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Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50017730
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604477(CHEMBL5185786)
Affinity DataEC50:  3.01E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataEC50:  2nMAssay Description:Activation of STING mediated immune response in human THP-1 cells assessed as induction of IFNbeta secretion measured after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604481(CHEMBL5174660)
Affinity DataEC50:  1.62nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataEC50:  0.354nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50511093(CHEMBL4522871)
Affinity DataEC50:  1.02E+5nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604480(CHEMBL5196300)
Affinity DataEC50:  5.11E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604479(CHEMBL5200249)
Affinity DataEC50:  4.86E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604478(CHEMBL5192829)
Affinity DataEC50:  3.91E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  3.01E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604476(CHEMBL5173411)
Affinity DataEC50:  2.98E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604475(CHEMBL5199858)
Affinity DataEC50:  2.86E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604474(CHEMBL5197505)
Affinity DataEC50:  1.76E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604472(CHEMBL5205725)
Affinity DataEC50:  6.55E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50509050(CHEMBL4438309)
Affinity DataEC50: <1nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50552734(CHEMBL4793625)
Affinity DataEC50:  804nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50509049(CHEMBL4440744)
Affinity DataEC50:  1.23E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604467(CHEMBL5169574)
Affinity DataEC50:  1.66E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604468(CHEMBL5187032)
Affinity DataEC50:  1.69E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604469(CHEMBL5187131)
Affinity DataEC50:  0.00400nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604470(CHEMBL5194415)
Affinity DataEC50:  4.60E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604471(CHEMBL5176115)
Affinity DataEC50:  6.22E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604473(CHEMBL5205871)
Affinity DataEC50:  9.12E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataIC50: 0.0623nMAssay Description:Binding affinity to recombinant human His-tagged STING by measuring fluorescent signals in the presence of d2 labelled STING wild type ligand by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50509049(CHEMBL4440744)
Affinity DataIC50: 6.20nMAssay Description:Binding affinity to recombinant human His-tagged STING by measuring fluorescent signals in the presence of d2 labelled STING wild type ligand by HTRF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using sorafenib as cocktail probe substrate preincubated for 5 mins followed by NADPH addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of hERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as cocktail probe substrate preincubated for 5 mins followed by NADPH addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes tolbutamide as cocktail probe substrate preincubated for 5 mins followed by NADPH addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as cocktail probe substrate preincubated for 5 mins followed by NADPH addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50604466(CHEMBL5201766)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as cocktail probe substrate preincubated for 5 mins followed by NADPH addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed