Compile Data Set for Download or QSAR
Report error Found 2564 Enz. Inhib. hit(s) with all data for entry = 2580
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Novartis

US Patent
LigandPNGBDBM87369(US9694016, 704 | US10245267, Example 704 | US10709...)
Affinity DataIC50: 0.0200nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202851(US9694016, 829 | US9242969, 204 | US10245267, Exam...)
Affinity DataIC50: 0.0400nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87817(US9694016, 847 | US10245267, Example 847 | US10709...)
Affinity DataIC50: 0.0400nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202729(US9694016, 75 | US9242969, 75 | US10245267, Exampl...)
Affinity DataIC50: 0.0560nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202729(US9694016, 75 | US9242969, 75 | US10245267, Exampl...)
Affinity DataIC50: 0.0600nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202850(US9694016, 824 | US9242969, 203 | US10245267, Exam...)
Affinity DataIC50: 0.0700nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM88127(US9694016, 1162 | US10245267, Example 1162 | US107...)
Affinity DataIC50: 0.0700nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87369(US9694016, 704 | US10245267, Example 704 | US10709...)
Affinity DataIC50: 0.0800nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87741(US9694016, 777 | US10245267, Example 777 | US10709...)
Affinity DataIC50: 0.0800nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87829(US9694016, 857 | US10245267, Example 857 | US10709...)
Affinity DataIC50: 0.0800nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202697(US9242969, 43 | US10245267, Example 42 | US1070971...)
Affinity DataIC50: 0.0900nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM81120(US9694016, 413 | US10245267, Example 413 | US10709...)
Affinity DataIC50: 0.0900nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM88121(US9694016, 1157 | US10245267, Example 1157 | US107...)
Affinity DataIC50: 0.0900nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202656(US9694016, 1 | US9242969, 1 | US10245267, Example ...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202658(US9694016, 3 | US9242969, 3 | US10245267, Example ...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202673(US9694016, 18 | US9242969, 18 | US10245267, Exampl...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202682(US9694016, 27 | US9242969, 27 | US10245267, Exampl...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202688(US9694016, 33 | US9242969, 33 | US10245267, Exampl...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202696(US9694016, 42 | US9242969, 42 | US10245267, Exampl...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202722(US9694016, 68 | US9242969, 68 | US10245267, Exampl...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202731(US9694016, 77 | US9242969, 77 | US10245267, Exampl...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202800(US9694016, 147 | US9242969, 147 | US10245267, Exam...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202830(US9694016, 177 | US9242969, 177 | US10245267, Exam...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM77771(US9694016, 231 | US10245267, Example 231 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM77866(US9694016, 307 | US10245267, Example 307 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM81176(US9694016, 475 | US10245267, Example 475 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM81177(US9694016, 476 | US10245267, Example 476 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM81181(US9694016, 480 | US10245267, Example 480 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM81185(US9694016, 484 | US10245267, Example 484 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM81235(US9694016, 519 | US10245267, Example 519 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM84273(US9694016, 561 | US10245267, Example 561 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM84292(US9694016, 580 | US10245267, Example 580 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM86368(US9694016, 659 | US10245267, Example 659 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87373(US9694016, 708 | US10245267, Example 708 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87785(US9694016, 820 | US10245267, Example 820 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87794(US9694016, 830 | US10245267, Example 830 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87803(US9694016, 837 | US10245267, Example 837 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87818(US9694016, 848 | US10245267, Example 848 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87824(US9694016, 854 | US10245267, Example 854 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87846(US9694016, 871 | US10245267, Example 879 | US10709...)
Affinity DataIC50: 0.100nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202665(US9694016, 10 | US9242969, 10 | US10245267, Exampl...)
Affinity DataIC50: 0.103nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202800(US9694016, 147 | US9242969, 147 | US10245267, Exam...)
Affinity DataIC50: 0.103nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202682(US9694016, 27 | US9242969, 27 | US10245267, Exampl...)
Affinity DataIC50: 0.110nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM87922(US9694016, 951 | US10245267, Example 951 | US10709...)
Affinity DataIC50: 0.110nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202747(US9694016, 93 | US9242969, 93 | US10245267, Exampl...)
Affinity DataIC50: 0.117nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202665(US9694016, 10 | US9242969, 10 | US10245267, Exampl...)
Affinity DataIC50: 0.118nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM202784(US9694016, 131 | US9242969, 131 | US10245267, Exam...)
Affinity DataIC50: 0.119nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM373387(US10245267, Example 1137 | US10709712, Example 113...)
Affinity DataIC50: 0.120nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM88118(US9694016, 1154 | US10245267, Example 1154 | US107...)
Affinity DataIC50: 0.120nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM88129(US9694016, 1164 | US10245267, Example 1164 | US107...)
Affinity DataIC50: 0.120nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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