The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.0M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 695K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Advanced Search

88 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.EBI
University of Bologna
Type I DNA Topoisomerases.EBI
University of Bologna
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.EBI
University of Bologna
Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.EBI
University of Bologna
Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors.EBI
University of Bologna
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.EBI
University of Bologna
Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.EBI
University of Bologna
Targeting integrinsavß3 anda5ß1 with newß-lactam derivatives.EBI
University of Bologna
Discovery of novel and selective SIRT6 inhibitors.EBI
University of Bologna
Oxidative stress in Alzheimer's disease: are we connecting the dots?EBI
University of Bologna
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.EBI
University of Bologna
Synthesis and assay of retro-a4ß1 integrin-targeting motifs.EBI
University of Bologna
Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.EBI
University of Bologna
Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI).EBI
University of Bologna
Modulation ofavß3- anda5ß1-integrin-mediated adhesion by dehydro-ß-amino acids containing peptidomimetics.EBI
University of Bologna
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition.EBI
University of Bologna
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.EBI
University of Bologna
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.EBI
University of Bologna
Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes.EBI
University of Bologna
Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.EBI
University of Bologna
Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics.EBI
University of Bologna
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold.EBI
University of Bologna
Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.EBI
University of Bologna
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.EBI
University of Bologna
Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus.EBI
University of Bologna
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.EBI
University of Bologna
Computational design and discovery of"minimally structured" hERG blockers.EBI
University of Bologna
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.EBI
University of Bologna
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.EBI
University of Bologna
Diphenidol-related diamines as novel muscarinic M4 receptor antagonists.EBI
University of Bologna
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.EBI
University of Bologna
Multi-target-directed ligands to combat neurodegenerative diseases.EBI
University of Bologna
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.EBI
University of Bologna
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.EBI
University of Bologna
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.EBI
University of Bologna
Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].EBI
University of Bologna
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.EBI
University of Bologna
Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance.EBI
University of Bologna
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.EBI
University of Bologna
Synthesis and binding activity of endomorphin-1 analogues containing beta-amino acids.EBI
University of Bologna
Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.EBI
University of Bologna
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.EBI
University of Bologna
Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors.EBI
University of Bologna
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI
University of Bologna
Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.EBI
University of Bologna
Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.EBI
University of Bologna
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.EBI
University of Bologna
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.EBI
University of Bologna
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.EBI
University of Bologna
Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.EBI
University of Bologna
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.EBI
University of Bologna
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.EBI
University of Bologna
Ligand-Based Competition Binding by Real-Time EBI
University of Bologna
Design and Pharmacological Characterization of αEBI
University of Bologna
Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5.EBI
University of Bologna
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects.EBI
University of Bologna
Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.EBI
University of Bologna
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.EBI
University of Bologna
ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.EBI
University of Bologna
Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives.EBI
University of Bologna
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.EBI
University of Bologna
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.EBI
University of Bologna
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.EBI
University of Bologna
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.EBI
University of Bologna
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.EBI
University of Bologna
Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.EBI
University of Bologna
Versatile Picklocks To Access All Opioid Receptors: Tuning the Selectivity and Functional Profile of the Cyclotetrapeptide c[Phe-d-Pro-Phe-Trp] (CJ-15,208).EBI
University of Bologna
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities.EBI
University of Bologna
Could Dissecting the Molecular Framework of β-Lactam Integrin Ligands Enhance Selectivity?EBI
University of Bologna
Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.EBI
University of Bologna
Dehydro-β-proline Containing α4β1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay.EBI
University of Bologna
Synthesis of tripeptides containing D-Trp substituted at the indole ring, assessment of opioid receptor binding and in vivo central antinociception.EBI
University of Bologna
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.EBI
University of Bologna
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.EBI
University of Bologna
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.EBI
University of Bologna
Constraining Endomorphin-1 by β,α-Hybrid Dipeptide/Heterocycle Scaffolds: Identification of a Novel κ-Opioid Receptor Selective Partial Agonist.EBI
University of Bologna
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.EBI
University of Bologna
Microbiota-Host Transgenomic Metabolism, Bioactive Molecules from the Inside.EBI
University of Bologna
5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvumBDB
University of Washington Through Its Center For Commercialization
Substituted imidazo[1,2-b]pyrazoles as bruton'S tyrosine kinase modulatorsBDB
Beigene
Substituted pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidines and JAK inhibitors comprising the sameBDB
Nissan Chemical Industries
Substituted imidazoles as casein kinase 1 D/E inhibitorsBDB
Bristol-Myers Squibb
Substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infectionBDB
Hoffmann-La Roche
Compounds and compositions for treating HIV with derivatives of BetulinBDB
Glaxosmithkline
2-amino-5,5-difluoro-6-(fluoromethyl)-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitorsBDB
H. Lundbeck
Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.BDB
Merck Research Laboratories
Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase.BDB
Boehringer Ingelheim Pharmaceuticals
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones.BDB
Boehringer Ingelheim Pharmaceuticals