Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 10470
TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538085(4-(4-fluoro-3-(1-neopentyl-4-oxido-l,4-azaphosphin...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538070(4-(4-fluoro-3-(1-(3,5- difluoropyridin-2-yl)-4- ox...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538043(4-(3-(1-benzyl-4-oxido-1,4-azaphosphinan-4-yl)-4-f...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538073(4-(4-fluoro-3-(4-oxido-1-(3- (acetyl)pyridin-2-yl)...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538074((+-)-4-(4-fluoro-3-(4-oxido- 1-(3-(1- hydoxyethyl)...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538075(4-(4-fluoro-3-(4-oxido-1-(5- (chloro)pyrimidin-2-y...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538077(4-(3-(1-cyclopropyl-4-oxido-1,4-azaphosphinan-4-yl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538078(4-(3-(1-cyclobutyl-4- oxido-1,4-azaphosphinan- 4-y...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538079(US11248013, Example 41 | 4-(4-fluoro-3-(1-methyl-4...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538081(4-(4-fluoro-3-(1-isopropyl-4-oxido-1,4-azaphosphin...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538082(4-(3-(1- (cyclopropylmethyl)-4- oxido-1,4-azaphosp...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538083(4-(4-fluoro-3-(1-isobutyl-4-oxido-1,4-azaphosphina...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538084(4-(4-fluoro-3-(4-oxido-4-propyl-1,4-azaphosphinan-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538071(4-(4-fluoro-3-(4-oxido-1- (quinazolin-2-yl)-1,4- a...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538087(4-(4-fluoro-3-(1-isopentyl)-4-oxido-1,4- azaphosph...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538088(4-(3-(1-cyclopropyl-4-oxido-1,4-azaphosphinan-4-yl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538089(4-[[4-fluoro-3-(4-methyl-4-oxo-1,4-azaphosphinane-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538090(4-[[4-fluoro-3-(4-ethyl-4-oxo-1,4- azaphosphinane-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538091(4-[[4-fluoro-3-(4-isopropyl-4-oxo-1,4- azaphosphin...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538092(4-[[4-fluoro-3-(4-ethoxyl-4-oxo-1,4- azaphosphinan...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538093(4-(3-(1-cyclopropyl-4-oxido-1,4-azaphosphinan-4-yl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538094(4-[(3-(1-cyclopropyl-4-oxido-1,4-azaphosphinan-4-y...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538095(US11248013, Example 57 | 4-(4-fluoro-3-(4-oxido-1-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538095(US11248013, Example 57 | 4-(4-fluoro-3-(4-oxido-1-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538097((�)-4-[(3-(1-cyclopropyl-4-oxido-1,4-azapho...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538098(US11248013, Example 59)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538068(4-(4-fluoro-3-(4-oxido-1-(4- (trifluoromethyl)pyri...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538045(4-(3-(1- (cyclopropanecarbonyl)- 4-oxido-1,4- azap...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538046(4-(3-(1- (cyclobutanecarbonyl)-4- oxido-1,4- azaph...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538047(4-(3-(1-(3,3- dimethylbutanoyl)-4- oxido-1,4- azap...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538048(4-(3-(1-(3,3- difluoropyrrolidine-1- carbonyl)-4-o...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538050(US11248013, Example 10 | 4-(4-fluoro-3-(4-oxido-1-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538053((E/Z)—N-(azetidin-1-yl(4-(2-fluoro-5-((4-oxo-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538054(4-(4-fluoro-3-(4-oxido-1-(pyrimidin-2-yl)-1,4-azap...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538055(4-(3-(1-(6-chloropyridazin- 3-yl)-4-oxido-1,4- aza...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538056(6-(4-(2-fluoro-5-((4-oxo- 3,4-dihydrophthalazin-1-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538058(2-(4-(2-fluoro-5-((4-oxo- 3,4-dihydrophthalazin-1-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538059(4-(3-(1-(2-chloropyrimidin- 4-yl)-4-oxido-1,4- aza...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538060(4-(3-(1-(4-chloropyrimidin- 2-yl)-4-oxido-1,4- aza...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538061(4-(4-fluoro-3-(4-oxido-1- (pyridin-2-yl)-1,4- azap...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538067(4-(4-fluoro-3-(1-(6- fluoropyridin-2-yl)-4-oxido- ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538063(4-(4-fluoro-3-(4-oxido-1- (quinazolin-4-yl)-1,4- a...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538066(4-(4-fluoro-3-(4-oxido-1-(5- (trifluoromethyl)pyri...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538064(4-(3-(1-(6-chloropyrimidin- 4-yl)-4-oxido-1,4- aza...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538065(4-(4-fluoro-3-(1-(3- fluoropyridin-2-yl)-4-oxido- ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538079(US11248013, Example 41 | 4-(4-fluoro-3-(1-methyl-4...)
Affinity DataIC50: 550nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538069(4-(4-fluoro-3-(4-oxido-1-(3- (trifluoromethyl)pyri...)
Affinity DataIC50: 550nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538072(4-(4-fluoro-3-(4-oxido-1-(6- (trifluoromethyl)pyri...)
Affinity DataIC50: 550nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538049(4-(4-fluoro-3-(4-oxido-1- (tetrahydrofuran-2- carb...)
Affinity DataIC50: 550nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandPNGBDBM538074((+-)-4-(4-fluoro-3-(4-oxido- 1-(3-(1- hydoxyethyl)...)
Affinity DataIC50: 550nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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