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Found
246
Enz. Inhib. hit(s) with all data for entry = 12453
Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703890
(7-(isothiazol-4-yl)-4-methyl-1,5-naphthyridin-2- a...)
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Affinity Data
Kd: 7.50E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703890
(7-(isothiazol-4-yl)-4-methyl-1,5-naphthyridin-2- a...)
Copy SMILES
Affinity Data
Kd: 1.91E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703893
(7-(2-fluorobenzyl)-4-methyl-1,5-naphthyridin-2- am...)
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Affinity Data
Kd: 5.29E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703893
(7-(2-fluorobenzyl)-4-methyl-1,5-naphthyridin-2- am...)
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Affinity Data
Kd: 3.91E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703894
(7-(2-chlorobenzyl)-4-methyl-1,5-naphthyridin-2- am...)
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Affinity Data
Kd: 4.68E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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PC sid
In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703894
(7-(2-chlorobenzyl)-4-methyl-1,5-naphthyridin-2- am...)
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Affinity Data
Kd: 3.15E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703895
(2-((6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
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Affinity Data
Kd: 874nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703895
(2-((6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
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Affinity Data
Kd: 3.09E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703898
(4-methyl-7-(3-pyridylmethyl)-1,5-naphthyridin-2- a...)
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Affinity Data
Kd: 232nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
PC cid
PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703898
(4-methyl-7-(3-pyridylmethyl)-1,5-naphthyridin-2- a...)
Copy SMILES
Affinity Data
Kd: 1.22E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703900
(4-methyl-7-[(1-methylpyrazol-4-yl)methyl]-1,5- nap...)
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Affinity Data
Kd: 137nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703900
(4-methyl-7-[(1-methylpyrazol-4-yl)methyl]-1,5- nap...)
Copy SMILES
Affinity Data
Kd: 748nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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PC sid
In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703907
(4-methyl-7-(3-pyridyloxy)-1,5-paphthyridin-2- amin...)
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Affinity Data
Kd: 2.46E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703915
(6-(2-fluorophenyl)-4-methyl-1,5-naphthyridin-2- am...)
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Affinity Data
Kd: 3.20E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703915
(6-(2-fluorophenyl)-4-methyl-1,5-naphthyridin-2- am...)
Copy SMILES
Affinity Data
Kd: 8.14E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703920
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
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Affinity Data
Kd: 94nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
Similars
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703920
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
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Affinity Data
Kd: 396nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
Similars
In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703921
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Copy SMILES
Affinity Data
Kd: 151nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703921
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Copy SMILES
Affinity Data
Kd: 2.22E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703922
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
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Affinity Data
Kd: 682nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703922
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Copy SMILES
Affinity Data
Kd: 1.25E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703923
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
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Affinity Data
Kd: 22nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
PC cid
PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703923
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Copy SMILES
Affinity Data
Kd: 81nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703924
(US20240368153, Example 7-5)
Copy SMILES
Affinity Data
Kd: 2nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703924
(US20240368153, Example 7-5)
Copy SMILES
Affinity Data
Kd: 2nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
PC cid
PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703925
(US20240368153, Example 7-6)
Copy SMILES
Affinity Data
Kd: 12nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703925
(US20240368153, Example 7-6)
Copy SMILES
Affinity Data
Kd: 105nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703927
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Copy SMILES
Affinity Data
Kd: 5nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703927
(N-[(6-amino-8-methyl-1,5-naphthyridin-3- yl)methyl...)
Copy SMILES
Affinity Data
Kd: 33nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703928
(N-[(5-amino-6-bromo-1H-pyrrolo[3,2-b]pyridin-2- yl...)
Copy SMILES
Affinity Data
Kd: 9nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703928
(N-[(5-amino-6-bromo-1H-pyrrolo[3,2-b]pyridin-2- yl...)
Copy SMILES
Affinity Data
Kd: 137nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703929
(US20240368153, Example 9-1)
Copy SMILES
Affinity Data
Kd: 456nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703929
(US20240368153, Example 9-1)
Copy SMILES
Affinity Data
Kd: 3.36E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703930
(US20240368153, Example 9-2)
Copy SMILES
Affinity Data
Kd: 3.26E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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PC sid
In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703930
(US20240368153, Example 9-2)
Copy SMILES
Affinity Data
Kd: 1.96E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
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Ligand Info
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703931
(US20240368153, Example 9-3)
Copy SMILES
Affinity Data
Kd: 1.17E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703931
(US20240368153, Example 9-3)
Copy SMILES
Affinity Data
Kd: 2.92E+4nM
More data for this Ligand-Target Pair
Target Info
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Ligand Info
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703936
(US20240368153, Example 12-1)
Copy SMILES
Affinity Data
Kd: 2.54E+3nM
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703936
(US20240368153, Example 12-1)
Copy SMILES
Affinity Data
Kd: 6.29E+3nM
More data for this Ligand-Target Pair
Target Info
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703939
(US20240368153, Example 12-4)
Copy SMILES
Affinity Data
Kd: 1.89E+3nM
More data for this Ligand-Target Pair
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703939
(US20240368153, Example 12-4)
Copy SMILES
Affinity Data
Kd: 4.95E+3nM
More data for this Ligand-Target Pair
Target Info
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Ligand Info
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703940
(US20240368153, Example 13-1)
Copy SMILES
Affinity Data
Kd: 510nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703940
(US20240368153, Example 13-1)
Copy SMILES
Affinity Data
Kd: 1.18E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703942
(US20240368153, Example 13-3)
Copy SMILES
Affinity Data
Kd: 680nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703942
(US20240368153, Example 13-3)
Copy SMILES
Affinity Data
Kd: 2.01E+3nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703943
(US20240368153, Example 13-4)
Copy SMILES
Affinity Data
Kd: 1.07E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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In Depth
Details
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703943
(US20240368153, Example 13-4)
Copy SMILES
Affinity Data
Kd: 3.09E+4nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703947
(US20240368153, Example 14-1)
Copy SMILES
Affinity Data
Kd: 1nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703947
(US20240368153, Example 14-1)
Copy SMILES
Affinity Data
Kd: 6nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
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PC sid
In Depth
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Target
Protein arginine N-methyltransferase 5 (PRMT5) and Methylosome protein WDR77 (MEP-50)
(Human)
TBA
Ligand
BDBM703948
(US20240368153, Example 14-2)
Copy SMILES
Affinity Data
Kd: 1nM
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
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