Compile Data Set for Download or QSAR
Report error Found 79 Enz. Inhib. hit(s) with all data for entry = 11660
TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637532((3-amino-6-((1rs,2RS,3SR)-2,3- dimethylcyclopropyl...)
Affinity DataIC50: 13nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637564((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 17nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637523([3-amino-6-(2,5-dihydrofuran-3- yl)pyrazolo[3,4-b]...)
Affinity DataIC50: 17nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637556((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 19nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637511([3-amino-6-(cyclopenten-1- yl)pyrazolo[3,4-b]pyrid...)
Affinity DataIC50: 20nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637537((3-amino-6-(2,2- difluorocyclopropyl)-1H- pyrazolo...)
Affinity DataIC50: 22nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637535([3-amino-6-(2,5-dihydrofuran-3- yl)pyrazolo[3,4-b]...)
Affinity DataIC50: 25nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637563((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 26nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637521((3-amino-6-((1RS,2RS)-2- methylcyclopropyl)-1H- py...)
Affinity DataIC50: 28nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637522((3-amino-6-((1RS,2RS)-2- methylcyclopropyl)-1H-pyr...)
Affinity DataIC50: 29nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637565((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 31nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637528((3-amino-6-(2,2- difluorocyclopropyl)-1H- pyrazolo...)
Affinity DataIC50: 32nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637547((3RS,4RS)-4-(3-amino-6- cyclopropylpyrazolo[3,4- b...)
Affinity DataIC50: 33nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637531((3-amino-6-((1rs,2RS,3SR)-2,3- dimethylcyclopropyl...)
Affinity DataIC50: 35nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637540(US20230382911, Example 52 | (3-amino-6-cyclopropyl...)
Affinity DataIC50: 35nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637540(US20230382911, Example 52 | (3-amino-6-cyclopropyl...)
Affinity DataIC50: 36nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637560(3-(3-amino-6-cyclopropyl-1H- cyclopropyl-1H-pyrazo...)
Affinity DataIC50: 37nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637548((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 37nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637552((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 41nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637555((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 49nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637518([3-amino-6-(cyclopenten-1- yl)pyrazolo[3,4-b]pyrid...)
Affinity DataIC50: 53nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637491(US20230382911, Example 3 | (3-amino-6-(pyrrolidin-...)
Affinity DataIC50: 53nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637554(3-(3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridi...)
Affinity DataIC50: 54nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637534((3-amino-5-fluoro-6-(pyrrolidin- 1-yl)-1H-pyrazolo...)
Affinity DataIC50: 55nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637496(US20230382911, Example 8 | (3-amino-5-chloro-6- cy...)
Affinity DataIC50: 56nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637520((3-amino-6-cyclobutyl-1H- pyrazolo[3,4-b]pyridin-1...)
Affinity DataIC50: 59nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637527((3-amino-6-((1RS,2SR)-2- fluorocyclopropyl)-1H- py...)
Affinity DataIC50: 64nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637504(US20230382911, Example 16 | (3-amino-6-(pyrrolidin...)
Affinity DataIC50: 65nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637499(US20230382911, Example 11 | (3-amino-5-fluoro-6-(p...)
Affinity DataIC50: 66nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637524([3-amino-6-(2,5-dihydrofuran-3- yl)pyrazolo[3,4-b]...)
Affinity DataIC50: 67nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637515((3-amino-6-(3,3-difluoroazetidin- 1-yl)-1H-pyrazol...)
Affinity DataIC50: 69nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637557(4-(3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridi...)
Affinity DataIC50: 79nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637533((3-amino-6-(2,2- difluorocyclopropyl)-1H- pyrazolo...)
Affinity DataIC50: 91nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637489(US20230382911, Example 1 | (3-amino-6-phenyl-1H- p...)
Affinity DataIC50: 92nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637493(US20230382911, Example 5 | (3-amino-6-(pyrrolidin-...)
Affinity DataIC50: 94nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637502(US20230382911, Example 14 | (3-amino-6-(3,3-difluo...)
Affinity DataIC50: 95nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637503(US20230382911, Example 15 | (3-amino-6-(tert-butyl...)
Affinity DataIC50: 99nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637545((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 110nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637490(US20230382911, Example 2 | (3-amino-6-isobutyl-1H-...)
Affinity DataIC50: 110nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637494(US20230382911, Example 6 | [3-amino-6-(cyclohexen-...)
Affinity DataIC50: 110nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637501(US20230382911, Example 13 | (3-amino-5-fluoro-6-(p...)
Affinity DataIC50: 110nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637526((3-amino-7-methyl-5,6,7,8- tetrahydro-1H-pyrazolo[...)
Affinity DataIC50: 120nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637495(US20230382911, Example 7 | (3-amino-6- cyclopropyl...)
Affinity DataIC50: 120nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637514((3-amino-6-(trifluoromethyl-1H- pyrazolo[3,4-b]pyr...)
Affinity DataIC50: 120nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637536((3-amino-6-(1- methylcyclopropyl)-1H- pyrazolo[3,4...)
Affinity DataIC50: 130nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637551((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 130nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637549((3-amino-6-cyclopropyl-1H- pyrazolo[3,4-b]pyridin-...)
Affinity DataIC50: 130nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637492(US20230382911, Example 4 | (3-amino-6-(pyrrolidin-...)
Affinity DataIC50: 140nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637500(US20230382911, Example 12 | (3-amino-5-fluoro-6-(p...)
Affinity DataIC50: 140nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM637509((3-amino-7,7-dimethyl-5,6,7,8- tetrahydro-1H-pyraz...)
Affinity DataIC50: 140nMAssay Description:Recombinant human Mat2a (12.5 nM) and serial diluted compounds in DMSO (range of concentrations from 10 μM to 508 μM) or controls (DMSO) ar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
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