Compile Data Set for Download or QSAR
Report error Found 98 Enz. Inhib. hit(s) with all data for entry = 8694
TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269343((R)-2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)...)
Affinity DataIC50: 20.4nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269309(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50: 28.2nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50119585(CHEMBL3617746 | US9718813, Compound 95 | US1041354...)
Affinity DataIC50: 30.2nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269334(2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)-1-(...)
Affinity DataIC50: 30.2nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM413526((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 33.1nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269337(2-(4-(6-fluoronaphthalen-2-yl)-2-methylphenyl)-4,4...)
Affinity DataIC50: 33.9nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269310(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50: 34.7nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269327(2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)-4,4...)
Affinity DataIC50: 35.5nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269270((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 39.8nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269351(6-(4-(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)me...)
Affinity DataIC50: 40.7nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269341((R)-2-(4-(6-fluoronaphthalen-2-yl)-2-methylphenyl)...)
Affinity DataIC50: 42.7nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM413527((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 42.7nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269296((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 45.7nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269304((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 45.7nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50119580(CHEMBL3617741 | US9718813, Compound 1 | US10413545...)
Affinity DataIC50: 47.9nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269301((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 52.5nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269339((R)-4,4-dimethyl-2-(3-methyl-4'-(1-methyl-1H-pyraz...)
Affinity DataIC50: 53.7nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269285((R)-1((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)met...)
Affinity DataIC50: 55nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269329((R)-2-(3-fluoro-4'-(1-methyl-1H-pyrazol-4-yl)-[1,1...)
Affinity DataIC50: 55nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269330((R)-2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)...)
Affinity DataIC50: 55nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM413528((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 55nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50119581(CHEMBL3617742 | US9718813, Compound 23 | US1041354...)
Affinity DataIC50: 56.2nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269283((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 58.9nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269344((R)-2-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-...)
Affinity DataIC50: 60.3nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269300((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 63.1nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269335((R)-4,4-dimethyl-2-(2-methyl-4-(1-methyl-1H-indazo...)
Affinity DataIC50: 63.1nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269328((R)-2-(2-fluoro-4-(1-methyl-1H-indazol-5-yl)phenyl...)
Affinity DataIC50: 66.1nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269325(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50: 66.1nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269311(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50: 67.6nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM413523((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 69.2nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM268885((4RS)-2-(4-(1H-Indol-5-yl)phenyl)-1-(((R)-1-(cyclo...)
Affinity DataIC50: 72.4nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269342(4,4-dimethyl-2-(3-methyl-4'-(1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 75.9nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269345((R)-2-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-...)
Affinity DataIC50: 79.4nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269340((R)-4,4-dimethyl-2-(2-methyl-4-(1-methyl-1H-benzo[...)
Affinity DataIC50: 79.4nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM268661((R)-2-(4-(benzofuran-5-yl)phenyl)-1-((1-(cycloprop...)
Affinity DataIC50: 81.3nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269331((R)-2-(2-fluoro-4-(1-methyl-1H-indazol-5-yl)phenyl...)
Affinity DataIC50: 85.1nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269294(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50: 89.1nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269347((R)-1-((1-(1-hydroxycyclopropanecarbonyl)pyrrolidi...)
Affinity DataIC50: 91.2nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50119583(CHEMBL3617744 | US9718813, Compound 53 | US1041354...)
Affinity DataIC50: 93.3nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269284(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50: 95.5nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269348(2-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)p...)
Affinity DataIC50: 100nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269271((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 102nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269338(4,4-dimethyl-2-(2-methyl-4-(1-methyl-1H-benzo[d]im...)
Affinity DataIC50: 102nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269287(US9718813, Compound 69 | 1-((1-(cyclopropanecarbon...)
Affinity DataIC50: 110nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269305((R)-2-(4-(benzo[d]thiazol-2-yl)-2-fluorophenyl)-1-...)
Affinity DataIC50: 115nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM268735((R)-2-(4-(benzofuran-5-yl)phenyl)-1-((1-(1-fluoroc...)
Affinity DataIC50: 120nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM268608((R)-1-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)me...)
Affinity DataIC50: 141nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269332(4,4-dimethyl-2-(2-methyl-4-(1-methyl-1H-indazol-5-...)
Affinity DataIC50: 151nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM268738((4RS)-2-(4-(Benzofuran-5-yl)phenyl)-1-(((R)-1-(cyc...)
Affinity DataIC50: 155nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

TargetFatty acid synthase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269277(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50: 158nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
Go to US Patent

Displayed 1 to 50 (of 98 total ) | Next | Last >>
Jump to: