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Found
43
Enz. Inhib. hit(s) with all data for entry = 454
Target
Epidermal growth factor receptor [L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM149404
(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.460nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Copy BDB DOI
US Patent
PDB
3D Structure (crystal)
Copy reaction URL
Target
Epidermal growth factor receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM149404
(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.510nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Copy BDB DOI
US Patent
PDB
3D Structure (crystal)
Copy reaction URL
Target
Epidermal growth factor receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM50391089
(CHEMBL2087361 | Icotinib | Conmana | BPI-2009 | Lc...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.23nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM50391089
(CHEMBL2087361 | Icotinib | Conmana | BPI-2009 | Lc...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.02nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270538
(US10059688, Example 4 | US9783524, Example 4)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.08nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M,L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270544
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.92nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270544
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.13nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M,L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270538
(US10059688, Example 4 | US9783524, Example 4)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.52nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
ALK tyrosine kinase receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270543
(US10059688, Example 115 | US9783524, Example 115)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8.62nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
ALK tyrosine kinase receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270541
(US10059688, Example 74)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9.33nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
ALK tyrosine kinase receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270544
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
ALK tyrosine kinase receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270539
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 12nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270543
(US10059688, Example 115 | US9783524, Example 115)
Copy SMILES
Copy InChI
Affinity Data
IC50: 12nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
ALK tyrosine kinase receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270542
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 15nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270542
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 15nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270540
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 15nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270541
(US10059688, Example 74)
Copy SMILES
Copy InChI
Affinity Data
IC50: 16nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M,L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270541
(US10059688, Example 74)
Copy SMILES
Copy InChI
Affinity Data
IC50: 16nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
ALK tyrosine kinase receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270540
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 17nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M,L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270543
(US10059688, Example 115 | US9783524, Example 115)
Copy SMILES
Copy InChI
Affinity Data
IC50: 19nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M,L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270540
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 19nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M,L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270542
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 21nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270539
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 23nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
ALK tyrosine kinase receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270538
(US10059688, Example 4 | US9783524, Example 4)
Copy SMILES
Copy InChI
Affinity Data
IC50: 28nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M,L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270539
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 38nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270538
(US10059688, Example 4 | US9783524, Example 4)
Copy SMILES
Copy InChI
Affinity Data
IC50: 44nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270538
(US10059688, Example 4 | US9783524, Example 4)
Copy SMILES
Copy InChI
Affinity Data
IC50: 45nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270544
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 78nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270544
(2-(2-(5-chloro-2-(4-(4- (dimethylamino)piperidin- ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 158nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M,L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM149404
(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 179nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Copy BDB DOI
US Patent
PDB
3D Structure (crystal)
Copy reaction URL
Target
Epidermal growth factor receptor [L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270542
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 225nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270540
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 273nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270542
(2-(2-(2-(4-acryloyl-3,4- dihydro-2H-benzo[b][1,4] ...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 354nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270543
(US10059688, Example 115 | US9783524, Example 115)
Copy SMILES
Copy InChI
Affinity Data
IC50: 397nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM149404
(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 412nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Copy BDB DOI
US Patent
PDB
3D Structure (crystal)
Copy reaction URL
Target
Epidermal growth factor receptor [L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270541
(US10059688, Example 74)
Copy SMILES
Copy InChI
Affinity Data
IC50: 422nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270540
(N-(3-(5-chloro-4-(2-(2- (dimethylamino)-2-oxoacety...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 500nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270541
(US10059688, Example 74)
Copy SMILES
Copy InChI
Affinity Data
IC50: 513nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270543
(US10059688, Example 115 | US9783524, Example 115)
Copy SMILES
Copy InChI
Affinity Data
IC50: 547nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270539
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 756nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM270539
(2-(2-(5-chloro-2-(3-methoxy- 4-(4-methylpiperazin-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+3nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M,L858R]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM50391089
(CHEMBL2087361 | Icotinib | Conmana | BPI-2009 | Lc...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+3nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
Target
Epidermal growth factor receptor [T790M]
(Human)
Betta Pharmaceuticals
US Patent
Ligand
BDBM50391089
(CHEMBL2087361 | Icotinib | Conmana | BPI-2009 | Lc...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.00E+3nM
Assay Description:
TBD
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Copy BDB DOI
US Patent
Copy reaction URL
BDBM270542
3D Structure (crystal)
