Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50017568
TargetTyrosine-protein kinase Fyn(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human Fyn using Cdc2 peptide as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Fyn(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of from NanoLuc-fused Fyn (unknown origin) transfected in HEK293 cells using tracer K4 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human GSK-3-beta using phospho GS2 peptide as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of from NanoLuc-fused GSK-3-beta (unknown origin) transfected in HEK293 cells using tracer K8 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of from NanoLuc-fused GSK-3-beta (unknown origin) transfected in HEK293 cells using tracer K8 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of NanoLuc-fused DYRK1A (unknown origin) transfected in HEK293 cells using tracer K10 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Fyn(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50: 91nMAssay Description:Inhibition of from NanoLuc-fused Fyn (unknown origin) transfected in HEK293 cells using tracer K4 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50: 903nMAssay Description:Inhibition of human DYRK1A using RRRFRPASPLRGPPK as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50602863(CHEMBL1997924)
Affinity DataIC50: 3.77E+3nMAssay Description:Inhibition of NanoLuc-fused DYRK1A (unknown origin) transfected in HEK293 cells using tracer K10 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed