Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 6672
TargetTyrosine-protein kinase SYK(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 1nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50: 4nMAssay Description:SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase SYK(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 6nMAssay Description:SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM144635(US8952027, 596)
Affinity DataIC50: 43nMAssay Description:SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase kinase kinase 9(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 60nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Fgr(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 81nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Yes(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 123nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 139nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase PAK 5(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 166nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Lyn(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 199nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 244nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Lck(Human)
Portola Pharmaceuticals

US Patent
LigandPNGBDBM50400047(CHEMBL2177736 | BIIB-057 | US9579320, Example 87)
Affinity DataIC50: 300nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
US Patent