Compile Data Set for Download or QSAR
Report error Found 1932 Enz. Inhib. hit(s) with all data for entry = 8609
TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407062((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  32nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407063(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-((R)- 2...)
Affinity DataEC50:  9nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407064(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N- ((1r,4...)
Affinity DataEC50:  62nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407065((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N- (2...)
Affinity DataEC50:  33nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407066(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(6-(2- ...)
Affinity DataEC50:  207nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407067(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopro...)
Affinity DataEC50:  152nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407068(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4- (isopr...)
Affinity DataEC50:  442nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407069(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((R)-2-...)
Affinity DataEC50:  774nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407070(7-(5-(((1,1-dioxidotetra- hydrothiophen- 3-yl)meth...)
Affinity DataEC50:  5.10E+3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407071((R)-6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N-(2-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407072((R)-4-amino-6-(3-cyano- pyrrolo[1,2-b]pyridazin-7-...)
Affinity DataEC50:  1.04E+3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407073(N-((1r,4r)-4-aminocyclo- hexyl)-6-(3-cyano- pyrrol...)
Affinity DataEC50:  97nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407074(N-((1r,4r)-4-acetamido- cyclohexyl)-6-(3-cyano- py...)
Affinity DataEC50:  79nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407075(4-(((1R,3r,5S)-8- azabicyclo[3.2.1]octan-3- yl)ami...)
Affinity DataEC50:  626nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407076(US10336762, Compound 29 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  302nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407077((R)-4-((1-acetylpiperidin- 4-yl)amino)-6-(3-cyano-...)
Affinity DataEC50:  204nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407078((R)-6-(3-(1H-tetrazol-5-yl) pyrrolo[1,2-b]pyridazi...)
Affinity DataEC50:  5.20E+3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407079(US10336762, Compound 45 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  757nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407080(7-(5-(2-(2-(hydroxy- methyl)cyclopropyl) acetyl)-4...)
Affinity DataEC50:  926nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407081(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopro...)
Affinity DataEC50:  128nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407082(6-(3-cyanopyrrolo[1,2-b] pyridazin-7- yl)-4-(isopr...)
Affinity DataEC50:  69nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407083(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopro...)
Affinity DataEC50:  87nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407084((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  676nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407075(4-(((1R,3r,5S)-8- azabicyclo[3.2.1]octan-3- yl)ami...)
Affinity DataEC50:  642nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407086(US10336762, Compound 26 | 4-(3-azabicyclo[3.1.1] h...)
Affinity DataEC50:  116nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407086(US10336762, Compound 26 | 4-(3-azabicyclo[3.1.1] h...)
Affinity DataEC50:  182nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407088(4-(3-azabicyclo[3.2.1] octan-8-ylamino)-6-(3- cyan...)
Affinity DataEC50:  175nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407088(4-(3-azabicyclo[3.2.1] octan-8-ylamino)-6-(3- cyan...)
Affinity DataEC50:  109nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407076(US10336762, Compound 29 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  100nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407091(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((R)-2-...)
Affinity DataEC50:  732nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407092(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((R)-2-...)
Affinity DataEC50:  757nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407093(4-(((1S,4S,5S)-2- azabicyclo[2.2.1]heptan- 5-yl)am...)
Affinity DataEC50: >1.00E+4nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407094((R)-4-(tert-butylamino)-6- (3-cyanopyrrolo[1,2- b]...)
Affinity DataEC50:  29nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407095(6-(3-cyanopyrrolo[1,2-b] pyridazin-7- yl)-4-(isopr...)
Affinity DataEC50: >1.00E+4nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407096(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-(isopro...)
Affinity DataEC50:  218nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407097((S)-6-(3-cyanopyrrolo[1,2-b] pyridazin- 7-yl)-4-(i...)
Affinity DataEC50:  221nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407098((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4- (i...)
Affinity DataEC50:  283nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407099(6-(3-cyanopyrrolo[1,2-b] pyridazin-7- yl)-4-(isopr...)
Affinity DataEC50:  91nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407100(6-(3-cyanopyrrolo[1,2-b] pyridazin-7- yl)-4-(isopr...)
Affinity DataEC50:  507nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407101((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((3...)
Affinity DataEC50:  73nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407102(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(3- hyd...)
Affinity DataEC50:  78nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407103((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  35nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407104((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  30nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407105((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407079(US10336762, Compound 45 | 6-(3-cyanopyrrolo[1,2-b]...)
Affinity DataEC50:  255nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407107((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  37nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407108((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  37nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407109((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-4-((1...)
Affinity DataEC50:  28nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407110((R)-6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-(2-...)
Affinity DataEC50:  8nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407111(4-(8-oxabicyclo[3.2.1] octan-3-ylamino)-6-(3- cyan...)
Affinity DataEC50:  351nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

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