Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 10261
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523870(US11136324, Example 10 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 1nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523874(US11136324, Example 15 | (R)-5-(4-(tert-Butyl)-1H-...)
Affinity DataIC50: 1.40nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523868(US11136324, Example 8 | (R)-5-(4-Cyclopropyl-1H-im...)
Affinity DataIC50: 1.80nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523892(US11136324, Example 55 | (R)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 1.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523886(US11136324, Example 43 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 1.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523896(US11136324, Example 61 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 1.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523884(US11136324, Example 40 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 1.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523872(US11136324, Example 13 | (R)-2-Fluoro-5-(4-isoprop...)
Affinity DataIC50: 2.70nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523894(US11136324, Example 59 | (R)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 2.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523897(US11136324, Example 62 | N-(6-(6′,7′-D...)
Affinity DataIC50: 3nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523882(US11136324, Example 37 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 3.5nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523887(US11136324, Example 44 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 3.60nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523875(US11136324, Example 16 | (S)-5-(4-(tert-Butyl)-1H-...)
Affinity DataIC50: 4.10nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523883(US11136324, Example 38 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 4.10nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523878(US11136324, Example 32 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 4.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523890(US11136324, Example 51 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 4.90nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523869(US11136324, Example 9 | (S)-5-(4-Cyclopropyl-1H-im...)
Affinity DataIC50: 5nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523893(US11136324, Example 56 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 5nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523880(US11136324, Example 34 | (R)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 5.20nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523899(US11136324, Example 64 | 6-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 5.5nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM504319(WX001 | US11040968, Example 001 | US11136324, Exam...)
Affinity DataIC50: 6nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523888(US11136324, Example 48 | (S) N-(6-(5-(Cyanomethyl)...)
Affinity DataIC50: 6.10nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523895(US11136324, Example 60 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 6.60nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523879(US11136324, Example 33 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 7.20nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523885(US11136324, Example 41 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 7.70nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523891(US11136324, Example 53 | (R)-2-Chloro-5-(4-cyclopr...)
Affinity DataIC50: 8.20nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523898(US11136324, Example 63 | 6-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 8.40nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523873(US11136324, Example 14 | (S)-2-Fluoro-5-(4-isoprop...)
Affinity DataIC50: 9nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523881(US11136324, Example 36 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 9.10nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523864(US11136324, Example 2 | 5-(4-Cyclopropyl-1H-imidaz...)
Affinity DataIC50: 9.30nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523900(US11136324, Example 65 | (S)-6-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 9.40nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523889(US11136324, Example 50 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 9.60nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523871(US11136324, Example 11 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 10.6nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523877(US11136324, Example 31 | N-(6-(5′H,7′H...)
Affinity DataIC50: 10.9nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523876(US11136324, Example 30 | 5-(4-Cyclopropyl-1H-imida...)
Affinity DataIC50: 11.4nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM504320(WX002 | US11040968, Example 002 | US11136324, Exam...)
Affinity DataIC50: 13.4nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523867(US11136324, Example 7 | 4-(4-Cyclopropyl-1H-imidaz...)
Affinity DataIC50: 19.6nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523866(US11136324, Example 4 | 5-(4-Cyclopropyl-1H-imidaz...)
Affinity DataIC50: 47.8nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent