Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with all data for entry = 8537
TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Galapagos

US Patent
LigandPNGBDBM128101(US8796457, 1 | US9505754, 1 | US10206907, Compound...)
Affinity DataIC50: 6.60nMT: 2°CAssay Description:Recombinant human JAK1 (catalytic domain, amino acids 866-1154; catalog number PV4774) was purchased from Invitrogen. 1 ng of JAK1 was incubated with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
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TargetTyrosine-protein kinase JAK2 [866-1054](Human)
Galapagos

US Patent
LigandPNGBDBM128101(US8796457, 1 | US9505754, 1 | US10206907, Compound...)
Affinity DataIC50: 67nMT: 2°CAssay Description:Recombinant human JAK2 (catalytic domain, amino acids 866-1154; catalog number PV4210) was purchased from Invitrogen. 0.0125 mU of JAK2 was incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
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LigandPNGBDBM128101(US8796457, 1 | US9505754, 1 | US10206907, Compound...)
Affinity DataIC50: 219nMpH: 7.5 T: 2°CAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
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TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Galapagos

US Patent
LigandPNGBDBM128101(US8796457, 1 | US9505754, 1 | US10206907, Compound...)
Affinity DataIC50: 408nMpH: 7.5 T: 2°CAssay Description:Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
Go to US Patent