Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 384
TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM264469(6-(3H-spiro[isobenzofuran-1,4'-piperidin]-1'-yl)-2...)
Affinity DataIC50: 766nMAssay Description:Representative Compounds of the Invention have been tested in the FLIPR, FLIPRTETRA, and/or electrophysiology (EP) assays for sodium channel blocking...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM264468(5-(3H-spiro[isobenzofuran-1,4'-piperidin]-1'-yl)-2...)
Affinity DataIC50: 1.38E+3nMAssay Description:Representative Compounds of the Invention have been tested in the FLIPR, FLIPRTETRA, and/or electrophysiology (EP) assays for sodium channel blocking...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM264470(6-([1,1'-biphenyl]-2-yloxy)-2-(thiazol-2-yl)-3,4-d...)
Affinity DataIC50: 1.70E+3nMAssay Description:Representative Compounds of the Invention have been tested in the FLIPR, FLIPRTETRA, and/or electrophysiology (EP) assays for sodium channel blocking...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM264465(5-(2-(pyridazin-4-yl)-4-(trifluoromethyl)phenoxy)-...)
Affinity DataIC50: 1.74E+3nMAssay Description:Representative Compounds of the Invention have been tested in the FLIPR, FLIPRTETRA, and/or electrophysiology (EP) assays for sodium channel blocking...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM264471(2-(thiazol-2-yl)-6-(4-(4-(trifluoromethyl)phenoxy)...)
Affinity DataIC50: 7.09E+3nMAssay Description:Representative Compounds of the Invention have been tested in the FLIPR, FLIPRTETRA, and/or electrophysiology (EP) assays for sodium channel blocking...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM264467(5-(4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-2...)
Affinity DataIC50: 9.10E+3nMAssay Description:Representative Compounds of the Invention have been tested in the FLIPR, FLIPRTETRA, and/or electrophysiology (EP) assays for sodium channel blocking...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Purdue Pharma

US Patent
LigandPNGBDBM264466(5-([1,1'-biphenyl]-2-yloxy)-2-(thiazol-2-yl)-2,3-d...)
Affinity DataIC50: 2.00E+4nMAssay Description:Representative Compounds of the Invention have been tested in the FLIPR, FLIPRTETRA, and/or electrophysiology (EP) assays for sodium channel blocking...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent