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TargetMuscarinic acetylcholine receptor M2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280422(ethyl 4-{4-[2- (difluoro- methoxy) pyridin-3- yl]p...)
Affinity DataEC50: >1.00E+7nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280433(ethyl 4-[4-(5- methoxy-2- methyl- pyrimidin-4- yl)...)
Affinity DataEC50:  560nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280432(ethyl 4-{4-[2- (methylamino) pyridin-3- yl]piperid...)
Affinity DataEC50:  360nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280431(ethyl 4-(4-{2- [1-(propan-2-yl)- 1H-pyrazol-4- yl]...)
Affinity DataEC50:  150nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280430(ethyl 4-{4-[5- methoxy-2- (trifluoromethyl) pyrimi...)
Affinity DataEC50:  180nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280429(ethyl 4-[4-(3,6- dimethylpyrazin- 2-yl)piperidin- ...)
Affinity DataEC50:  530nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280428(ethyl 4-[4-(5- chloro-2- methoxy- pyridin-3- yl)pi...)
Affinity DataEC50:  2nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280427(ethyl 4-[4-(1- ethyl-2-oxo-1,2- dihydropyridin- 3-...)
Affinity DataEC50:  890nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280426(ethyl 4-{4-[1- (cyanomethyl)- 2-oxo-1,2- dihydro- ...)
Affinity DataEC50:  2.35E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280425(ethyl 4-{4-[2- (propan-2- yloxy)pyridin-3- yl]pipe...)
Affinity DataEC50: >1.00E+7nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280425(ethyl 4-{4-[2- (propan-2- yloxy)pyridin-3- yl]pipe...)
Affinity DataEC50:  130nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280424(ethyl 4-(4-{2-[(3- methyl-1,2- oxazol-5- yl)methox...)
Affinity DataEC50:  20nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280423(ethyl 4-[4-(2- ethoxypyridin-3- yl)piperidin-1- yl...)
Affinity DataEC50:  60nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280434(ethyl 4-{4-[2- (1-methyl-1H- pyrazol-5- yl)pyridin...)
Affinity DataEC50:  3.14E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280422(ethyl 4-{4-[2- (difluoro- methoxy) pyridin-3- yl]p...)
Affinity DataEC50:  10nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280421(ethyl 4-[4-(4- methoxy- pyrimidin-5- yl)piperidin-...)
Affinity DataEC50:  310nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280420(ethyl 4-{4-[6- (dimethylamino) pyrazin-2- yl]piper...)
Affinity DataEC50:  460nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280419(ethyl 4-{4-[3- (dimethylamino) pyrazin-2- yl]piper...)
Affinity DataEC50:  210nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280418(ethyl 4-[4-(4- methoxypyridin- 3-yl)piperidin-1- y...)
Affinity DataEC50:  250nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280417(ethyl 4-[4-(2- ethoxy-5-methyl- pyridin-3- yl)pipe...)
Affinity DataEC50:  160nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280416(ethyl 4-[4-(2- methylpyridin-3- yl)piperidin-1- yl...)
Affinity DataEC50:  1.55E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280415(ethyl 4-[4-(5- methoxypyridin- 3-yl)piperidin-1- y...)
Affinity DataEC50:  460nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280414(ethyl 4-[4-(3- methoxypyridin- 4-yl)piperidin- 1-y...)
Affinity DataEC50:  370nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280413(ethyl 4-{4-[2- methoxy-5- (trifluoro- methyl)pyrid...)
Affinity DataEC50:  180nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280413(ethyl 4-{4-[2- methoxy-5- (trifluoro- methyl)pyrid...)
Affinity DataEC50:  20nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280444(ethyl 4-[4- (pyrimidin-2- yl)piperidin-1- yl]azepa...)
Affinity DataEC50:  1.05E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280455(ethyl (4R)-4-[4- (2-methoxy- pyridin- 3-yl)piperid...)
Affinity DataEC50:  310nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280454(ethyl (4S)-4-[4- (2-methoxy- pyridin- 3-yl)piperid...)
Affinity DataEC50:  26nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280453(ethyl (4S)-4-[4- (1-methyl-1H- imidazol-2- yl)pipe...)
Affinity DataEC50:  1.50E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280452(ethyl (4R)-4-[4- (1H-pyrazol-1- yl)piperidin-1- yl...)
Affinity DataEC50:  460nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280451(ethyl (4S)-4-[4- (1H-pyrazol-1- yl)piperidin-1- yl...)
Affinity DataEC50:  85nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280450(ethyl 4-{4-[2- (1,3-oxazol-2- yl)pyridin-3- yl]pip...)
Affinity DataEC50:  850nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280449(ethyl 4-{[3-(3,5- dimethyl-1H- pyrazol-1-yl) pyrro...)
Affinity DataEC50:  340nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280448(methyl 4-{[3- (3,5-dimethyl- 1H-pyrazol-1- yl)pyrr...)
Affinity DataEC50:  2.68E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280447(ethyl 4-{4-[2- (2-methyl- propyl)pyridin- 3-yl]pip...)
Affinity DataEC50:  670nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280446(ethyl 4-{4-[2- (1,3-thiazol-4- ylmethoxy) pyridin-...)
Affinity DataEC50:  22nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280445(ethyl 4-[4-(4- methylpyrimidin- 5-yl)piperidin-1- ...)
Affinity DataEC50:  1.01E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280444(ethyl 4-[4- (pyrimidin-2- yl)piperidin-1- yl]azepa...)
Affinity DataEC50: >1.00E+7nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280412(ethyl 4-[4-(2- ethoxy-5-methyl- pyridin-3- yl)pipe...)
Affinity DataEC50:  20nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280443(ethyl 4-{4-[2- (1-methyl-1H- pyrazol- 4-yl)pyridin...)
Affinity DataEC50:  650nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280442(ethyl 4-[4-(6- ethoxypyridin-2- yl)piperidin-1- yl...)
Affinity DataEC50:  2.02E+3nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280442(ethyl 4-[4-(6- ethoxypyridin-2- yl)piperidin-1- yl...)
Affinity DataEC50:  270nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280441(ethyl 4-[4-(4- methoxy- pyridazin- 3-yl)piperidin-...)
Affinity DataEC50:  1.05E+3nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280440(ethyl 4-[4-(2- ethylpyridin-3- yl)piperidin-1- yl]...)
Affinity DataEC50:  210nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280439(ethyl 4-{4-[5- (trifluoromethyl)- 1H-pyrazol-1- yl...)
Affinity DataEC50: >1.00E+7nMMore data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280439(ethyl 4-{4-[5- (trifluoromethyl)- 1H-pyrazol-1- yl...)
Affinity DataEC50:  630nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280438(ethyl 4-[4-(1,3- thiazol-2- yl)piperidin-1- yl]pip...)
Affinity DataEC50:  540nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280437(ethyl 4-(4-{2- [(cyclopropyl- methyl)amino] pyridi...)
Affinity DataEC50:  990nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280436(ethyl 4-[4-(2- cyclopropyl- pyridin- 3-yl)piperidi...)
Affinity DataEC50:  120nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Heptares Therapeutics

US Patent
LigandPNGBDBM280435(ethyl 4-{4-[2- (dimethylamino) pyridin-3- yl]piper...)
Affinity DataEC50:  190nMAssay Description:The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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