Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 7114
TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175209(US9115126, Example 1)
Affinity DataIC50: 0.800nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175205(US9115126, Example 2a)
Affinity DataIC50: 1.5nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175204(US9115126, Example 35)
Affinity DataIC50: 3.30nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323250(1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(triflu...)
Affinity DataIC50: 8nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50336043(2-(4-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyri...)
Affinity DataIC50: 8.30nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175206(US9115126, Example 4b)
Affinity DataIC50: 9nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175208(US9115126, Example 44)
Affinity DataIC50: 13nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM175207(US9115126, Reference imidazopyridine derivative EP...)
Affinity DataIC50: 26nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323247(6-(4-(3-(dimethylamino)propoxy)-3-(trifluoromethyl...)
Affinity DataIC50: 32nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50323258(6-(4-(3-hydroxypropyl)-3-(trifluoromethyl)phenyl)-...)
Affinity DataIC50: 234nMAssay Description:The inhibitory activity of the compounds of the invention was demonstrated in vitro by measuring the inhibition of recombinant human Cathepsin S as f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
Go to US Patent