Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 693
TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 1nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287608(US10085983, Compound J-3 | N-(2-(2-(dimethylamino)...)
Affinity DataIC50: 1nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287595(US10085983, Compound J-1 | N-(2-((2-(dimethylamino...)
Affinity DataIC50: 1nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287615(US10085983, Compound J-10 | N-(2-((2-(dimethylamin...)
Affinity DataIC50: 1nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287617(US10085983, Compound J-12)
Affinity DataIC50: 1.90nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287607(US10085983, Compound J-2 | N-(2-(4-(dimethylamino)...)
Affinity DataIC50: 2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287609(US10085983, Compound J-4 | N-(4-methoxy-5-(7-(1-m...)
Affinity DataIC50: 2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287612(US10085983, Compound J-7 | N-(2-((2-(dimethylamino...)
Affinity DataIC50: 2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287613(US10085983, Compound J-8 | N-(5(7-cyclopropylpyrro...)
Affinity DataIC50: 2nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287616(US10085983, Compound J-11 | N-(2-((2-(dimethylamin...)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287611(US10085983, Compound J-6 | N-(2-((2-(dimethylamino...)
Affinity DataIC50: 2.40nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287615(US10085983, Compound J-10 | N-(2-((2-(dimethylamin...)
Affinity DataIC50: 3nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 3nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287610(US10085983, Compound J-5 | N-(5(7-cyclohexenyl-pyr...)
Affinity DataIC50: 3nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287595(US10085983, Compound J-1 | N-(2-((2-(dimethylamino...)
Affinity DataIC50: 4nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 5nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287612(US10085983, Compound J-7 | N-(2-((2-(dimethylamino...)
Affinity DataIC50: 5nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287618(US10085983, Compound J-13 | N-(2-(4-(dimethylamino...)
Affinity DataIC50: 5nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287617(US10085983, Compound J-12)
Affinity DataIC50: 8nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287619(US10085983, Compound J-14 | N-(2-(4-(dimethylamino...)
Affinity DataIC50: 9nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287610(US10085983, Compound J-5 | N-(5(7-cyclohexenyl-pyr...)
Affinity DataIC50: 9nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287616(US10085983, Compound J-11 | N-(2-((2-(dimethylamin...)
Affinity DataIC50: 10nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287608(US10085983, Compound J-3 | N-(2-(2-(dimethylamino)...)
Affinity DataIC50: 10nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287621(US10085983, Compound J-20 | N-(2-((2-(dimethylamin...)
Affinity DataIC50: 12nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287611(US10085983, Compound J-6 | N-(2-((2-(dimethylamino...)
Affinity DataIC50: 13nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287614(US10085983, Compound J-9 | N-(2-((2-(dimethylamino...)
Affinity DataIC50: 16nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287618(US10085983, Compound J-13 | N-(2-(4-(dimethylamino...)
Affinity DataIC50: 21nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287607(US10085983, Compound J-2 | N-(2-(4-(dimethylamino)...)
Affinity DataIC50: 23nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287609(US10085983, Compound J-4 | N-(4-methoxy-5-(7-(1-m...)
Affinity DataIC50: 35nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287619(US10085983, Compound J-14 | N-(2-(4-(dimethylamino...)
Affinity DataIC50: 104nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287614(US10085983, Compound J-9 | N-(2-((2-(dimethylamino...)
Affinity DataIC50: 105nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287613(US10085983, Compound J-8 | N-(5(7-cyclopropylpyrro...)
Affinity DataIC50: 112nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287620(US10085983, Compound J-15 | N-(5(7-cyclopropylpyrr...)
Affinity DataIC50: 262nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor [668-1210,T790M,L858R](Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287622(US10085983, Compound J-21 | The Preparation of N-(...)
Affinity DataIC50: 294nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287621(US10085983, Compound J-20 | N-(2-((2-(dimethylamin...)
Affinity DataIC50: 294nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287622(US10085983, Compound J-21 | The Preparation of N-(...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM287620(US10085983, Compound J-15 | N-(5(7-cyclopropylpyrr...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:All reagents used in the following z′-lyte assay were purchased from Invitrogen.The inhibitory activity on T790M/L858R double mutant EGFR kinas...More data for this Ligand-Target Pair
In DepthDetails
US Patent