Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 252
TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255228(2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d...)
Affinity DataIC50: 1nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255748(2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d...)
Affinity DataIC50: 4nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255761(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 6nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255752(2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d...)
Affinity DataIC50: 11nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255749(2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d...)
Affinity DataIC50: 41nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255754(2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d...)
Affinity DataIC50: 41nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255769(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 58nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255750(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 79nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255755(2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d...)
Affinity DataIC50: 122nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM254893(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 139nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255751(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 143nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255762(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 146nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255770(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 168nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255753(2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d...)
Affinity DataIC50: 225nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255767(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 238nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255765(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 280nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255763(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 413nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255757(2-(2-Amino-ethylamino)- thieno[3,2-d]pyrimidine- 7...)
Affinity DataIC50: 435nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255768(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 560nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255756(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 615nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255764(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 852nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255766(2-((3R,4R)-3-Amino- tetrahydro-pyran-4- ylamino)-t...)
Affinity DataIC50: 1.11E+3nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255759(2-(2-Methylamino- ethylamino)-thieno[3,2- d]pyrimi...)
Affinity DataIC50: 2.46E+3nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255760(2-((1R,2S)-2-Amino- cyclohexylamino)- thieno[3,2-d...)
Affinity DataIC50: 5.98E+3nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM255758(2-(Azetidin-3-ylamino)- thieno[3,2-d]pyrimidine- 7...)
Affinity DataIC50: 1.00E+4nMAssay Description:Determination of IC50 of Spleen Tyrosine Kinase (SYK) inhibition: SYK kinase assay is a standard kinase assay adapted to a 96 well plate format. This...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent