Compile Data Set for Download or QSAR
Report error Found 448 Enz. Inhib. hit(s) with all data for entry = 191
TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205119(US9546152, example 28 | 2-{[(3r,6r)-1-{[5-fluoro-2...)
Affinity DataIC50: 5nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206466(US9546152, example 115)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205109(US9546152, example 19 | 2-({(3r,6r)-1-[(2- ethoxyp...)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205124(US9546152, example 33 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205260(US9546152, example 95)
Affinity DataIC50: 6nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM203422(US9546152, example 6 | 3-methyl-2-{[(3r,6r)-6- met...)
Affinity DataIC50: 7nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205108(US9546152, example 18 | 2-{[(3r,6r)-1-{[2-fluoro-6...)
Affinity DataIC50: 7nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205170(US9546152, example 70 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 7.70nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM202473(US9546152, example 1)
Affinity DataIC50: 8nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205111(US9546152, example 21 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 8nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205137(US9546152, example 44 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 8nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205228(US9546152, example 91)
Affinity DataIC50: 8nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205245(US9546152, example 93 | 3-ethyl-2-{[(3r,6r)-6- met...)
Affinity DataIC50: 8nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206335(US9546152, example 106 | 3-methoxy-2-{[(3r,6r)-6- ...)
Affinity DataIC50: 8nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205103(US9546152, example 13 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 9nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205106(US9546152, example 16 | 2-({(3r,6r)-1-[(2- cyclopr...)
Affinity DataIC50: 9nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205125(US9546152, example 34 | 2-{[(3r,6r)-1-{[4-fluoro-2...)
Affinity DataIC50: 9nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205131(US9546152, example 39 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 9nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205345(US9546152, example 96)
Affinity DataIC50: 9nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205101(US9546152, example 11 | 2-{[(3r,6r)-1-{[2-fluoro-6...)
Affinity DataIC50: 10nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205117(US9546152, example 26 | 2-{[(3r,6r)-1-{[5-fluoro-2...)
Affinity DataIC50: 10nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205136(US9546152, example 43 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 10nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM204068(US9546152, example 8 | 3-methyl-2-{[(3r,6r)-6- met...)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205122(US9546152, example 31 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205128(US9546152, example 37 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205130(US9546152, example 38 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205132(US9546152, example 40 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205166(US9546152, example 69 | 2-{[(3r,6r)-1-{[5-fluoro-2...)
Affinity DataIC50: 11nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM203393(US9546152, example 4 | 2-{[(3r,6r)-1-{[4-chloro-2-...)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205099(US9546152, example 9 | 2-{[(3r,6r)-1-{[4-fluoro-2-...)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205102(US9546152, example 12 | 2-{[(3r,6r)-1-{[3-fluoro-2...)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205105(US9546152, example 15 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205134(US9546152, example 42 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205154(US9546152, example 58 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205244(US9546152, example 92)
Affinity DataIC50: 12nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM203999(US9546152, example 7 | 2-{[(3r,6r)-1-{[4-methoxy-2...)
Affinity DataIC50: 13nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205126(US9546152, example 35 | 2-{[(3r,6r)-1-{[5-fluoro-2...)
Affinity DataIC50: 13nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206337(US9546152, example 108 | 3-methoxy-2- ({(3r,6r)-6-...)
Affinity DataIC50: 14nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205104(US9546152, example 14 | 2-{[(3r,6r)-1-{[2-methoxy-...)
Affinity DataIC50: 15nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205142(US9546152, example 49 | 2-{[(3r,6r)-1-{[2-(6- meth...)
Affinity DataIC50: 15nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205182(US9546152, example 75 | 3-methyl-2-({(3r,6r)-6- me...)
Affinity DataIC50: 15nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205651(US9546152, example 99 | 2-{[(3r,6r)-1-{[5-fluoro-2...)
Affinity DataIC50: 15nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205158(US9546152, example 62 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 16nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205118(US9546152, example 27 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 17nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206340(US9546152, example 111 | 2-({(3r,6r)-1-[(5-fluoro-...)
Affinity DataIC50: 18nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205349(US9546152, example 97)
Affinity DataIC50: 19nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205352(US9546152, example 98 | 2-{[(3r,6r)-1-{[4-fluoro-2...)
Affinity DataIC50: 19nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205112(US9546152, example 22 | 2-{[(3r,6r)-1-{[2-fluoro-6...)
Affinity DataIC50: 20nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM205127(US9546152, example 36 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataIC50: 20nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM202595(US9546152, example 2)
Affinity DataIC50: 21nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Displayed 1 to 50 (of 448 total ) | Next | Last >>
Jump to: