Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 10117
TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514512(8-(7- (Trifluoromethyl)imidazo[1,5- a]pyridin-5-yl...)
Affinity DataIC50: 29.5nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514513(8-(7-bromoimidazo[1,5- a]pyridin-5-yl)-1,3,8- tria...)
Affinity DataIC50: 64.6nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514559(8-(7-bromoimidazo[1,5- a]pyridin-5-yl)-6,6-dimethy...)
Affinity DataIC50: 87.1nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514527(8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-6,6-dimeth...)
Affinity DataIC50: 102nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514527(8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-6,6-dimeth...)
Affinity DataIC50: 148nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514528(3-phenyl-8-(7- (trifluoromethyl)imidazo[1,5- a]pyr...)
Affinity DataIC50: 263nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514517(8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-1,3,8- tri...)
Affinity DataIC50: 282nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514556(8-(7- (trifluoromethyl)imidazo[1,5- a]pyridin-5-yl...)
Affinity DataIC50: 295nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514527(8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-6,6-dimeth...)
Affinity DataIC50: 468nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514513(8-(7-bromoimidazo[1,5- a]pyridin-5-yl)-1,3,8- tria...)
Affinity DataIC50: 513nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514531(3,6,6-trimethyl-8-(7- (trifluoromethyl)imidazo[1,5...)
Affinity DataIC50: 631nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514549(6,6-dimethyl-8-(6- (trifluoromethyl)imidazo[1,5- a...)
Affinity DataIC50: 794nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514519(8-(6- (trifluoromethyl)imidazo[1,5- a]pyridin-8-yl...)
Affinity DataIC50: 1.02E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514557(6,6-dimethyl-3-((tetrahydro- 2H-pyran-4-yl)methyl)...)
Affinity DataIC50: 1.20E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514525(3-((tetrahydro-2H-pyran-4- yl)methyl)-8-(7- (trifl...)
Affinity DataIC50: 1.20E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514522(6,6-dimethyl-8-(7- (trifluoromethyl)imidazo[1,5- a...)
Affinity DataIC50: 1.20E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514559(8-(7-bromoimidazo[1,5- a]pyridin-5-yl)-6,6-dimethy...)
Affinity DataIC50: 1.20E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514524(3-methyl-8-(7- (trifluoromethyl)imidazo[1,5- a]pyr...)
Affinity DataIC50: 1.29E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514517(8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-1,3,8- tri...)
Affinity DataIC50: 1.41E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514519(8-(6- (trifluoromethyl)imidazo[1,5- a]pyridin-8-yl...)
Affinity DataIC50: 1.45E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514527(8-(7-chloroimidazo[1,5- a]pyridin-5-yl)-6,6-dimeth...)
Affinity DataIC50: 1.59E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514528(3-phenyl-8-(7- (trifluoromethyl)imidazo[1,5- a]pyr...)
Affinity DataIC50: 1.66E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514556(8-(7- (trifluoromethyl)imidazo[1,5- a]pyridin-5-yl...)
Affinity DataIC50: 1.70E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514549(6,6-dimethyl-8-(6- (trifluoromethyl)imidazo[1,5- a...)
Affinity DataIC50: 1.82E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514524(3-methyl-8-(7- (trifluoromethyl)imidazo[1,5- a]pyr...)
Affinity DataIC50: 1.82E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514560(8-(7- (trifluoromethyl)imidazo[1,5- a]pyridin-5-yl...)
Affinity DataIC50: 2.00E+3nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514561(2-methyl-8-(7- (trifluoromethyl)imidazo[1,5- a]pyr...)
Affinity DataIC50: 2.00E+3nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514558(6,6-dimethyl-3-phenyl-8-(7- (trifluoromethyl)imida...)
Affinity DataIC50: 2.19E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514512(8-(7- (Trifluoromethyl)imidazo[1,5- a]pyridin-5-yl...)
Affinity DataIC50: 2.51E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514531(3,6,6-trimethyl-8-(7- (trifluoromethyl)imidazo[1,5...)
Affinity DataIC50: 2.69E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514522(6,6-dimethyl-8-(7- (trifluoromethyl)imidazo[1,5- a...)
Affinity DataIC50: 3.02E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514525(3-((tetrahydro-2H-pyran-4- yl)methyl)-8-(7- (trifl...)
Affinity DataIC50: 3.98E+3nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514564(3-acetyl-9-[7- (trifluoromethyl)imidazo[1,5- a]pyr...)
Affinity DataIC50: 6.31E+3nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514563(8-(7- (trifluoromethyl)imidazo[1,5- a]pyridin-5-yl...)
Affinity DataIC50: 7.94E+3nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514557(6,6-dimethyl-3-((tetrahydro- 2H-pyran-4-yl)methyl)...)
Affinity DataIC50: 1.66E+4nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM514558(6,6-dimethyl-3-phenyl-8-(7- (trifluoromethyl)imida...)
Affinity DataIC50: 3.80E+4nMAssay Description:Recombinant human IDO or TDO was incubated in 50 mM KPO4 (pH 7.0), 0.5 mM EGTA, 0.5 mM EDTA, 0.05% Triton X100, 20 mM ascorbate, 10 μM methylene...More data for this Ligand-Target Pair
In DepthDetails
US Patent