Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 9574
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM475604(US10851092, Example 5)
Affinity DataIC50: 2.20nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
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LigandPNGBDBM475604(US10851092, Example 5)
Affinity DataIC50: 2.70nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
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TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM475603(US10851092, Example 3)
Affinity DataIC50: 4.60nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
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LigandPNGBDBM475603(US10851092, Example 3)
Affinity DataIC50: 6.30nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 52nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
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LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 811nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
Go to US Patent