Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 2898
TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384541(N-(1-(((R)-1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.0400nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384539(N-(1-(((R)-1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.0500nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384538((R)-N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.0800nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384543((R)-N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.0900nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384542(N-(1-(((R)-1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.0900nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384540(N-(1-(((R)-1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.100nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384539(N-(1-(((R)-1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.200nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384542(N-(1-(((R)-1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.300nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384541(N-(1-(((R)-1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.300nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384538((R)-N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.300nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384543((R)-N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.300nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384544(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 0.300nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384540(N-(1-(((R)-1-acryloylpyrrolidin-2-yl)methyl)-5-(((...)
Affinity DataIC50: 0.5nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384534(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 0.600nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384537(N-1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyrr...)
Affinity DataIC50: 0.800nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384535(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 0.800nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384533(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 0.800nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384536(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 0.900nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384535(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 0.900nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384534(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 0.900nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384394((R)-N-(1-((1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 1.10nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384544(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 1.20nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384381((R)-N-(1-((1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 1.20nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384536(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 1.30nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384381((R)-N-(1-((1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 1.40nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384533(N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 1.5nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384537(N-1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyrr...)
Affinity DataIC50: 2.10nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase TXK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM384394((R)-N-(1-((1-(2-cyano-4,4-dimethylpent-2-enoyl)pyr...)
Affinity DataIC50: 3.5nMAssay Description:The ability of the compounds of the present disclosure to inhibit ITK was measured using the Caliper assay format, which is an electrophoretic separa...More data for this Ligand-Target Pair
In DepthDetails
US Patent