Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 11498
TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621051(US20230303556, Compound Formula (A))
Affinity DataEC50:  1.90nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621052(US20230303556, Compound Formula (C))
Affinity DataEC50:  15nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621053(US20230303556, Compound Formula (B))
Affinity DataEC50:  51nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM421525(US10508086, Example 115 | N-(1-Methylcyclopropyl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM616694(US20230278998, Comparative Compound 1' | US2023030...)
Affinity DataEC50:  19nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621056(US20230303556, Example 82 from WO2021/055744)
Affinity DataEC50:  39nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621057(US20230303556, Example 88 from WO2021/055744)
Affinity DataEC50:  76nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621058(US20230303556, Example 89 from WO2021/055744)
Affinity DataEC50:  79nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621059(US20230303556, Example 102 from WO2021/055744)
Affinity DataEC50:  201nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621060(US20230303556, Example 24 from WO2021/055744)
Affinity DataEC50:  7.30nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621061(US20230303556, Example 43 from WO2021/055744)
Affinity DataEC50:  6.60nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621062(US20230303556, Example 35 from WO2021/055744)
Affinity DataEC50:  9.90nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
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TargetPoly(ADP-ribose) glycohydrolase(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM621063(US20230303556, Example 83 from WO2021/055744)
Affinity DataEC50:  14nMAssay Description:PARG enzyme was incubated with compound or vehicle (DMSO) and the biotinylated-PARylated PARP-1 substrate in a microtiter plate. After adding detecti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent