Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 8785
TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataKi:  0.0350nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataKi:  0.200nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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PDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataKi:  0.5nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataKi:  1.5nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataKi:  2.80nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM24498(CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...)
Affinity DataKi:  3nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM24773(N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...)
Affinity DataKi:  3nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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PDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataKi:  4.20nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataKi:  6.5nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Ontogenesis

US Patent
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKi:  9nMAssay Description:Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2020
Entry Details
Go to US Patent