Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 816
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
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Date in BDB:
2/21/2019
Entry Details
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PDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292716(US10105349, Example 22 | 1-(2-Chloro-5-(cyclobutyl...)
Affinity DataIC50: 5.90nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292715(US10105349, Example 21 | 1-(5-Butoxy-2-chloropheny...)
Affinity DataIC50: 9.40nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292713(US10105349, Example 20 | 1-(5-Butoxy-2-chloropheny...)
Affinity DataIC50: 12nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292714(US10105349, Example 17 | 1-(5-Butoxy-2-chloropheny...)
Affinity DataIC50: 28nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292712(US10105349, Example 19 | 8-Chloro-1-(2,5-dichlorop...)
Affinity DataIC50: 73nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent