40 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors.
National Health Research Institutes
Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor.
Huazhong University of Science and Technology
Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold.
Johns Hopkins University
Glutaminase GLS1 Inhibitors as Potential Cancer Treatment.
Therachem Research Medilab (India)
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
Johns Hopkins University
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
Johann Wolfgang Goethe University
Diselenide Covalent Allosteric Inhibitors of Glutaminase with Strong
Zhejiang University
Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group.
China Pharmaceutical University
Design, synthesis, and pharmacological evaluation of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol analogs as novel glutaminase 1 inhibitors.
Sichuan University
Targeting glutaminase 1 (GLS1) by small molecules for anticancer therapeutics.
Sichuan University
An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds.
Universita Degli Studi Di Palermo
Synthesis of Novel Kidney-Type Glutaminase Allosteric Inhibitors Targeting the Critical Lys-320 Residue.
Zhejiang University
Novel allosteric glutaminase 1 inhibitors with macrocyclic structure activity relationship analysis.
Yonsei University College of Medicine
Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles.
China Pharmaceutical University
Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification.
University of Palermo
Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site.
China Pharmaceutical University
Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer.
China Pharmaceutical University
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.
The University of Texas Md Anderson Cancer Center
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker.
Johns Hopkins University
Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions.
China Pharmaceutical University
GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency.
University of Pittsburgh
Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity.
Zhejiang University
Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.
Astrazeneca
Design and synthesis of biotinylated Hexylselen as a probe to identify KGA allosteric inhibitors by a convenient biomolecular interaction assay.
Zhejiang University
Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors.
China Pharmaceutical University
Discovery and development of small molecule modulators targeting glutamine metabolism.
China Pharmaceutical University
Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase.
TBA
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
University of North Carolina at Chapel Hill
2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.
Sun Yat-Sen University