Compile Data Set for Download or QSAR
Report error Found 59 Enz. Inhib. hit(s) with all data for entry = 9464
TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403470(US10335399, Example 3-1A | US10806724, Example 3-1...)
Affinity DataIC50: 7nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403486(US10335399, Example 3-9A | US10806724, Example 3-9...)
Affinity DataIC50: 7nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403464(US10335399, Example 2-8A | US10806724, Example 2-8...)
Affinity DataIC50: 8nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403489(US10335399, Example 3-9D | US10806724, Example 3-9...)
Affinity DataIC50: 9nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403481(US10335399, Example 3-6B | US10806724, Example 3-6...)
Affinity DataIC50: 10nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403461(US10335399, Example 2-6A | US10806724, Example 2-6...)
Affinity DataIC50: 10nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403468(US10335399, Example 2-9C | US10806724, Example 2-9...)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403484(US10335399, Example 3-8A | US10806724, Example 3-8...)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403441(US10335399, Example 1-3B | (6R,9S)- or (6S,9R)- 4-...)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403465(US10335399, Example 2-8B | US10806724, Example 2-8...)
Affinity DataIC50: 14nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403488(US10335399, Example 3-9C | US10806724, Example 3-9...)
Affinity DataIC50: 15nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403453(US10335399, Example 2-2B | US10806724, Example 2-2...)
Affinity DataIC50: 15nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403472(US10335399, Example 3-2A | (S)- or (R)-2- ((difluo...)
Affinity DataIC50: 18nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403482(US10335399, Example 3-7A | US10806724, Example 3-7...)
Affinity DataIC50: 18nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403466(US10335399, Example 2-9A | US10806724, Example 2-9...)
Affinity DataIC50: 18nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403471(US10335399, Example 3-1B | US10806724, Example 3-1...)
Affinity DataIC50: 19nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403487(US10335399, Example 3-9B | US10806724, Example 3-9...)
Affinity DataIC50: 19nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403456(US10335399, Example 2-3A | US10806724, Example 2-3...)
Affinity DataIC50: 20nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403458(US10335399, Example 2-4A | US10806724, Example 2-4...)
Affinity DataIC50: 20nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403439(US10335399, Example 1-2B | US10806724, Example 1-2...)
Affinity DataIC50: 21nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403492(US10335399, Example 4-2A | US10806724, Example 4-2...)
Affinity DataIC50: 21nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403485(US10335399, Example 3-8B | US10806724, Example 3-8...)
Affinity DataIC50: 24nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403463(US10335399, Example 2-7 | US10806724, Example 2-7)
Affinity DataIC50: 25nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403490(US10335399, Example 4-1A | US10806724, Example 4-1...)
Affinity DataIC50: 25nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403462(US10335399, Example 2-6B | US10806724, Example 2-6...)
Affinity DataIC50: 26nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403479(US10335399, Example 3-5B | US10806724, Example 3-5...)
Affinity DataIC50: 26nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403478(US10335399, Example 3-5A | US10806724, Example 3-5...)
Affinity DataIC50: 27nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403493(US10335399, Example 4-2B | US10806724, Example 4-2...)
Affinity DataIC50: 28nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403457(US10335399, Example 2-3B | US10806724, Example 2-3...)
Affinity DataIC50: 32nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403454(US10335399, Example 2-2C | US10806724, Example 2-2...)
Affinity DataIC50: 35nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403451(US10335399, Example 2-1B | US10806724, Example 2-1...)
Affinity DataIC50: 38nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403480(US10335399, Example 3-6A | US10806724, Example 3-6...)
Affinity DataIC50: 52nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403469(US10335399, Example 2-9D | US10806724, Example 2-9...)
Affinity DataIC50: 57nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403440(US10335399, Example 1-3A | (6S,9R)- or (6R,9S)- 4-...)
Affinity DataIC50: 65nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403459(US10335399, Example 2-4B | US10806724, Example 2-4...)
Affinity DataIC50: 69nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403491(US10335399, Example 4-1B | US10806724, Example 4-1...)
Affinity DataIC50: 74nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403455(US10335399, Example 2-2D | US10806724, Example 2-2...)
Affinity DataIC50: 81nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403473(US10335399, Example 3-2B | (R)- or (S)-2- ((difluo...)
Affinity DataIC50: 86nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403483(US10335399, Example 3-7B | US10806724, Example 3-7...)
Affinity DataIC50: 90nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403467(US10335399, Example 2-9B | US10806724, Example 2-9...)
Affinity DataIC50: 114nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403495(US10335399, Example 5-1B | US10806724, Example 5-1...)
Affinity DataIC50: 159nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403449(US10335399, Example 1-7B | US10806724, Example 1-7...)
Affinity DataIC50: 172nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403450(US10335399, Example 2-1A | US10806724, Example 2-1...)
Affinity DataIC50: 179nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403452(US10335399, Example 2-2A | US10806724, Example 2-2...)
Affinity DataIC50: 195nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403476(US10335399, Example 3-4A | (S)- or (R)-2- ((difluo...)
Affinity DataIC50: 274nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403437(US10335399, Example 1-1 | US10806724, Example 1-1)
Affinity DataIC50: 277nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403445(US10335399, Example 1-5B | (6S,9R)- or (6R,9S)- 4-...)
Affinity DataIC50: 326nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403438(US10335399, Example 1-2A | US10806724, Example 1-2...)
Affinity DataIC50: 376nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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TargetMetabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM403494(US10335399, Example 5-1A | US10806724, Example 5-1...)
Affinity DataIC50: 500nMAssay Description:The utility of the compounds of the invention as an inhibitor of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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