boehringer Ingelheim International
05/19/18
-
83
Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
Allergan
05/19/18
-
115
Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors
Nerviano Medical Sciences
05/19/18
-
46
Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
Novartis
05/19/18
-
39
Substituted aminopyrimidine compounds and methods of use
Calitor Sciences
05/19/18
-
3
Glycosidase inhibitors and uses thereof
Alectos Therapeutics
05/19/18
-
12
Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors
Merck Sharp & Dohme
05/19/18
-
104
Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
Pfizer
05/19/18
-
21
Substituted triazolopyridines
Bayer Pharma Aktiengesellschaft
05/19/18
-
33
BET bromodomain inhibitors and therapeutic methods using the same
The Regents of The University of Michigan
04/16/18
-
95
Cyclopropylamine derivatives useful as LSD1 inhibitors
Oryzon Genomics
04/16/18
-
6
Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
Cayman Chemical
04/16/18
-
29
Substituted biaryl compound
Ube Industries
04/16/18
-
111
Compounds and compositions for the inhibition of NAMPT
Forma Tm
04/16/18
-
17
2-benzyl-benzimidazole complement factor B inhibitors and uses thereof
Novartis
04/16/18
-
74
Ethynyl derivatives
Hoffmann-La Roche
04/16/18
-
115
Piperidine/piperazine derivatives
Janssen Pharmaceutica
04/12/18
-
160
Inhibitors of sodium glucose cotransporter 1
Lexicon Pharmaceuticals
04/12/18
-
21
Polyetherimide compositions and methods for the manufacture and use thereof
Sabic Global Technologies
04/12/18
-
45
Substituted thiazolopyrimidines
Bayer Pharma Aktiengesellschaft
04/12/18
-
329
PRMT5 inhibitors and uses thereof
Epizyme
04/12/18
-
7
Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-C]quinolines
Bayer Intellectual Property
04/12/18
-
64
Tyrosine kinase inhibitors
Principia Biopharma
03/27/18
-
36
Oxindole compounds carrying a nitrogen-bound spiro substituent and use thereof for treating vasopressin-related diseases
Abbvie Deutschland
03/27/18
-
313
Compositions useful for treating disorders related to kit
Blueprint Medicines
03/27/18
-
30
Substituted condensed pyrimidine compounds
GrÜNenthal
03/27/18
-
162
Substituted tetrazolo[1,5-a]pyrazines as ROR-gamma inhibitors
Merck Patent
03/27/18
-
312
Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
Bristol-Myers Squibb
03/27/18
-
50
Substituted pyrroles active as kinases inhibitors
Nerviano Medical Sciences
03/19/18
-
2
Modulators of fatty acid amide hydrolase
Janssen Pharmaceutica
03/19/18
-
72
Long chain base sphingosine kinase inhibitors
University of Virginia Patent Foundation
03/19/18
-
113
Oxazolidinones as modulators of mGluR5
Bristol-Myers Squibb
03/19/18
-
375
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
Novartis
03/19/18
-
2
Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
SRMLSC
03/16/18
-
28
Inhibitors of indoleamine 2,3-dioxygenase (IDO)
SRMLSC
03/16/18
-
1
Methods for treating seizure disorders and pain
University of California
03/16/18
-
518
Anti-fibrotic pyridinones
SRMLSC
03/16/18
-
23
Arylpyrrolopyridine derived compounds as LRRK2 inhibitors
H. Lundbeck
03/16/18
-
83
Substituted naphthyridine and quinoline compounds as MAO inhibitors
Dart Neuroscience (Cayman)
03/16/18
-
25
Macrocyclic urea and sulfamide derivatives as inhibitors of TAFIa
Sanofi
03/16/18
-
47
Substituted pyrazines as GPR40 agonists
Janssen Pharmaceutica
03/12/18
-
325
Triazine derivative and pharmaceutical composition comprising the same
Shionogi
03/12/18
-
8
Opioid agonists and uses thereof
Nektar Therapeutics
03/11/18
-
66
BMP inhibitors and methods of use thereof
The Brigham and Women'S Hospital
03/10/18
-
91
Tricyclic compounds for use as kinase inhibitors
FundaciÓN Centro Nacional De Investigaciones Oncologicas Carlos Iii
03/10/18
-
11
Anticancer compounds
St. Jude Children'S Research Hospital
03/10/18
-
122
Amino-substituted isothiazoles
Bayer Pharma Aktiengesellschaft
03/10/18
-
34
Quinuclidine derivatives and medicinal compositions containing the same
Almirall
03/10/18
-
390
Multisubstituted aromatic compounds as serine protease inhibitors
Verseon
03/10/18
-
2
Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors
Bioaxone Biosciences
03/10/18
-
11
Iminothiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
Ambit Biosciences
03/10/18
-
99
Benzimidazole inhibitors of the sodium channel
SRMLSC
03/10/18
-
6
DP2 antagonist and uses thereof
NMMLSC
03/10/18
-
223
Indole carboxamide compounds
Bristol-Myers Squibb
03/10/18
-
216
1,2,5-Substituted benzimidazoles as flap modulators
Janssen Pharmaceutica
02/14/18
-
83
Positive allosteric modulators of mGluR2
Bristol-Myers Squibb
02/14/18
-
296
Protein kinase C inhibitors and uses thereof
Rigel Pharmaceuticals
02/14/18
-
6
Ethynyl derivatives
Hoffmann-La Roche
02/13/18
-
127
Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
Endorecherche
02/13/18
-
26
Quinazoline derivative
Carna Biosciences
02/13/18
-
16
Pyridine derivatives as soft rock inhibitors
Redx Pharma
02/13/18
-
75
Fumagillol heterocyclic compounds and methods of making and using same
Zafgen
02/13/18
-
547
Kappa opioid ligands
The Scripps Research Institute
02/13/18
-
49
N-substituted-5-substituted phthalamic acids as sortilin inhibitors
H. Lundbeck
02/13/18
-
98
Piperidinyl-indole derivatives complement factor B inhibitors and uses thereof
Novartis
02/13/18
-
26
Phthalazinone compounds and methods for the treatment of cystic fibrosis
Flatley Discovery Lab
02/13/18
-
35
Series of skin-whitening (lightening) compounds
Unigen
02/07/18
-
236
Indazole derivatives useful as CB-1 inverse agonists
Janssen Pharmaceutica
02/07/18
-
586
Combination of kinase inhibitors and uses thereof
Intellikine
02/07/18
-
95
Amide compounds, compositions and applications thereof
Advinus Therapeutics
02/07/18
-
140
Quinazoline derivatives useful as CB-1 inverse agonists
Janssen Pharmaceutica
02/07/18
-
95
Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
Theravance Respiratory
02/07/18
-
30
Bisaryl-bonded aryltriazolones and use thereof
Bayer Intellectual Property
02/07/18
-
151
5-HT3 receptor antagonists
Takeda Pharmaceutical
02/06/18
-
6
Glycosidase inhibitors and uses thereof
Alectos Therapeutics
02/06/18
-
92
Heterocyclic ITK inhibitors for treating inflammation and cancer
Confluence Life Sciences
02/06/18
-
53
Amide compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals
02/06/18
-
41
3,4-dihydro-2H-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds
Hoffmann-La Roche
01/26/18
-
38
3,4-dihydro-2H-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds
Hoffmann-La Roche
01/26/18
-
36
Piperazine derivatives for treating disorders
The University of Nottingham
01/26/18
-
38
Thiazole orexin receptor antagonists
Merck Sharp & Dohme
01/26/18
-
55
Inhibitors of the fibroblast growth factor receptor
Blueprint Medicines
01/26/18
-
13
Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
Incyte
01/26/18
-
158
Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors
Incyte
01/26/18
-
199
Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase
Fibrogen
01/26/18
-
5
Diazepane derivatives and uses thereof
Dana-Farber Cancer Institute
01/26/18
-
8
Inhibitor of breast cancer resistance protein (BCRP)
Millennium Pharmaceuticals
01/26/18
-
51
Highly selective c-Met inhibitors as anticancer agents
Cb Therapeutics
01/26/18
-
4
Substituted imidazo[1,5-a]pyrazines as CGRP receptor antagonists
Bristol-Myers Squibb
01/26/18
-
17
Methods and compositions for inhibition of bromodomain-containing proteins
Convergene
01/26/18
-
119
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
Incyte
01/26/18
-
6
Hydroximic acid derivatives and medical applications therof
Double Rider Medicine
01/26/18
-
266
Substituted 7-azabicycles and their use as orexin receptor modulators
Janssen Pharmaceutica
01/26/18
-
5
Synthetic methods for spiro-oxindole compounds
Xenon Pharmaceuticals
01/26/18
-
18
Benzoxazinone derivatives for treatment of skin diseases
Sixera Pharma
01/26/18
-
2
Substituted pyrazolopyrimidines as kinases inhibitors
Jiangsu Medolution
01/19/18
-
38
Pyrazol derivatives
Hoffmann-La Roche
01/19/18
-
10
Methods for the treatment of locally advanced breast cancer
Celgene
01/19/18
-
1061
Biaryl amide compounds as kinase inhibitors
Novartis
01/19/18
-
12
IBAT inhibitors for the treatment of liver disease
Albireo
01/19/18
-
7
Methods of treating retroviral infections and related dosage regimes
Chimerix
01/19/18
-
382
Benzamide derivative
Chugai Seiyaku Kabushiki Kaisha
01/19/18
-
13
Ethynyl derivatives
Hoffmann-La Roche
01/19/18
-
50
Substituted uracils as chymase inhibitors
Bayer Pharma Aktiengesellschaft
01/19/18
-
190
Heteroaryl compounds and uses thereof
Celgene Car
01/19/18
-
217
1,2,6-substituted benzimidazoles as flap modulators
Janssen Pharmaceutica
01/19/18
-
249
IRE-1α inhibitors
Mannkind
01/14/18
-
293
Antiviral compounds
Hoffmann-La Roche
01/14/18
-
574
Substituted benzamides and methods of use thereof
Genentech
01/14/18
-
45
Selective inhibition of MALT1 protease by phenothiazine derivatives
Helmholtz Munich
12/04/17
-
54
2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment
Merck Sharp & Dohme
12/04/17
-
25
Benzimidazole tetrahydropyran derivatives
Merck Sharp & Dohme
12/04/17
-
119
Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
Zhejiang Dtrm Biopharma
12/04/17
-
6
Materials and method for inhibiting replication protein A and uses thereof
Indiana University Research and Technology
12/04/17
-
104
Sulfonamide derivative and medicinal use thereof
Ea Pharma
12/04/17
-
116
Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors
Ziarco Pharma
12/04/17
-
145
Quinazolinone compounds and derivatives thereof
Amgen
11/27/17
-
169
Purine derivatives as CB2 receptor agonists
Hoffmann-La Roche
11/27/17
-
77
Kinase inhibitors
University of California
11/27/17
-
28
Thienopyranones as kinase and epigenetic inhibitors
Signal Rx Pharmaceuticals
11/27/17
-
29
Inhibitors
Probiodrug
11/27/17
-
47
[1,2,4] triazol [4,3-A] pyridine derivative, preparation method therefor or medical application thereof
Jiangsu Hansoh Pharmaceutical
11/27/17
-
37
Pyrazole compounds as CB2 agonists
Hoffmann-La Roche
11/27/17
-
42
Pyrazine derivatives as CB2 receptor agonists
Hoffmann-La Roche
11/27/17
-
48
Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)
Indiana University Research and Technology
11/27/17
-
90
Pyridine derivatives
Hoffmann-La Roche
11/27/17
-
8
Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon
Obshchestvo S Ogranichennoy Otvetstvennostyou “Fusion Pharma”
11/27/17
-
112
Diazaspirocycloalkane and azaspirocycloalkane
Hoffmann-La Roche
11/20/17
-
10
Boron-containing small molecules
Anacor Pharmaceuticals
11/20/17
-
247
Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
Bristol-Myers Squibb
11/20/17
-
42
4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amines containing a sulfoximine group
Bayer Pharma Aktiengesellschaft
11/20/17
-
363
5-substituted iminothiazines and their mono- and dioxides as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
11/20/17
-
64
Amino-substituted imidazopyridazines
Bayer Intellectual Property
11/20/17
-
76
Enhancer of zeste homolog 2 inhibitors
Glaxosmithkline
11/20/17
-
40
Amino pyrimidine derivatives
Novartis
11/20/17
-
22
Substituted aminopyrimidine compounds and methods of use
Calitor Sciences
11/20/17
-
25
Substituted imidazopyridazines
Bayer Intellectual Property
11/20/17
-
29
Inhibitors of beta-secretase
Vitae Pharmaceutical
11/20/17
-
565
Orexin receptor antagonists which are [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
Actelion Pharmaceuticals
11/13/17
-
150
Cycloalkane derivatives
Daiichi Sankyo
11/13/17
-
65
Spirocyclic dihydro-thiazine and dihydro-oxazine BACE inhibitors, and compositions and uses thereof
Imago Pharmaceuticals
11/13/17
-
68
Inhibitors of D-amino acid oxidase
The Johns Hopkins University
11/13/17
-
59
Substituted annulated triazines and use thereof
Bayer Pharma Aktiengesellschaft
11/13/17
-
1
Incontinence treatment methods
Ixaltis
11/13/17
-
1
Polymorphs of N-[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride
Kalvista Pharmaceuticals
11/13/17
-
14
Augmenting moieties for anti-inflammatory compounds
Rutgers, The State University of New Jersey
11/13/17
-
7
Inhibitors of glutaminyl cyclase
Probiodrug
11/13/17
-
4
Substituted imidazopyridazines
Bayer Pharma Aktiengesellschaft
11/13/17
-
19
3-substituted estra-1,3,5(10),16-tetraene derivatives, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments
Bayer Pharma Aktiengesellschaft
11/13/17
-
242
Substituted bicyclic compounds
Bristol-Myers Squibb
11/13/17
-
113
Cyclopropanamine compound and use thereof
Takeda Pharmaceutical
11/06/17
-
97
C6-azaspiro iminothiadiazine dioxides as bace inhibitors, compositions, and their use
Merck Sharp & Dohme
11/06/17
-
76
Protein kinase B inhibitors
Astrazeneca
11/06/17
-
104
Cyclopentylbenzamide derivatives and their use for the treatment of psychotic and cognitive disorders
Takeda Pharmaceutical
11/06/17
-
174
IRE-1α inhibitors
Mannking
11/06/17
-
223
Compounds inhibiting leucine-rich repeat kinase enzyme activity
Merck Sharp & Dohme
11/06/17
-
108
Acyclic cyanoethylpyrazoles as janus kinase inhibitors
Merck Sharp & Dohme
11/06/17
-
11
Syk inhibitors
Gilead Sciences
11/06/17
-
16
Histone deacetylase inhibitors and compositions and methods of use thereof
Chdi Foundation
11/06/17
-
18
Rapamycin analogues and their pharmaceutical use
Isomerase Therapeutics
11/06/17
-
1
Glycosidase inhibitors and uses thereof
Alectos Therapeutics
11/06/17
-
130
Substituted benzothienyl-pyrrolotriazines and uses thereof
Bayer Intelletual Property
10/30/17
-
120
Kinase inhibitors
Respivert
10/30/17
-
246
Bicyclically substituted uracils and the use thereof
Bayer Pharma Aktiengesellschaft
10/30/17
-
29
Inhibitors of matrix metalloproteinases
Pharmahungary 2000
10/30/17
-
128
Complement pathway modulators and uses thereof
Novartis
10/30/17
-
60
Sulfonamide compound
Mitsubishi Tanabe Pharma
10/30/17
-
63
3-cyclohexenyl and cyclohexyl substituted indole and indazole compounds as RORgammaT inhibitors and uses thereof
Merck Sharp & Dohme
10/30/17
-
57
Pyrazole carboxamide compounds and uses thereof
Hoffmann-La Roche
10/30/17
-
44
(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
Oryzon Genomics
10/30/17
-
2
Matrix metalloproteinase inhibitors and methods for the treatment of pain and other diseases
TBA
10/30/17
-
1
Compound useful for the treatment of degenerative and inflammatory diseases
Galapagos
10/30/17
-
67
Tricyclic pyrrolopyridine compound, and JAK inhibitor
Nissan Chemical Industries
10/23/17
-
200
Pyrazole substituted imidazopyrazines as casein kinase 1 d/e inhibitors
Bristol-Myers Squibb
10/23/17
-
282
Substituted 7-azabicycles and their use as orexin receptor modulators
Janssen Pharmaceutica
10/23/17
-
220
Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors
Merck Sharp & Dohme
10/23/17
-
1
(Thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity H1 inverse agonists/5-HT2A antagonists
Eli Lilly
10/23/17
-
1
Kinase inhibitor
Respivert
10/23/17
-
50
2,4-pyrimidinediamine compounds and their uses
Rigel Pharmaceuticals
10/23/17
-
21
Phosphatidylinositol 3-kinase inhibitors
Gilead Sciences
10/23/17
-
42
Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
Merck Sharp & Dohme
10/23/17
-
23
Fused pyrimidine compound, and preparation method, intermediate, composition, and uses thereof
Shanghai Yingli Pharmaceutical
10/23/17
-
14
Boron containing small molecules
Anacor Pharmaceuticals
10/23/17
-
293
P2X7 modulators
Janssen Pharmaceutica
10/16/17
-
116
Pyrrolidine derivatives and their use as complement pathway modulators
Novartis
10/16/17
-
59
(Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
Oryzon Genomics
10/16/17
-
130
N-cyclopropyl-N-piperidinyl-amides, pharmaceutical compositions containing them, and uses thereof
Boehringer Ingelheim International
10/16/17
-
78
Benzazepine dicarboxamide compounds
Hoffmann-La Roche
10/16/17
-
31
Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, processes for their preparation, pharmaceutical preparations comprising them and their use for preparing medicaments
Bayer Intellectual Property
10/16/17
-
34
Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
Bristol-Myers Squibb
10/16/17
-
31
Substituted benzoxazoles
Bayer Pharma Aktiengesellschaft
10/16/17
-
5
Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof
Constellation Pharmaceuticals
10/16/17
-
23
Arylpyrrolopyridine derived compounds as LRRK2 inhibitors
H. Lundbeck
10/16/17
-
1
Phenyl C-glucoside derivative containing deoxyglucose structure, preparation method and use thereof
Tianjin Institute of Pharmaceutical Research
10/16/17
-
36
4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds as TAK1 inhibitors in disease treatment
Confluence Life Sciences
10/16/17
-
37
Biaryl ether sulfonamides and their use as therapeutic agents
Xenon Pharmaceuticals
10/10/17
-
568
Pyrrolidinyl sulfone RORγ modulators
Bristol-Myers Squibb
10/09/17
-
125
Melanocortin receptor-specific heptapeptides
Palatin Technologies
10/09/17
-
250
Use of T1R3 venus flytrap region polypeptide to screen for taste modulators
Senomyx
10/09/17
-
76
Transient protection of normal cells during chemotherapy
G1 Therapeutics
10/09/17
-
22
6-alkynyl-pyridine derivatives
Boehringer Ingelheim International
10/09/17
-
41
Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as CETP inhibitors
Chong Kun Dang Pharmaceutical
10/09/17
-
44
Apoptosis-inducing agent for the treatment of cancer and immune and autoimmune diseases
Abbvie
10/09/17
-
3
4,5,6,7-tetrahyroimidazo[4,5-c]pyridine compounds
Proximagen
10/09/17
-
34
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
10/09/17
-
11
Spiropyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
Merck Sharp & Dohme
10/09/17
-
285
Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
Bristol-Myers Squibb
10/02/17
-
184
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
Boehringer Ingelheim International
10/02/17
-
168
Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives
TBA
10/02/17
-
244
Tetrahydroimidazo(1,5-D)[1,4]oxazepine derivative
Eisai R&D Management
10/02/17
-
94
Benzothiophene derivative
Daiichi Sankyo
10/02/17
-
43
Thrombin inhibitors
Merck Sharp & Dohme
10/02/17
-
11
Orvinol and thevinol derivatives useful in the treatment of anxiety or a compulsive disorder
The University of Bath
10/02/17
-
8
Imaging neuroinflammation
Ge Healthcare
10/02/17
-
9
Cyclic hydrocarbon compounds for the treatment of diseases
Leo Pharma
10/02/17
-
9
Substituted benzoxazoles and methods of use thereof
Genentech
10/02/17
-
3
Optically active PDE10 inhibitor
Omeros
10/02/17
-
54
Melanocortin-1 receptor-specific cyclic peptides
Palatin Technologies
09/25/17
-
619
6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use
Abbvie
09/25/17
-
130
Complement pathway modulators and uses thereof
Novartis
09/25/17
-
116
Protein kinase C inhibitors and methods of their use
Novartis
09/25/17
-
87
Chemical entities
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii
09/25/17
-
83
Compounds
Takeda Pharmaceutical
09/25/17
-
46
Imidazopyrazines
Bayer Intellectual Property
09/25/17
-
23
Pharmaceutical compositions for preventing or treating degenerative brain disease and method of screening the same
Korea Institute of Science and Technology
09/25/17
-
55
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
Boehringer Ingelheim International
09/25/17
-
21
Complement factor B inhibitors and uses there of
Novartis
09/25/17
-
16
Substituted oxopyridine derivatives and use thereof as factor xia/plasma
Bayer Pharma Aktiengesellschaft
09/25/17
-
31
Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Euroscreen
09/25/17
-
1
Quinoline inhibitor of the macrophage stimulating 1 receptor MSTR1
Merck Patent
09/25/17
-
66
Pyrimidine FGFR4 inhibitors
Eisai R&D Management
09/18/17
-
112
Substituted 4-phenylpiperidines, their preparation and use
Columbia University
09/18/17
-
203
Substituted B-amino acid derivatives as CXCR3 receptor antagonists
Sanofi
09/18/17
-
88
Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders
University of Utah Research Foundation
09/18/17
-
217
Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators
Beigene
09/18/17
-
321
Substituted benzamides
Hoffmann-La Roche
09/18/17
-
98
Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient
Ahn-Gook Pharmaceutical
09/18/17
-
12
Spirocyclic sulfones as gamma secretase inhibitors
Merck Sharp & Dohme
09/18/17
-
1
(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide
Gilead Sciences
09/18/17
-
3
Phenyloxadiazole derivatives as PGDS inhibitors
Sanofi
09/18/17
-
7
Naphthylurea derivatives and medical applications thereof
Radiant Pharma & Tech.
09/18/17
-
7
Inhibitors of Bruton's tyrosine kinase
Hoffmann-La Roche
09/18/17
-
107
Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Takeda Pharmaceutical
09/18/17
-
701
Sulfonamides as TRPM8 modulators
Janssen Pharmaceutica
09/11/17
-
199
5-azaindazole compounds and methods of use
F. Hoffmann-La Roche
09/11/17
-
36
C2-azaspiro iminothiazine dioxides as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
09/11/17
-
34
Glucokinase activator compounds, compositions containing such compounds, and methods of treatment
Merck Sharp & Dohme
09/11/17
-
17
IAP antagonists
Bristol-Myers Squibb
09/11/17
-
19
2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
09/11/17
-
10
Inhibitors of Bruton's tyrosine kinase
Hoffmann-La Roche
09/11/17
-
30
Dihydroquinoline-2-one derivatives
Hoffmann-La Roche
09/11/17
-
1
Crystalline forms and processes for the preparation of cannabinoid receptor modulators
Arena Pharmaceuticals
09/11/17
-
29
Furanone compounds as kinase inhibitors
Eternity Bioscience
09/11/17
-
42
Benzimidazole derivatives as bromodomain inhibitors
Gilead Sciences
09/11/17
-
43
Trk-inhibiting compound
Ono Pharmaceutical
09/11/17
-
6
Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2B activity modulators
Temple University
09/11/17
-
4
Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
Acetylon Pharmaceuticals
09/11/17
-
23
Pyrrolidine derivatives and their use as complement pathway modulators
Novartis
09/11/17
-
471
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
Novartis
09/05/17
-
84
Quinuclidines for modulating alpha 7 activity
Alpharmagen
09/05/17
-
71
PDE9 inhibitors with imidazo triazinone backbone
H. Lundbeck
09/05/17
-
1
Ocular formulations for drug-delivery to the posterior segment of the eye
Panoptica
09/05/17
-
28
Fluorinated arylalkylaminocarboxamide derivatives
Newron Pharmaceuticals
09/05/17
-
17
Iminothiadiazine dioxides containing a thioamide, amidine, or amide oxime group as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
09/05/17
-
34
Imidazopyridine compounds
Astellas Pharma
09/05/17
-
40
Protein kinase inhibitors
Orion
09/05/17
-
5
Pharmaceutically active compounds
Cancer Research Technology
09/05/17
-
30
Pyrimidine derivatives as phosphodiesterase 10 inhibitors (PDE-10)
Palobiofarma
09/05/17
-
8
Tau imaging probe
Ge Healthcare
09/05/17
-
3
Antiviral therapies with phospholipase D inhibitors
Vanderbilt University
09/05/17
-
8
Pyrimidinones as factor XIa inhibitors
Bristol-Myers Squibb
09/05/17
-
17
Pyrimidodiazepinone compound
Kyowa Hakko Kirin
09/05/17
-
39
Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
Sanofi
09/05/17
-
79
Imidazo[4,5-c]quinolin-2-one compounds and their use in treating Cancer
Astrazeneca
08/28/17
-
161
2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors
Centaurus Biopharma
08/28/17
-
73
Imidazopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
Bristol-Myers Squibb
08/28/17
-
29
Triazolopyrazine
Boehringer Ingelheim International
08/28/17
-
104
Bromodomain inhibitors
Abbvie
08/28/17
-
20
Benzimidazole-imidazole derivatives
Janssen Ireland
08/28/17
-
165
Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms
Case Western Reserve University
08/28/17
-
143
Substituted oxopyridine derivatives and use thereof in the treatment of cardiovascular disorders
Bayer Pharma Aktiengesellschaft
08/28/17
-
4
Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
08/28/17
-
45
Substituted pyrazoles as N-type calcium channel blockers
Janssen Pharmaceutica
08/28/17
-
65
DYRK1 inhibitors and uses thereof
Diaxonhit
08/28/17
-
25
BTK inhibitors
Merck Sharp & Dohme
08/28/17
-
29
Schiff bases of thiazoles: a new class of ureases inhibitors
TBA
08/28/17
-
23
Thieno- and furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives
Hydra Biosciences
08/28/17
-
2
Highly active nucleoside derivative for the treatment of HCV
Achillion Pharmaceuticals
08/28/17
-
17
Hydantoin derivative
Chugai Seiyaku Kabushiki Kaisha
08/24/17
-
29
Antiviral compounds
F. Hoffmann-La Roche
08/22/17
-
377
Tetrahydro-pyrimidoazepines as modulators of TRPV1
Janssen Pharmaceutica
08/21/17
-
20
Benzimidazole-imidazole derivatives
Janssen Ireland
08/21/17
-
27
Macrocyclic indole derivatives useful as hepatitis C virus inhibitors
Janssen Ireland
08/21/17
-
498
1-[m-carboxamido(hetero)aryl-methyl]-heterocyclyl-carboxamide derivatives
Actelion Pharmaceuticals
08/21/17
-
32
N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products
Bayer Pharma Aktiengesellschaft
08/21/17
-
9
S-imino-S-oxo-iminothiadiazine compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
08/21/17
-
41
Piperazine derivatives, compositions, and uses related thereto
Emory University
08/21/17
-
10
Substituted azoles, antiviral active component, pharmaceutical composition, method for preparation and use thereof
TBA
08/21/17
-
24
Secondary alcohol substituted triazoles as PDE10 inhibitors
Merck Sharp & Dohme
08/21/17
-
57
Alpha-carbolines for the treatment of cancer
Universita Degli Studi Di Milano—Bicocca
08/21/17
-
19
Bicyclic nitrogen-containing aromatic heterocyclic amide compound
Astellas Pharma
08/21/17
-
169
7-hydroxy-spiropipiperidine indolinyl antagonists of P2Y1 receptor
Bristol-Myers Squibb
08/21/17
-
335
Heterocyclic modulators of lipid synthesis
3-V Biosciences
08/21/17
-
9
Combination therapy for treating cancer
Epizyme
08/21/17
-
2
α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
Merck Serono
08/21/17
-
223
Cyclic amines
H. Lundbeck
08/14/17
-
120
Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use
Merck Sharp & Dohme
08/14/17
-
103
Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
Tolero Pharmaceuticals
08/14/17
-
95
Sulfonamide derivatives with therapeutic indications
Pharmos
08/14/17
-
51
Partially saturated nitrogen-containing heterocyclic compound
Taisho Pharmaceutical
08/14/17
-
20
S-imino-S-oxo-iminothiazine compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
08/14/17
-
83
Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use
Merck Sharp & Dohme
08/14/17
-
36
Triazolopyridazine
Boehringer Ingelheim International
08/14/17
-
27
Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
Duquesne University of The Holy Ghost
08/14/17
-
46
Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
Euroscreen
08/14/17
-
35
Epoxyeicosatrienoic acid analogs and methods of making and using the same
The Medical College of Wisconsin
08/14/17
-
54
2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the treatment of cancer
Hoffmann-La Roche
08/14/17
-
47
Azaheterocycles as BIR2 and/or BIR3 inhibitors
Hoffmann-La Roche
08/14/17
-
29
Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds
Bristol-Myers Squibb
08/14/17
-
21
Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer
The Royal Institution For The Advancement of Learning/Mcgill University
08/14/17
-
30
2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
Gilead Pharmasset
08/07/17
-
27
Dimeric compounds
Hoffmann-La Roche
08/07/17
-
183
4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors
Fibrogen
08/07/17
-
69
Autotaxin inhibitors
Novartis
08/07/17
-
204
Inhibitor compounds
Cancer Research Technology
08/07/17
-
216
Dihydropyridone p1 as factor XIa inhibitors
Bristol-Myers Squibb
08/07/17
-
90
Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
Janssen Pharmaceutica
08/07/17
-
86
Heterocyclic amide derivatives as P2X7 receptor antagonists
Actelion Pharmaceuticals
08/07/17
-
16
Kinase modulators for the treatment of cancer
Synovo
08/07/17
-
34
Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof
Sunshine Lake Pharma
08/07/17
-
44
5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
08/07/17
-
36
Imidamide sphingosine kinase inhibitors
University of Virginia Patent Foundation
08/07/17
-
4
HCV protease inhibitors and uses thereof
Celgene Avilomics Research
08/07/17
-
15
Acid ceramidase inhibitors and their use as medicaments
Fondazione Istituto Italiano Di Technologia
08/07/17
-
5
Methods for reducing uric acid levels using barbiturate derivatives
TBA
08/07/17
-
5
Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
Allergan
08/01/17
-
17
2,4,7-substituted thieno[3,2-d]pyrimidine compounds as protein kinase inhibitors
Korea Institute of Science and Technology
08/01/17
-
21
Azabenzimidazole derivatives
Boehringer Ingelheim International
08/01/17
-
4
6-substituted demethyl-estradiol derivatives as selective ER-β agonists
Endece
08/01/17
-
170
Substituted phenylimidazopyrazoles and their use
Bayer Pharma Aktiengesellschaft
07/31/17
-
134
Triazolo compounds as PDE10 inhibitors
Hoffmann-La Roche
07/31/17
-
71
Substituted 4-aminocyclohexane derivatives
Gruenenthal
07/31/17
-
40
Substituted heteroaryl compounds and methods of use
Calitor Sciences
07/31/17
-
105
Pyrazine derivatives
Hoffmann-La Roche
07/31/17
-
135
Azetidine amide derivatives as orexin receptor antagonists
Actelion Pharmaceuticals
07/31/17
-
54
Cysteine protease inhibitors and uses thereof
Columbia University
07/31/17
-
221
Pyridine-2-amides useful as CB2 agonists
Hoffmann-La Roche
07/31/17
-
48
Pyridine derivatives
Hoffmann-La Roche
07/31/17
-
19
Selective glycosidase inhibitors and uses thereof
Alectos Therapeutics
07/31/17
-
32
Triazole carboxamides and uses thereof
Hoffmann-La Roche
07/31/17
-
5
Method for inhibiting Trypanosoma cruzi
Howard University
07/31/17
-
19
3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors
Nerviano Medical Sciences
07/31/17
-
11
Heterocyclic resorcinol derivatives, preparation of same and cosmetic uses thereof
Pierre Fabre Dermo-Cosmetique
07/31/17
-
10
Fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof
Bayer Pharma Aktiengesellschaft
07/31/17
-
48
Carboxamide derivatives
Novartis
07/25/17
-
430
Amides as pim inhibitors
Amgen
07/24/17
-
12
Indolines
Hoffmann-La Roche
07/24/17
-
10
Indole-3-carboxamides as kinase inhibitors
Allergan
07/24/17
-
25
Substituted purinone compounds
Novartis
07/24/17
-
41
Triazolopyrazine derivative and use thereof
Korea Research Institute of Chemical Technology
07/24/17
-
16
Carboxamide derivatives
Novartis
07/24/17
-
25
Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
Pfizer
07/24/17
-
37
Substituted indazole derivatives active as kinase inhibitors
Nerviano Medical Sciences
07/24/17
-
13
5′-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
07/24/17
-
22
Alpha-(3,5-dimethoxybenzylidene)-alpha′-hydrocarbyl methylene cyclic ketone and preparation method thereof
Pharmaxyn Laboratories
07/24/17
-
19
Selective histone deactylase 6 inhibitors
H. Lee Moffitt Cancer Center and Research Institute
07/24/17
-
22
Inhibitors of rho associated protein kinases (ROCK) and methods of use
H. Lee Moffin Cancer Center and Research Institute
07/24/17
-
4
Compound for increasing kinase active and application thereof
Fujian Haixi Pharmaceuticals
07/24/17
-
4
3-O-acyl-ingenol analogues
Leo Laboratories
07/24/17
-
11
Use of the aminoalkylindole JWH-073-M4 and related compounds as neutral CB1 receptor antagonists for the treatment of alcoholism, drug abuse, obesity, and obesity-related diseases
University of Arkansas
07/24/17
-
366
Compounds inhibiting leucine-rich repeat kinase enzyme activity
Merck Sharp & Dohme
07/24/17
-
16
Therapeutic prostaglandin receptor agonists
Allergan
07/18/17
-
93
Diamide compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity
Theravance Respiratory
07/18/17
-
9
Isoquinoline-5-carboxamide derivative having inhibitory activity for protein kinase
Hanmi Pharm.
07/17/17
-
13
Neuroactive 17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
Washington University
07/17/17
-
122
Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones
Beigene
07/17/17
-
19
Substituted pyrrolidines as factor xia inhibitors for the treatment thromboembolic diseases
Ono Pharmaceutical
07/17/17
-
131
Substituted hetero-azepinones
F. Hoffmann-La Roche
07/17/17
-
196
Pyrazole carboxamides as Janus kinase inhibitors
Merck Sharp & Dohme
07/17/17
-
177
Indole and indazole compounds that activate AMPK
Pfizer
07/17/17
-
44
Inhibitors of c-fms kinase
Janssen Pharmaceutica
07/17/17
-
46
Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
Universitaet Des Saarlandes Campus Saarbruecken
07/17/17
-
10
Benzoxazinone amides as mineralocorticoid receptor modulators
Astrazeneca
07/17/17
-
6
TRPV1 antagonists including dihydroxy substituent and uses thereof
Purdue Pharma
07/17/17
-
23
Small molecule inhibitors of MCL-1 and uses thereof
The Regents of The University of Michigan
07/17/17
-
20
Method for the treatment of neurological disorders by enhancing the activity of β-glucocerebrosidase
Amicus Therapeutics
07/17/17
-
12
Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors
Purdue Research Foundation
07/17/17
-
6
Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
Bristol-Myers Squibb
07/17/17
-
2
5-(pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use
Cancer Research Technology
07/17/17
-
10
Inhibitors of c-fms kinase
Janssen Pharmaceutica
07/17/17
-
5
Mutant-selective EGFR inhibitors and uses thereof
Celgene Avilomics Research
07/17/17
-
6
PI3K and/or mTOR inhibitor
Xuanzhu Pharma
07/10/17
-
12
Macrocyclic inhibitors of hepatitis C virus
Janssen Ireland
07/10/17
-
37
C5, C6 oxacyclic-fused thiazine dioxide compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
07/10/17
-
19
Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof
Chroma Therapeutics
07/10/17
-
28
Derivatives of celeboxib, use thereof and preparation thereof
German University
07/10/17
-
117
Substituted benzimidazoles
Bayer Intellectual Property
07/10/17
-
25
Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases
Galderma Research & Development
07/10/17
-
60
Substituted morphinans and the use thereof
Purdue Pharma
07/10/17
-
14
Serine/threonine kinase inhibitors
Genetech
07/10/17
-
87
Method of treating conditiions with kinase inhibitors
Allergan
07/10/17
-
7
Substituted 1,2,3,4-tetrahydropyrido[3,4-E] pyrrolo[1,2-A]pyrimidines as kinase
Allergan
07/10/17
-
81
Pyrrolotriazinone derivatives as PI3K inhibitors
Almirall
07/10/17
-
75
Heterocyclic amide derivatives as P2X7 receptor antagonists
Actelion Pharmaceuticals
07/10/17
-
16
Heterocyclic amide derivatives as P2X7 receptor antagonists
Actelion Pharmaceuticals
07/10/17
-
44
Pyrrolidine derivatives and their use as complement pathway modulators
Novartis
07/10/17
-
4
Antibiotic and anti-parasitic agents that modulate class II fructose 1,6-bisphosphate aldolase
The University of Denver and Regis University
07/10/17
-
16
Substituted 1,2,3,4-tetrahydro-2,6-naphthyridines as factor XIa inhibitors
Bristol-Myers Squibb
07/10/17
-
18
Imidazopyridine derivatives
Hoffmann-La Roche
07/10/17
-
5
Fused heteroaryl pyridyl and phenyl benzenesuflonamides as CCR2 modulators for the treatment of inflammation
Chemocentryx
07/10/17
-
2
Depsipeptide and uses thereof
Novobiotic Pharmaceuticals
07/10/17
-
2
Pyrimidinyl-pyridazinone derivatives for treating a disease which is influenced by inhibition of met kinase
Merck Patent
07/10/17
-
5
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Abbvie
07/10/17
-
22
Thyroid hormone analogs
Hoffmann-La Roche
07/10/17
-
20
Immune system modulators
Janus Biotherapeutics
07/03/17
-
34
Bicyclic substituted pyrimidine compounds
Xuanzhu Pharma
07/03/17
-
29
Hexahydrodibenzo[a,g]quinolizine compound, preparation method thereof, pharmaceutical composition and use thereof
Shanghai Institute of Material Medica, Chinese Academy of Sciences
07/03/17
-
36
Synthetic peptide amides
Cara Therapeutics
07/03/17
-
15
3-(indolyl)- or 3-(azaindolyl)- 4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma
Johannes Gutenberg-UniversitäT Mainz
07/03/17
-
67
Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
07/03/17
-
18
Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
Washington University
07/03/17
-
13
Aroyl thiourea derivatives
University Court of The University of St Andrews
07/03/17
-
26
Biphenyl-ethyl-pyrrolidine derivatives as histamine H3 receptor modulators for the treatment of cognitive disorders
Arena Pharmaceuticals
07/03/17
-
20
Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
Galderma Research & Devlopment
07/03/17
-
19
Arylated camphenes, processes for their preparation and uses thereof
Yissum Research Development Company of The Hebrew University of Jerusalem
07/03/17
-
11
Prolylcarboxypeptidase inhibitors
Merck Sharp & Dohme
07/03/17
-
2
Substituted pyridinone-pyridinyl compounds
Confluence Life Sciences
07/03/17
-
126
1,3 substituted azetidine PDE10 inhibitors
Merck Sharp & Dohme
07/03/17
-
137
TRPV1 antagonists including dihydroxy substituent and uses thereof
Purdue Pharma
07/03/17
-
25
Kinase inhibitors
Allergan
07/03/17
-
238
Pyrrolopyrrolidinone compounds
Novartis
07/03/17
-
7
Matriptase inhibitors and uses thereof against orthomyxoviridae infections
TBA
07/03/17
-
8
Quaternized amines as sodium channel blockers
Purdue Pharma
07/03/17
-
5
Substituted heteroaryl compounds and methods of use
Calitor Sciences
07/03/17
-
1
Salt form of a human histone methyltransferase EZH2 inhibitor
Epizyme
07/03/17
-
240
Cyclopropanecarboxamido-substitute aromatic compounds as anti-tumor agents
Crown Bioscience Inc. (Taiwan)
06/27/17
-
2
Quinazoline derivatives as kinases inhibitors and methods of use thereof
Teligene
06/27/17
-
3
Substituted aminoquinazolines useful as kinases inhibitors
TBA
06/27/17
-
49
2-amino 3,5,5-trifluoro-3,4,5,6-tetrahydropyridines as BACE1 inhibitors for treatment of Alzheimer's disease
H. Lundbeck
06/26/17
-
82
Compositions and methods for the treatment of malaria
Saint Louis University
06/26/17
-
26
Indole-1-carboxamides as kinase inhibitors
Allergan
06/26/17
-
64
Cyclic amine substituted heterocyclic CETP inhibitors
Merck Sharp & Dohme
06/26/17
-
42
Non-annulated thiophenylamides
Hoffmann-La Roche
06/26/17
-
130
Substituted pyridizinone derivatives as PDE10 inhibitors
Merck Sharp & Dohme
06/26/17
-
27
Methods and compositions for kinase inhibition
University of California
06/26/17
-
12
Acetamide derivatives
Hoffmann-La Roche
06/26/17
-
19
Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
Merck Sharp & Dohme
06/26/17
-
2
Aldehyde derivative of substitute oxazolidinones
Wanbury
06/26/17
-
12
Thiazole derivatives as inhibitors of Bruton's tyrosine kinase
Hoffmann-La Roche
06/26/17
-
11
Cyclopropyl imidazopyridine PDE10 inhibitors
Merck Sharp & Dohme
06/26/17
-
94
Dihydropyridinone MGAT2 inhibitors
Bristol-Myers Squibb
06/26/17
-
64
Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors
Vtv Therapeutics
06/26/17
-
122
Pyrrolidine compounds
Hoffmann-La Roche
06/19/17
-
49
FAP inhibitors
Universiteit Antwerp
06/19/17
-
33
Heterocyclic carboxylic acid ester derivative
Ajinomoto
06/19/17
-
29
5-HT3 receptor antagonists
Takeda Pharmaceutical
06/19/17
-
123
Indazole derivatives useful as ERK inhibitors
Merck Sharp & Dohme
06/19/17
-
7
3,5,N-trihydroxy-alkanamide and derivatives: method for making same and use thereof
National Taiwan University
06/19/17
-
225
Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors
Merck Sharp & Dohme
06/19/17
-
55
Disubstituted beta-lactones as inhibitors of N-acylethanolamine acid amidase (NAAA)
University of California
06/19/17
-
46
Bicyclic dihydroquinoline-2-one derivatives
Hoffmann-La Roche
06/19/17
-
323
Heterocyclic carboxylic acids as activators of soluble guanylate cyclase
Boehringer Ingelheim International
06/19/17
-
4
Methods of treatment using modulators of SIRT2
Cornell University
06/19/17
-
6
Ethynyl derivatives
Hoffmann-La Roche
06/19/17
-
23
Substituted piperidines as sodium channel blockers
Purdue Pharma
06/19/17
-
42
Aminostatin derivatives for the treatment of arthrosis
Merck Patent
06/12/17
-
10
Compounds having activating effect on subtypes of peroxisome proliferator-activated receptors and its preparation method and uses
Zhejiang Hisun Pharmaceutical
06/12/17
-
64
Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
Boehringer Ingelheim International
06/12/17
-
93
Substituted sulfonamides useful as antiapoptotic Bcl inhibitors
Bristol-Myers Squibb
06/12/17
-
465
5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof
Genentech
06/12/17
-
9
Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease
University of Kansas
06/12/17
-
9
Pyrazolopyridyl compounds as aldosterone synthase inhibitors
Merck Sharp & Dohme
06/12/17
-
3
Heterocyclic compounds and uses thereof in the treatment of sexual disorders
Atir Holding
06/12/17
-
2
Oxazetidine derivatives, process for preparing them and use in human medicine and in cosmetics
Galderma Research & Development
06/12/17
-
13
Tetrahydrocarboline derivative
Ono Pharmaceutical
06/12/17
-
11
Immune system modulators
Janus Biotherapeutics
06/12/17
-
7
Pharmaceutical uses of 6-amino quinazoline or 3-cyano quinoline derivatives
Jiangsu Hengrui Medicine
06/12/17
-
178
Oxazolidinone compounds and derivatives thereof
Amgen
06/05/17
-
3
Inhibitors of protein tyrosine phosphatases
Indiana University Research and Technology
06/05/17
-
53
Compositions and methods useful for treating diseases
Eutropics Pharmaceuticals
06/05/17
-
16
Alkyl linked quinolinyl modulators of RORγt
Janssen Pharmaceutica
06/05/17
-
14
Piperidine compound or salt thereof
Taiho Pharmaceutical
06/05/17
-
258
Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors
Amgen
06/05/17
-
11
Indomethacin analogs for the treatment of castrate-resistant prostate cancer
Vanderbilt University
06/05/17
-
39
Benzodioxole derivative and preparation method and use thereof
Zhejiang Hisun Pharmaceutical
06/05/17
-
10
5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
Amgen
06/05/17
-
327
Carboxamides as inhibitors of voltage-gated sodium channels
Amgen
05/31/17
-
107
Pharmacologically active compounds
Cancer Research Technology
05/31/17
-
60
Substituted tetrahydrocarbazole and carbazole carboxamide compounds
Bristol-Myers Squibb
05/31/17
-
50
17a-hydroxylase/C17,20-lyase inhibitors
Novartis
05/31/17
-
129
Aromatic heterocyclic derivative having TRPV4-inhibiting activity
Shionogi
05/31/17
-
109
Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
Boehringer Ingelheim International
05/31/17
-
245
Tetrahydroisoquinoline derivatives, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
05/31/17
-
489
Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor
Mimetica
05/31/17
-
76
Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists
Merck Sharp & Dohme
05/31/17
-
102
Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
Novatis
05/31/17
-
15
Hydroxylated aminotriazole derivatives as ALX receptor agonists
Actelion Pharmaceuticals
05/31/17
-
12
2-amino 6-(difluoromethyl)-5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
H. Lundbeck
05/31/17
-
2
Thienopyrimidine compounds and use thereof
Takeda Pharmaceutical
05/31/17
-
2
Substituted quinolines as bruton's tyrosine kinases inhibitors
Hangzhouderenyucheng Biotechnology
05/31/17
-
65
Hepatitis C virus inhibitors
Bristol-Myers Squibb
05/22/17
-
9
Selective β-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents
University of North Carolina At Chapel Hill
05/22/17
-
6
Pyridine and piperidine derivatives as novel sodium channel blockers
Purdue Pharma
05/22/17
-
34
Acetamide derivatives as glucokinase activators, their process and medicinal applications
Advinus Therapeutics
05/22/17
-
65
Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives
Green Cross
05/22/17
-
7
Propellane-based compounds and the use thereof
Purdue Pharma
05/22/17
-
69
Compounds as tyrosine kinase modulators
Allergan
05/22/17
-
14
Azaindolines
Hoffmann-La Roche
05/22/17
-
12
IAP antagonists
Bristol-Myers Squibb
05/22/17
-
5
Specific inhibitors and active site probes for legumain
The Board of Trustees of The Leland Stanford Junior University
05/22/17
-
20
Compounds for binding to the platelet specific glycoprotein IIB/IIIA and their use for imaging of thrombi
Piramal Imaging
05/22/17
-
144
Pyrrolopyrimidine compounds and uses thereof
Hutchison Medipharma
05/22/17
-
660
Cyanomethylpyrazole carboxamides as janus kinase inhibitors
Merck Sharp & Dohme
05/18/17
-
34
Quinuclidine derivatives and medicinal compositions containing the same
Almirall
05/18/17
-
119
Pyrimidinone derivatives as antimalarial agents
Sanofi
05/15/17
-
794
Tropomyosin-related kinase inhibitors
Pfizer
05/15/17
-
284
Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
Genentech
05/15/17
-
7
Methods of treatment of histamine H-4 receptor-related pruritus associated with nerve disorders
Bridge Pharma
05/15/17
-
3
Isoxazolo-quinazolines as modulators of protein kinase activity
Nerviano Medical Sciences
05/15/17
-
2
Inhibitors of human EZH2, and methods of use thereof
Epizyme
05/15/17
-
13
4-amino-imidazoquinoline compounds
Hoffmann-La Roche
05/15/17
-
32
Purine derivatives and their use in the treatment of disease
Novarits
05/15/17
-
38
Pyrrolo[2,3-B]pyrazines as SYK inhibitors
Hoffmann-La Roche
05/15/17
-
4
Heterocyclic modulators of cannabinoid receptors
The Cleveland Clinic Foundation
05/15/17
-
7
Process for making isoquinoline compounds
Fibrogen
05/15/17
-
1
Compounds and methods for treating ocular diseases
Allergan
05/15/17
-
293
Azole compounds as PIM inhibitors
Amgen
05/08/17
-
242
Aminopyrimidine derivatives for use as modulators of kinase activity
Merck Patent
05/08/17
-
7
Compounds
Respivert
05/08/17
-
46
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
Boehringer Ingelheim International
05/08/17
-
5
A3 adenosine receptor allosteric modulators
The United States of America, Represented By The Secretary, Dept. of Health and Human Services
05/08/17
-
5
Ethynyl derivatives
Hoffmann-La Roche
05/08/17
-
18
Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors
Beigene
05/08/17
-
123
Nitrogen-containing bicyclic aromatic heterocyclic compound
Astellas Pharma
05/08/17
-
28
6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
Boehringer Ingelheim International
05/08/17
-
4
Rotenone derivatives and a use thereof
Korea Atomic Energy Research Institute
05/08/17
-
3
BACE inhibitors
Eli Lilly
05/08/17
-
9
Apoptosis signal-regulating kinase inhibitor
Gilead Sciences
05/08/17
-
193
Tetracyclic CDK9 kinase inhibitors
Abbvie
05/03/17
-
115
2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
Pfizer
05/01/17
-
55
Regulators of aldehyde dehydrogenase ALDH3A1 and related therapeutic methods
Indiana University Research and Technology
05/01/17
-
44
Small molecule inhibitors of the pleckstrin homology domain and methods for using same
The University of Texas System
05/01/17
-
7
Compositions and methods for treating neoplasia, inflammatory disease and other disorders
Dana-Farber Cancer Institute
05/01/17
-
33
Beta-alanine derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising same as active ingredient
Korea Research Institute of Chemical Technology
05/01/17
-
14
N-alkyltriazole compounds as LPAR antagonists
Hoffmann-La Roche
05/01/17
-
25
Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase
University of California
05/01/17
-
30
Aminopyridine derived compounds as LRRK2 inhibitors
H. Lundbeck
05/01/17
-
5
ROR modulators and their uses
Innov17
05/01/17
-
10
Pyrazole derivative
Green Tech
05/01/17
-
5
Kinase inhibitors
Allergan
05/01/17
-
64
Compounds and uses
Astrazeneca
04/27/17
-
80
Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
Novartis
04/24/17
-
129
Pyrimidine compounds as mTOR and PI3K inhibitors
Development Center For Biotechnology
04/24/17
-
18
Phenylpyridine derivative and drug containing same
Kowa
04/24/17
-
173
Arlethynyl derivatives
Hoffmann-La Roche
04/24/17
-
41
Cytomegalovirus inhibitor compounds
Boehringer Ingelheim International
04/24/17
-
26
Bicyclic heteroaryl cycloalkyldiamine derivatives
Novartis
04/24/17
-
3
Treating diabetes with dipeptidyl peptidase-IV inhibitors
Merck Sharp & Dohme
04/24/17
-
9
1,3-dioxanomorphides and 1,3-dioxanocodides
Rhodes Technologies
04/24/17
-
25
Imidazopyridin-2-one derivatives
Merck Sharp & Dohme
04/24/17
-
6
Guanidine substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
Bristol-Myers Squibb
04/24/17
-
20
1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
Incyte
04/24/17
-
32
Substituted imidazopyridazines
Bayer Intellectual Property
04/24/17
-
7
Kinase inhibitors
Allergan
04/24/17
-
7
Acid addition salt of substituted pyridine compound
Daiichi Sankyo
04/24/17
-
152
Pyridine-2-amides useful as CB2 agonists
Hoffmann-La Roche
04/10/17
-
44
Heteroaryl linked quinolinyl modulators of RORγt
Janssen Pharmaceutica
04/10/17
-
12
2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof
Georgetown University
04/10/17
-
145
Pyrazole and imidazole derivatives useful as orexin antagonists
Actelion Pharmaceuticals
04/10/17
-
404
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Abbvie
04/10/17
-
34
Substituted pyrazino[1′,2′:1,2]pyrrolo[3,4-d]pyrimidines, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,4]oxazines and pyrimido[4′,5′:3,4]pyrrolo[1,2-d][1,4]oxazepines for inhibiting the CFTR channel
Novartis
04/10/17
-
153
5-HT3 receptor antagonists
Takeda Pharmaceutical
04/10/17
-
22
Compounds and compositions as protein kinase inhibitors
Novartis
04/10/17
-
122
Chemokine receptor modulators
Altiris Therapeutics
04/10/17
-
5
Optically pure benzyl-4-chlorophenyl-C-glucoside derivative
Xuanzhu Pharma
04/10/17
-
15
Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities
Almirall
04/10/17
-
19
Heterocyclic group contained amino-methanol derivative, and salt, synthetic method and use thereof
Beijing Foreland Biopharma
04/10/17
-
16
Nicotinic receptor compounds
Research Triangle Institute
04/04/17
-
27
Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof
University of Pennsylvania
04/03/17
-
27
Selective inhibitors of human corticosteroid synthases
Universitat Des Saarlandes
04/03/17
-
25
Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
Pharmacyclics
04/03/17
-
10
Substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one
Bayer Intellectual Property
04/03/17
-
94
Methylene linked quinolinyl modulators of RORγt
Janssen Pharmaceutica
04/03/17
-
39
Azetidine-substituted quinoxalines as opioid receptor like-1 modulators
Purdue Pharma
04/03/17
-
17
Chimeric small molecules for the recruitment of antibodies to cancer cells
Yale University
04/03/17
-
348
Bromodomain inhibitors
Abbvie
04/03/17
-
93
Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
Amgen
04/03/17
-
26
Substituted 3-haloallylamine inhibitors of ASSAO and uses thereof
Boehringer Ingelheim International
04/03/17
-
145
Continuous arycyclic compound
Mitsubishi Tanabe Pharma
04/03/17
-
1176
Pyrazolopyrimidines and related heterocycles as CK2 inhibitors
Senhwa Biosciences
03/30/17
-
650
Bicyclic sulfonamide compounds as sodium channel inhibitors
Amgen
03/21/17
-
50
HDAC inhibitors and therapeutic methods using the same
University of Illinois
03/21/17
-
8
Substituted imidazopyrazines as Akt kinase inhibitors
Bayer Pharma Aktiengesellschaft
03/21/17
-
363
Fused pyrroledicarboxamides and their use as pharmaceuticals
Sanofi
03/21/17
-
2
D3 dopamine receptor agonists to treat dyskinesia in parkinson's disease
Drexel University
03/21/17
-
10
Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
Albert Einstein College of Medicine
03/21/17
-
12
Cycloalkylmethylamines
Reviva Pharmaceuticals
03/21/17
-
89
Substituted benzothienopyrimidines
Bayer Pharma Aktiengesellschaft
03/21/17
-
17
Benzyl sulfonamide derivatives as RORc modulators
Genentech
03/21/17
-
1518
NAMPT and rock inhibitors
Abbvie
03/13/17
-
23
Inhibitors of leukotriene production
Boehringer Ingelheim International
03/13/17
-
242
Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
Amgen
03/06/17
-
405
Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer
Amgen
03/06/17
-
213
Diacylglycerol acyltransferase 2 inhibitors
Pfizer
03/06/17
-
112
Pyridinones
Boehringer Ingelheim International
03/06/17
-
2
Synthesis, methods of using, and compositions of cycloalkylmethylamines
Reviva Pharmaceuticals
03/06/17
-
4
Use of dibenzofuranone derivatives to inhibit kinases
TBA
03/06/17
-
6
Amino-pyrroline derivatives, and use thereof in the prevention and/or treatment of metabolic syndrome
Universite De Strasbourg
03/06/17
-
2
Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
University of Utah Research Foundation
02/28/17
-
26
Therapeutic compounds
Regents of The University of Minnesota
02/28/17
-
17
Piperidylpyrimidine derivatives as modulators of protein kinase inhibitors and of vascular endothelial growth factor receptor 2
Allergan
02/28/17
-
725
Inhibitors of poly(ADP-ribose)polymerase
Abbvie
02/27/17
-
18
Heterocyclyl aminoimidazopyridazines
Bayer Intellectual Property
02/27/17
-
29
1,4-dihydro-naphthyridine derivative and pharmaceutical composition and use thereof
Jiangsu Simovay Pharmaceutical
02/27/17
-
3
Optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
Ambit Biosciences
02/27/17
-
66
Acyl piperidine inhibitors of soluble epoxide hydrolase
University of California
02/27/17
-
106
Imidazopyridine compounds
Astellas Pharma
02/21/17
-
8
Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
Merck Sharp & Dohme
02/21/17
-
42
6-Alkynyl Pyridine
Boehringer Ingelheim International
02/21/17
-
297
Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
Novartis
02/21/17
-
2
Pyrido-pyrimidine derivatives
Merck Patent
02/21/17
-
32
Oxazine derivatives and their use in the treatment of disease
Novartis
02/21/17
-
6
Pyrazolyl-pyrimidine derivatives as kinase inhibitors
Nerviano Medical Sciences
02/21/17
-
25
Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions
University of Utah Research Foundation
02/21/17
-
4
Cyclobutyl benzimidazoles as PDE 10 inhibitors
Merck Sharp & Dohme
02/21/17
-
16
Three-ring PI3K and/or mTOR inhibitor
Zuanzhu Pharma
02/21/17
-
29
Substituted imidazo[1,2-a]pyrazines as MPS-1 inhibitors
Bayer Intellectual Property
02/21/17
-
1
Pyrazole compounds
Eli Lilly
02/21/17
-
290
Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use
Merck Sharp & Dohme
02/14/17
-
31
Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
Acetylon Pharmaceuticals
02/14/17
-
25
Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives
Merck Sharp & Dohme
02/14/17
-
4
Optically active diazabicyclooctane derivatives and process for preparing the same
Meiji Seika Pharma
02/13/17
-
4
Aldosterone synthase inhibitors
Merck Sharp & Dohme
02/13/17
-
1
SARMs and method of use thereof
University of Tennessee Research Foundation
02/13/17
-
16
Urea derivatives and their use as fatty-acid binding protein (FABP) inhibitors
Hoffmann-La Roche
02/13/17
-
16
Methods for increasing the stabilization of hypoxia inducible factor-α
Aerpio Therapeutics
02/13/17
-
128
Nitrogen-containing saturated heterocyclic compound
Mitsubishi Tanabe Pharma
02/13/17
-
14
Antagonists of prostaglandin EP3 receptor
Pfizer
02/13/17
-
149
Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
02/13/17
-
211
Substituted dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
Boehringer Ingelheim International
02/06/17
-
270
Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
Boehringer Ingelheim International
02/06/17
-
13
Monocyclic heteroaryl cycloalkyldiamine derivatives
Novartis
02/06/17
-
8
Amino-substituted imidazopyridazines
Bayer Pharma Aktiengesellschaft
02/06/17
-
182
N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
Novartis
02/06/17
-
74
Pharmaceutical composition for treating diabetes
Ajinomoto
02/06/17
-
33
Aminopyrimidines as Syk inhibitors
Merck Sharp & Dohme
02/06/17
-
11
Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
Gilead Sciences
02/06/17
-
137
B-RAF kinase inhibitors
Boehringer Ingelheim International
02/06/17
-
422
Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
Senomyx
02/02/17
-
34
TRPV1 antagonists including dihydroxy substituent and uses thereof
Purdue Pharma
01/30/17
-
58
Fused tricyclic compounds as Raf kinase inhibitors
Beigene
01/30/17
-
79
Sulfur-containing heterocyclic derivative having Beta secretase inhibitory activity
Shionogi
01/30/17
-
382
Pyridine derivatives as agonists of the CB2 receptor
Hoffmann-La Roche
01/30/17
-
26
Substituted isoquinolines as CRTH2 receptor modulators
Merck Sharp & Dohme
01/30/17
-
66
Pyridazinone compounds and their use as DAAO inhibitors
Takeda Pharmaceutical
01/30/17
-
5
Radiolabeled compounds and uses thereof
Columbia University
01/30/17
-
49
Cyclic amides
Hoffmann-La Roche
01/30/17
-
7
Inhibitors of β-secretase
Vitae Pharmaceuticals
01/30/17
-
83
Aurora kinase inhibitors and methods of making and using thereof
H. Lee Moffitt Cancer Center and Research Institute
01/27/17
-
9
5-amino[1,4]thiazines as BACE 1 inhibitors
Hoffmann-La Roche
01/25/17
-
39
Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof
Bristol-Myers Squibb
01/24/17
-
187
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Abbvie
01/23/17
-
143
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
Novartis
01/23/17
-
19
Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
Dana-Farber Cancer Institute
01/23/17
-
61
Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
Boehringer Ingelheim International
01/23/17
-
67
Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
Kainos Medicine
01/23/17
-
2
Pyrrolo[2,3-D]pyrimidine compounds
Zoetis Services
01/23/17
-
14
Substituted pyridazines for the treatment of pain
Inhibitaxin
01/23/17
-
3
Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof
Boston College
01/23/17
-
58
Pyridine-and pyrazine derivatives
Merck Patent
01/23/17
-
135
Substituted pyridone derivatives as PDE10 inhibitors
Merck Sharp & Dohme
01/23/17
-
5
Phthalazinone ketone derivative, preparation method thereof, and pharmaceutical use thereof
Jiangsu Hansoh Pharmaceutical
01/23/17
-
36
Oligomer-opioid agonist conjugates
Nektar Therapeutics
01/18/17
-
11
Sulfamides as TRPM8 modulators
Janssen Pharmaceutica
01/18/17
-
29
Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof
President and Fellows of Harvard College
01/18/17
-
42
Substituted dialkyl(oxido)-lambda4-sulfanylidene nicotinamide derivatives as kinase inhibitors
Allergan
01/17/17
-
45
Heteroaromatic methyl cyclic amine derivative
Taisho Pharmaceutical
01/17/17
-
243
4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives
Actelion Pharmaceuticals
01/17/17
-
163
Phosphatidylinositol 3-kinase inhibitors
Gilead Calistoga
01/17/17
-
8
Substituted azaindazole compounds
Bristol-Myers Squibb
01/17/17
-
22
Triazolopyridinone PDE10 inhibitors
Merck Sharp & Dohme
01/17/17
-
33
Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
Principia Biopharma
01/17/17
-
195
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
01/16/17
-
171
Quinoline derivatives useful as CB-1 inverse agonists
Janssen Pharmaceutica
01/16/17
-
34
Potent poxvirus inhibitor
University of Pennsylvania
01/14/17
-
509
Dihydropyrrolopyrimidine derivatives
Pfizer
01/09/17
-
68
Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors
Beigene
01/09/17
-
9
Therapeutic pyrazolyl thienopyridines
Thesan Pharmaceuticals
01/09/17
-
8
Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
Pfizer
01/09/17
-
206
Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
Biomarin Pharmaceutical
01/09/17
-
5
Inhibitors of Furin and other pro-protein convertases
Sanford-Burnham Medical Research Institute
01/09/17
-
89
Compounds for the treatment of neurodegenerative diseases
Katholieke Universiteit Levun
01/09/17
-
2
Trifluoromethyl pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof
Lycera
01/09/17
-
12
4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases
Galderma Research & Development
01/09/17
-
2
Orally available viridiofungin derivative possessing anti-HCV activity
Chugai Seiyaku Kabushiki Kaisha
01/09/17
-
110
3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta
Sanofi
01/07/17
-
35
Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
The United States of America, As Represented By The Secretary, Department of Health and Human Services
12/31/16
-
117
PDE10a inhibitors for the treatment of type II diabetes
Janssen Pharmaceutica
12/31/16
-
11
Orvinol and thevinol derivatives useful in the treatment of depression
The University of Bath
12/28/16
-
42
Serine/threonine kinase inhibitors
Array Biopharma
12/28/16
-
3
P38 MAP kinase inhibitors
Respivert
12/28/16
-
5
Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders
Merck Sharp & Dohme
12/28/16
-
17
Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality
Genentech
12/28/16
-
405
Pyrazolo[3,4-c]pyridine compounds and methods of use
Genetech
12/28/16
-
5
Synthetic methods for spiro-oxindole compounds
Xenon Pharmaceuticals
12/28/16
-
11
Thienopyrimidinone derivatives as mGluR1 antagonists
Korea Institute of Science and Technology
12/28/16
-
33
Alkylamine derivative
Ajinomoto
12/20/16
-
432
Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
Actelion Pharmaceuticals
12/20/16
-
5
Benzothiazole-based pyridinium compounds
The University of Montana
12/20/16
-
8
Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors
Allergan
12/20/16
-
4
Xanthine derivative
Chengdu Easton Pharmaceutical
12/20/16
-
52
Substituted pyrazolo[1,5-a]pyrazines as mGluR5 receptor modulators
Vanderbilt University
12/20/16
-
25
Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors
Shanghai Institute of Material Medica, Chinese Academy of Sciences
12/20/16
-
8
Heteroaryl alkyne compound and use thereof
Nanjing Sanhome Pharmaceutical
12/20/16
-
176
Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
Roche Palo Alto
12/20/16
-
1
Therapeutic methods and compositions involving allosteric kinase inhibition
Amitech Therapeutic Solutions
12/15/16
-
12
Selective glycosidase inhibitors and uses thereof
Alectos Therapeutics
12/12/16
-
32
Chemical compounds
Astrazeneca
12/12/16
-
52
Aniline derivatives, their preparation and their therapeutic application
Fovea Pharmaceuticals
12/12/16
-
30
Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
Bristol-Myers Squibb
12/12/16
-
47
Thiazole derivatives
Merck Patent
12/12/16
-
7
Pyridinones/pyrazinones, method of making, and method of use thereof
Genentech
12/12/16
-
93
Pyrazole derivatives as p38 MAP inhibitors
Respivert
12/12/16
-
9
Indolizinone based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof
Council of Scientific & Industrial Research
12/12/16
-
60
Bis-amido pyridines
Boehringer Ingelheim International
12/12/16
-
30
Fluorescent antagonists of the A3 adenosine receptor
The United States of America, As Represented By The Secretary, Department of Health and Human Services
12/08/16
-
40
Isothiazolopyridine-2-carboxamides and their use as pharmaceuticals
Sanofi
12/08/16
-
24
Trk-inhibiting compound
Ono Pharmaceutical
12/06/16
-
211
Chromane compounds
Comentis
12/05/16
-
7
2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
12/05/16
-
459
Aminoheteroaryl benzamides as kinase inhibitors
Novartis
12/05/16
-
59
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
Merck Sharp & Dohme
12/05/16
-
84
Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
Merck Sharp & Dohme
12/05/16
-
349
Aminopyrimidinones as interleukin receptor-associated kinase inhibitors
Merck Sharp & Dohme
11/29/16
-
11
Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
Reviva Pharmaceuticals
11/28/16
-
36
1,4 oxazines as BACE1 and/or BACE2 inhibitors
Siena Biotech
11/28/16
-
24
Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors
Northwestern University
11/28/16
-
2
P38MAP kinase inhibitors
Respivert
11/28/16
-
202
Biaryl amide compounds as kinase inhibitors
Novartis
11/28/16
-
464
Lactam derivatives useful as orexin receptor antagonists
Actelion Pharmaceuticals
11/28/16
-
26
Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors
Bristol-Myers Squibb
11/28/16
-
24
Fused pyrazole derivatives as novel ERK inhibitors
Merck Sharp & Dohme
11/28/16
-
7
Pyridopyrimidine based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof
Council of Scientific & Industrial Research
11/28/16
-
3
Isoxazolopyridine orexin receptor antagonists
Merck Sharp & Dohme
11/28/16
-
446
Compounds that are ERK inhibitors
Merck Sharp & Dohme
11/21/16
-
32
Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
Pfizer
11/21/16
-
147
Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof
Advinus Therapeutics
11/21/16
-
76
Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie Deutschland
11/21/16
-
11
Beta-amyloid-directed multitarget compounds for the treatment of alzheimer's disease
Universitat De Barcelona
11/21/16
-
22
Heteroaryl compounds and uses thereof
Celgene Avilomics Research
11/21/16
-
81
VEGFR3 inhibitors
Cancer Therapeutics Crc Pty
11/21/16
-
36
1-H-pyrrolo[2,3-b]pyridine derivatives
Merck Patent
11/21/16
-
44
Substituted piperidinyl-carboxamide derivatives useful as SCD 1 inhibitors
Janssen Pharmaceutica
11/21/16
-
278
IRE-1α inhibitors
Mannkind
11/21/16
-
289
Aryl dihydropyridinones and piperidinone MGAT2 inhibitors
Bristol-Myers Squibb
11/15/16
-
15
Gamma secretase inhibitors
Merck Sharp & Dohme
11/14/16
-
41
Substituted amide compounds
Pfizer
11/14/16
-
99
Compounds and compositions as inhibitors of MEK
Novartis
11/14/16
-
42
Triazolopyridine compounds
Hoffmann-La Roche
11/14/16
-
11
Pyridine CGRP receptor antagonists
Merck Sharp & Dohme
11/14/16
-
60
Method of treatment using substituted imidazo[1,2B]pyridazine compounds
Array Biopharma
11/14/16
-
4
Phosphoinositide 3-kinase inhibitors
Respivert
11/14/16
-
100
Inhibition of WDR5 interaction with its binding partners
The Regents of The University of Michigan
11/14/16
-
15
Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities
Almirall
11/14/16
-
67
Pyrrolo pyrimidine derivatives
Novartis
11/14/16
-
57
Sulfonamide compounds
Kancera
11/14/16
-
160
Derivatives of 4-(piperazinylcarbonyl)thiane-1, 1-dione which inhibit GlyT1
Boehringer Ingelheim International
11/14/16
-
30
Kinase inhibitors
Allergan
11/14/16
-
27
Tricyclic indole derivatives useful endothelial lipase inhibitors
Janssen Pharmaceutica
11/08/16
-
88
Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use
H. Lee Moffitt Cancer Center and Research Institute
11/08/16
-
97
Buprenorphine analogs
Purdue Pharma
11/08/16
-
458
Compounds that are ERK inhibitors
Merck Sharp & Dohme
11/08/16
-
6
Spirocyclic molecules as protein kinase inhibitors
Nanjing Allgen Pharma
11/08/16
-
15
Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie
11/08/16
-
94
Heteroarylcarboxylic acid ester derivative
Ajinomoto
11/08/16
-
6
Ethynyl derivatives
Hoffmann-La Roche
11/08/16
-
26
4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors
Novartis
11/08/16
-
198
Benzylamine derivatives as inhibitors of plasma kallikrein
Kalvista Pharmaceuticals
11/08/16
-
4
Inhibitors of protein tyrosine phosphatases
Indiana University Research and Technology
11/02/16
-
459
Substituted pyrrolo[2,3-h][1,6]naphthyridines and compositions thereof as JAK inhibitors
Nissan Chemical Industries
10/31/16
-
6
Metalloenzyme inhibitor compounds
Viamet Pharmaceuticals
10/31/16
-
137
Selective NR2B antagonists
Bristol-Myers Squibb
10/31/16
-
85
Inhibitors of c-fms kinase
Janssen Pharmaceutica
10/31/16
-
10
Arylethynyl derivatives
Hoffmann-La Roche
10/31/16
-
5
Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
Incyte Holdings
10/31/16
-
21
N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]sulfonamides as pharmaceuticals
Sanofi
10/31/16
-
120
Heterocyclic amide derivatives as P2X7 receptor antagonists
Actelion Pharmaceuticals
10/31/16
-
15
C5-C6 oxacyclic-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
10/31/16
-
75
Thiazole compounds, methods for preparation and use thereof
Shanghai Puyi Chemical
10/24/16
-
237
Heterocyclic derivative and pharmaceutical drug
Nippon Shinyaku
10/24/16
-
23
Tricyclic heterocyclic compounds
Bristol-Myers Squibb
10/24/16
-
44
Purinylpyridinylamino-2,4-difluorophenyl sulfonamide derivative, pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition with inhibitory activity against Raf kinase, containing same as active ingredient
Medpacto
10/24/16
-
2
3-[4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane—or heptane-nitrile as JAK inhibitors
Incyte
10/24/16
-
12
3-aryl-2-((arylamino)methyl)quinazolin-4-(3H)-ones
Scifluor Life Sciences
10/24/16
-
50
Quinoline derivatives as PDE10A enzyme inhibitors
H. Lundbeck
10/24/16
-
203
Benzyl sulfonamide derivatives as RORc modulators
Genentech
10/24/16
-
21
Tri-heterocyclic derivatives, preparation process and uses thereof
Shanghai De Novo Pharmatech
10/24/16
-
13
Substituted phthalazinones as rock inhibitors
Bristol-Myers Squibb
10/24/16
-
16
Benzamide derivatives
Dong-A Pharm.
10/24/16
-
95
Phosphatidylinositol 3-kinase inhibitors
Gilead Sciences
10/24/16
-
99
Tyrosine kinase inhibitors
Principia Biopharma
10/19/16
-
109
Pyrazole compounds as CRTH2 antagonists
Boehringer Ingelheim International
10/18/16
-
4
4-Fluoro-Thio-containing inhibitors of APP2, compositions thereof and method of use
TBA
10/18/16
-
102
Carbamate/urea derivatives containing piperidin and piperazin rings as H3 receptor inhibitors
Novartis
10/18/16
-
16
2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition
Northwestern University
10/17/16
-
3
Urea derivatives and uses thereof
Kala Pharmaceuticals
10/17/16
-
34
Dihydroxy aromatic heterocyclic compound
Takeda Pharmaceutical
10/17/16
-
43
Ethynyl compounds
Hoffmann-La Roche
10/17/16
-
36
Pyrazole aminopyrimidine derivatives as LRRK2 modulators
Genentech
10/17/16
-
32
Substituted pyrimidine compounds and their use as SYK inhibitors
Genosco
10/17/16
-
4
6-thio-substituted imidazo[1,2-a]pyrazines as Mps-1 inhibitors
Bayer Intellectual Property
10/17/16
-
19
Bicyclic pyrazole LRRK2 small molecule inhibitors
Genentech
10/17/16
-
13
Nitrogen-containing compounds and pharmaceutical compositions thereof for the treatment of atrial fibrillation
Otsuka Pharmaceutical
10/17/16
-
59
Bicyclic carboxamide inhibitors of kinases
Abbvie
10/17/16
-
33
Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof
Universite Paris Descartes
10/17/16
-
54
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
Arrien Pharmaceuticals
10/11/16
-
196
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
10/11/16
-
1
Boronic acid bearing liphagane compounds as inhibitors of P13K-α and/or β
Counsel of Scientific & Industrial Research
10/11/16
-
201
Organic compounds and their uses
Novartis
10/11/16
-
35
Therapeutic compounds for blocking DNA synthesis of POX viruses
University of Pennsylvania
10/11/16
-
179
Heterocyclic derivative and pharmaceutical composition comprising the same
Shionogi
10/11/16
-
67
Aryl substituted indoles and their use as blockers of sodium channels
Purdue Pharma
10/11/16
-
3
(5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment
Bayer Intellectual Property
10/11/16
-
25
Bicarbocyclic and tricarbocyclic ethynyl derivatives and uses of same
H. Lundbeck
10/11/16
-
88
Heterocyclic compounds for the treatment of stress-related conditions
Otsuka Pharmaceutical
10/10/16
-
15
Phenoxazine derivatives and methods of use thereof
Washington University
10/04/16
-
72
Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction
Emory University
10/03/16
-
53
Agent for treatment of eye diseases
Daito Chemix
10/03/16
-
5
Aggrecanase inhibitors
Eli Lilly
10/03/16
-
50
Triazole compounds that modulate Hsp90 activity
Synta Pharmaceuticals
10/03/16
-
65
Piperazine-substituted benzothiophenes for treatment of mental disorders
Otsuka Pharmaceutical
10/03/16
-
115
Disubstituted benzothienyl-pyrrolotriazines and uses thereof
Bayer Intellectual Property
10/03/16
-
76
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
10/03/16
-
541
Inhibitors of beta-secretase
Vitae Pharmaceuticals
10/03/16
-
17
Haematopoietic-prostaglandin D2 synthase inhibitors
The University of Queensland
09/27/16
-
168
Compounds and compositions as C-kit kinase inhibitors
Novartis
09/27/16
-
1
Purinone derivative hydrochloride
Ono Pharmaceutical
09/27/16
-
117
Triazolyl PDE10 inhibitors
Merck Sharp & Dohme
09/27/16
-
6
Protease inhibitors
Medivir
09/27/16
-
73
Substituted imidazopyrazines
Bayer Intellectual Property
09/27/16
-
167
Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
Allergan
09/27/16
-
27
6-oxopurine phosphoribosyltransferase inhibitors
The University of Queensland
09/27/16
-
5
Compounds and methods for purification of serine proteases
Portola Pharmaceuticals
09/27/16
-
1
N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide for the treatment of chronic myelogenous leukemia
Pfizer
09/27/16
-
55
Guanidinobenzoic acid compound
Astellas Pharma
09/20/16
-
90
N2,N4-bis(4-(piperazine-1-yl)phenyl)pirimidine-2,4-diamine derivative or pharmaceutically acceptable salt thereof, and composition containing same as active ingredient for preventing or treating cancer
Korea Research Institute of Chemical Technology
09/20/16
-
139
Biaryl-propionic acid derivatives and their use as pharmaceuticals
Sanofi
09/20/16
-
7
Selective glycosidase inhibitors and uses thereof
Alectos Therapeutics
09/20/16
-
46
Azaindole derivatives as tyrosine kinase inhibitors
Principia Biopharma
09/19/16
-
66
Heterocyclic sulfone mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
09/19/16
-
18
3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
Institute of Cancer Research
09/19/16
-
38
Oxazole derivatives useful as modulators of FAAH
Merck Sharp & Dohme
09/19/16
-
72
Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
Pfizer
09/19/16
-
166
PDE 10a inhibitors for the treatment of type II diabetes
Janssen Pharmaceutica
09/19/16
-
32
Selective inhibitors of prolylcarboxypeptidase
University of Mississippi
09/19/16
-
24
Substituted oxadiazole compounds
Bristol-Myers Squibb
09/12/16
-
84
p53-Mdm2 antagonists
University of Pittsburgh
09/12/16
-
56
Substituted pyridine compound
Daiichi Sankyo
09/12/16
-
5
Quinazoline-7-ether compounds and methods of use
Newgen Therapeutics
09/12/16
-
118
Substituted quinazolines as serine/threonine kinase inhibitors
Array Biopharma
09/12/16
-
30
Bisaryl-bonded aryltriazolones and use thereof
Bayer Intellectual Property
09/12/16
-
17
Morpholinylbenzotriazines for use in cancer therapy
Merck Patent
09/12/16
-
9
Anti-mucus drugs and uses therefor
Washington University
09/12/16
-
2
Raf inhibitor compounds
Deciphera Pharmaceuticals
09/12/16
-
15
Azabenzimidazole derivatives
Boehringer Ingelheim International
09/12/16
-
22
Peripherally restricted diphenyl purine derivatives
Research Triangle Institute
09/12/16
-
101
Bicyclic pyridazine compounds as Pim inhibitors
Amgen
09/12/16
-
25
Inhibitors of bruton's tyrosine kinase
Pharmacyclics
09/06/16
-
16
Hepsin inhibitors
Fred Hutchinson Cancer Research Center
09/06/16
-
2
Quinolyl-containing hydroxamic acid compound and preparation method thereof, and pharmaceutical composition containing this compound and use thereof
Beijing Konruns Pharmaceutical
09/06/16
-
102
Treatment of respiratory disorders using TRPA1 antagonists
Glenmark Pharmaceuticals
09/06/16
-
11
Therapeutic curcumin derivatives
Stc.Unm
09/06/16
-
9
Curcumin analogues as zinc chelators and their uses
The Research Foundation of State University of New York
09/06/16
-
6
Peripherally restricted FAAH inhibitors
University of California
09/06/16
-
49
Substituted dicyanopyridines and use thereof
Bayer Intellectual Property
09/06/16
-
72
Phenyl-tetrahydroisoquinoline derivatives
Hoffmann-La Roche
09/06/16
-
9
Poly (ADP-ribose) polymerase inhibitor
Chengdu Di'Ao Pharmaceutical Group
09/06/16
-
28
Inhibitors of glutaminyl cyclase
Probiodrug
08/29/16
-
174
2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
Merck Sharp & Dohme
08/29/16
-
140
Substituted pyrido[3,4-b]pyrazines as GPR6 modulators
Takeda Pharmaceutical
08/29/16
-
22
Adenosine receptor agonists, partial agonists, and antagonists
The United States of America, As Represented By The Secretary, Department of Health and Human Services
08/29/16
-
64
Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors
Nerviano Medical Sciences
08/29/16
-
10
TrkA kinase inhibitors, compositions and methods thereof
Merck Sharp & Dohme
08/29/16
-
98
2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
Novartis
08/29/16
-
265
Aldosterone synthase inhibitors
Boehringer Ingelheim International
08/29/16
-
4
Mercaptoamidine derivatives and methods of use
Abbvie
08/29/16
-
15
Cyclic amine derivatives as EP4 receptor antagonists
Rottapharm Biotech
08/29/16
-
23
Fragment ligated inhibitors selective for the polo box domain of PLK1
University of South Carolina
08/15/16
-
31
Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
Cayman Chemical
08/15/16
-
19
Substituted N-phenethyltriazoloneacetamides and use thereof
Bayer Intellectual Property
08/15/16
-
35
5- or 6-substituted 3-hydroxy-2 (1 H)-pyridinones as D-amino acid oxidase (DAAO) inhibitors in therapy of diseases such as schizophrenia, cognitive disorder and pain
Takeda Pharmaceutical
08/15/16
-
8
Phospholipid drug analogs
Telormedix
08/15/16
-
46
mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
08/15/16
-
41
2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease
Albireo
08/15/16
-
35
S1P receptors modulators
Akaal Pharma
08/15/16
-
17
Method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
Amicus Therapeutics
08/15/16
-
22
Heteroaryl compounds as sodium channel blockers
Purdue Pharma
08/15/16
-
12
Therapeutic agent for urinary excretion disorder
Ono Pharmaceutical
08/15/16
-
20
Compounds of modulating TRPV3 function
Hydra Biosciences
08/15/16
-
54
Morpholine compounds and uses thereof
Hoffmann-La Roche
08/15/16
-
7
Buprenorphine analogs
Purdue Pharma
08/08/16
-
68
Indoline scaffold SHP-2 inhibitors and cancer treatment method
University of South Florida
08/08/16
-
43
Macrocyclic factor VIIa inhibitors
Bristol-Myers Squibb
08/08/16
-
346
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Abbvie
08/08/16
-
27
N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides and their use as pharmaceuticals
Sanofi
08/08/16
-
29
4-(4-cyano-2-thioaryl)dihydropyrimidinones and use thereof
Bayer Intellectual Property
08/08/16
-
11
Methods and compositions for studying, imaging, and treating pain
The Board of Trustees of The Leland Stanford Junior University
08/08/16
-
233
Substituted azoanthracene derivatives and intermediates for preparation thereof
Vtv Therapeutics
08/08/16
-
1
Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof
Arena Pharmaceuticals
08/08/16
-
63
Inhibitors of human EZH2, and methods of use thereof
Epizyme
08/08/16
-
25
Inhibitors of phosphodiesterase 11 (PDE11)
Boston College
08/02/16
-
8
Phospholipid drug analogs
Telormedix
08/02/16
-
24
TSH receptor antagonizing tetrahydroquinoline compounds
Merck Sharp & Dohme
08/02/16
-
6
Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators
Bristol-Myers Squibb
08/02/16
-
205
Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof
Sanofi
08/01/16
-
394
Amidopyrazole inhibitors of interleukin receptor-associated kinases
Merck Sharp & Dohme
08/01/16
-
120
1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
Actelion Pharmaceuticals
08/01/16
-
43
Mediators of hedgehog signaling pathways, compositions and uses related thereto
Curis
08/01/16
-
1
Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a ]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
Bristol-Myers Squibb
08/01/16
-
134
Compounds and methods for treating tuberculosis infection
Academia Sinica
07/26/16
-
155
Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase
Janssen Pharmaceutica
07/26/16
-
35
Morpholino compounds, uses and methods
University of Dundee
07/25/16
-
118
Compounds and compositions for the inhibition of NAMPT
Forma Tm
07/25/16
-
12
Sepiapterin reductase inhibitors for the treatment of pain
Solace Pharmaceuticals
07/25/16
-
83
Ketone linked benzothiazole inhibitors of endothelial lipase
Bristol-Myers Squibb
07/25/16
-
45
Apoptosis signal-regulating kinase inhibitors
Gilead Sciences
07/25/16
-
585
Heteroaryl substituted nicotinamide compounds
Bristol-Myers Squibb
07/25/16
-
91
Imidazopyridazine compounds
Hoffmann-La Roche
07/25/16
-
37
Oxazine derivatives and their use in the treatment of disease
Novartis
07/18/16
-
74
Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
Vitae Pharmaceuticals
07/18/16
-
31
Use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.
07/18/16
-
90
Pyrazolopyridine, pyrarolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
Vanderbilt University
07/18/16
-
17
Anti-viral compounds
Abbvie
07/18/16
-
210
Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors
Pfizer
07/18/16
-
1
Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors
Novartis
07/18/16
-
24
Prodrugs of pyridone amides useful as modulators of sodium channels
Vertex Pharmaceuticals
07/18/16
-
6
Beta carboline derivatives useful in the treatment of proliferative disorders
Facultes Universitaires Notre Dame De La Paix
07/18/16
-
26
Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
Merck Canada
07/18/16
-
197
Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
07/18/16
-
44
Functionally selective ligands of dopamine D2 receptors
University of North Carolina At Chapel Hill
07/11/16
-
2
Pyrrolo[2,3-d]pyrimidine compounds
Zoetis Services
07/11/16
-
1
4-isopropyl-6-methoxyphenyl glucitol compound
Taisho Pharmaceutical
07/11/16
-
47
1,5-Diary1-2-alkylpyrrole-3-substituted nitro esters, selective COX-2 inhibitors and nitric oxide donors
Rottapharm Biotech
07/11/16
-
5
Reactivators of organophosphorous inhibited acetylcholinesterase
Southwest Research Institute
07/11/16
-
53
Cinnamoyl inhibitors of transglutaminase
University of Ottawa
07/11/16
-
38
4-piperidinyl compounds for use as tankyrase inhibitors
Novartis
07/11/16
-
87
5-substituted indazoles as kinase inhibitors
Abbvie
07/11/16
-
103
Pyrimidines as sodium channel blockers
Purdue Pharma
07/11/16
-
2
Indolinone protein kinase inhibitors
Beta Pharma
07/11/16
-
30
Quinazoline compounds as sodium channel blockers
Purdue Pharma
07/11/16
-
2
Chrysophaentin analogs that inhibit FtsZ protein
The United States of America, As Represented By The Secretary, Department of Health and Human Services
07/11/16
-
148
Cycloalkyl and heterocycloalkyl compounds as orexin receptor antagonists
Takeda Pharmaceutical
06/30/16
-
52
Heterocyclic compounds
Shionogi
06/30/16
-
10
Chemical compounds
Astrazeneca
06/30/16
-
5
Tricyclic triazole compounds that modulate HSP90 activity
Synta Pharmaceuticals
06/30/16
-
204
4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors
Pfizer
06/30/16
-
4
Treating diabetes with dipeptidyl peptidase-IV inhibitors
Merck Sharp & Dohme
06/30/16
-
8
Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases
Hanmi Pharm.
06/30/16
-
44
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Abbvie
06/30/16
-
26
Amine oxidase inhibitors
Case Western Reserve University
06/30/16
-
5
Factor IXa inhibitors
Merck Sharp & Dohme
06/30/16
-
208
Biaryl-propionic acid derivatives and their use as pharmaceuticals
Sanofi
06/20/16
-
198
2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-YL)picolinamide derivatives as orexin receptor antagonists
Actelion Pharmaceuticals
06/20/16
-
237
Heterocyclic compounds containing an indole core
Boehringer Ingelheim International
06/20/16
-
171
5,8-dihydro-6H-pyrazolo[3,4-h]quinazolines as IGF-1R/IR inhibitors
Boehringer Ingelheim International
06/20/16
-
6
Selective PI3K delta inhibitors
Rhizen Pharmaceuticals
06/20/16
-
11
Nicotinic receptor compounds
Research Triangle Institute
06/20/16
-
8
Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
Boehringer Ingelheim International
06/20/16
-
44
Bicyclic heterocycle compounds and their uses in therapy
Astex Therapeutics
06/20/16
-
22
Treatment of inflammatory bowel disease
Allergan
06/20/16
-
505
N-myristoyl transferase inhibitors
Univeristy of Dundee
06/20/16
-
153
6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
Merck Serono
06/14/16
-
68
Cosmetic compositions containing substituted azole and methods for alleviating the signs of photoaged skin
The Procter & Gamble
06/13/16
-
239
Bis-(sulfonylamino) derivatives for use in therapy
Astrazeneca
06/13/16
-
242
Bipyridylaminopyridines as Syk inhibitors
Merck Sharp & Dohme
06/13/16
-
399
Imidazole amines as modulators of kinase activity
Merck Patent
06/13/16
-
37
Aminopyrimidine derivatives as LRRK2 modulators
Genentech
06/13/16
-
7
Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators
Purdue Pharma
06/13/16
-
26
Selective HDAC1 and HDAC2 inhibitors
Acetylon Pharmaceuticals
06/13/16
-
68
1,2,4-triazine-6-carboxamide derivative
Taiho Pharmaceutical
06/13/16
-
5
Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones as protein kinase inhibitors
Nerviano Medical Sciences
06/13/16
-
19
Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
06/13/16
-
5
5-fluoro-3-phenyl-2-[1-(9h-purin-6-ylamino)propyl]-3h-quinazolin-4-one as an inhibitor of human phosphatidylinositol 3-kinase delta
Icos
06/13/16
-
13
Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
Dartmouth College
06/13/16
-
2
Metalloenzyme inhibitor compounds
Innocrin Pharmaceuticals
06/13/16
-
91
Sulphonylaminopyrrolidinone derivatives, their preparation and their therapeutic application
Sanofi
06/13/16
-
325
Triazine derivative and pharmaceutical composition comprising the same
Shionogi
06/13/16
-
10
Imidazopyridazinyl compounds
Bristol-Myers Squibb
06/13/16
-
217
Pharmaceutical compounds
Astex Therapeutics
06/13/16
-
68
Cosmetic compositions containing substituted azole and methods for improving the appearance of aging skin
The Procter & Gamble
06/06/16
-
2
Use of inhibitors of porphobilinogen deaminase in the treatment of congenital erythropoietic porphyria
AsociacióN Centro De InvestigacióN Cooperativa En Biociencias—Cic Biogune
06/06/16
-
7
Methods of treatment of histamine H-4 receptor-related pruritus
Bridge Pharma
06/06/16
-
8
Radiolabeled PDE10A ligands
Abbvie
06/06/16
-
80
Substituted quinoxalines as sodium channel modulators
Vertex Pharmaceuticals
06/06/16
-
16
Tri-aryl/heteroaromatic cannabinoids and use thereof
The University of Tennessee Research Foundation
06/06/16
-
119
Heterocyclic carboxamides as modulators of kinase activity
Merck Patent
06/06/16
-
295
Sulfoximine substituted quinazolines for pharmaceutical compositions
Boehringer Ingelheim International
06/06/16
-
24
Amide or urea containing benzothiazole inhibitors of endothelial lipase
Bristol-Myers Squibb
06/06/16
-
49
Inhibitors of the Renal Outer Medullary Potassium channel
Merck Sharp & Dohme
06/06/16
-
21
Azetidine compounds, compositions and methods of use
Hoffmann-La Roche
06/06/16
-
259
Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists
Boehringer Ingelheim International
05/23/16
-
82
Dual modulators of 5HT2A and D3 receptors
Hoffmann-La Roche
05/23/16
-
19
Pyrazolone derivatives as PDE4 inhibitors
Takeda
05/23/16
-
39
Disubstituted 5-fluoro pyrimidine derivatives containing a sulfoximine group
Bayer Intellectual Property
05/23/16
-
11
Aurora and FLT3 kinases modulators
Sareum
05/23/16
-
37
Selective androgen receptor modulators
Radius Health
05/23/16
-
9
Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities
Deciphera Pharmaceuticals
05/23/16
-
85
Serine/threonine kinase inhibitors
Array Biopharma
05/23/16
-
7
Oxidated derivatives of triazolylpurines useful as ligands of the adenosine A2A receptor and their use as medicaments
Sigma-Tau Industrie Farmaceutiche Riunite
05/23/16
-
2
Pyrimidine derivatives as protein kinase inhibitors
Cyclacel
05/23/16
-
10
Inhibitors of Bruton's tyrosine kinase
Pharmacyclics
05/23/16
-
6
Antiviral compounds
Katholieke Universiteit Leuven
05/16/16
-
4
Methods for treating GI tract disorders
Neurogastrx
05/16/16
-
4
Transcription factor modulators
C&C Biopharma
05/16/16
-
38
Morphan and morphinan analogues, and methods of use
Alkermes Pharma Ireland
05/16/16
-
19
Pyrimidine diol amides as sodium channel blockers
Purdue Pharma
05/16/16
-
1
Inhibitors of bruton's tyrosine kinase
Pharmacyclics
05/16/16
-
91
Carbamate compounds and of making and using same
The Scripps Research Institute
05/16/16
-
130
HIV protease inhibitors
Merck Canada
05/16/16
-
15
Substituted benzimidazole and imidazopyridine compounds useful as CYP17 modulators
Bristol-Meyers Squibb
05/16/16
-
7
Substituted quinoline compounds and methods of use
Sunshine Lake Pharma
05/16/16
-
117
Pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
Sanofi
05/16/16
-
67
Morpholinylquinazolines
Merck Patent
05/09/16
-
10
Selective glycosidase inhibitors and uses thereof
Merck Sharp & Dohme
05/09/16
-
57
Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
Cayman Chemical
05/09/16
-
41
Substituted benzopiperazines as CETP inhibitors
Merck Sharp & Dohme
05/09/16
-
5
1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
The Regents of The University of Michigan
05/09/16
-
12
Compounds for inhibiting the interaction of BCL2 with binding partners
Novartis
05/09/16
-
45
Compounds for inhibiting the interaction of BCL2 with binding partners
Novartis
05/09/16
-
25
Inhibitors of glutaminyl cyclase
Probiodrug
05/09/16
-
63
Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them
Sanofi
05/09/16
-
9
Isoform selective phospholipase D inhibitors
Vanderbilt University
05/09/16
-
36
Epoxyeicosatrienoic acid analogs and methods of making and using the same
The Medical College of Wisconsin
05/09/16
-
42
Substituted clavulanic acid
Nabriva Therapeutics
05/02/16
-
260
Pyrimidooxazocine derivatives as mTOR-inhibitors
Sanofi
05/02/16
-
4
Saccharide conjugates
Curators of The University of Missouri
05/02/16
-
431
Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
Abbvie
05/02/16
-
17
Antitumor agent
Mitsubishi Tanabe Pharma
05/02/16
-
262
Tetracyclic compound
Chugai Seiyaku Kabushiki Kaisha
05/02/16
-
39
Treatment of hyperproliferative disorders with diarylhydantoin compounds
University of California
05/02/16
-
6
Substituted pyridazine carboxamide compounds
Xcovery Holding
05/02/16
-
14
Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
Incyte Holdings
05/02/16
-
171
Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
Boehringer Ingelheim International
04/25/16
-
17
Azetidine derivative and antidepressant composition including the same
Korea Institute of Science and Technology
04/25/16
-
3
Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases
Galderma Research & Development
04/25/16
-
37
Indole or indazole derivative or salt thereof
Taiho Pharmaceutical
04/25/16
-
7
Selective glycosidase inhibitors and uses thereof
Simon Fraser University
04/25/16
-
11
Pyridyl aminopyridines as Syk inhibitors
Merck Sharp & Dohme
04/25/16
-
14
Triazine carboxamides as sodium channel blockers
Purdue Pharma
04/25/16
-
115
Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
Les Laboratoires Servier
04/25/16
-
27
Process for preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of using such compounds
Gruenenthal
04/25/16
-
50
Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of P2Y1 receptor
Bristol-Myers Squibb
04/25/16
-
7
Thienopyrimidine compounds
Vernalis (R&D)
04/25/16
-
70
1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof
Sanofi
04/18/16
-
8
Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK)
University of Maryland, Baltimore
04/18/16
-
20
Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase
Amicus Therapeutics
04/18/16
-
38
Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism
University of Michigan
04/18/16
-
4
Triazole compounds that modualte HSP90 activity
Synta Pharmaceuticals
04/18/16
-
612
Quinoline derivatives and MELK inhibitors containing the same
Oncotherapy Science
04/18/16
-
40
Pyridine compounds as sodium channel blockers
Purdue Pharma
04/18/16
-
40
Substituted phenylureas and phenylamides as vanilloid receptor ligands
Gruenenthal
04/18/16
-
13
Selective FAK inhibitors
Cancer Therapeutics Crc
04/18/16
-
1
Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
Confluence Life Sciences
04/12/16
-
20
Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof
Sanofi
04/12/16
-
61
Compounds and methods for kinase modulation, and indications therefor
Plexxikon
04/11/16
-
7
Dipeptidyl-peptidase-IV inhibitors for treatment of type 2 diabetes complex with hypertension
TBA
04/11/16
-
70
Compounds from Antrodia cinnamomea and use thereof
Simpson Biotech
04/11/16
-
1
Crystalline forms of a prolyl hydroxylase inhibitor
Fibrogen
04/11/16
-
21
N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors
Galderma Research & Development
04/11/16
-
7
Dual action inhibitors against histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme a reductase
National Taiwan University
04/11/16
-
98
Substituted piperidine compounds and their use as orexin receptor modulators
Janssen Pharmaceutica
04/11/16
-
10
1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derivatives
Merck Sharp & Dohme
04/11/16
-
5
Fused heterocyclic derivative and pharmaceutical use thereof
Kissei Pharmaceutical
04/11/16
-
84
Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors
Janssen Pharmaceutica
04/05/16
-
1
Hydroxamic acid derivatives
Purdue Pharmaceutical Products
04/04/16
-
180
Benzamides
H. Lundbeck
04/04/16
-
15
N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
Bristol-Myers Squibb
04/04/16
-
59
Fatty acid amide hydrolase inhibitors
University of Connecticut
04/04/16
-
93
Bicyclic thiazole compounds
Carna Biosciences
04/04/16
-
12
Use of rosuvastatin lactols as medicaments
Redx Pharma
04/04/16
-
440
Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors
Kudos Pharmaceuticals
04/04/16
-
45
5,6,7,8,9,10-hexahydro-6,10-epimino[1,2,4]triazolo[4,3-a]azocines as P2X7 modulators
Janssen Pharmaceutica
04/04/16
-
10
Na/K-ATPase ligands, ouabain antagonists, assays and uses thereof
The University of Toledo
04/04/16
-
13
Naphthalene-based inhibitors of anti-apoptotic proteins
Burnham Institute For Medical Research
04/04/16
-
12
Methods of using cycloalkylmethylamine derivatives
Reviva Pharmaceuticals
03/28/16
-
22
Inhibition of memapsin 1 cleavage in the treatment of diabetes
Oklahoma Medical Research Foundation
03/28/16
-
17
Selective HDAC3 inhibitors
Acetylon Pharmaceuticals
03/28/16
-
125
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
Merck Sharp & Dohme
03/28/16
-
175
Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
Boehringer Ingelheim International
03/28/16
-
5
Benzofuran derivatives for the treatment of hepatitis C
Bristol-Myers Squibb
03/28/16
-
111
Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors
H. Lundbeck
03/28/16
-
5
Kinase inhibitors and methods of use thereof
The Broad Institute
03/28/16
-
51
7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin D2 receptor modulators
Actelion Pharmaceuticals
03/28/16
-
111
P2X7 modulators
Janssen Pharmaceutica
03/28/16
-
26
Arylamino purine derivatives, preparation method and pharmaceutical use thereof
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)
03/28/16
-
24
Quarternized buprenorphine analogs
Purdue Pharma
03/28/16
-
53
Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase
Board of Regents, The University of Texas System
03/28/16
-
121
Substituted pyrido[3,2-E][1,2,4]-triazolo[4,3-A]pyrazines for the treatment of central nervous system disorders
Boehringer Ingelheim International
03/21/16
-
174
1,2,6-substituted benzimidazoles as flap modulators
Janssen Pharmaceutica
03/21/16
-
184
Aryl- or heteroaryl-substituted benzene compounds
Epizyme
03/21/16
-
130
5-alkynyl-pyridines
Boehringer Ingelheim International
03/21/16
-
9
Specific nNOS inhibitors for the therapy and prevention of human melanoma
Northwestern University
03/21/16
-
36
Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies
Galderma Research & Development
03/21/16
-
73
Substituted benzimidazole-type piperidine compounds and uses thereof
Purdue Pharma
03/21/16
-
9
Therapeutic pyrazolyl thienopyridines
Thesan Pharmaceuticals
03/21/16
-
89
Benzoxazepin compounds selective for PI3K P110 delta and methods of use
Genentech
03/21/16
-
4
Compound and methods for its production
Neurovive Pharmaceutical
03/21/16
-
10
4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases
Bayer Intellectual Property
03/16/16
-
65
Heteroaryl sodium channel inhibitors
Amgen
03/14/16
-
172
Spiro-oxindole MDM2 antagonists
The Regents of The University of Michigan
03/14/16
-
28
Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
Bristol-Myers Squibb
03/14/16
-
36
Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
Albany Molecular Research
03/14/16
-
17
Pyrazinecarboxamide compound
Astellas Pharma
03/14/16
-
33
Compounds for the treatment of neurodegenerative diseases
Proteotech
03/14/16
-
768
Complement pathway modulators and uses thereof
Novartis
03/14/16
-
30
Nonpeptide HIV-1 protease inhibitors
Purdue Research Foundation
03/14/16
-
396
Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
Amgen
03/14/16
-
427
Tricyclic pyrazol amine derivatives
Merck Serono
03/09/16
-
105
Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core
Boehringer Ingelheim International
03/07/16
-
43
Liver X receptor modulators
Vitae Pharmaceuticals
03/07/16
-
4
Organic compounds
Intra-Cellular Therapies
03/07/16
-
5
Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof
Bayer Intellectual Property
03/07/16
-
10
HIV protease inhibitors
Merck Canada
03/07/16
-
10
NMDA receptor antagonists for neuroprotection
Emory University
03/07/16
-
818
Flap modulators
Janssen Pharmaceutica
03/07/16
-
1
Selective glycosidase inhibitors and uses thereof
Simon Fraser University
03/07/16
-
112
Rho kinase inhibitors
Boehringer Ingelheim International
03/07/16
-
27
Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments
Sanofi
03/07/16
-
25
Method of using substituted 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
Boehringer Ingelheim International
02/29/16
-
181
Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
Boehringer Ingelheim International
02/29/16
-
332
Flap modulators
Janssen Pharmaceutica
02/29/16
-
149
Benzoic acid derivatives
Hoffmann-La Roche
02/29/16
-
9
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
02/29/16
-
24
3-Oxo-2,3-dihydro-1H-indazole-4-carboxamide derivatives as PARP-1 inhibitors
Nerviano Medical Sciences
02/29/16
-
23
Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt
Korea Research Institute of Chemical Technology
02/29/16
-
54
Pyrazole derivatives
Hoffmann-La Roche
02/29/16
-
12
Anti-cancer compound and pharmaceutical composition containing the same
Sanofi
02/29/16
-
368
Pyrrolo[2,3-B]pyridine CDK9 kinase inhibitors
Abbvie
02/29/16
-
10
Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
Albany Molecular Research
02/29/16
-
240
Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators
Senhwa Biosciences
02/22/16
-
241
Chemical compounds
Pfizer
02/22/16
-
14
1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
Hoffmann-La Roche
02/22/16
-
19
2-heteroaryl carboxamides
Bayer Intellectual Property
02/22/16
-
109
Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators
Janssen Pharmaceutica
02/22/16
-
113
1,5-naphthyridine derivatives and MELK inhibitors containing the same
Oncotherapy Science
02/22/16
-
1
Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes
Boehringer Ingehleim International
02/22/16
-
201
Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
Albany Molecular Research
02/22/16
-
47
Hydroxamic acid derivative
Taisho Pharmaceutical
02/22/16
-
8
Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same
Chang Gung University
02/22/16
-
157
Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists
Sanofi
02/22/16
-
20
Pyrimidine PDE10 inhibitors
Merck Sharp & Dohme
02/16/16
-
11
Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors
H. Lundbeck
02/16/16
-
1
Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same
Korea Institute of Science and Technology
02/16/16
-
89
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
02/16/16
-
274
Substituted 7-azabicyles and their use as orexin receptor modulators
Janssen Pharmaceutica
02/16/16
-
107
Fused heterocyclic derivatives and methods of use
Amgen
02/16/16
-
302
Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie Deutschland
02/16/16
-
2
Inhibitors of protein kinases
Astrazeneca
02/16/16
-
79
Tropomyosin-related kinase (TRK) inhibitors
Genzyme
02/16/16
-
215
1,2,5-substituted benzimidazoles as FLAP modulators
Janssen Pharmaceutica
02/16/16
-
155
Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
Novartis
02/09/16
-
11
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
02/09/16
-
3
Substituted 2,3,5,9,9B-pentaazacyclopenta[a]naphthalenes and uses thereof
H. Lundbeck
02/09/16
-
149
Pyridine-2-derivatives as smoothened receptor modulators
Pfizer
02/09/16
-
2
Management and treatment of benign prostatic hyperplasia
CSIR, Pretoria (Za)
02/09/16
-
6
2′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
Merck Sharp & Dohme
02/09/16
-
36
Cannabinoid-2 agonists
Allergan
02/09/16
-
88
Fused pyrimidines and substituted quinazolines as inhibitors of p97
Cleave Biosciences
02/09/16
-
92
Triazolopyridine compounds
Novartis
02/09/16
-
160
Cyclohexyl-azetidinyl antagonists of CCR2
Janssen Pharmaceutica
02/09/16
-
98
Substituted isoquinolinones and quinazolinones
Novartis
01/25/16
-
10
Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie Deutschland
01/25/16
-
64
Sulfamide sodium channel inhibitors
Amgen
01/25/16
-
18
Apoptosis signal-regulating kinase inhibitors
Gildead Sciences
01/25/16
-
27
Heterocyclic acrylamides and their use as pharmaceuticals
Fab Pharma
01/25/16
-
8
Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
Merck Sharp & Dohme
01/25/16
-
152
Pyridine compounds and the users thereof
Purdue Pharma
01/25/16
-
5
Benzomorphan analogs and the use thereof
Purdue Pharma
01/25/16
-
4
Activity based probes (ABPs) interacting with glycosidases
Academisch Medisch Centrum Bij Universiteit Van Amsterdam
01/25/16
-
7
Methods for treating or preventing cancer and neurodegenerative diseases
Sloan-Kettering Institute For Cancer Research
01/25/16
-
51
3,5-disubstituted alkynylbenzene compound and salt thereof
Taiho Pharmaceutical
01/19/16
-
6
Antimicrobial compounds
Monash University
01/19/16
-
169
Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
Les Laboratoires Servier
01/19/16
-
2
Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
Incyte
01/19/16
-
7
Substituted 2-[2-(phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
Newron Pharmaceuticals
01/18/16
-
85
N-benzylindole modulators of PPARG
The Scripps Research Institute
01/18/16
-
157
Pyridone amides as modulators of sodium channels
Vertex Pharmaceuticals
01/18/16
-
1
1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as p38 MAP kinase inhibitors
Respivert
01/18/16
-
4
Cyclic ether DGAT1 inhibitorscyclic ether DGAT1 inhibitors
Novartis
01/18/16
-
20
Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
Pfizer
01/11/16
-
32
Inhibitors of beta-secretase
Vitae Pharmaceuticals
01/11/16
-
26
5-HT3 receptor modulators, methods of making, and use thereof
Albany Molecular Research
01/11/16
-
28
Selective caspase inhibitors and uses thereof
Novagenesis Foundation
01/11/16
-
74
Heteroaromatic compounds and their use as dopamine D1 ligands
Pfizer
01/11/16
-
6
Bivalent ligands for the treatment of neurological disorders
Virginia Commonwealth University
01/11/16
-
74
Amides as modulators of sodium channels
Vertex Pharmaceuticals
01/11/16
-
19
TRPA1 antagonists
Abbvie
01/11/16
-
17
Inhibitors of the Renal Outer Medullary Potassium channel
Merck Sharp & Dohme
01/11/16
-
16
Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors
Bristol-Myers Squibb
01/11/16
-
40
Hydroxymethylaryl-substituted pyrrolotriazines as ALK1 inhibitors
Bayer Intellectual Property
12/21/15
-
15
Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof
Kissei Pharmaceutical
12/21/15
-
6
Compounds and methods useful for directing stem cell differentiation
Vanderbilt University
12/21/15
-
137
IRE-1α inhibitors
Mannkind
12/21/15
-
6
Pyrazole-amide compounds and pharmaceutical use thereof
Japan Tobacco
12/21/15
-
18
Histone deacetylase inhibitor of benzamides and use thereof
Shanghai Institute of Pharmaceutical Industry
12/21/15
-
9
Biphenyl derivatives useful as glucagon receptor antagonists
Janssen Pharmaceutica
12/21/15
-
3
Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie Deutschland
12/21/15
-
55
2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
Albany Molecular Research
12/21/15
-
13
Inhibition of small ubiquitin-like modifier enzymes with substituted pyrrolo[2,3-b]quinoxalines
City of Hope
12/21/15
-
143
Nitrogen-containing condensed heterocyclic compound
Taisho Pharmaceutical
12/14/15
-
42
Pyrrolo[2,3-D]pyrimidine derivatives
Pfizer
12/14/15
-
5
Compositions and methods for treating cancer
Otsuka Pharmaceutical
12/14/15
-
3
Method of treating human skin and a skin care composition for use in such a method
Pantarhei Bioscience
12/14/15
-
72
Chemical compounds
Glaxosmithkline
12/14/15
-
190
Chemical compounds 542
Astrazeneca
12/14/15
-
90
[1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
Janssen Pharmaceutica
12/14/15
-
1
Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
Vertex Pharmaceuticals
12/14/15
-
116
Melanocortin receptor-specific peptides
Astrazeneca
12/14/15
-
202
Diphenylmethane derivatives as SGLT2 inhibitors
Green Cross
12/08/15
-
3
Process for preparing a compound useful for producing an optically active diazabicyclooctane compound
Meiji Seika Pharma
12/08/15
-
3
Method of using 4,5,6,7-tetrahydroimidazo[4,5-C]pyridine compounds
Proximagen
12/08/15
-
12
Agents for reversing epigenetic silencing of genes
The Johns Hopkins University
12/07/15
-
14
17-(1′propenyl)-17-3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative
Bayer Intellectual Property
12/07/15
-
608
Tricyclic compounds and methods of use therefor
Genentech
12/07/15
-
10
Carbamate/urea derivatives
Novartis
12/07/15
-
5
4-aminoquinazoline derivatives and uses thereof
Shanghai Institute of Pharmaceutical Industry
12/07/15
-
44
Indanyl-substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them
Sanofi
12/07/15
-
26
Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
Albany Molecular Research
12/07/15
-
36
Inhibitors of glutaminyl cyclase
Probiodrug
12/07/15
-
10
Iminothiadiazine dioxide compounds as brace inhibitors, compositions, and their use
Merck Sharp & Dohme
11/23/15
-
17
2,5-disubstituted thiomorpholine orexin receptor antagonists
Merck Sharp & Dohme
11/23/15
-
138
Substituted benzamide derivatives
Hoffmann-La Roche
11/23/15
-
32
Cyclopropyl amide derivatives
Astrazeneca
11/23/15
-
22
Adenosine receptor ligands and uses thereof
Kaldi Pharma
11/23/15
-
50
17α-hydroxylase/C17,20-lyase inhibitors
Novartis
11/23/15
-
30
Sorafenib derivatives as sEH inhibitors
University of California
11/23/15
-
5
Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof
TBA
11/23/15
-
3
Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy
Pantarhei Bioscience
11/23/15
-
2
γ-Secretase substrates and methods of use
Memorial Sloan-Kettering Cancer Center
11/16/15
-
22
Substituted fused imidazoles and pyrazoles and use thereof
Bayer Intellectual Property
11/16/15
-
655
Compounds that are ERK inhibitors
Merck Sharp & Dohme
11/16/15
-
212
5-membered nitrogen containing heterocyclic derivatives and pharmaceutical compositions comprising the same
Kissei Pharmaceutical
11/16/15
-
81
Heteroarylcarboxylic acid ester derivative
Ajinomoto
11/16/15
-
4
Substituted indazole derivatives active as kinase inhibitors
Nerviano Medical Sciences
11/16/15
-
19
Pyrazolopyrimidines as metabotropic glutamate 5 receptor antagonists
Boehringer Ingelheim International
11/16/15
-
5
BACE inhibitors
Eli Lilly
11/16/15
-
124
Phenylimidazole derivatives as PDE10A enzyme inhibitors
H. Lundbeck
11/11/15
-
15
Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
Fm Therapeutics
11/11/15
-
32
Chemical compounds
Astrazeneca
11/11/15
-
42
Combination therapy with MDM2 and EFGR inhibitors
TBA
11/11/15
-
500
Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
Sanofi
11/11/15
-
20
Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof
The Board of Trustees of The Leland Stanford Junior University
11/02/15
-
38
FAK inhibitors
Cancer Therapeutics Crc
11/02/15
-
13
Method for enhancing anti-tumor effect of a microtubule-targeting drug, and a method for treatment of tumor
Taiho Pharmaceutical
11/02/15
-
291
TRPV3 modulators
Abbvie
11/02/15
-
9
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme
11/02/15
-
6
Alicyclic[c] benzopyrone derivatives and uses thereof
Huazhong University of Science & Technology
11/02/15
-
217
Bicyclic heterocycle compounds and their uses in therapy
Astex Therapeutics
11/02/15
-
7
Fluoro-substituted 2-aryl-3,5-dicyano-4-indazolyl-6-methyl-1,4-dihydropyridines and uses thereof
Bayer Intellectual Property
11/02/15
-
7
Esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them, and their use as inhibitors of the thioredoxin—thioredoxin reductase system
Instytut Chemii Organicznej Polskiej Akademii Nauk
11/02/15
-
16
Inhibitors of beta-secretase
Boehringer Ingelheim International
11/02/15
-
98
Pyrimidone derivatives
Mitsubishi Tanabe Pharma
10/26/15
-
3
Substituted benzene compounds
Epizyme
10/26/15
-
7
Liver X receptor modulators
Vitae Pharmaceuticals
10/26/15
-
15
Tetrahydrocarboline derivative
Ono Pharmaceutical
10/26/15
-
13
Substituted aminobutyric derivatives as neprilysin inhibitors
Novartis
10/26/15
-
10
Prolylcarboxypeptidase inhibitors
Merck Sharp & Dohme
10/26/15
-
19
Azetidine derivatives
Vernalis (R&D)
10/26/15
-
20
Rosuvastatin and atorvastatin derivatives
Redx Pharma
10/26/15
-
6
Methods of modifying amyloid β oligomers using non-peptidic compounds
Acumen Pharmaceuticals
10/26/15
-
110
Dihydroorotate dehydrogenase inhibitors
Merck Serono
10/26/15
-
315
Heterocyclic compounds as ERK inhibitors
Merck Sharp & Dohme
10/19/15
-
59
Proline sulfonamide derivatives as orexin receptor antagonists
Actelion Pharmaceuticals
10/19/15
-
1
Phenoxyethoxy compounds
Eli Lilly
10/19/15
-
61
Substituted naphthylacetic acids
Hoffmann-La Roche
10/19/15
-
43
Imidazo[4,5-c]quinolines as DNA-PK inhibitors
Merck Patent
10/19/15
-
24
2H-imidazol-4-amine compounds and their use as BACE inhibitors
Astrazeneca
10/19/15
-
12
Cyclohexane-1,2′-indene-1′,2″-imidazol compounds and their use as BACE inhibitors
Astrazeneca
10/19/15
-
17
Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors
Astrazeneca
10/19/15
-
10
Cycloalkyl ether compounds and their use as BACE inhibitors
Astrazeneca
10/19/15
-
34
Thiophene derivative as SGLT2 inhibitor and pharmaceutical composition comprising same
Green Cross
10/19/15
-
240
3-amido-pyrrolo[3,4-C]pyrazole-5(1H, 4H,6H) carbaldehyde derivatives
Pfizer
10/12/15
-
500
Bicyclic aryl and heteroaryl sodium channel inhibitors
Amgen
10/12/15
-
65
Phenylcyclopropylamine derivatives and their medical use
Oryzon Genomics
10/05/15
-
5
Tetrahydrocyclopenta[c]acridine derivatives as kinase inhibitors and biological
Centre National De La Recherche Scientifique
10/05/15
-
138
Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C
Boehringer Ingelheim International
10/05/15
-
19
Oxazine derivatives
Shionogi
10/05/15
-
16
Pharmaceutically active compounds as Axl inhibitors
Lead Discovery Center
10/05/15
-
9
Derivatives of propargylamine having neuroprotective capacity for the treatment of Alzheimer's and Parkinson's diseases
Consejo Superior De Investigaciones Cientificas
10/05/15
-
24
Pyrazolopyrimidine JAK inhibitor compounds and methods
Genentech
10/05/15
-
5
Amides of acetic and propionic acids
Bayer Intellectual Property
10/05/15
-
14
Compounds for the treatment of addiction
Gilead Sciences
10/05/15
-
5
Morpholinyl derivatives useful as MOGAT-2 inhibitors
Eli Lilly
09/28/15
-
6
[1,3,4] oxadiazole derivative and application thereof
Huazhong University of Science & Technology
09/28/15
-
124
N1/N2-lactam acetyl-CoA carboxylase inhibitors
Pfizer
09/28/15
-
3
4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmetics
Galderma Research & Development
09/28/15
-
10
Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
Rhizen Pharmaceuticals
09/28/15
-
48
Substituted pyrrolidine-2-carboxamides
F. Hoffmann-La Roche
09/28/15
-
113
(aza)indole derivative and use thereof for medical purposes
Kissei Pharmaceutical
09/28/15
-
42
Method of treating contrast-induced nephropathy
Novartis
09/28/15
-
112
Pyrrolopyrimidines as janus kinase inhibitors
Merck Sharp & Dohme
09/28/15
-
26
Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
Albany Molecular Research
09/28/15
-
37
Selective androgen receptor modulators
Radius Health
09/03/15
-
26
Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
University of Utah Research Foundation
09/03/15
-
180
Sulfonamide compounds having TRPM8 antagonistic activity
Mitsubishi Tanabe Pharma
09/03/15
-
202
Ring-substituted N-pyridinyl amides as kinase inhibitors
Novartis
09/03/15
-
72
Ring-fused compound
Sato Pharmaceutical
09/03/15
-
124
Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs
University of South Florida
09/03/15
-
63
Compositions and methods for treatment of leukemia
University of Michigan
09/03/15
-
18
Resorcinol derivatives as HSP90 inhibitors
Nerviano Medical Sciences
09/03/15
-
10
Pyridinedione carboxamide inhibitors of endothelial lipase
Bristol-Myers Squibb
09/03/15
-
153
(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors
Sanofi
09/03/15
-
177
Pyrimidinecarboxamides as CXCR2 modulators
Syntrix Biosystems
08/25/15
-
38
Heterocyclic derivatives
Novartis
08/25/15
-
60
Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
Bristol-Myers Squibb
08/25/15
-
3
Compounds and method for treatment of HIV
Critical Outcome Technologies
08/25/15
-
38
Substituted imidazo[1,2-B]pyridazines
Bayer Intellectual Property
08/25/15
-
45
Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway
Bayer Intellectual Property
08/25/15
-
12
Spirocyclic morphinans and their use
Purdue Pharma
08/25/15
-
17
Inhibitors of cytochrome P450
Gilead Sciences
08/25/15
-
375
Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase
Bristol-Myers Squibb
08/25/15
-
5
Metalloenzyme inhibitor compounds
Innocrin Pharmaceuticals
08/25/15
-
10
Cancer targeting using carbonic anhydrase isoform IX inhibitors
Maastro-Clinic
08/19/15
-
7
CXCR2 inhibitors
Sanofi
08/19/15
-
13
Substituted cis- and trans-stilbenes as therapeutic agents
Stc.Unm
08/19/15
-
10
19-nor-steroid derivatives with a 15α,16α-methylene group and a saturated 17,17-spirolactone ring, use thereof, and medicaments containing said derivatives
Bayer Intellectual Property Gbmh
08/19/15
-
15
Morpholinone compounds as factor IXA inhibitors
Merck Sharp & Dohme
08/19/15
-
1
Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders
Janssen Pharmaceutica
08/19/15
-
25
Substituted piperidines as Par-1 antagonists
Bayer Intellectual Property
08/19/15
-
357
Substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C
Boehringer Ingelheim International
08/19/15
-
8
Tetrahydropyrrolothiazine compounds
Eli Lilly
08/19/15
-
25
Inhibitors of β-secretase
Vitae Pharmaceuticals
08/19/15
-
9
Phenyl derivative
Ono Pharmaceutical
08/10/15
-
211
Chromane compounds
Comentis
08/10/15
-
189
Pyrazolopyrrolidine derivatives and their use in the treatment of disease
Novartis
08/10/15
-
25
Aryl glycoside compound, preparation method and use thereof
Shanghai Yingli Science and Technology
08/10/15
-
7
2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof
Toxicology Academy of Military Medical Sciences P.L.A.
08/10/15
-
5
5-fluoro-3-phenyl-2[1-(9H-purin-6-ylamino)propyl]-3H-quinazolin-4-one and 6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)ethyl]-3H-quinazolin-4-one as inhibitors of human phosphatidylinositol 3-kinase delta
Icos
08/10/15
-
18
Heterocyclic substituted pyrimidine compound
Xuanzhu Pharma
08/10/15
-
10
Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
Leo Pharma
08/10/15
-
27
Pyridonemorphinan analogs and biological activity on opioid receptors
Purdue Pharma
08/10/15
-
3
Factor IXa inhibitors
Merck Sharp & Dohme
08/10/15
-
13
Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
Merck Sharp & Dohme
08/10/15
-
19
Inhibitors of glutaminyl cyclase
Probiodrug
08/03/15
-
27
Methods and compositions of treating a flaviviridae family viral infection
The Board of Trustees of The Leland Stanford Junion University
08/03/15
-
45
Heterocyclic compounds and uses thereof
Celgene Avilomics Research
08/03/15
-
13
5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases
Sanofi
08/03/15
-
2
Morpholine derivative
Shanghai Pharmaceuticals Holding
08/03/15
-
12
Pyridazinones, method of making, and method of use thereof
Genetech
08/03/15
-
14
Aryloxmethyl cyclopropane derivatives as PDE10 inhibitors
Merck Sharp & Dohme
08/03/15
-
189
Substituted imidazo[1,2-a]pyrimidines and —pyridines
Bayer Intellectual Property
08/03/15
-
17
Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors
Nerviano Medical Sciences
08/03/15
-
8
Inhibitors of PDE10
Bristol-Myers Squibb
08/03/15
-
4
Substituted pyrazolone compounds and methods of use
Sunshine Lake Pharma
08/03/15
-
97
Pyrrolopyrimidine compounds and their uses
Novartis
07/22/15
-
42
Bicyclic compounds and their uses as dual c-SRC/JAK inhibitors
Debiopharm
07/22/15
-
483
Pyrimidine-substituted pyrrolidine derivatives, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
07/22/15
-
13
Peripherally acting opioid compounds
Alkermes
07/22/15
-
223
Tricyclic compounds and PBK inhibitors containing the same
Oncotherapy Science
07/22/15
-
8
Compounds for the treatment of hepatitis C
Bristol-Myers Squibb
07/22/15
-
1
Phenoxyethyl piperidine compounds
Eli Lilly
07/22/15
-
3
Selective glycosidase inhibitors and uses thereof
Simon Fraser University
07/22/15
-
92
Curcumin derivative
Tokyo Institute of Technology
07/22/15
-
24
Nitrogen heterocycle derivatives, preparation thereof and application thereof in human therapeutics
Pierre Fabre Medicament
07/22/15
-
11
Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
Amgen
07/22/15
-
5
7,8-cyclicmorphinan analogs
Purdue Pharma
07/15/15
-
261
N-biphenylmethylindole modulators of PPARG
The Scripps Research Institute
07/15/15
-
5
Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
Johannes Gutenberg—Universitat Mainz
07/15/15
-
12
Acetic acid amide derivative having inhibitory activity on endothelial lipase
Shionogi
07/15/15
-
563
Cycloalkylnitrile pyrazole carboxamides as janus kinase inhibitors
Merck Sharp & Dohme
07/15/15
-
72
Pyrimidine compounds as inhibitors of protein kinases IKK epsilon and/or TBK-1, processes for their preparation, and pharmaceutical compositions containing them
Domainex
07/15/15
-
270
Substituted imidazopyridines as HDM2 inhibitors
Merck Sharp & Dohme
07/15/15
-
20
Tetrahydroisoquinoline derivative
Astellas Pharma
07/15/15
-
22
Heterocyclic substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
Pfizer
07/15/15
-
20
Substituted imidazopyridinyl-aminopyridine compounds
Arqule
07/15/15
-
144
Pyrrolopyrimidine compounds as inhibitors of CDK4/6
Novartis
07/10/15
-
26
O-GlcNAc transferase inhibitors and uses thereof
President and Fellows of Harvard College
07/10/15
-
14
Pyrazolopyrimidine PDE 10 inhibitors
Merck Sharp & Dohme
07/10/15
-
29
Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use
Amgen
07/10/15
-
1
Use of azaphilone compounds for the modulation of the activity of a nuclear hormone receptor
Food Industry Research and Development Institute
07/09/15
-
66
Modulators of serotonin receptors
Janssen Pharmaceutica
07/09/15
-
91
Fused pyrimidines
Bayer Intellectual Property
07/09/15
-
504
3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
Novartis
07/09/15
-
372
Unsaturated nitrogen heterocyclic compounds useful as PDE10 inhibitors
Amgen
07/09/15
-
3
Multifunctional radical quenchers and their uses
Arizona Board of Regents, A Body Corporate of The State of Arizona Acting For and On Behalf of Arizona State University
06/29/15
-
3
Inhibitors of syk and JAK protein kinases
Portola Pharmaceuticals
06/29/15
-
5
Benzoic acid derivative MDM2 inhibitor for the treatment of cancer
Amgen
06/29/15
-
93
Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors
Amgen
06/29/15
-
49
Somatostatin-dopamine chimeric analogs
Ipsen Pharma
06/29/15
-
28
Prostaglandin transporter inhibitors and uses thereof
Albert Einstein College of Medicine of Yeshiva University
06/29/15
-
404
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Abbvie
06/29/15
-
407
N-substituted benzamides and methods of use thereof
Xenon Pharmaceuticals
06/29/15
-
176
1,2,6-substituted benzimidazoles as FLAP modulators
Janssen Pharmaceutica
06/29/15
-
22
Imaging diagnostic agent and extracorporeal diagnostic agent for incurable neurological diseases
Shiga University of Medical Science
06/29/15
-
3
Aminoheteroaryl compounds and preparation method and use thereof
Shanghai Allist Pharmaceuticals
06/22/15
-
50
Chemical compounds
Pfizer
06/22/15
-
6
Therapeutic compositions and methods
The Penn State Research Foundation
06/22/15
-
50
Diamino heterocyclic carboxamide compound
Astellas Pharma
06/22/15
-
10
Chymase inhibitors
Boehringer Ingelheim International
06/22/15
-
38
Buprenorphine analogs
Purdue Pharma
06/22/15
-
43
Pyrazolopyrimidine compounds and their use as PDE10 inhibitors
Mitsubishi Tanabe Pharma
06/22/15
-
24
Thiophenecarboxamide derivatives as EP4 receptor ligands
Merck Frosst Canada
06/22/15
-
115
Substituted naphthyridines and their use as medicaments
Boehringer Ingelheim Pharma
06/22/15
-
13
Inhibitors of STAT3
University of Central Florida Research Foundation
06/22/15
-
29
3-phenyl-5-ureidoisothiazole-4-carboximide and 3-amino-5-phenylisothiazole derivatives as kinase inhibitors
Allergan
06/22/15
-
18
Substituted bicyclic heteroaryl compounds
Bristol-Myers Squibb
06/22/15
-
77
Macrocycles as factor XIa inhibitors
Bristol-Myers Squibb
06/16/15
-
187
Compound of a reverse-turn mimetic and a production method and use therefor
Jw Pharmaceutical
06/16/15
-
33
Pyrazolopyrimidine compounds as kinase inhibitors
Principia Biopharma
06/16/15
-
11
Iminothiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
Merck Sharp & Dohme
06/16/15
-
29
Organic compounds
Novartis
06/16/15
-
17
Heteroaromatic compounds as BTK inhibitors
Boehringer Ingelheim International
06/16/15
-
199
Pyrazolopyrrolidine compounds
Novartis
06/16/15
-
47
Substituted 2-azabicycles and their use as orexin receptor modulators
Janssen Pharmaceutica
06/16/15
-
331
TRPV1 antagonists
Abbvie
06/16/15
-
95
Benzonitrile derivatives as kinase inhibitors
Merck Patent
06/16/15
-
4
Inhibitors of protein kinases
Portola Pharmaceuticals
06/15/15
-
169
Triazine derivatives
Pfizer
06/08/15
-
36
Respiratory formulations and compounds for use therein
Respivert
06/08/15
-
19
17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivative, use thereof, and medicament containing the derivative
TBA
06/08/15
-
51
Pyridopyrazine derivatives and their use
Zentaris
06/08/15
-
15
Nitrogen containing morphinan derivatives and the use thereof
Purdue Pharma
06/08/15
-
22
Aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands
Gruenenthal
06/08/15
-
6
Anticancer compounds
Boehringer Ingelheim International
06/08/15
-
12
Apogossypolone derivatives as anticancer agents
Sanford-Burnham Medical Research Institute
06/08/15
-
16
Lithocholic acid analogues that inhibit sialyltransferase
Academia Sinica
06/08/15
-
71
Imidazotriazinecarbonitriles useful as kinase inhibitors
Bristol-Myers Squibb
06/08/15
-
11
Pyrimidone compounds
Mitsubishi Tanabe Pharma
06/08/15
-
1
Kinase inhibitor
Respivert
06/01/15
-
23
Quinolinyl glucagon receptor modulators
Pfizer
06/01/15
-
8
Intramolecular hydrogen-bonded nitric oxide synthase inhibitors
Northwestern University
06/01/15
-
22
Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
Sanofi
06/01/15
-
7
Selective glycosidase inhibitors and uses thereof
TBA
06/01/15
-
27
Soft protease inhibitors and pro-soft forms thereof
Tufts College
06/01/15
-
119
Pyridone and pyridazinone derivatives as anti-obesity agents
Boehringer Ingelheim International
06/01/15
-
29
KAT II inhibitors
Pfizer
06/01/15
-
1
Dimethyl-benzoic acid compounds
Eli Lilly
06/01/15
-
128
Monocyclic pyridine derivative
Eisai R&D Management
06/01/15
-
29
Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
Pfizer
06/01/15
-
26
2-arylimidazole derivatives as PDE10A enzyme inhibitors
H. Lundbeck
06/01/15
-
217
Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase
Fibrogen
05/26/15
-
88
Benzofurane-piperidine compounds
Hoffmann-La Roche
05/26/15
-
79
Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes
Targacept
05/26/15
-
16
C-aryl ansa SGLT2 inhibitors
Green Cross
05/26/15
-
2
Inhibitors of dimethylarginine dimethylaminohydrolase
Christian-Albrechts-Universitaet Zu Kiel
05/26/15
-
13
Histone deacetylase inhibitors, process for preparation and uses thereof
Zhejiang Hisun Pharmaceutical
05/26/15
-
53
4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2
Janssen Pharmaceutica
05/26/15
-
8
Selective glycosidase inhibitors and uses thereof
TBA
05/26/15
-
3
Antibacterial compounds
Institut Curie
05/26/15
-
12
Compounds for the inhibition of integrins and use thereof
Shire Orphan Therapies
05/26/15
-
14
Tetrahydrothiazepine derivative
Daiichi Sankyo
05/26/15
-
10
Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
Vitae Pharmaceuticals
05/26/15
-
180
Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
Abbvie
05/18/15
-
5
Dibenzothiazepine derivatives and uses thereof—424
Astrazeneca
05/18/15
-
9
2,3-dihydro-1H-indene-2-yl urea derivative and pharmaceutical application of same
Toray Industries
05/18/15
-
16
Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
Nerviano Medical Sciences
05/18/15
-
25
5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity
Shionogi
05/18/15
-
17
Phenyl and benzodioxinyl substituted indazoles derivatives
Astrazeneca
05/18/15
-
15
Serine protease inhibitors
The Medicines Company (Leipzig)
05/18/15
-
56
Modulators of calcium release-activated calcium channel
Rhizen Pharmaceuticals
05/18/15
-
53
Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases
Bristol-Myers Squibb
05/18/15
-
10
Bicyclo[3.2.1]octyl amide derivatives and uses of same
H. Lundbeck
05/18/15
-
22
Compounds having TRPV1 antagonistic activity and uses thereof
Shionogi
05/18/15
-
9
Azole derivatives in the form of lipase and phospholipase inhibitors
Sanofi
05/18/15
-
10
Synthetic compounds and methods to decrease nicotine self-administration
TBA
05/11/15
-
8
Fused bicyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
Merck Sharp & Dohme
05/11/15
-
119
Substituted quinolines and their use as medicaments
Boehringer Ingelheim International
05/11/15
-
115
Bicyclic compound or salt thereof
Taiho Pharmaceutical
05/11/15
-
4
(4-{4-[5-(benzooxazol-2-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid useful for treating or preventing conditions or disorders associated with DGAT1 activity
Novartis
05/11/15
-
12
Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors
Purdue Research Foundation
05/11/15
-
10
Aryl sulfamide and sulfamate derivatives as RORc modulators
Genentech
05/11/15
-
44
Biaryl amide derivatives
Hoffmann-La Roche
05/11/15
-
360
Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals
Sanofi
05/11/15
-
45
Sulfonamide compounds useful as CYP17 inhibitors
Bristol-Myers Squibb
05/11/15
-
6
4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors
Qilu Pharmaceutical
05/11/15
-
51
Pharmacokinetically improved compounds
Surface Logix
05/11/15
-
94
1H-imidazo[4,5-c]quinolines
Boehringer Ingelheim International
05/04/15
-
38
Compounds as cannabinoid receptor ligands
Abbvie
05/04/15
-
17
Bicyclic heterocyclic compounds as FGFR inhibitors
Astex Therapeutics
05/04/15
-
39
Selective glycosidase inhibitors and uses thereof
Merck Sharp & Dohme
05/04/15
-
24
Cyclic P1 linkers as factor XIa inhibitors
Bristol-Myers Squibb
05/04/15
-
7
6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof
Jiangsu Hengrui Medicine
05/04/15
-
16
Inhibitors of cyclophilins and uses thereof
University of Montpellier
05/04/15
-
14
Tricyclic compounds, compositions, and methods
Pfizer
05/04/15
-
165
Thienopyrazole derivative having PDE7 inhibitory activity
Daiichi Sankyo
05/04/15
-
68
Chemokine receptor antagonists
Abbvie
05/04/15
-
20
Dihydropyrimidin-2(1H)-one compounds as neurokinin-3 receptor antagonists
N30 Pharmaceuticals
05/04/15
-
138
Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof
Acetylon Pharmaceuticals
05/03/15
-
77
Compounds and methods for treating bacterial infections
Astrazeneca
04/27/15
-
11
Glycoside derivatives and uses thereof
Novartis
04/27/15
-
26
Compounds, formulations, and methods of protein kinase C inhibition
University of Michigan
04/27/15
-
10
Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
Boehringer Ingelheim International
04/27/15
-
30
Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
Boehringer Ingelheim International
04/27/15
-
7
Tetrazole compounds for reducing uric acid
Wellstat Therapeutics
04/27/15
-
2
Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
Temple University
04/27/15
-
88
Kinase inhibitors
Allergan
04/27/15
-
57
PARP inhibitor compounds, compositions and methods of use
Eisai
04/27/15
-
2
Inhibitors of human EZH2 and methods of use thereof
Epizyme
04/27/15
-
28
Indazoles
Pfizer
04/27/15
-
35
Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
Bayer Intellectual Property
04/27/15
-
478
Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
04/20/15
-
21
2-heteroarylcarboxylic acid amides
Bayer Intellectual Property
04/20/15
-
15
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Abbvie
04/20/15
-
50
Bivalent inhibitors of IAP proteins and therapeutic methods using the same
The Regents of The University of Michigan
04/20/15
-
20
Anti-tumor effect potentiator
Taiho Pharmaceutical
04/20/15
-
15
Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
Nerviano Medical Sciences
04/20/15
-
82
Cyclohexyl amide derivatives and their use as CRF-1 receptor antagonists
Novartis
04/20/15
-
31
Oxadiazole diaryl compounds
Merck Serono
04/20/15
-
2
1′-substituted pyrimidine N-nucleoside analogs for antiviral treatment
Gilead Sciences
04/20/15
-
4
Synthesis of bicyclic compounds and method for their use as therapeutic agents
Uvic Industry Partnerships
04/20/15
-
4
Metalloenzyme inhibitor compounds
Viamet Pharmaceuticals
04/20/15
-
28
Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof
Georgia Tech Research
04/13/15
-
13
Compositions and methods for inhibition of cathepsins
Oxigene
04/13/15
-
26
1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
Neurovance
04/13/15
-
22
Substituted pyrimidine compounds and their use as SYK inhibitors
Genosco
04/13/15
-
74
Fused bicyclic oxazolidinone CETP inhibitor
Merck Sharp & Dohme
04/13/15
-
53
3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors
Nerviano Medical Sciences
04/13/15
-
33
Identification of stabilizers of multimeric proteins
The Board of Trustees of The Leland Stanford Junior University
04/13/15
-
8
Inhibitors of pyruvate kinase and methods of treating disease
Beth Israel Deaconess Medical Center
04/13/15
-
7
Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
Novartis
04/13/15
-
95
Benzofurane compounds
Hoffmann-La Roche
04/13/15
-
25
Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
Boehringer Ingelheim International
04/13/15
-
7
Pyrazine derivatives and use as PI3K inhibitors
Merck Serono
04/13/15
-
143
Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
Array Biopharma
04/06/15
-
35
Piperazine compound capable of inhibiting prostaglandin D synthase
Taiho Pharmaceutical
04/06/15
-
11
Spiropyrrolidine beta-secretase inhibitors for the treatment of alzheimer'S disease
Merck Sharp & Dohme
04/06/15
-
30
Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
Pfizer
04/06/15
-
105
Method of treatment using substituted pyrazolo[1,5-a]pyrimidine compounds
Array Biopharma
04/06/15
-
8
Tetracycline compounds as tyrosyl-DNA phosphodiesterase I inhibitors
The United States of America, As Represented By The Secretary, Dept. of Health and Human Services
04/06/15
-
5
Macrolides and their use
Basilea Pharmaceutica
04/06/15
-
4
Depsipeptides and their therapeutic use
Karus Therapeutics
04/06/15
-
153
Compounds and their use as BACE inhibitors
Astrazeneca
04/06/15
-
472
Heterocyclic modulators of lipid synthesis
3-V Biosciences
04/06/15
-
653
Fluorene compound and pharmaceutical use thereof
Japan Tobacco
04/06/15
-
26
Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides inhibitors of cathepsin C
Boehringer Ingelheim International
04/06/15
-
9
Methotrexate adjuvants to reduce toxicity and methods for using the same
Tosk
03/16/15
-
13
Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
High Point Pharmaceuticals
03/16/15
-
17
Derivatives of N-acyl-N′-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
Takeda Pharmaceutical
03/16/15
-
11
Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments
Sanofi
03/16/15
-
64
Compounds as cannabinoid receptor ligands
Abbvie
03/16/15
-
32
Cyclohexyl isoquinolinone compounds
Novartis
03/16/15
-
185
Diazepinone derivatives
Novartis
03/16/15
-
165
Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
Boehringer Ingelheim International
03/16/15
-
16
Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
Merck Sharp & Dohme
03/16/15
-
31
Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
Industrial Research
03/16/15
-
53
2-carboxamide-7-piperazinyl-benzofuran derivatives
Acturum Life Science
03/16/15
-
4
Small molecule inhibitors of RGS proteins
University of Michigan
03/16/15
-
26
Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase
University of Connecticut
03/09/15
-
180
Oxazine derivatives and their use in the treatment of neurological disorders
Novartis
03/09/15
-
143
Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators
Novartis
03/09/15
-
506
Pyrrolo[2,3-d]pyrimidine tropomysin-related kinase inhibitors
Pfizer
03/09/15
-
282
Substituted imidazopyridines as HDM2 inhibitors
Merck Sharp & Dohme
03/09/15
-
197
C-linked hydroxamic acid derivatives useful as antibacterial agents
Pfizer
03/09/15
-
8
Therapeutic applications in the cardiovascular field of quinazolinedione derivatives
Sanofi
03/09/15
-
35
Radiolabeled PDE10 inhibitors
Merck Sharp & Dohme
03/09/15
-
126
Melanocortin receptor-specific peptides
Palatin Technologies
03/09/15
-
18
Nitrogenous-ring acylguanidine derivative
Astellas Pharma
03/09/15
-
6
Heterocyclic pyrazole compounds, method for preparing the same and use thereof
Development Center For Biotechnology
03/09/15
-
511
Pyrazole compound and pharmaceutical use thereof
Japan Tobacco
03/03/15
-
8
N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
Abbvie
03/03/15
-
65
Compounds as cannabinoid receptor ligands
Abbvie
03/03/15
-
371
Isoxazolo-pyridine derivatives
Roche Palo Alto
03/03/15
-
28
Heterocyclic acrylamides and their use as pharmaceuticals
Fab Pharma
03/03/15
-
170
Quinazoline derivatives as a multiplex inhibitor and method for the preparation thereof
Hanmi Pharm.
03/03/15
-
250
Substituted-quinoxaline-type piperidine compounds and the uses thereof
Purdue Pharma
03/03/15
-
211
Substituted pyrimidines for the treatment of diseases such as cancer
Boehringer Ingelheim International
03/03/15
-
38
Azaindazoles as kinase inhibitors and use thereof
Bristol-Myers Squibb
03/03/15
-
29
Seven-membered ring compound and pharmaceutical use therefor
Daiichi Sankyo
03/03/15
-
10
Purine derivatives
Cyclacel
03/03/15
-
2
Compounds useful as inhibitors of ATR kinase
Vertex Pharmaceuticals
02/23/15
-
50
Triazole compounds that modulate HSP90 activity
Synta Pharmaceuticals
02/23/15
-
40
Dihydrofolate reductase inhibitors
Trius Therapeutics
02/23/15
-
28
Cyclohexyl amide derivatives as CRF receptor antagonists
Novartis
02/23/15
-
60
Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same
Green Cross
02/23/15
-
165
Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as cFMS inhibitors
Array Biopharma
02/23/15
-
18
Hybrid cholinesterase inhibitors
Uniwersytet Warszawski
02/23/15
-
10
Quinolin-4 (1H)-one derivatives as inhibitors of phosphatidylinositol 3-kinases
Universtà
02/23/15
-
146
Inhibitors of CYP 17
Novartis
02/23/15
-
480
Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
Amgen
02/23/15
-
1
Compounds useful as inhibitors of ATR kinase
Vertex Pharmaceuticals
02/23/15
-
28
Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
Leo Pharma
02/16/15
-
6
Substituted 2-amino-3-(sulfonyl)pyrazolo[1,5-a]pyrimidines - serotonin 5-HT6 receptor antagonists, method for use thereof
TBA
02/16/15
-
55
Pyrazolo[3,4-d]pyrimidine compounds and their use as PDE2 inhibitors and/or CYP3A4 inhibitors
Pfizer
02/16/15
-
11
Substituted imidazo[1,5-A]quinoxalines as phosphodiesterase 9 inhibitors
Aska Pharmaceutical
02/16/15
-
12
Macrocycles as factor XIa inhibitors
Bristol-Myers Squibb
02/16/15
-
7
Polysubstituted benzofurans and medicinal applications thereof
Ikerchem
02/16/15
-
663
Compounds, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
02/16/15
-
25
Mandelamide heterocyclic compounds
Bristol-Myers Squibb
02/16/15
-
3
Pyrazolylaminopyridine derivatives useful as kinase inhibitors
Astrazeneca
02/16/15
-
54
PIM kinase inhibitors and methods of their use
Novartis
02/16/15
-
15
Substituted 3-phenyl-1,2,4-Oxadiazole compounds
Bristol-Myers Squibb
02/02/15
-
40
Azetidine derivatives
Genentech
02/02/15
-
42
Heteroaromatic compounds and their use as dopamine D1 ligands
Pfizer
02/02/15
-
7
6-cyclylmethyl-and 6-alkylmethyl-substituted pyrazolepyrimidines
Boehringer Ingelheim International
02/02/15
-
10
Fused cyclopentyl antagonists of CCR2
Janssen Pharmaceutica
02/02/15
-
60
Substituted oxazolidinones and their use in the field of blood coagulation
Bayer Intellectual Property
02/02/15
-
154
Indazole compounds useful as ketohexokinase inhibitors
Janssen Pharmaceutica
02/02/15
-
30
Benzimidazole inhibitors of leukotriene production
Boehringer Ingelheim International
02/02/15
-
100
Pyrazoloquinoline compound
Astellas Pharma
02/02/15
-
111
Aminopyrazole derivative
Chugai Seiyaku Kabushiki Kaisha
02/02/15
-
14
Tyrosine kinase inhibitors
Chembridge
02/02/15
-
310
Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases
Novartis
01/26/15
-
6
Bivalent diazo bicyclic Smac mimetics and the uses thereof
The Regents of The University of Michigan
01/26/15
-
14
Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives
Centro Nacional de Investigaciones Oncologicas (CNIO)
01/26/15
-
51
Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors
Novartis
01/26/15
-
112
Tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same
Jeil Pharmaceutical
01/26/15
-
20
1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds
Hoffmann-La Roche
01/26/15
-
24
Substituted imidazopyridinyl compounds
Arqule
01/26/15
-
17
Carbamoyloxy arylalkan arylpiperazine analgesics
Sk Biopharmaceuticals
01/26/15
-
94
Carbazole and carboline kinase inhibitors
Bristol-Myers Squibb
01/26/15
-
20
Substituted aminopropionic derivatives as neprilysin inhibitors
Novartis
01/26/15
-
5
1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
The Regents of The University of Michigan
01/26/15
-
80
Pyrazoloquinolines
Merck Patent
01/19/15
-
155
TRPV1 antagonists
Abbvie
01/19/15
-
22
Glycine compound
Astellas Pharma
01/19/15
-
207
Aminopyrimidine derivatives as LRRK2 modulators
Genentech
01/19/15
-
150
Inhibitors of epoxide hydrolases for the treatment of inflammation
University of California
01/19/15
-
16
Sulfone-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as a medicine
Bayer Intellectual Property
01/19/15
-
210
Heterocyclic amine derivatives
Hoffmann-La Roche
01/19/15
-
42
Pyrazole oxadiazole derivatives as S1P1 agonists
Merck Serono
01/19/15
-
94
Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
Theravance Respiratory
01/19/15
-
53
2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations
Wyeth
01/19/15
-
48
Pyrrolidine derivatives
Genentech
01/19/15
-
9
Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
Richter Gedeon
01/19/15
-
32
Aminopyrimidine derivatives as LRRK2 modulators
Genentech
01/12/15
-
15
Substituted benzamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
Vanderbilt University
01/12/15
-
9
Purine and deazapurine derivatives as pharmaceutical compounds
The Institute of Cancer Research
01/12/15
-
17
4-aminopyrimidine derivatives and their as as adenosine A2a receptor antagonists
Palobiofarma
01/12/15
-
46
2,3-disubstituted pyrazinesulfonamides as CRTH2 inhibitors
Merck Serono
01/12/15
-
12
Triazolones as fatty acid synthase inhibitors
Glaxosmithkline
01/12/15
-
17
Thiazole derivatives and use thereof
Merck Serono
01/12/15
-
9
Thiophene compounds for inflammation and immune-related uses
Synta Pharmaceuticals
01/12/15
-
24
Apoptosis signal-regulating kinase 1 inhibitors
Takeda Pharmaceutical
01/12/15
-
3
Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans
Purdue Research Foundation
01/12/15
-
312
Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases
Astex Therapeutics
01/12/15
-
77
Aryl benzylamine compounds
Novartis
12/22/14
-
38
Pyridopyrazines as highly selective ras-Raf-Mek-Erk signal transduction pathway inhibitors
Aeterna Zentaris
12/22/14
-
233
Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors
Array Biopharma
12/22/14
-
46
Aminopyrimidine derivatives as LRRK2 modulators
Genentech
12/22/14
-
18
Tricyclic imidazole compounds as PDE10 inhibitors
H. Lundbeck
12/22/14
-
79
Amino-pyridine-containing spleen tyrosine kinase (SYK) inhibitors
Merck Sharp & Dohme
12/22/14
-
44
TRPV1 antagonists
TBA
12/22/14
-
74
Inhibitors of histone deacetylase and prodrugs thereof
Methylgene
12/22/14
-
1
Compound useful for the treatment of degenerative and inflammatory diseases
Galapagos
12/22/14
-
23
4-substituted-2-amino-pyrimidine derivatives
Abbvie
12/22/14
-
97
Heteroaryl substituted indole compounds useful as MMP-13 inhibitors
Boehringer Ingelheim International
12/16/14
-
9
Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof
Shanghai Sun-Sail Pharmaceutical Science & Technology
12/16/14
-
20
Alkoxy pyrimidine PDE10 inhibitors
Merck Sharp & Dohme
12/16/14
-
80
Pyrimidine derivatives that inhibit FAK/PTK2
Boehringer Ingelheim International
12/16/14
-
128
Quinazoline compounds as kinase inhibitors
Development Center For Biotechnology
12/16/14
-
214
Pyrazole compounds as CRTH2 antagonists
Boehringer Ingelheim International
12/16/14
-
15
Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions
Gruenenthal
12/16/14
-
30
Substituted pyrrolotriazines as protein kinase inhibitors
Bristol-Myers Squibb
12/16/14
-
152
Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
Pfizer
12/16/14
-
9
Spiropiperidine prolylcarboxypeptidase inhibitors
Merck Sharp & Dohme
12/15/14
-
5
Dihydro-oxazolobenzodiazepinone compounds, a process for there preparation and pharmaceutical compositions containing them
Les Laboratoires Servier
12/15/14
-
8
Targeting NAD biosynthesis in bacterial pathogens
University of Maryland, Baltimore
12/15/14
-
33
Benzimidazole inhibitors of leukotriene production
Boehringer Ingelheim International
12/08/14
-
20
TGF-β signal transduction inhibitor
Kyoto University
12/08/14
-
36
Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors
Almirall
12/08/14
-
2
Benzothiazoles having histamine H3 receptor activity
High Point Pharmaceuticals
12/08/14
-
6
Tetrahydropyrrolothiazine compounds
Eli Lilly
12/08/14
-
157
Azabicyclo compound and salt thereof
Taiho Pharmaceutical
12/08/14
-
20
CGRP receptor antagonists
Merck Sharp & Dohme
12/08/14
-
350
Heteroaryl compounds and their uses
Novartis
12/08/14
-
64
Imidazo-oxazine compound or salt thereof
Taiho Pharmaceutical
12/08/14
-
16
Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
Aerpio Therapeutics
12/08/14
-
70
Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors
Katholieke Universiteit Leuven
12/08/14
-
18
Benzyl piperidine compound
Dainippon Sumitomo Pharma
12/08/14
-
17
Inhibitors of glutaminyl cyclase
Probiodrug
11/24/14
-
65
PDE10 modulators
Hoffmann-La Roche
11/24/14
-
7
Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists
Bayer Intellectual Property
11/24/14
-
21
Amine substituted methanesulfonamide derivatives as vanilloid receptor ligands
Gruenenthal
11/24/14
-
128
Azaspirohexanones
Boehringer Ingelheim International
11/24/14
-
1
5-lipoxygenase-activating protein inhibitor
Panmira Pharmaceuticals
11/24/14
-
21
Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof
Amgen
11/24/14
-
343
Inhibitors of PI3 kinase and/or mTOR
Amgen
11/24/14
-
84
Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A)
Allergan
11/24/14
-
292
Substituted pyridinyl-pyrimidines and their use as medicaments
Boehringer Ingelheim International
11/24/14
-
19
Macrocyclic compounds and their use as kinase inhibitors
Incyte
11/24/14
-
9
Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
Galderma Research & Development
11/24/14
-
85
3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
Boehringer Ingelheim International
11/18/14
-
253
Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
Amgen
11/18/14
-
46
Aminopyrimidines as SYK inhibitors
Merck Sharp & Dohme
11/18/14
-
162
Heterocyclic compounds and their uses
Amgen
11/18/14
-
59
Pyrazole compounds as CRTH2 antagonists
Boehringer Ingelheim International
11/18/14
-
22
Organic compounds
Novartis
11/18/14
-
11
Bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives and uses thereof
Bayer Intellectual Property
11/18/14
-
19
Heterocyclic kinase inhibitors
Novartis
11/18/14
-
27
Piperazine compound having a PGDS inhibitory effect
Taiho Pharmaceutical
11/18/14
-
19
3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides with selective PARP-1 inhibition
Nerviano Medical Sciences
11/18/14
-
8
Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2
Sapienza University of Rome
11/18/14
-
1
Fused 2-aminothiazole compounds
Dana-Farber Cancer Institute
11/18/14
-
29
4-phenylpiperazine derivatives with functionalized linkers as dopamine D3 receptor selective ligands and methods of use
The United States of America As Represented By The Secretary of The Department of Health and Human Services
11/11/14
-
26
1,4-oxazepines as BACE1 and/or BACE2 inhibitors
Hoffmann-La Roche
11/11/14
-
39
Oxadiazole derivative having endothelial lipase inhibitory activity
Shionogi
11/11/14
-
151
Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
Dermira (Canada)
11/11/14
-
32
Heterocyclic compounds and their uses
Amgen
11/11/14
-
8
Macrocyclic inhibitors of hepatitis C virus
Janssen Ireland
11/11/14
-
6
Macrocyclic inhibitors of hepatitis C virus
Medivir
11/11/14
-
5
Oxadiazole beta carboline derivatives as antidiabetic compounds
Merck Sharp & Dohme
11/11/14
-
52
1,3-oxazines as BACE1 and/or BACE2 inhibitors
Hoffmann-La Roche
11/11/14
-
5
Metalloenzyme inhibitor compounds
Viamet Pharmaceuticals
11/11/14
-
12
HDAC inhibitors and therapeutic methods of using same
University of Illinois
11/11/14
-
10
Scriptaid isosteres and their use in therapy
Karus Therapeutics
11/11/14
-
79
Disubstituted heteroaryl-fused pyridines
Novartis
11/05/14
-
10
Macrocyclic inhibitors of hepatitis C virus
Janssen Ireland
11/05/14
-
37
Anti-infective agents against intracellular pathogens
The Ohio State University Research Foundation
11/05/14
-
19
Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis
Merck Serono
11/05/14
-
8
Oxazole and thiazole compounds as KSP inhibitors
Novartis
11/05/14
-
37
Pyrazolo pyrimidine derivatives
Novartis
11/05/14
-
138
Picolinamido-propanoic acid derivatives useful as glucagon receptor antagonists
Janssen Pharmaceutica
11/05/14
-
34
Inhibitors of inv(16) leukemia
University of Virginia Patent Foundation
11/05/14
-
7
Alkyl-substituted pyrazolopyrimidines
Boehringer Ingelheim International
11/05/14
-
23
Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors
N30 Pharmaceuticals
11/05/14
-
21
Furanone derivative
Sbi Biotech
11/04/14
-
169
Spiroxazolidinone compounds
Merck Sharp & Dohme
11/04/14
-
722
Compounds and compositions as Syk kinase inhibitors
TBA
10/28/14
-
97
4,5-dihydro-oxazol-2yl derivatives
Hoffmann-La Roche
10/28/14
-
50
Inhibitors of bruton's tyrosine kinase
Hoffmann-La Roche
10/28/14
-
25
Inhibitors of PI3 kinase
Amgen
10/28/14
-
62
Pyrrolidine derivatives
Hoffmann-La Roche
10/28/14
-
5
Aminopyridines useful as inhibitors of protein kinases
Vertex Pharmaceuticals
10/28/14
-
422
Aminopyrazoloquinazolines
Boehringer Ingelheim International
10/28/14
-
43
Protease inhibitors
Taimed Biologies
10/28/14
-
34
Compounds as hypoxia mimetics, and compositions and uses thereof
Betta Pharmaceuticals
10/28/14
-
4
7-azoniabicyclo[2.2.1]heptane derivatives, methods of production, and pharmaceutical uses thereof
Theron Pharmaceuticals
10/28/14
-
35
Co-crystals and salts of CCR3-inhibitors
Boehringer Ingelheim International
10/28/14
-
5
Protease inhibitors
Medivir
10/28/14
-
12
Boron-containing small molecules
Anacor Pharmaceuticals
10/20/14
-
65
Pharmaceutical compounds
Sentinel Oncology
10/20/14
-
10
Inhibitors of protein kinases
Ingenium Pharmaceuticals
10/20/14
-
65
N-hydroxy-benzamids for the treatment of cancer
Hoffmann-La Roche
10/20/14
-
17
SEC-hydroxycyclohexyl derivatives
Hoffmann-La Roche
10/20/14
-
315
Prokineticin receptor antagonists and uses thereof
University of California
10/20/14
-
24
Prolyl hydroxylase inhibitors and method of use
Akebia Therapeutics
10/20/14
-
5
Thieno[3,2-C]pyridine kinase inhibitors with improved CYP safety profile
Abbvie
10/20/14
-
5
7-deazapurine modulators of histone methyltransferase, and methods of use thereof
Epizyme
10/20/14
-
2
Inhibitors of C-FMS kinase
Janssen Pharmaceutica
10/20/14
-
57
Mineralocorticoid receptor antagonists
Boehringer Ingelheim International
10/20/14
-
77
Benzodioxole piperazine compounds
Hoffmann-La Roche
10/20/14
-
31
Compounds effective as xanthine oxidase inhibitors, method for preparing the same, and pharmaceutical composition containing the same
Lg Life Sciences
10/20/14
-
10
Compounds for treatment of Alzheimer's disease
Purdue Research Foundation
10/14/14
-
95
Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase
Genzyme
10/14/14
-
12
Azaspirodecanone compounds
Hoffmann-La Roche
10/14/14
-
9
2-aminopyrimidin-4-one and 2-aminopyridine derivatives both having BACE1-inhibiting activity
Shionogi
10/14/14
-
2
Pyridazine carboxamide orexin receptor antagonists
Merck Sharp & Dohme
10/14/14
-
12
Preparation method of dihydroindene amide compounds, their pharmaceutical compositions containing compounds thereof and use as protein kinases inhibitor
Harbin Gloria Pharmaceuticals
10/14/14
-
329
Nitrogen containing heteroaryl compounds
Hoffmann-La Roche
10/14/14
-
12
Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
University of Utah Research Foundation
10/14/14
-
15
Organic compounds
Novartis
10/14/14
-
9
Galactoside inhibitors of galectins
Galecto Biotech
10/14/14
-
4
2,5-disubstituted piperidine orexin receptor antagonists
Merck Sharp & Dohme
10/14/14
-
17
Imidazole derivatives used as TAFIa inhibitors
Sanofi-Aventis Deutschland
10/14/14
-
17
Substituted aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes
Merck Sharp & Dohme
10/14/14
-
116
Rho kinase inhibitors
Boehringer Ingelheim International
10/06/14
-
56
3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives and their use as prostaglandin D2 receptor modulators
Actelion Pharmaceuticals
10/06/14
-
10
8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
Boehringer Ingelheim International
10/06/14
-
17
Method of inhibiting C-KIT kinase
Janssen Pharmaceutica
10/06/14
-
42
Serine/threonine kinase inhibitors
Array Biopharma
10/06/14
-
16
Azabenzothiazole compounds, compositions and methods of use
F. Hoffmann-La Roche
10/06/14
-
11
Triazole compounds II
Roche Palo Alto
10/06/14
-
103
Pseudodipeptides as MMP inhibitors
French Alternative Energies and Atomic Energy Commission
10/06/14
-
16
Therapeutic agents
Astrazeneca
09/30/14
-
9
Amino tetrahydro-pyridopyrimidine PDE10 inhibitors
Merck Sharp & Dohme
09/30/14
-
4
Treatment of liver disorders with PI3K inhibitors
Gilead Calistoga
09/30/14
-
20
Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
Merck Sharp & Dohme
09/30/14
-
5
N-biarylamides
Bayer Intellectual Property
09/30/14
-
26
Amino nicotinic and isonicotinic acid derivatives as DHODH inhibitors
Amirall
09/30/14
-
2
Glucagon receptor antagonists, preparation and therapeutic uses
Eli Lilly
09/30/14
-
17
Azetidine and piperidine compounds useful as PDE10 inhibitors
Amgen
09/30/14
-
13
Piperidinyl naphthylacetic acids
Hoffmann-La Roche
09/30/14
-
12
Medical composition for treatment or prophylaxis of glaucoma
Ube Industries
09/16/14
-
9
Pharmaceutical composition
Eisai R&D Management
09/16/14
-
31
Indole derivative or pharmaceutically acceptable salt thereof
Kissei Pharmaceutical
09/16/14
-
173
Fused heterocyclic compounds as orexin receptor modulators
Janssen Pharmaceutica
09/16/14
-
4
Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
09/16/14
-
9
Quinolinone PDE2 inhibitors
Merck Sharp & Dohme
09/16/14
-
2
GSK-3 inhibitors
Neuropharma
09/16/14
-
18
Histone deacetylase inhibitors based simultaneously on trisubstituted 1H-pyrroles and aromatic and heteroaromatic spacers
Universidad Del PaíS Vasco
09/16/14
-
48
Spiro-oxindole MDM2 antagonists
University of Michigan
09/16/14
-
75
Dihydrooxazol-2-amine derivatives
Hoffmann-La Roche
09/08/14
-
23
Chemical compounds
Astrazeneca
09/08/14
-
93
Chromenone derivatives
Astrazeneca
09/08/14
-
42
Imidazo pyrazines
Hoffmann-La Roche
09/08/14
-
5
Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
Pfizer
09/08/14
-
29
Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
F. Hoffmann-La Roche
09/08/14
-
14
Prolylcarboxypeptidase inhibitors
Merck Sharp & Dohme
09/08/14
-
17
Quinoline-carboxamide derivatives as P2Y12 antagonists
Sanofi
09/08/14
-
23
Cyclohexane derivative having NPY Y5 receptor antagonism
Shionogi
09/03/14
-
41
ALDH-2 inhibitors in the treatment of addiction
Gilead Sciences
09/03/14
-
94
Tetrahydro-pyrido-pyrimidine derivatives
Novartis
09/03/14
-
20
Substituted dihydropyrazolones for treating cardiovascular and hematological diseases
Bayer Intellectual Property
09/03/14
-
377
Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
Janssen Pharmaceutica
09/03/14
-
180
Compounds
Boehringer Ingelheim International
09/03/14
-
85
Inhibitors of C-FMS kinase
Janssen Pharmaceutica
09/03/14
-
5
Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
Arena Pharmaceuticals
08/26/14
-
35
1H-pyrrolo[2,3 b]-pyridine derivatives
Merck Patent
08/26/14
-
6
Pyridopyrimidine derivatives and use thereof
The Asan Foundation
08/26/14
-
141
Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications
Mei Pharma
08/26/14
-
737
Pyrido [5, 4-D] pyrimidines as cell proliferation inhibitors
Boehringer Ingelheim International
08/26/14
-
124
Thiazolidinedione derivative and use thereof
Industry-Academic Cooperation Foundation, Chosun University
08/26/14
-
12
Aminopyrimidines useful as inhibitors of protein kinases
Vertex Pharmaceuticals
08/26/14
-
46
Pyrid-2yl fused heterocyclic compounds, and compositions and uses thereof
Evotec
08/26/14
-
351
Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors
Amgen
08/22/14
-
574
5-alkynyl-pyrimidines
Boehringer Ingelheim International
08/22/14
-
31
2,3,4,5-tetrahydro-benzo{B}{1,4}diazepine-comprising compounds of formula(III) for treating pain
Purde Pharma
08/22/14
-
45
Heterocyclic derivatives and their use in the treatment of neurological disorders
Novartis
08/22/14
-
37
Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
Shionogi
08/22/14
-
4
Use of PDE7 inhibitors for the treatment of movement disorders
Omeros
08/22/14
-
10
Pyrazolopyrimidine JAK inhibitor compounds and methods
Genentech
08/22/14
-
692
Amino azaheterocyclic carboxamides
Merck Patent
08/22/14
-
24
6-1H-imidazo-quinazoline and quinolines derivatives, new MAO inhibitors and imidazoline receptor ligands
Rottapharm
08/06/14
-
139
Pyrrolo[2,3-D]pyrimidine compounds
Pfizer
08/06/14
-
163
Inhibitors of beta-secretase
Vitae Pharmaceuticals
08/06/14
-
173
4-methylpyridopyrimidinone compounds
Pfizer
08/06/14
-
18
Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
Galderma Research & Development
08/06/14
-
60
Aminodihydrothiazine derivatives
Shionogi
08/06/14
-
111
Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
Albany Molecular Research
08/06/14
-
14
Bicyclic compounds as inhibitors of diacylglycerol acyltransferase
Merck Sharp & Dohme
08/06/14
-
5
Piperidinyl derivative as a modulator of chemokine receptor activity
Bristol-Myers Squibb
08/06/14
-
20
Substituted imidazolones, compositions containing such compounds and methods of use
Merck Sharp & Dohme
08/05/14
-
12
Disubstituted azepan orexin receptor antagonists
Merck Sharp & Dohme
07/28/14
-
13
Heterocyclic compounds as S1P1 agonists for the treatment of autoimmune and vascular diseases
Bristol-Myers Squibb
07/28/14
-
40
Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
Albany Molecular Research
07/28/14
-
5
Substituted cycloalcano[e and d] pyrazolo [1,5-a]pyrimidines/antagonists of serotonin 5-HT6 receptors and methods for production and the use thereof
TBA
07/28/14
-
39
Spiro-oxindole MDM2 antagonists
University of Michigan
07/28/14
-
13
Pharmaceutical compositions comprising RET inhibitors and methods for the treatment of cancer
Queen'S University At Kingston
07/28/14
-
7
Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof
Tufts University
07/28/14
-
93
Selective androgen receptor modulators
Radius Health
07/28/14
-
150
Azetidine derivatives, pharmaceutical compositions and uses thereof
Boehringer Ingelheim International
07/28/14
-
43
Compounds for the treatment of CNS disorders
Boehringer Ingelheim International
07/22/14
-
64
Pyridone and aza-pyridone compounds and methods of use
Gilead Connecticut
07/22/14
-
4
Metalloenzyme inhibitor compounds
Viamet Pharmaceuticals
07/22/14
-
427
Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof
Genentech
07/22/14
-
26
Fused tricyclic dual inhibitors of CDK 4/6 and FLT3
Amgen
07/22/14
-
7
4-phenylamino-quinazolin-6-yl-amides
Warner-Lambert
07/22/14
-
119
Inhibitors of JAK
Hoffmann-La Roche
07/22/14
-
3
Acylpiperazinones and their use as pharmaceuticals
Fab Pharma
07/22/14
-
67
Carboxy isatin hydrazones and their esters as Shp2 inhibitors
H. Lee Moffitt Cancer Center and Research Institute
07/21/14
-
55
Substituted 3-arylsulfonyl-pyrazolo[1,5-A]pyrimidines, serotonin 5-HT6 receptor antagonists and methods for the production and use thereof
TBA
07/09/14
-
29
Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity
Neuraxon
07/08/14
-
78
Therapeutic agents
Cancer Research Technology
07/08/14
-
16
Modified macrophage migration inhibitory factor inhibitors
The Feinstein Institute For Medical Research
07/08/14
-
9
Certain compounds, compositions and methods
Eisai
07/08/14
-
4
Inhibitors of bruton's tyrosine kinase
Roche Palo Alto
07/08/14
-
7
Substituted aniline derivatives
Ucb Pharma
07/08/14
-
17
Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity
Shionogi
07/08/14
-
141
5-alkynyl-pyrimidines
Boehringer Ingelheim International
07/08/14
-
272
IRE-1α inhibitors
Mannkind
06/25/14
-
17
HSP90 inhibitors
Takeda Pharmaceutical
06/24/14
-
197
Peptidomimetic sulfamide compounds and antiviral uses thereof
Novartis
06/24/14
-
103
Quinoxaline inhibitors of phosphoinositide-3-kinases (PI3Ks)
Merck Serono
06/24/14
-
146
Compounds as tyrosine kinase modulators
Allergan
06/24/14
-
215
Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
F. Hoffmann-La Roche
06/24/14
-
35
Pyrrolidine derivatives
Hoffmann-La Roche
06/16/14
-
89
Synthetic compounds and derivatives as modulators of smoking or nicotine ingestion and lung cancer
Human Biomolecular Research Institute
06/16/14
-
52
Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
Albany Molecular Research
06/16/14
-
24
Spirocyclic nitriles as protease inhibitors
Sanofi
06/16/14
-
67
Nitrogen-containing spirocyclic compounds and pharmaceutical uses thereof
Japan Tobacco
06/16/14
-
176
Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
Acetylon Pharmaceuticals
06/16/14
-
29
Cycloalkyl-substituted imidazole derivative
Daiichi Sankyo
06/04/14
-
8
Substituted dipyridyl-dihydropyrazolones and use thereof
Bayer Intellectual Property
06/04/14
-
7
C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof
Shanghai Hengrui Pharmaceutical
06/04/14
-
67
2-morpholino-pyrido[3,2-D]pyrimidines
Merck Serono
06/04/14
-
221
2-aminooxazolines as TAAR1 ligands
Hoffmann-La Roche
06/04/14
-
129
Heteroarylcarboxylic acid ester derivative
Ajinomoto
06/04/14
-
102
Thiazolyl mGluR5 antagonists and methods for their use
Merck Sharp & Dohme
05/13/14
-
6
Furopyridinyl-substituted 1,4-dihydropyridine derivatives and methods of use thereof
Bayer Intellectual Property
05/13/14
-
7
Compositions for preventing and/or treating degenerative disorders of the central nervous system
Amicus Therapeutics
05/12/14
-
20
Substituted imidazopyridinyl-aminopyridine compounds
Arqule
05/12/14
-
664
Heterocyclic inhibitors of glutaminase
Calithera Biosciences
05/12/14
-
11
Methods and compositions for sleep disorders and other disorders
Intra-Cellular Therapies
05/05/14
-
2
Glucagon receptor antagonists, preparation and therapeutic uses
Eli Lilly
05/05/14
-
6
Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
Inotek Pharmaceuticals
05/05/14
-
69
Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
Sanofi
05/05/14
-
78
Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent
Selvita
05/05/14
-
24
Derivatives of [1,3]Oxazin-2-one useful for the treatment of metabolic diseases such as lipid disorders
Vitae Pharmaceuticals
04/28/14
-
23
Trypsin-like serine protease inhibitors, and their preparation and use
The Medicines Company (Leipzig)
04/28/14
-
5
Protein kinase inhibitors
Tiger Pharmatech
04/28/14
-
89
5-alkynyl-pyridines
Boehringer Ingelheim International
04/28/14
-
2
Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
Nerviano Medical Sciences
04/28/14
-
24
Prolyl hydroxylase inhibitors and methods of use
Akebia Therapeutics
04/18/14
-
29
KAT II inhibitors
Pfizer
04/18/14
-
20
Imidazole derivatives and their use as modulators of cyclin dependent kinases
Astex Therapeutics
04/18/14
-
84
Imidazo[5,1-f][1,2,4]triazines for the treatment of neurological disorders
Pfizer
04/18/14
-
165
Cytoskeletal active rho kinase inhibitor compounds, composition and use
Inspire Pharmaceuticals
04/18/14
-
61
Compounds and compositions as protein kinase inhibitors
TBA
04/14/14
-
8
Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
Merck Sharpe & Dohme
04/14/14
-
5
Imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines as mark inhibitors
Merck Sharp & Dohme
04/14/14
-
3
Inhibitors of PDE10
Bristol-Myers Squibb
04/14/14
-
36
Selective kinase inhibitors
Reaction Biology
04/14/14
-
60
Aryl-benzocycloalkyl amide derivatives
Hoffmann-La Roche
04/14/14
-
77
Substituted heteroarylamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
Vanderbilt University
04/14/14
-
9
Metastin derivative and use thereof
Kyoto University
04/14/14
-
145
Fused ring compound and use thereof
Takeda Pharmaceutical
04/14/14
-
34
Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
Vitae Pharmaceuticals
04/14/14
-
79
Benzodioxole piperidine compounds
Hoffmann-La Roche
04/14/14
-
109
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
Vitae Pharmaceuticals
04/14/14
-
139
Kinase inhibitors and methods of their use
Novartis
03/17/14
-
14
Bacterial thioredoxin reductase inhibitors and methods for use thereof
Thioredoxin Systems
03/17/14
-
16
Trisubstituted purine derivatives
Cyclacel
03/17/14
-
5
Isonicotinamide orexin receptor antagonists
Merck Sharp & Dohme
03/17/14
-
12
Nitrogen-containing heterocyclic compound and use of same
Takeda Pharmaceutical
03/17/14
-
45
Pyrrolotriazine kinase inhibitors
Bristol-Myers Squibb
03/17/14
-
141
Anellated pyridine compounds
Hoffmann-La Roche
03/12/14
-
14
Heterocyclic compounds and uses thereof
Celgene Avilomics Research
03/12/14
-
103
Aminomethyl-4-imidazoles
Hoffmann-La Roche
03/12/14
-
8
2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors
Korea Institute of Science and Technology
03/12/14
-
15
Heterocyclic compound
Takeda Pharmaceutical
03/12/14
-
53
Substituted indole compounds having NOS inhibitory activity
Neuraxon
03/12/14
-
9
Substituted dihydropyrazolones and their use
Bayer Intellectual Property
03/06/14
-
9
1,4-diaryl-pyrimidopyridazine-2,5-diones and their use
Bayer Intellectual Property
03/06/14
-
5
6-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)ethyl]-3H-quinazolin-4-one as an inhibitor of human phosphatidylinositol 3-kinase delta
Icos
03/06/14
-
7
Opioid antagonists
Adolor
03/06/14
-
253
Chemical compounds
Boehringer Ingelheim International
03/06/14
-
750
Pyrolinone derivative and pharmaceutical composition comprising the same
Shionogi
03/06/14
-
12
Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
Merck Sharp & Dohme
03/06/14
-
116
Triazolopyridine compounds as PIM kinase inhibitors
Array Biopharma
02/24/14
-
4
Derivatives of azaindoles as inhibitors of protein kinases ABL and SRC
Oribase Pharma
02/24/14
-
152
Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
Albany Molecular Research
02/24/14
-
5
Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
Icos
02/24/14
-
22
SGLT-2 inhibitors, methods of making them, and uses thereof
Albany Molecular Research
02/24/14
-
173
Oxadiazole inhibitors of leukotriene production
Boehringer Ingelheim International
02/24/14
-
24
Pyridyl piperidine orexin receptor antagonists
Merch Sharp & Dohme
02/24/14
-
87
Substituted heteroarylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
Vanderbilt University
02/24/14
-
10
Prolylcarboxypeptidase inhibitors
Merck Sharp & Dohme
02/24/14
-
10
Triazolo and tetrazolo pyrimidine derivatives as HNE inhibitors for treating COPD
Bayer Intellectual Property
02/24/14
-
64
Pyrimido [5,4-D] pyrimidine derivatives for the inhibition of tyrosine kinases
Boehringer Ingelheim International
02/24/14
-
47
Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors
The Medicines Company (Leipzig)
02/24/14
-
31
5-substituted-2-phenylamino benzamides as MEK inhibitors
Chugai Seiyaku Kabushiki Kaisha
02/24/14
-
11
JNK modulators
Hoffmann-La Roche
02/24/14
-
5
Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
Research Triangle Institute
02/24/14
-
10
Bicyclic dihydroimidazolone CGRP receptor antagonists
Merck Sharp & Dohme
02/24/14
-
66
Modulators of serotonin receptor
Janssen Pharmaceutica
02/24/14
-
119
Compounds and their administration for treating a neurodegenerative disease as well as a method for identifying a compound capable of inhibiting a kinase, such as LRRK
Medical Research Council Technology
02/24/14
-
7
Tetrahydro-pyrazolo[1,5-a]pyrido-pyrimidines as antagonists of serotonin 5-HT6 receptors, methods for the production and use thereof
TBA
01/21/14
-
10
Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
Merck Sharp & Dohme
01/21/14
-
6
Pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists
Bristol-Myers Squibb
01/20/14
-
11
Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Molecular Insight Pharmaceuticals
01/20/14
-
21
Substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs as inhibitors of the PDK1 kinase
University of Utah Research Foundation
01/20/14
-
3
Methods of using 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine compounds
Proximagen
01/20/14
-
96
Benzimidazole derivatives: preparation and pharmaceutical applications
Mei Pharma
01/14/14
-
16
S1P3 receptor inhibitors for treating pain
Allergan
01/14/14
-
2
Imidazolothiazole compounds and methods of use thereof
Ambit Biosciences
01/14/14
-
103
Compounds and compositions as protein kinase inhibitors
Novartis
01/14/14
-
11
Compound useful for the treatment of degenerative and inflammatory diseases
Galapagos
01/14/14
-
93
Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity
Theravance
01/14/14
-
8
Substituted 4-(indazolyl)-1,4-dihydropyridines and methods of use thereof
Bayer Intellectual Property
01/03/14
-
27
Chemical compounds
Astrazeneca
01/03/14
-
5
Non-amidic linkers with branched termini as CGRP receptor antagonists
Merck Sharp & Dohme
01/03/14
-
4
2-amino-3-sulphonyl-tetrahydro-pyrazolo[1,5-A]pyrido-pyrimidine antagonists of serotonin 5-HT6 receptors, methods for the production and use thereof
TBA
01/03/14
-
13
(EN) 3-sulfonyl-pyrazolo[1,5-a] pyrimidines / antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof
Avincuro Pharmaceuticals
01/03/14
-
23
Compounds and compositions as kinase inhibitors
Irm
01/03/14
-
21
Furo[3, 2-B] pyrrol-3-ones as cathespin S inhibitors
Amura Therapeutics
12/22/13
-
2
Inhibitors of CXCR2
Sanofi
12/22/13
-
60
Aminodihydrothiazine derivatives
Shionogi
12/22/13
-
8
Phytoestrogenic formulations for alleviation or prevention of neurodegenerative diseases
University of Southern California
12/22/13
-
21
Tricyclic compound and pharmaceutical use thereof
Takeda Pharmaceutical
12/22/13
-
38
Viral polymerase inhibitors
Biota Scientific Management
12/09/13
-
14
Compounds that are ERK inhibitors
Merck Sharp & Dohme
12/09/13
-
14
Triazole compounds as KSP inhibitors
Novartis
12/09/13
-
24
Substituted indanes, method for the production thereof, and use thereof as drugs
Sanofi
12/09/13
-
17
17Beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of hormone-related diseases
Universitaet Des Saarlandes
12/09/13
-
9
Triazole derivatives with improved receptor activity and bioavailability properties as ghrelin antagonists of growth hormone secretagogue receptors
Aeterna Zentaris
12/03/13
-
10
Estrogen receptor ligands and methods of use thereof
Gtx
12/03/13
-
97
C-aryl glucoside SGLT2 inhibitors and pharmaceutical compositions comprising same
Green Cross
12/03/13
-
4
Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use
St George'S Hosptial Medical School
12/03/13
-
230
Substituted benzo-pyrido-triazolo-diazepine compounds
Arqule
12/03/13
-
289
Compounds for the treatment of inflammatory disorders
Merck Sharp & Dohme
11/26/13
-
48
Aminodihydrothiazine derivatives substituted with a cyclic group
Shionogi
11/26/13
-
10
Inhibitors
Probiodrug
11/26/13
-
6
3-substituted-2-(arlyalkyl)-1-azabicycloalkanes and methods of use thereof
Targacept
11/26/13
-
43
Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
Merck Sharp & Dohme
11/26/13
-
10
Tetrahydroquinoxaline urea derivatives as modulators of 11-B-hydroxysteroid dehydrogenase type I
Sanofi
11/18/13
-
8
Compounds having CRTH2 antagonist activity
Atopix Therapeutics
11/18/13
-
4
Inhibitors of Burton's tyrosine kinase
Roche Palo Alto
11/18/13
-
55
Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors
Almirall
11/18/13
-
50
Quinoxaline carboxamide derivatives as protein tyrosine kinase inhibitors
Novartis
11/18/13
-
66
Inhibitors of JNK
Roche Palo Alto
11/18/13
-
8
Inhibitors of AKT activity
Merck Sharp & Dohme
11/11/13
-
23
Piperidine derivatives as modulators of chemokine receptor activity
Bristol-Myers Squibb
11/11/13
-
16
Prolyl hydroxylase inhibitors
Aerpio Therapeutics
11/11/13
-
19
Compounds for inhibiting semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) and uses thereof for treatment and prevention of diseases
Semmelweis Egyetem
11/11/13
-
31
6,7-unsaturated-7-carbamoyl substituted morphinan derivative
Shionogi
11/11/13
-
82
Pyrazolothiazole compound
Eisai R&D Management
11/04/13
-
141
Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity
Taiho Pharmaceutical
11/04/13
-
10
Modulators of protein kinase signaling
Novotyr Therapeutics
11/04/13
-
199
Azetidine derivatives
Boehringer Ingelheim International
11/04/13
-
155
Diaza-spiro[5.5]undecanes
Novartis
11/04/13
-
26
Macrocyclic indoles as hepatitis C virus inhibitors
Janssen Ireland
10/25/13
-
83
Pyrrolidine derivatives
Hoffmann-La Roche
10/25/13
-
11
Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors
Bayer Intellectual Property
10/25/13
-
5
Inhibitors
Probiodrug
10/25/13
-
31
Buprenophine analogs
Purdue Pharma
10/25/13
-
82
Pyrrolopyrazoles, potent kinase inhibitors
Agouron Pharmaceuticals
10/25/13
-
10
3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists
Merck Sharp & Dohme
10/18/13
-
60
Sulfoximine-substituted pyrimidines as CDK- and/or VEGF inhibitors, their production and use as pharmaceutical agents
Bayer Intellectual Property
10/18/13
-
50
Tetrahydro-pyran derivatives
Hoffmann-La Roche
10/18/13
-
48
Aminodihydrothiazine derivatives substituted with a cyclic group
Shionogi
10/18/13
-
154
6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
Allergan
10/18/13
-
21
Substituted tricyclic compounds and methods of use thereof
Bayer Intellectual Property
10/18/13
-
59
Oxidase inhibitors and their use
Oryzon Genomics
10/18/13
-
210
Aminomethyl quinolone compounds
Hoffmann-La Roche
10/07/13
-
88
Heterocyclic oxime compounds
Novartis
10/07/13
-
17
7-membered ring compound and method of production and pharmaceutical application thereof
Daiichi Sankyo
10/07/13
-
7
Compounds for the treatment of hepatitis C
Bristol-Myers Squibb
10/07/13
-
25
Methyl-pyrrolidine ether derivatives
Hoffmann-La Roche
10/07/13
-
74
Glucagon receptor modulators
Pfizer
10/07/13
-
22
Piperazine compounds
Amura Therapeutics
09/30/13
-
31
Azaquinazolinediones chymase inhibitors
Boehringer Ingelheim International
09/30/13
-
6
CXCR2 inhibitors
Sanofi
09/30/13
-
4
Inhibitors of protein kinases
Portola Pharmaceuticals
09/30/13
-
76
Conformationally restricted urea inhibitors of soluble epoxide hydrolase
University of California
09/30/13
-
365
Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
Cephalon
09/16/13
-
18
Imidazopyridines and imidazopyrimidines as HIV-1 reverse transcriptase inhibitors
CSIR, Pretoria (Za)
09/16/13
-
20
HIV protease inhibitors and methods for using
Purdue Research Foundation
09/16/13
-
6
P53 activating compounds
University Court of The University of Dundee
09/16/13
-
34
5-HT3 receptor modulators, methods of making, and use thereof
Albany Molecular Research
09/16/13
-
52
Heterocyclic compound and use thereof
Takeda Pharmaceutical
09/16/13
-
80
Heterocyclic hydrazone compounds
Novartis
09/10/13
-
176
Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
Vitae Pharmaceuticals
09/10/13
-
6
Heterocyclic compound and use thereof
Takeda Pharmaceutical
09/10/13
-
36
Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
Hoffmann-La Roche
09/10/13
-
320
Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors
Amgen
09/09/13
-
18
Adenosine compounds and their use thereof
Inotek Pharmaceuticals
09/09/13
-
27
Inhibitors of c-fms kinase
Janssen Pharmaceutica
09/03/13
-
9
Inhibitors of Bruton's tyrosine kinase
Pharmacyclics
09/03/13
-
6
Bryostatin analogues, synthetic methods and uses
The Board of Trustees of The Leland Stanford Junior University
09/03/13
-
8
Macrocyclic integrase inhibitors
Elanco Animal Health Ireland
09/03/13
-
17
Organic compounds
Novartis
09/03/13
-
40
Hexahydropyrroloimidazolone compounds
Hoffmann-La Roche
09/03/13
-
111
Beta-lactamase inhibitors
Merck Sharp & Dohme
09/03/13
-
29
Urokinase inhibitors, production and use thereof
The Medicines
08/29/13
-
14
Derivatives of 7-alkynyl-1,8-Naphthyridones, Preparation Method Therefore and Use of Same in Therapeutics
Sanofi
08/29/13
-
17
Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors
Merck Sharp & Dohme
08/28/13
-
11
Salvinorin derivatives and uses thereof
The Mclean Hospital
08/28/13
-
1
Chromane derivatives as TRPV3 modulators
Glenmark Pharamceuticals
08/28/13
-
9
2-aminoimidazole beta-secretase inhibitors for the treatment of alzheimer's disease
Merck Sharp & Dohme
08/28/13
-
4
Benzimidazole derivatives and their use for modulating the GABAA receptor complex
Aniona
08/28/13
-
15
(3-aryl-piperazin-1-yl), (2-aryl-morpholin-4-yl) and (2-aryl-thiomorpholin-4-yl) derivatives of 6,7-dialkoxy-quinazoline, 6,7-dialkoxyphtalazine and 6,7-dialkoxyisoquinoline as PDE10A enzyme inhibitors
H. Lundbeck
08/28/13
-
1
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
Vertex Pharmaceuticals
08/19/13
-
4
Substituted oxazolidinones and their use
Bayer Intellectual Property
08/19/13
-
10
Translocator protein ligands
The University of Sydney
08/19/13
-
184
Inhibitors
Probiodrug
08/19/13
-
346
Substituted imidazopyr- and imidazotri-azines
Osi Pharmaceuticals
08/19/13
-
262
Benzotriazine inhibitors of kinases
Targegen
08/12/13
-
4
Phenylpropionamide compounds and the use thereof
Purdue Pharma
08/12/13
-
22
9-(pyrazol-3-yl)-9H-purine-2-amine and 3-(pyrazol-3-yl) -3H-imidazo[4,5-B] pyridin-5-amine derivatives and their use for the treatment of cancer
Astrazeneca
08/12/13
-
5
Imidazo[1,2-B][1,2,4]triazines as C-MET inhibitors
Incyte
08/12/13
-
6
Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors
Centre National De La Recherche Scientifique
08/12/13
-
10
Thienopyrimidines for pharmaceutical compositions
Boehringer Ingelheim International
08/12/13
-
7
Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators
Purdue Pharma
08/05/13
-
8
Imidazo-, pyrazolopyrazines and imidazotriazines and their use
Bayer Intellectual Property
08/05/13
-
3
Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
Merck Patent
08/05/13
-
14
Inhibitors of c-fms kinase
Janssen Pharmaceutica
08/05/13
-
66
Antiviral compounds
Gilead Sciences
08/05/13
-
6
Bridged bicyclic RHO kinase inhibitor compounds, composition and use
Inspire
07/29/13
-
12
Inhibitors of Bruton's tyrosine kinase
Pharmacyclics
07/29/13
-
30
Histone deacetylase inhibitors
Orchid Chemicals & Pharmaceuticals
07/29/13
-
1
Pyrimidinecarboxamide derivatives as inhibitors of Syk kinase
Glaxo Group
07/24/13
-
22
Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent
Lg Life Sciences
07/24/13
-
33
Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
Sanofi
07/24/13
-
14
Azacyclic compounds
Hoffmann-La Roche
07/24/13
-
6
Botryllamides and method of inhibiting PGP in a mammal afflicted with cancer
The United States of America, As Represented By The Secretary, Department of Health and Human Services
07/24/13
-
44
MAPK/ERK kinase inhibitors
Takeda Pharmaceutical
07/24/13
-
10
Method of reducing intraocular pressure in humans
Inotek Pharmaceuticals
07/08/13
-
20
Nitrogen-containing heterocyclic compound and use thereof
Takeda Pharmaceutical
07/08/13
-
63
Nitrogen-containing heteroaryl derivatives
Hoffmann-La Roche
07/08/13
-
17
Diazabenzo[de] anthracen-3-one compounds and methods for inhibiting PARP
Eisai
07/08/13
-
38
2-pyridyloxy-4-nitrile orexin receptor antagonists
TBA
06/25/13
-
1
Compounds useful as inhibitors of atr kinase
Vertex Pharmaceuticals
06/24/13