Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 1588
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239101(US9403810, 2.2 | US10195181, Example 2.2)
Affinity DataIC50: 0.900nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239117(US9403810, 22 | US10195181, Example 22c)
Affinity DataIC50: 1.40nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239094(US9403810, 1.3 | US10195181, Example 1.3)
Affinity DataIC50: 1.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239092(US9403810, 1.1 | US10195181, Example 1.1)
Affinity DataIC50: 2.10nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239099(US9403810, 2 | US10195181, Example 2)
Affinity DataIC50: 2.5nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239091(US9403810, 1 | US10195181, Example 1)
Affinity DataIC50: 2.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239095(US9403810, 1.4 | US10195181, Example 1.4)
Affinity DataIC50: 3.20nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239105(US9403810, 6 | US10195181, Example 6)
Affinity DataIC50: 5.70nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239096(US9403810, 1.5 | US10195181, Example 1.5)
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239102(US9403810, 3 | US10195181, Example 3)
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239097(US9403810, 1.6 | US10195181, Example 1.6)
Affinity DataIC50: 8nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239093(US9403810, 1.2 | US10195181, Example 1.2)
Affinity DataIC50: 14nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239107(US9403810, 7 | US10195181, Example 7)
Affinity DataIC50: 19nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239106(US9403810, 6.1 | US10195181, Example 6.1)
Affinity DataIC50: 23nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239098(US9403810, 1.7 | US10195181, Example 1.7)
Affinity DataIC50: 33nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM331990(US10195181, Example 16 | 5-((2S,6R)-6-(tert-butyl)...)
Affinity DataIC50: 37nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239108(US9403810, 8 | US10195181, Example 8)
Affinity DataIC50: 46nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239110(US9403810, 10 | US10195181, Example 10)
Affinity DataIC50: 50nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239109(US9403810, 9 | US10195181, Example 9)
Affinity DataIC50: 58nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239100(US9403810, 2.1 | US10195181, Example 2.1)
Affinity DataIC50: 64nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM332005(US10195181, Example 25a | US10195181, Example 25b ...)
Affinity DataIC50: 74nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM332005(US10195181, Example 25a | US10195181, Example 25b ...)
Affinity DataIC50: 75nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM331992(US10195181, Example 18 | N-(2-cyclohexyl-1,5-dimet...)
Affinity DataIC50: 91nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239122(US9403810, 12 | US10195181, Example 12)
Affinity DataIC50: 100nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239103(US9403810, 4 | US10195181, Example 4)
Affinity DataIC50: 100nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM332005(US10195181, Example 25a | US10195181, Example 25b ...)
Affinity DataIC50: 160nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM332001(US10195181, Example 23 | A mixture of 5-((2R,4S)-4...)
Affinity DataIC50: 160nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239115(US9403810, 20 | US10195181, Example 20)
Affinity DataIC50: 180nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239135(US9403810, 24a | US10195181, Example 24b)
Affinity DataIC50: 250nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239113(US9403810, 13b | US10195181, Example 13a)
Affinity DataIC50: 290nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM331988(US10195181, Example 15a | US10195181, Example 15b)
Affinity DataIC50: 290nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239104(US9403810, 5 | US10195181, Example 5)
Affinity DataIC50: 310nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239135(US9403810, 24a | US10195181, Example 24b)
Affinity DataIC50: 340nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239135(US9403810, 24a | US10195181, Example 24b)
Affinity DataIC50: 350nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239111(US9403810, 11 | US10195181, Example 11)
Affinity DataIC50: 420nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239117(US9403810, 22 | US10195181, Example 22c)
Affinity DataIC50: 420nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239130(US9403810, 21.2 | US10195181, Example 21.2)
Affinity DataIC50: 490nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239117(US9403810, 22 | US10195181, Example 22c)
Affinity DataIC50: 570nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239121(US9403810, 26 | US10195181, Example 26)
Affinity DataIC50: 580nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239116(US9403810, 21.1 | US10195181, Example 21.1)
Affinity DataIC50: 630nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM331988(US10195181, Example 15a | US10195181, Example 15b)
Affinity DataIC50: 630nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM331984(A mixture of 5-((2S,4R,6R)-6-(tert-butyl)-4-methox...)
Affinity DataIC50: 640nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM331984(A mixture of 5-((2S,4R,6R)-6-(tert-butyl)-4-methox...)
Affinity DataIC50: 730nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM332005(US10195181, Example 25a | US10195181, Example 25b ...)
Affinity DataIC50: 840nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM331991(US10195181, Example 17 | A mixture of 5-((2R,6S)-6...)
Affinity DataIC50: 980nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM331993(US10195181, Example 19 | A mixture of N-(2-cyclohe...)
Affinity DataIC50: 1.80E+3nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM331987(US10195181, Example 14 | A diastereomeric mixture ...)
Affinity DataIC50: 2.50E+3nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis

US Patent
LigandPNGBDBM239117(US9403810, 22 | US10195181, Example 22c)
Affinity DataIC50: 5.10E+3nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In DepthDetails
US Patent