Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 1653
TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335414(US9732085, 391 | 4-(2-{(3S)-8-chloro-7-[5-chloro-2...)
Affinity DataIC50: 1.10nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335416(US9732085, 399 | 5-(2-{(3S)-7-[5-chloro-2-(1H-tetr...)
Affinity DataIC50: 1.10nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335412(US9732085, 363 | 4-(2-{(3S)-7-[5-chloro-2-(1H-tetr...)
Affinity DataIC50: 1.40nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335399(US9732085, 198 | (3S)-3-[5-(6-amino-3-pyridinyl)-4...)
Affinity DataIC50: 1.5nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335413(US9732085, 387 | 5-(2-{(3S)-8-chloro-7-[5-chloro-2...)
Affinity DataIC50: 1.60nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335418(US9732085, 834 | 4-(2-{(3S)-7-[5-chloro-2-(1H-tetr...)
Affinity DataIC50: 1.60nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335419(US9732085, 848 | 4-(5-{7-[5-chloro-2-(1H-tetrazol-...)
Affinity DataIC50: 1.70nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335415(US9732085, 392 | 4-(2-{(6S)-2-[5-chloro-2-(1H-tetr...)
Affinity DataIC50: 2.10nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335393(US9732085, 57 | methyl{4-[5-chloro-2-({4-[5-chloro...)
Affinity DataIC50: 2.40nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335393(US9732085, 57 | methyl{4-[5-chloro-2-({4-[5-chloro...)
Affinity DataIC50: 2.40nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335408(US9732085, 290 | methyl[4-(2-{(3S)-7-[5-chloro-2-(...)
Affinity DataIC50: 2.5nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335400(US9732085, 210 | (3S)-3-[5-(6-amino-2-chloro-3-pyr...)
Affinity DataIC50: 2.80nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335420(US9732085, Comp Ex 1)
Affinity DataIC50: 3.60nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335401(US9732085, 216 | (3S)-3-[5-(6-amino-2-fluoro-3-pyr...)
Affinity DataIC50: 3.80nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335396(US9732085, 86 | 6-(2-{7-[5-chloro-2-(1H-tetrazol-1...)
Affinity DataIC50: 3.90nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335411(US9732085, 347 | 5-(2-{(3S)-7-[5-chloro-2-(1H-tetr...)
Affinity DataIC50: 4.20nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335397(US9732085, 129(2) | isopropyl[4-(2-{7-[5-chloro-2-...)
Affinity DataIC50: 4.60nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335403(US9732085, 241 | methyl[4-(4-chloro-5-{7-[5-chloro...)
Affinity DataIC50: 4.80nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335410(US9732085, 310 | methyl[4-(2-{(3S)-7-[5-chloro-2-(...)
Affinity DataIC50: 4.90nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335407(US9732085, 278 | methyl(4-{2-[1-{4-[5-chloro-2-(1H...)
Affinity DataIC50: 5.70nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335405(US9732085, 264 | methyl{4-[4-chloro-2-(1-{4-[5-chl...)
Affinity DataIC50: 6.10nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335391(US9732085, 41 | methyl[4-(2-{2-[5-chloro-2-(1H-tet...)
Affinity DataIC50: 6.5nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335391(US9732085, 41 | methyl[4-(2-{2-[5-chloro-2-(1H-tet...)
Affinity DataIC50: 6.5nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335394(US9732085, 60 | methyl{4-[5-chloro-2-(1-{4-[5-chlo...)
Affinity DataIC50: 7.20nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335409(US9732085, 309 | methyl[4-(2-{(3S)-7-[5-methyl-2-(...)
Affinity DataIC50: 8.30nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335406(US9732085, 270 | methyl[4-(2-{(3R)-7-[5-chloro-2-(...)
Affinity DataIC50: 11nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335402(US9732085, 230 | methyl[6-(4-chloro-2-{(3S)-7-[5-c...)
Affinity DataIC50: 11nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335417(US9732085, 400 | 4-[2-({4-[5-chloro-2-(1H-tetrazol...)
Affinity DataIC50: 13nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335395(US9732085, 61 | methyl{4-[2-(1-{4-[5-chloro-2-(1H-...)
Affinity DataIC50: 14nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335392(US9732085, 45 | US10717738, Example 45)
Affinity DataIC50: 15nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335392(US9732085, 45 | US10717738, Example 45)
Affinity DataIC50: 15nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335404(US9732085, 245 | methyl[4-(5-{7-[5-chloro-2-(1H-te...)
Affinity DataIC50: 17nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335421(US9732085, Comp Ex 2)
Affinity DataIC50: 40nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335398(US9732085, 181 | methyl[5-(2-{7-[5-chloro-2-(1H-te...)
Affinity DataIC50: 47nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335422(US9732085, Comp Ex 3)
Affinity DataIC50: 130nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335423(US9732085, Comp. Ex 4)
Affinity DataIC50: 1.00E+4nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent