Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 1175
TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM155343(US9006249, Example 49-2 | US9603819, Example 49-2)
Affinity DataIC50: 0.0300nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM309469(US9603819, Example 49-1 | (2R,4S)-5-(3′-Chlo...)
Affinity DataIC50: 0.0400nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM155344(US9006249, Example 49-3 | US9603819, Example 49-3)
Affinity DataIC50: 0.300nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM153108(US8993631, 16-5 | US9006249, Example 3-32 | US9603...)
Affinity DataIC50: 1nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM309463(US9603819, Example 3-60)
Affinity DataIC50: 7.30nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM309468(US9603819, Example 13-1 | (2R,4S)-5-biphenyl-4-yl-...)
Affinity DataIC50: 14nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM153116(US8993631, 19 | US9006249, Example 7-1 | US9603819...)
Affinity DataIC50: 93nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM153117(US8993631, 20 | US9006249, Example 9-1 | US9603819...)
Affinity DataIC50: 142nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM153107(US8993631, 16-3 | US9006249, Example 3-6 | US96038...)
Affinity DataIC50: 250nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM153113(US8993631, 15-1 | US9006249, Example 2-1 | US96038...)
Affinity DataIC50: 267nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM153112(US8993631, 14-1 | US9006249, Example 1-1 | US96038...)
Affinity DataIC50: 283nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM153114(US8993631, 17 | US9006249, Example 5-1 | US9603819...)
Affinity DataIC50: 350nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeprilysin(Human)
Novartis

US Patent
LigandPNGBDBM153115(US8993631, 18-1 | US9006249, Example 6-1 | US96038...)
Affinity DataIC50: 450nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent