88 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.
University of Bologna
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
University of Bologna
Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis.
University of Bologna
Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors.
University of Bologna
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.
University of Bologna
Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.
University of Bologna
Oxidative stress in Alzheimer's disease: are we connecting the dots?
University of Bologna
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.
University of Bologna
Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.
University of Bologna
Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI).
University of Bologna
Modulation ofavß3- anda5ß1-integrin-mediated adhesion by dehydro-ß-amino acids containing peptidomimetics.
University of Bologna
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition.
University of Bologna
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.
University of Bologna
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.
University of Bologna
Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes.
University of Bologna
Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.
University of Bologna
Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics.
University of Bologna
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold.
University of Bologna
Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.
University of Bologna
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
University of Bologna
Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus.
University of Bologna
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.
University of Bologna
Computational design and discovery of"minimally structured" hERG blockers.
University of Bologna
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation.
University of Bologna
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.
University of Bologna
Diphenidol-related diamines as novel muscarinic M4 receptor antagonists.
University of Bologna
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.
University of Bologna
Multi-target-directed ligands to combat neurodegenerative diseases.
University of Bologna
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
University of Bologna
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.
University of Bologna
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.
University of Bologna
Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].
University of Bologna
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
University of Bologna
Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance.
University of Bologna
Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.
University of Bologna
Synthesis and binding activity of endomorphin-1 analogues containing beta-amino acids.
University of Bologna
Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.
University of Bologna
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.
University of Bologna
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
University of Bologna
Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.
University of Bologna
Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.
University of Bologna
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.
University of Bologna
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.
University of Bologna
Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.
University of Bologna
Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.
University of Bologna
Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.
University of Bologna
Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.
University of Bologna
Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5.
University of Bologna
Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects.
University of Bologna
Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.
University of Bologna
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme.
University of Bologna
ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.
University of Bologna
Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives.
University of Bologna
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.
University of Bologna
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
University of Bologna
New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins.
University of Bologna
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.
University of Bologna
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
University of Bologna
Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.
University of Bologna
Versatile Picklocks To Access All Opioid Receptors: Tuning the Selectivity and Functional Profile of the Cyclotetrapeptide c[Phe-d-Pro-Phe-Trp] (CJ-15,208).
University of Bologna
Polycyclic Maleimide-based Scaffold as New Privileged Structure for Navigating the Cannabinoid System Opportunities.
University of Bologna
Could Dissecting the Molecular Framework of β-Lactam Integrin Ligands Enhance Selectivity?
University of Bologna
Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.
University of Bologna
Dehydro-β-proline Containing α4β1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay.
University of Bologna
Synthesis of tripeptides containing D-Trp substituted at the indole ring, assessment of opioid receptor binding and in vivo central antinociception.
University of Bologna
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.
University of Bologna
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.
University of Bologna
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
University of Bologna
Constraining Endomorphin-1 by β,α-Hybrid Dipeptide/Heterocycle Scaffolds: Identification of a Novel κ-Opioid Receptor Selective Partial Agonist.
University of Bologna
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.
University of Bologna
Microbiota-Host Transgenomic Metabolism, Bioactive Molecules from the Inside.
University of Bologna
5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum
University of Washington Through Its Center For Commercialization
Substituted pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidines and JAK inhibitors comprising the same
Nissan Chemical Industries
Substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
Hoffmann-La Roche
Compounds and compositions for treating HIV with derivatives of Betulin
Glaxosmithkline
2-amino-5,5-difluoro-6-(fluoromethyl)-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors
H. Lundbeck
Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Merck Research Laboratories
Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Boehringer Ingelheim Pharmaceuticals