Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 9505
TargetTyrosine-protein kinase SYK(Human)
Kronos Bio

US Patent
LigandPNGBDBM212270(US9504684, Ex.-1 | 6-(6-amino-5-methylpyrazin-2-yl...)
Affinity DataIC50: 6.20nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
Kronos Bio

US Patent
LigandPNGBDBM212276(US9504684, Ex.-7 | 2-(5-((6-(6-amino-5-methylpyraz...)
Affinity DataIC50: 8.70nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Kronos Bio

US Patent
LigandPNGBDBM212274(US9504684, Ex.-5 | 2-(5-((6-(6-aminopyrazin-2-yl)i...)
Affinity DataIC50: 12.2nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Kronos Bio

US Patent
LigandPNGBDBM212272(US9504684, Ex.-3 | (R)-(4-(4-((6-(6-aminopyrazin-2...)
Affinity DataIC50: 13.3nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Kronos Bio

US Patent
LigandPNGBDBM212271(US9504684, Ex.-2 | 6-(6-aminopyrazin-2-yl)-N-(4-(4...)
Affinity DataIC50: 13.5nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Kronos Bio

US Patent
LigandPNGBDBM212275(US9504684, Ex.-6 | 2-((4-(4-((6-(6-aminopyrazin-2-...)
Affinity DataIC50: 14.5nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Kronos Bio

US Patent
LigandPNGBDBM212273(US9504684, Ex.-4 | 6-(6-aminopyrazin-2-yl)-5-methy...)
Affinity DataIC50: 44nMAssay Description:Syk activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, Syk-ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent