Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 7658
TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209049(US9243038, 26)
Affinity DataIC50: 54nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209051(US9243038, 27)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209041(US9243038, 15)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209054(US9243038, 13)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209053(US9243038, 8)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209032(US9243038, 6b (trans olefin) | US9243038, 6a (cis ...)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209045(US9243038, 20)
Affinity DataIC50: 65nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209048(US9243038, 28)
Affinity DataIC50: 80nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209046(US9243038, 21)
Affinity DataIC50: 85nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Mouse)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209045(US9243038, 20)
Affinity DataIC50: 90nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Mouse)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209032(US9243038, 6b (trans olefin) | US9243038, 6a (cis ...)
Affinity DataIC50: 90nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209052(US9243038, 29)
Affinity DataIC50: 100nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209024(US9243038, 2a (cis olefin) | US9243038, 2b (trans ...)
Affinity DataIC50: 150nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209042(US9243038, 16)
Affinity DataIC50: 370nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209043(US9243038, 17)
Affinity DataIC50: 500nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209034(US9243038, 6c )
Affinity DataIC50: 570nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209025(US9243038, 5b (trans olefin) | US9243038, 5a (cis ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209037(US9243038, 10)
Affinity DataIC50: 1.50E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209027(US9243038, 3b (trans olefin))
Affinity DataIC50: 1.50E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209038(US9243038, 11)
Affinity DataIC50: 2.10E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209044(US9243038, 19)
Affinity DataIC50: 3.20E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209050(US9243038, 25)
Affinity DataIC50: 5.00E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209032(US9243038, 6b (trans olefin) | US9243038, 6a (cis ...)
Affinity DataIC50: 5.60E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209036(US9243038, 9)
Affinity DataIC50: 6.00E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209047(US9243038, 24)
Affinity DataIC50: 7.00E+3nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209039(US9243038, 12)
Affinity DataIC50: 1.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209035(US9243038, 7)
Affinity DataIC50: 1.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209024(US9243038, 2a (cis olefin) | US9243038, 2b (trans ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209040(US9243038, 14)
Affinity DataIC50: 2.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209026(US9243038, 3a (cis olefin))
Affinity DataIC50: 2.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209025(US9243038, 5b (trans olefin) | US9243038, 5a (cis ...)
Affinity DataIC50: 2.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM60940(US9243038, 18 | US9243038, 23)
Affinity DataIC50: 2.00E+4nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209028(US9243038, 4b (trans olefin) | US9243038, 4a (cis ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209028(US9243038, 4b (trans olefin) | US9243038, 4a (cis ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInsulin-degrading enzyme(Human)
President and Fellows of Harvard College

US Patent
LigandPNGBDBM209023(US9243038, 1 (cis olefin))
Affinity DataIC50: 1.00E+5nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In DepthDetails
US Patent