PMID

Data

Article Title

Organization

Romazarit: a potential disease-modifying antirheumatic drug.

Roche Products

Synthesis and quantitative structure-activity relationships of diclofenac analogues.

Ciba-Geigy

Antiinflammatory activity of a series of substituted 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-diones.

Schering-Plough

Antiinflammatory 2,6-di-tert-butyl-4-(2-arylethenyl)phenols.

Boehringer Ingelheim Pharmaceuticals

Benzimidazole derivatives with atypical antiinflammatory activity.

TBA

Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids.

TBA

Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents.

TBA

Bulky amine analogues of ketoprofen: potent antiinflammatory agents.

TBA

Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues.

TBA

Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.

TBA

Antiinflammatory agents. 2. Syntheses and antiinflammatory activity of substituted 2-aminophenylacetic acid derivatives.

TBA

2,3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents.

TBA

Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.

TBA

Basic antiinflammatory compounds. N,N',N''-Trisubstituted guanidines.

TBA

Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines.

Universiti Kebangsaan Malaysia

Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.

Ici Pharmaceuticals Group

Designed multiple ligands. An emerging drug discovery paradigm.

Organon Laboratories

Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.

Warner-Lambert

5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.

Wyeth-Ayerst Research

1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.

Pfizer

2-substituted-1-naphthols as potent 5-lipoxygenase inhibitors with topical antiinflammatory activity.

E.I. Du Pont De Nemours

4-Hydroxy-3-quinolinecarboxamides with antiarthritic and analgesic activities.

Centre De Recherches Roussel-Uclaf

Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors.

TBA

 

Antiinflammatory -benzeneethanamines. III

TBA

 

Topical antiinflammatory dehydroabietylamine derivatives. IV

TBA

 

Cyclooxygenase and 5-lipoxygenase inhibitory activity of 2,6 di-t-butylphenols linked by a sulfur atom to 1,3,4-thiadiazoles and 1,3,4-oxadiazoles

TBA

 

Vinylogous hydroxamic acids: 5-lipoxygenase inhibitors

TBA

 

Synthesis and cyclooxygenase and 5-lipoxygenase inhibitory activity of some thiazolidene-4-one analogs of meclofenamic acid

TBA

 

Synthesis of reversed hydroxamic acids of indomethacin: dual inhibitors of cyclooxygenase and 5-lipoxygenase

TBA

 

1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitor

TBA

 

Conversion of NSAIDS into balanced dual inhibitors of cyclooxygenase and 5-lipoxygenase

TBA

Distribution of Bibenzyls, Prenyl Bibenzyls, Bis-bibenzyls, and Terpenoids in the Liverwort Genus

Tokushima Bunri University

N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.

The R. W. Johnson Pharmaceutical Research Institute

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.

University of Pennsylvania

1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.

Warner-Lambert

3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.

Tokushima Bunri University

Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.

Ciba-Geigy

Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.

Shionogi

Design, synthesis, and biochemical evaluation of N-substituted maleimides as inhibitors of prostaglandin endoperoxide synthases.

Vanderbilt University School of Medicine

Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.

TBA

Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters.

TBA

Phenylephrine derivatives as leukotriene D4 antagonists.

Wyeth Laboratories

Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.

Wellcome Research Laboratories

Selective thromboxane synthetase inhibitors. 4. 2-(1H-imidazol-1-ylmethyl) carboxylic acids of benzo[b]furan, benzo[b]thiophene, indole, and naphthalene.

TBA

Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.

TBA

Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues.

TBA

Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.

University of Pennsylvania

Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis.

Rorer Central Research

N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.

Wyeth-Ayerst Research

Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities.

Damanhour University

Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors.

Centre De Recherches De Vitry

Antiinflammatory agents. 4. Syntheses and biological evaluation of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid.

A.H. Robins

Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.

Warner-Lambert

Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors.

Boehringer Ingelheim Pharmaceuticals

N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.

Wyeth-Ayerst Research

Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.

Warner-Lambert

Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.

Dupont Pharmaceuticals