Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 8937
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430271(US10556883, Compound 10)
Affinity DataIC50: 2.80nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
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TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453839(CHEMBL4209541 | US10556883, Compound 18)
Affinity DataIC50: 3.5nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453825(CHEMBL4215407 | US10556883, Compound 19a)
Affinity DataIC50: 3.70nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453843(CHEMBL4210459 | US10556883, Compound 7b)
Affinity DataIC50: 5.20nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430278(US10556883, Compound 28b)
Affinity DataIC50: 5.60nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 7.20nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430272(US10556883, Compound 11)
Affinity DataIC50: 8.20nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453844(CHEMBL4206013 | US10556883, Compound 22)
Affinity DataIC50: 11nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430277(US10556883, Compound 26f)
Affinity DataIC50: 11.4nMAssay Description:Activity of the compounds was investigated using TACE (ADAM17) isolated enzyme. The screening of ADAM17 inhibitors was performed with a profluorescen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453825(CHEMBL4215407 | US10556883, Compound 19a)
Affinity DataIC50: 4.46E+3nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
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TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453823(CHEMBL4208519 | US10556883, Compound 19d)
Affinity DataIC50: 4.63E+3nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430278(US10556883, Compound 28b)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430277(US10556883, Compound 26f)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453844(CHEMBL4206013 | US10556883, Compound 22)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453839(CHEMBL4209541 | US10556883, Compound 18)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430272(US10556883, Compound 11)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM430271(US10556883, Compound 10)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

TargetInterstitial collagenase(Human)
Galderma Research & Development

US Patent
LigandPNGBDBM50453843(CHEMBL4210459 | US10556883, Compound 7b)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzymatic reaction was performed in 384-well microplates with a final volume of 10 L containing 1% DMSO. Recombinant Human catalytic domains of M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent