Compile Data Set for Download or QSAR
Report error Found 355 Enz. Inhib. hit(s) with all data for entry = 3381
TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398147(US10323000, Compound 83 | 4-chloro-N-((1-hydroxy-3...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398215(US10323000, Compound 153 | (S)-4-chloro-N-((4,4-di...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398085(US10323000, Compound 21 | (R)-4-chloro-N-((3,3-dif...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398106(US10323000, Compound 41 | Preparations of 4-chloro...)
Affinity DataIC50: 10nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398146(US10323000, Compound 82 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398263(US10323000, Compound 208 | 4-Chloro-1-dimethylcarb...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398141(US10323000, Compound 75 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398261(US10323000, Compound 205 | 4-Chloro-1-dimethylcarb...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398157(US10323000, Compound 93 | 4-chloro-N-(((1R,3R)-1-h...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398259(US10323000, Compound 200 | 4-chloro-N-((4, 4-diflu...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398117(US10323000, Compound 51 | 4-chloro-1-(oxetan-3-yl)...)
Affinity DataIC50: 10nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398224(US10323000, Compound 163)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398220(US10323000, Compound 158 | 4-chloro-N-((4,4-difluo...)
Affinity DataIC50: 10nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398073(US10323000, Compound 9 | 4-Chloro-1-(3,3-difluoro-...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398154(US10323000, Compound 90 | Preparations of 4-chloro...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398218(US10323000, Compound 156 | 4-chloro-N-((3,3-difluo...)
Affinity DataIC50: 10nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398219(US10323000, Compound 157 | 4-chloro-N-((3,3-difluo...)
Affinity DataIC50: 10nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398071(US10323000, Compound 7 | US10676433, Compound 7)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398134(US10323000, Compound 68 | 4-chloro-1-(oxetan-3-yl)...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398220(US10323000, Compound 158 | 4-chloro-N-((4,4-difluo...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398233(US10323000, Compound 173 | 4-chloro-N-((4,4-difluo...)
Affinity DataIC50: 10nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398233(US10323000, Compound 173 | 4-chloro-N-((4,4-difluo...)
Affinity DataIC50: 10nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398217(US10323000, Compound 155 | 4-chloro-N-((3, 3-diflu...)
Affinity DataIC50: 10nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398105(US10323000, Compound 40 | 4-chloro-N-((4,4-difluor...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398247(US10323000, Compound 187 | (S)-4-chloro-N-((3, 3-d...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398105(US10323000, Compound 40 | 4-chloro-N-((4,4-difluor...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398106(US10323000, Compound 41 | Preparations of 4-chloro...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398248(US10323000, Compound 188 | 4-chloro-N-((3, 3-diflu...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398248(US10323000, Compound 188 | 4-chloro-N-((3, 3-diflu...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398103(US10323000, Compound 38)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398245(US10323000, Compound 185 | 4-Chloro-1-(2-oxo-2-pyr...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398245(US10323000, Compound 185 | 4-Chloro-1-(2-oxo-2-pyr...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398104(US10323000, Compound 39 | 4-chloro-1-(2-methoxyeth...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398243(US10323000, Compound 183 | 4-chloro-N-((4,4-difluo...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398243(US10323000, Compound 183 | 4-chloro-N-((4,4-difluo...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398102(US10323000, Compound 37 | 4-chloro-N-((4,4-difluor...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398102(US10323000, Compound 37 | 4-chloro-N-((4,4-difluor...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398242(US10323000, Compound 182 | (R)-4-chloro-N-((4, 4-d...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398242(US10323000, Compound 182 | (R)-4-chloro-N-((4, 4-d...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398117(US10323000, Compound 51 | 4-chloro-1-(oxetan-3-yl)...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398256(US10323000, Compound 197 | 4-chloro-1-((1-cyclopro...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398256(US10323000, Compound 197 | 4-chloro-1-((1-cyclopro...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398119(US10323000, Compound 53 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetInterleukin-1 beta(Human)
Merck Patent

US Patent
LigandPNGBDBM398253(US10323000, Compound 193 | 4-chloro-N-((4,4-difluo...)
Affinity DataIC50: 55nMAssay Description:The activation of P2X7 by ATP leads to a fast transient activation of cells resulting in influx of Ca2+ followed by conversion of pro-IL-1β to a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398254(US10323000, Compound 195 | 4-Chloro-1-(2-oxo-2-pip...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398255(US10323000, Compound 196 | 4-chloro-N-((4,4-difluo...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398253(US10323000, Compound 193 | 4-chloro-N-((4,4-difluo...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398249(US10323000, Compound 189 | 4-chloro-N-((4, 4-diflu...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398110(US10323000, Compound 44 | 4-chloro-1-(oxetan-3-yl)...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Merck Patent

US Patent
LigandPNGBDBM398128(US10323000, Compound 62 | 4-Chloro-1-oxetan-3-yl-1...)
Affinity DataIC50: 55nMAssay Description:Agonist-induced pore formation was determined by measuring cellular uptake of YO PRO fluorescence dye in HEK293 transfected with human P2X7 receptor....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent

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