Compile Data Set for Download or QSAR
Report error Found 55 Enz. Inhib. hit(s) with all data for entry = 9063
TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374724(US10246466, Example 52 | 12-chloro-11-fluoro-13-me...)
Affinity DataKd:  6.5nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374720(US10246466, Example 49 | 14-methyl-6,7,13,14-tetra...)
Affinity DataKd:  24nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374721(US10246466, Example 50 | 11-fluoro-6,7,13,14-tetra...)
Affinity DataKd:  0.200nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374721(US10246466, Example 50 | 11-fluoro-6,7,13,14-tetra...)
Affinity DataKd:  0.570nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374722(US10246466, Example 51 | 11-fluoro-13-methyl-6,7,1...)
Affinity DataKd:  0.0650nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374722(US10246466, Example 51 | 11-fluoro-13-methyl-6,7,1...)
Affinity DataKd:  65nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374722(US10246466, Example 51 | 11-fluoro-13-methyl-6,7,1...)
Affinity DataKd:  0.150nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374722(US10246466, Example 51 | 11-fluoro-13-methyl-6,7,1...)
Affinity DataKd:  4.30nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  0.0510nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  37nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  0.0480nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  1.80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  6.80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374723(US10246466, Example 51-1 | (13R)-11-fluoro-13-meth...)
Affinity DataKd:  0.730nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374720(US10246466, Example 49 | 14-methyl-6,7,13,14-tetra...)
Affinity DataKd:  0.140nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374724(US10246466, Example 52 | 12-chloro-11-fluoro-13-me...)
Affinity DataKd:  270nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374724(US10246466, Example 52 | 12-chloro-11-fluoro-13-me...)
Affinity DataKd:  62nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374725(US10246466, Example 75 | 12-fluoro-15-methyl-5,6,7...)
Affinity DataKd:  0.0150nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374725(US10246466, Example 75 | 12-fluoro-15-methyl-5,6,7...)
Affinity DataKd:  6.5nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374726(US10246466, Example 92 | (7R,13R)-11-fluoro-7,13-d...)
Affinity DataKd:  0.120nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374726(US10246466, Example 92 | (7R,13R)-11-fluoro-7,13-d...)
Affinity DataKd:  8.20nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataKd:  0.0820nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataKd:  5.70nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374728(US10246466, Example 98 | 11-fluoro-13-(hydroxymeth...)
Affinity DataKd:  0.740nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374728(US10246466, Example 98 | 11-fluoro-13-(hydroxymeth...)
Affinity DataKd:  14nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374729(US10246466, Example 103 | 12-fluoro-5,6,7,8,14,15-...)
Affinity DataKd:  1.90nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374729(US10246466, Example 103 | 12-fluoro-5,6,7,8,14,15-...)
Affinity DataKd:  28nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase PLK4(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  2.90nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374714(US10246466, Example 39 | 12-chloro-11-fluoro-14-me...)
Affinity DataKd:  4.70nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374712(US10246466, Example 11-1 | 12-chloro-11-fluoro-13-...)
Affinity DataKd: >3.00E+4nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374712(US10246466, Example 11-1 | 12-chloro-11-fluoro-13-...)
Affinity DataKd:  1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.0310nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.180nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetNT-3 growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  0.300nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd: >1.00E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  4.80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  120nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(US10246466, Example 20 | 11-fluoro-14-methyl-6,7,1...)
Affinity DataKd:  21nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374714(US10246466, Example 39 | 12-chloro-11-fluoro-14-me...)
Affinity DataKd:  0.230nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374714(US10246466, Example 39 | 12-chloro-11-fluoro-14-me...)
Affinity DataKd:  27nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374714(US10246466, Example 39 | 12-chloro-11-fluoro-14-me...)
Affinity DataKd:  180nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374712(US10246466, Example 11-1 | 12-chloro-11-fluoro-13-...)
Affinity DataKd:  1.90E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374715(US10246466, Example 40 | 11-fluoro-3,14-dimethyl-6...)
Affinity DataKd:  600nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374715(US10246466, Example 40 | 11-fluoro-3,14-dimethyl-6...)
Affinity DataKd:  410nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374716(US10246466, Example 41 | 10-fluoro-8-methyl-15,16-...)
Affinity DataKd:  6nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374716(US10246466, Example 41 | 10-fluoro-8-methyl-15,16-...)
Affinity DataKd:  280nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374716(US10246466, Example 41 | 10-fluoro-8-methyl-15,16-...)
Affinity DataKd:  2.60nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374716(US10246466, Example 41 | 10-fluoro-8-methyl-15,16-...)
Affinity DataKd:  33nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374716(US10246466, Example 41 | 10-fluoro-8-methyl-15,16-...)
Affinity DataKd:  200nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

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