Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 10468
LigandPNGBDBM537926(US11248003, Example 1)
Affinity DataIC50: 0.0800nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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LigandPNGBDBM537926(US11248003, Example 1)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetHepatocyte growth factor receptor(Human)
Oncobix

US Patent
LigandPNGBDBM537926(US11248003, Example 1)
Affinity DataIC50: 1nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 2nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM537979(US11248003, Example TRE-069)
Affinity DataIC50: 6nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Oncobix

US Patent
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 70nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetHepatocyte growth factor receptor(Human)
Oncobix

US Patent
LigandPNGBDBM537979(US11248003, Example TRE-069)
Affinity DataIC50: 120nMAssay Description:The inhibitory activity on a C797S-containing epidermal growth factor receptor (EGFR) kinase and an MET kinase was measured for compound 1 obtained i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent