Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 11710
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504495(US11065249, Example 9 | First-eluting isomer (see ...)
Affinity DataIC50: 4.40nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504419(2-{5-[(3-Ethoxy-5-fluoropyridin-2-yl)oxy]pyridin-3...)
Affinity DataIC50: 5.80nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504424(2-{5-[(3-Ethoxy-5-fluoropyridin-2-yl)oxy]pyridin-3...)
Affinity DataIC50: 8.60nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 10nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642329(US20230405002, Example 10 | rac-2-{5-[(3-ethoxypyr...)
Affinity DataIC50: 19nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642329(US20230405002, Example 10 | rac-2-{5-[(3-ethoxypyr...)
Affinity DataIC50: 39nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504482(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 40nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504494(2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}-N-[...)
Affinity DataIC50: 42nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504500(2-{5-[(3-ethoxy-5-fluoropyridin-2- yl)oxy]pyridin-...)
Affinity DataIC50: 57nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504493(2-{5-[(3-Ethoxy-5-fluoropyridin-2-yl)oxy]pyridin-3...)
Affinity DataIC50: 80nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504492(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 110nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504505(US11065249, Example 19 | First-eluting enantiomer ...)
Affinity DataIC50: 140nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642345(ac-2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}-...)
Affinity DataIC50: 200nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504504(N-(5,5-difluoropiperidin-3-yl)-2-{5-[(3- ethoxypyr...)
Affinity DataIC50: 230nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642339(N-[(3S)-5,5-difluoropiperidin-3-yl]-2-{5-[(3- etho...)
Affinity DataIC50: 240nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM576482(US11471458, Example 16 | US20230405002, Example 16)
Affinity DataIC50: 480nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504499(2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}-N-[...)
Affinity DataIC50: 590nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504495(US11065249, Example 9 | First-eluting isomer (see ...)
Affinity DataIC50: 650nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642340(rac-2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}...)
Affinity DataIC50: 2.10E+3nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504501(US11065249, Example 22 | 2-{5-[(3-ethoxypyridin-2-...)
Affinity DataIC50: 3.10E+3nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504502(US11065249, Example 16 | From first-eluting enanti...)
Affinity DataIC50: 3.30E+3nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504501(US11065249, Example 22 | 2-{5-[(3-ethoxypyridin-2-...)
Affinity DataIC50: 5.00E+3nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
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TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504510(2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}-N-(...)
Affinity DataIC50: 1.40E+4nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM504511(rac-2-{5-[(3-ethoxypyridin-2- yl)oxy]pyridin-3-yl}...)
Affinity DataIC50: 1.60E+4nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642342(2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3- yl}-N-[...)
Affinity DataIC50: 2.10E+4nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
Go to US Patent