Compile Data Set for Download or QSAR
Report error Found 139 Enz. Inhib. hit(s) with all data for entry = 577
TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116254(US8637508, 31 | US10035794, Example 31 | US1068328...)
Affinity DataIC50: 1nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116236(US8637508, 11 | US10035794, Example 11 | US1068328...)
Affinity DataIC50: 2nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116247(US8637508, 24 | US10035794, Example 24 | US1068328...)
Affinity DataIC50: 3nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 3nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116236(US8637508, 11 | US10035794, Example 11 | US1068328...)
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116233(US8637508, 8 | US10035794, Example 8 | US10683287,...)
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116245(US8637508, 22 | US10035794, Example 22 | US1068328...)
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116269(US8637508, 46 | US10035794, Example 46)
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 5nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116250(US8637508, 27 | US10035794, Example 27 | US1068328...)
Affinity DataIC50: 5nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116261(US8637508, 38 | US10035794, Example 38 | US1068328...)
Affinity DataIC50: 5nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116247(US8637508, 24 | US10035794, Example 24 | US1068328...)
Affinity DataIC50: 6nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116233(US8637508, 8 | US10035794, Example 8 | US10683287,...)
Affinity DataIC50: 6nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116254(US8637508, 31 | US10035794, Example 31 | US1068328...)
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116255(US8637508, 32 | US10035794, Example 32 | US1068328...)
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM279677(US10035794, Example 21)
Affinity DataIC50: 8nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 10nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116269(US8637508, 46 | US10035794, Example 46)
Affinity DataIC50: 10nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116247(US8637508, 24 | US10035794, Example 24 | US1068328...)
Affinity DataIC50: 10nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116254(US8637508, 31 | US10035794, Example 31 | US1068328...)
Affinity DataIC50: 10nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116250(US8637508, 27 | US10035794, Example 27 | US1068328...)
Affinity DataIC50: 11nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116236(US8637508, 11 | US10035794, Example 11 | US1068328...)
Affinity DataIC50: 12nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116250(US8637508, 27 | US10035794, Example 27 | US1068328...)
Affinity DataIC50: 12nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116263(US8637508, 40 | US10035794, Example 40 | US1068328...)
Affinity DataIC50: 12nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116245(US8637508, 22 | US10035794, Example 22 | US1068328...)
Affinity DataIC50: 13nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116248(US8637508, 25 | US10035794, Example 25 | US1068328...)
Affinity DataIC50: 15nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM279674(5-Bromo-pyridine-2-carboxylic acid [5-(5-amino-3-f...)
Affinity DataIC50: 15nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116235(US8637508, 10 | US10035794, Example 10 | US1068328...)
Affinity DataIC50: 17nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116233(US8637508, 8 | US10035794, Example 8 | US10683287,...)
Affinity DataIC50: 20nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116252(US8637508, 29 | US10035794, Example 29 | US1068328...)
Affinity DataIC50: 24nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116253(US8637508, 30 | US10035794, Example 30 | US1068328...)
Affinity DataIC50: 24nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116252(US8637508, 29 | US10035794, Example 29 | US1068328...)
Affinity DataIC50: 24nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116253(US8637508, 30 | US10035794, Example 30 | US1068328...)
Affinity DataIC50: 24nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116253(US8637508, 30 | US10035794, Example 30 | US1068328...)
Affinity DataIC50: 25nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116252(US8637508, 29 | US10035794, Example 29 | US1068328...)
Affinity DataIC50: 26nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116255(US8637508, 32 | US10035794, Example 32 | US1068328...)
Affinity DataIC50: 26nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116245(US8637508, 22 | US10035794, Example 22 | US1068328...)
Affinity DataIC50: 29nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116257(US8637508, 34 | US10035794, Example 34 | US1068328...)
Affinity DataIC50: 30nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116267(US8637508, 44 | US10035794, Example 44 | US1068328...)
Affinity DataIC50: 30nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM279677(US10035794, Example 21)
Affinity DataIC50: 31nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116261(US8637508, 38 | US10035794, Example 38 | US1068328...)
Affinity DataIC50: 33nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116235(US8637508, 10 | US10035794, Example 10 | US1068328...)
Affinity DataIC50: 39nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116267(US8637508, 44 | US10035794, Example 44 | US1068328...)
Affinity DataIC50: 40nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116231(US8637508, 5 | BDBM279661)
Affinity DataIC50: 40nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116244(US8637508, 20 | US10035794, Example 20 | US1068328...)
Affinity DataIC50: 41nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116227(US8637508, 1 | US10035794, Example 1 | US10683287,...)
Affinity DataIC50: 41nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116263(US8637508, 40 | US10035794, Example 40 | US1068328...)
Affinity DataIC50: 42nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116243(US8637508, 19 | US10035794, Example 19 | US1068328...)
Affinity DataIC50: 43nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116255(US8637508, 32 | US10035794, Example 32 | US1068328...)
Affinity DataIC50: 45nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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