77 articles for thisTarget
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Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R.
Korea Research Institute of Chemical Technology
Benzo[b]thiophene-2-carboxamide derivatives as potent urotensin-II receptor antagonists.
Korea Research Institute of Chemical Technology
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.
Korea Research Institute of Chemical Technology
Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes.
Korea Research Institute of Chemical Technology
Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor.
Korea Research Institute of Chemical Technology
Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists.
Korea Research Institute of Chemical Technology
4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors.
Korea Research Institute of Chemical Technology
Synthesis and SAR of thieno[3,2-b]pyridinyl urea derivatives as urotensin-II receptor antagonists.
Korea Research Institute of Chemical Technology
Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors.
Korea Research Institute of Chemical Technology
Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors.
Korea Research Institute of Chemical Technology
Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents.
Korea Research Institute of Chemical Technology
Discovery of non-LBD inhibitor for androgen receptor by structure-guide design.
Korea Research Institute of Chemical Technology
Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists.
Korea Research Institute of Chemical Technology
Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity.
Korea Research Institute of Chemical Technology
Predictive models of Cannabinoid-1 receptor antagonists derived from diverse classes.
Korea Research Institute of Chemical Technology
Docking-based 3D-QSAR study for 11beta-HSD1 inhibitors.
Korea Research Institute of Chemical Technology
Docking-based 3D-QSAR study for selectivity of DPP4, DPP8, and DPP9 inhibitors.
Korea Research Institute of Chemical Technology
Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors.
Korea Research Institute of Chemical Technology
Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors.
Korea Research Institute of Chemical Technology
Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors.
Korea Research Institute of Chemical Technology
Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors.
Korea Research Institute of Chemical Technology
Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors.
Korea Research Institute of Chemical Technology
Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents.
Korea Research Institute of Chemical Technology
4-arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1).
Korea Research Institute of Chemical Technology
Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors.
Korea Research Institute of Chemical Technology
Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.
Korea Research Institute of Chemical Technology
Discovery of new inhibitor for PDE3 by virtual screening.
Korea Research Institute of Chemical Technology
Discovery ofß-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors.
Korea Research Institute of Chemical Technology
1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.
Korea Research Institute of Chemical Technology
Discovery of cannabinoid-1 receptor antagonists by virtual screening.
Korea Research Institute of Chemical Technology
Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: a novel series of atypical antipsychotic agents.
Korea Research Institute of Chemical Technology
Design, synthesis, and evaluation of 2-aryl-7-(3',4'-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors.
Korea Research Institute of Chemical Technology
(2-Aryl-5-methylimidazol-4-ylcarbonyl)guanidines and (2-aryl-5-methyloxazol-4-ylcarbonyl)guanidines as NHE-1 inhibitors.
Korea Research Institute of Chemical Technology
Identification of small molecules that inhibit GSK-3beta through virtual screening.
Korea Research Institute of Chemical Technology
Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors.
Korea Research Institute of Chemical Technology
Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.
Korea Research Institute of Chemical Technology
Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclasts.
Korea Research Institute of Chemical Technology
Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors.
Korea Research Institute of Chemical Technology
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.
Korea Research Institute of Chemical Technology
Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists.
Korea Research Institute of Chemical Technology
Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents.
Korea Research Institute of Chemical Technology
3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors.
Korea Research Institute of Chemical Technology
Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists.
Korea Research Institute of Chemical Technology
Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor.
Korea Research Institute of Chemical Technology
Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors.
Korea Research Institute of Chemical Technology
Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases.
Korea Research Institute of Chemical Technology
PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.
Korea Research Institute of Chemical Technology
Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases.
Korea Research Institute of Chemical Technology
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors.
Korea Research Institute of Chemical Technology
(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1.
Korea Research Institute of Chemical Technology
Sulfamoylbenzamide-based Capsid Assembly Modulators for Selective Inhibition of Hepatitis B Viral Replication.
Korea Research Institute of Chemical Technology
Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors.
Korea Research Institute of Chemical Technology
Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.
Korea Research Institute of Chemical Technology
Optimization of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury.
Korea Research Institute of Chemical Technology
Synthesis and pharmacological profile of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines.
Korea Research Institute of Chemical Technology
Discovery of a New Sulfonamide Hepatitis B Capsid Assembly Modulator.
Korea Research Institute of Chemical Technology
Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists.
Korea Research Institute of Chemical Technology
Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.
Korea Research Institute of Chemical Technology
Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro.
Korea Research Institute of Chemical Technology
Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists.
Korea Research Institute of Chemical Technology
Discovery of novel [1,2,4]triazolo[4,3-a]quinoxaline aminophenyl derivatives as BET inhibitors for cancer treatment.
Korea Research Institute of Chemical Technology
Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors.
Korea Research Institute of Chemical Technology
Targeted drug rescue with novel compositions, combinations, and methods thereof
Exciva
Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
Abbvie