Compile Data Set for Download or QSAR
Report error Found 198 Enz. Inhib. hit(s) with all data for entry = 9789
TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488661(US10961228, Example 1 | (R)-N-(3-(2-((2-fluoro- 3-...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488662(US10961228, Example 2 | (R)-N-(3-(2-(2-fluoro-3- (...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488663(US10961228, Example 3 | (R)-N-(3-(2-(3- (ethylsulf...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488667(US10961228, Example 4 | (R)-N-(3-(2-(3- cyclopropy...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488685(US10961228, Example 14 | (R)-N-(3-(2-((2-fluoro- 3...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488689(US10961228, Example 16 | (R)-N-(3-(2-((2-fluoro- 3...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488710(US10961228, Example 22 | (R)-N-(3-(2-((2-fluoro- 3...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488719(US10961228, Example 26 | (R)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488735(US10961228, Example 27 | (S)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488758(US10961228, Example 29 | (R)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488777(US10961228, Example 33 | (R)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488809(US10961228, Example 37 | (R)-N-(3-(2-((2-fluoro-3-...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489047(US10961228, Example 42 | (R)-N-(3-(2-((2-fluoro- 3...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489073(US10961228, Example 45 | (R)-N-(3-(5-fluoro-2- ((2...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489165(US10961228, Example 48 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489168(US10961228, Example 51 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489170(US10961228, Example 53 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489172(US10961228, Example 55 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489174(US10961228, Example 57 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489179(US10961228, Example 62 | (R)-3-ethoxy-N-(3-(2- ((2...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488811(US10961228, Example 38 | (R)-N-(3-(5-fluoro-2 ((2-...)
Affinity DataIC50: 3.30nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488674(US10961228, Example 9 | (R)-2-((3S,5S)-3,5- dimeth...)
Affinity DataIC50: 3.40nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488690(US10961228, Example 17 | (R)-N-(3-(5-fluoro-2- ((2...)
Affinity DataIC50: 3.60nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489046(US10961228, Example 41 | (R)-N-(3-(5-fluoro-2- ((2...)
Affinity DataIC50: 3.95nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488713(US10961228, Example 24 | (R)-N-(3-(2-((2-fluoro-3-...)
Affinity DataIC50: 4.20nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM50503287(ABT-494 | Rinvoq | Upadacitinib | US10961228, Exam...)
Affinity DataIC50: 5nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488668(US10961228, Example 5 | (R)-N-(3-(5-chloro-2- ((2-...)
Affinity DataIC50: 5.10nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488763(US10961228, Example 31 | (R)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 6.40nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488672(US10961228, Example 7 | (R)-N-(3-(2-((2-fluoro-3- ...)
Affinity DataIC50: 6.60nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489177(US10961228, Example 60 | (R)-2-((S)-2,4- dimethylp...)
Affinity DataIC50: 7.40nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489166(US10961228, Example 49 | (R)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 13nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488676(US10961228, Example 11 | (R)-2-((3S,5S)-3,5- dimet...)
Affinity DataIC50: 13.1nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489171(US10961228, Example 54 | (S)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 14nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488761(US10961228, Example 30 | (S)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 14.2nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489163(US10961228, Example 46 | (R)-N-(3-(5-fluoro-2- ((2...)
Affinity DataIC50: 19.8nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488684(US10961228, Example 13 | (S)-N-(3-(2-((2-fluoro- 3...)
Affinity DataIC50: 22.4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488717(US10961228, Example 25 | (S)-N-(3-(2-((2-fluoro-3-...)
Affinity DataIC50: 22.8nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488673(US10961228, Example 8 | (R)-N-(3-(5-fluoro-2- ((2-...)
Affinity DataIC50: 24.5nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488640(US10961228, Example Tofacitinib | US11414413, Exam...)
Affinity DataIC50: 30nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489180(US10961228, Example 64 | (R)-3-(benzyloxy)-N- 3-(2...)
Affinity DataIC50: 30nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488675(US10961228, Example 10 | (S)-2-((3S,5S)-3,5- dimet...)
Affinity DataIC50: 39.8nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489178(US10961228, Example 61 | (S)-2-((S)-2,4- dimethylp...)
Affinity DataIC50: 42.8nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488746(US10961228, Example 28 | (S)-2-((3R,5R)-3,5- dimet...)
Affinity DataIC50: 45.2nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489167(US10961228, Example 50 | (S)-2-((R)-2,4- dimethylp...)
Affinity DataIC50: 48.5nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489175(US10961228, Example 58 | (R)-2-((S)-2,4- dimethylp...)
Affinity DataIC50: 48.6nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488669(US10961228, Example 6 | (S)-N-(3-(2-((2-fluoro-3- ...)
Affinity DataIC50: 57.4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandPNGBDBM50503287(ABT-494 | Rinvoq | Upadacitinib | US10961228, Exam...)
Affinity DataIC50: 64nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488788(US10961228, Example 36 | (S)-N-(3-(2-((2-fluoro-3-...)
Affinity DataIC50: 70.3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
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TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM489181(US10961228, Example 65 | (S)-3-(benzyloxy)-N- (3-(...)
Affinity DataIC50: 73nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

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