Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 779
TargetHistone H3.1 [22-45](Human)
Epizyme

US Patent
LigandPNGBDBM155253(US9006242, 1 | US10098888, Compound 1)
Affinity DataIC50: 5nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetHistone H3.1 [22-45](Human)
Epizyme

US Patent
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 8.40nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Epizyme

US Patent
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 9.67nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Epizyme

US Patent
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 10nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetHistone H3.1 [22-45](Human)
Epizyme

US Patent
LigandPNGBDBM155254(US9006242, 2 | US10098888, Compound 2)
Affinity DataIC50: 15nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Epizyme

US Patent
LigandPNGBDBM155253(US9006242, 1 | US10098888, Compound 1)
Affinity DataIC50: 22.9nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Epizyme

US Patent
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 33.6nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C8(Human)
Epizyme

US Patent
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 47.4nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Epizyme

US Patent
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 75.7nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetHistone H3.1 [22-45](Human)
Epizyme

US Patent
LigandPNGBDBM155253(US9006242, 1 | US10098888, Compound 1)
Affinity DataIC50: 77nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Epizyme

US Patent
LigandPNGBDBM155253(US9006242, 1 | US10098888, Compound 1)
Affinity DataIC50: 89.6nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C8(Human)
Epizyme

US Patent
LigandPNGBDBM155254(US9006242, 2 | US10098888, Compound 2)
Affinity DataIC50: 100nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Epizyme

US Patent
LigandPNGBDBM155254(US9006242, 2 | US10098888, Compound 2)
Affinity DataIC50: 100nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Epizyme

US Patent
LigandPNGBDBM155254(US9006242, 2 | US10098888, Compound 2)
Affinity DataIC50: 100nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Epizyme

US Patent
LigandPNGBDBM155254(US9006242, 2 | US10098888, Compound 2)
Affinity DataIC50: 100nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Epizyme

US Patent
LigandPNGBDBM155253(US9006242, 1 | US10098888, Compound 1)
Affinity DataIC50: 100nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 2C8(Human)
Epizyme

US Patent
LigandPNGBDBM155253(US9006242, 1 | US10098888, Compound 1)
Affinity DataIC50: 100nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Epizyme

US Patent
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 100nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Epizyme

US Patent
LigandPNGBDBM155254(US9006242, 2 | US10098888, Compound 2)
Affinity DataIC50: 100nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Epizyme

US Patent
LigandPNGBDBM155253(US9006242, 1 | US10098888, Compound 1)
Affinity DataIC50: 100nMAssay Description:The potential inhibition of enzyme activities of human cytochromes P450 (CYP) of Compound 1, 2, or 105 was evaluated using pooled human liver microso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetHistone H3.1 [22-45](Human)
Epizyme

US Patent
LigandPNGBDBM155255(US9006242, 105 | US10098888, Compound 105 | US1164...)
Affinity DataIC50: 104nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent

TargetHistone H3.1 [22-45](Human)
Epizyme

US Patent
LigandPNGBDBM155254(US9006242, 2 | US10098888, Compound 2)
Affinity DataIC50: 110nMAssay Description:General Materials. S-adenosylmethionine (SAM), S-adenosylhomocyteine (SAH), bicine, KCI, Tween20, dimethylsulfoxide (DMSO) and bovine skin gelatin (B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
Go to US Patent