Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 2485
TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50: 0.0700nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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PDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368203(US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-meth...)
Affinity DataIC50: 0.130nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368197((-)-2-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50: 0.210nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50169743(CHEMBL1358 | (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9...)
Affinity DataIC50: 0.570nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368198((R)-2-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50: 4.30nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368202(US10227334, Example 2-(4-((S)-2-(azetidin-1-yl)pro...)
Affinity DataIC50: 100nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368200(3-(3-Hydroxyphenyl)-4-methyl-2-(4-(2-(3-methylazet...)
Affinity DataIC50: 200nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM368201(US10227334, Example 2-(4-((S)-2-((R)-3-fluoropyrro...)
Affinity DataIC50: 200nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent