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Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 6042
TargetMu-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199896(US8580788, 56 | CHEMBL426523 | 3-((2R,3R,7S,9-alph...)
Affinity DataKi:  0.570nM ΔG°:  -52.8kJ/mole IC50: 0.530nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetMu-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199914(CHEMBL376690 | US8580788, 60 | 3-((7R,8R,9alphaR)-...)
Affinity DataKi:  1.10nM ΔG°:  -51.1kJ/mole IC50: 11nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetMu-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199913(US8580788, 59 | CHEMBL218404 | ((7R,8R,9alphaR)-8-...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/mole IC50: 21nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetMu-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199912(CHEMBL218520 | US8580788, 64 | 3-((3S,7R,8R,9alpha...)
Affinity DataKi:  3.30nM ΔG°:  -48.4kJ/mole IC50: 26nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetMu-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199943(CHEMBL219319 | US8580788, 63 | 3-((3S,7R,8R,9alpha...)
Affinity DataKi:  3.60nM ΔG°:  -48.2kJ/mole IC50: 12nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetMu-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199934(US8580788, 58 | CHEMBL219495 | 3-((7R,8R,9alphaR)-...)
Affinity DataKi:  5.5nM ΔG°:  -47.1kJ/mole IC50: 21nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetKappa-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199896(US8580788, 56 | CHEMBL426523 | 3-((2R,3R,7S,9-alph...)
Affinity DataKi:  8.90nM ΔG°:  -46.0kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetMu-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199907(US8580788, 70 | CHEMBL435746 | 3-((3S,7R,8R,9alpha...)
Affinity DataKi:  8.90nM ΔG°:  -46.0kJ/mole IC50: 29nMpH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetKappa-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199912(CHEMBL218520 | US8580788, 64 | 3-((3S,7R,8R,9alpha...)
Affinity DataKi:  12nM ΔG°:  -45.2kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetKappa-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199943(CHEMBL219319 | US8580788, 63 | 3-((3S,7R,8R,9alpha...)
Affinity DataKi:  18nM ΔG°:  -44.2kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetDelta-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199913(US8580788, 59 | CHEMBL218404 | ((7R,8R,9alphaR)-8-...)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetDelta-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199896(US8580788, 56 | CHEMBL426523 | 3-((2R,3R,7S,9-alph...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetDelta-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199907(US8580788, 70 | CHEMBL435746 | 3-((3S,7R,8R,9alpha...)
Affinity DataKi:  36nM ΔG°:  -42.5kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetKappa-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199914(CHEMBL376690 | US8580788, 60 | 3-((7R,8R,9alphaR)-...)
Affinity DataKi:  44nM ΔG°:  -42.0kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199907(US8580788, 70 | CHEMBL435746 | 3-((3S,7R,8R,9alpha...)
Affinity DataKi:  85nM ΔG°:  -40.4kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199943(CHEMBL219319 | US8580788, 63 | 3-((3S,7R,8R,9alpha...)
Affinity DataKi:  88nM ΔG°:  -40.3kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetKappa-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199934(US8580788, 58 | CHEMBL219495 | 3-((7R,8R,9alphaR)-...)
Affinity DataKi:  112nM ΔG°:  -39.7kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
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TargetDelta-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199914(CHEMBL376690 | US8580788, 60 | 3-((7R,8R,9alphaR)-...)
Affinity DataKi:  139nM ΔG°:  -39.1kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
Go to US Patent

TargetKappa-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199913(US8580788, 59 | CHEMBL218404 | ((7R,8R,9alphaR)-8-...)
Affinity DataKi:  190nM ΔG°:  -38.4kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199934(US8580788, 58 | CHEMBL219495 | 3-((7R,8R,9alphaR)-...)
Affinity DataKi:  242nM ΔG°:  -37.8kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
Go to US Patent

TargetDelta-type opioid receptor(Human)
Adolor

US Patent
LigandPNGBDBM50199912(CHEMBL218520 | US8580788, 64 | 3-((3S,7R,8R,9alpha...)
Affinity DataKi:  716nM ΔG°:  -35.1kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2014
Entry Details
Go to US Patent