Compile Data Set for Download or QSAR
Report error Found 219 Enz. Inhib. hit(s) with all data for entry = 11193
TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598596(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indaz...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598601(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598664(US11613531, Example 342 | Ethyl 2-(3,8-diazabicycl...)
Affinity DataIC50: 0.100nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598584(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...)
Affinity DataIC50: 0.200nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598602(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 0.400nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598630(US11613531, Example 301 | N-(2-(3,6-diazabicyclo[3...)
Affinity DataIC50: 0.400nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50: 0.900nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598603(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 1nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598647(US11613531, Example 319 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 1.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598604(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 1.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598655(US11613531, Example 332 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 1.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598562(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)pyrimidin...)
Affinity DataIC50: 1.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598584(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...)
Affinity DataIC50: 1.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598666(US11613531, Example 344 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 1.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598652(US11613531, Example 329 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 1.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598631(US11613531, Example 302 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 2.20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598606(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3,8-diazabicyclo[...)
Affinity DataIC50: 2.30nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598636(US11613531, Example 307 | 2-(3,6-diazabicyclo[3.1....)
Affinity DataIC50: 2.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50: 2.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598517(US11613531, Example 228 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 3nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598577(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...)
Affinity DataIC50: 3.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598659(US11613531, Example 336 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 3.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598579(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluorop...)
Affinity DataIC50: 3.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598597(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-fluoro...)
Affinity DataIC50: 3.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598639(US11613531, Example 310 | 2-(3,6-diazabicyclo[3.1....)
Affinity DataIC50: 3.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598517(US11613531, Example 228 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 4nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598586(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-methoxy...)
Affinity DataIC50: 4.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598594(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-chloro...)
Affinity DataIC50: 4.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598569(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-6-methylp...)
Affinity DataIC50: 5nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598570(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chlorop...)
Affinity DataIC50: 5nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598586(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-methoxy...)
Affinity DataIC50: 5nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598665(US11613531, Example 343 | 4-((1H-indazol-5-yl)amin...)
Affinity DataIC50: 5.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598663(US11613531, Example 341 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 5.80nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598577(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...)
Affinity DataIC50: 5.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598654(US11613531, Example 331 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 5.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598571(N-(2-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluorop...)
Affinity DataIC50: 6nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598598(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-N-(1H-indazo...)
Affinity DataIC50: 6.60nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598648(US11613531, Example 321 | N-(2-(3,8-diazabicyclo[3...)
Affinity DataIC50: 8nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598649(US11613531, Example 320 | 6-((1H-indazol-5-yl)amin...)
Affinity DataIC50: 8.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598616(N-(6-methyl-2-(3-(piperidin-3-yl)indolin-1-yl)pyri...)
Affinity DataIC50: 9.30nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598593(N-(2-(3,7-diazabicyclo[4.2.0]octan-3-yl)-6-methylp...)
Affinity DataIC50: 9.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598592(N-(2-(3,6-diazabicyclo[3.2.0]heptan-3-yl)-6-methyl...)
Affinity DataIC50: 11nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598653(US11613531, Example 330 | 2-(3,8-diazabicyclo[3.2....)
Affinity DataIC50: 11nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598570(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chlorop...)
Affinity DataIC50: 12nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598588(N-(2-((1R,6S)-3,7-diazabicyclo[4.2.0]octan-3-yl)py...)
Affinity DataIC50: 12nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598642(US11613531, Example 313 | 2-(3,6-diazabicyclo[3.1....)
Affinity DataIC50: 14nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598567(N-(6-methyl-2-(2-methyl-1,4-diazepan-1-yl)pyrimidi...)
Affinity DataIC50: 15nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598609(N-(2-(1,4-diazepan-1-yl)pyrimidin-4-yl)-1H-indazol...)
Affinity DataIC50: 15nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598637(US11613531, Example 308 | N-(2-(3,6-diazabicyclo[3...)
Affinity DataIC50: 15nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598617(8-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-8-aza...)
Affinity DataIC50: 15.8nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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