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Development of 4,5-dihydro-benzodiazepinone derivatives as a new chemical series of BRD4 inhibitors.

Zhejiang University

6-Oxooxazolidine-quinazolines as noncovalent inhibitors with the potential to target mutant forms of EGFR.

Zhejiang University

Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors.

Zhejiang University

Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3ß inhibitors and neuroprotective agents.

Zhejiang University

Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.

Zhejiang University

Development of Quinoline-2,4(1H,3H)-diones as Potent and Selective Ligands of the Cannabinoid Type 2 Receptor.

Zhejiang University

Design, syntheses, structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor.

Zhejiang University

Synthesis and biological evaluations of novel endomorphin analogues containinga-hydroxy-ß-phenylalanine (AHPBA) displaying mixedµ/d opioid receptor agonist andd opioid receptor antagonist activities.

Zhejiang University

Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold.

Zhejiang University

Design, synthesis, and biological evaluation of novel 2-methylpiperazine derivatives as potent CCR5 antagonists.

Zhejiang University

Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors.

Zhejiang University

Design, synthesis and biological evaluation of 6-(nitroimidazole-1H-alkyloxyl)-4-anilinoquinazolines as efficient EGFR inhibitors exerting cytotoxic effects both under normoxia and hypoxia.

Zhejiang University

A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles.

Zhejiang University

Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.

Zhejiang University

Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed fromß-amino acid as proteasome inhibitors.

Zhejiang University

Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays.

Zhejiang University

Integrating docking scores, interaction profiles and molecular descriptors to improve the accuracy of molecular docking: toward the discovery of novel Akt1 inhibitors.

Zhejiang University

Structure-based design, synthesis and biological evaluation of diphenylmethylamine derivatives as novel Akt1 inhibitors.

Zhejiang University

Design, synthesis, and biological evaluation of novel piperidine-4-carboxamide derivatives as potent CCR5 inhibitors.

Zhejiang University

Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3ß (GSK-3ß) inhibitors.

Zhejiang University

Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR.

Zhejiang University

Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors.

Zhejiang University

Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinasea (PI3Ka) inhibitors.

Zhejiang University

Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities.

Zhejiang University

Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists.

Zhejiang University

Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease.

Zhejiang University

Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors.

Zhejiang University

3D-QSAR studies on 4-hydroxyphenylpyruvate dioxygenase inhibitors by comparative molecular field analysis (CoMFA).

Zhejiang University

Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities.

Zhejiang University

Investigation of the diastereomerism of dihydrobenzoxathiin SERMs for ER alpha by molecular modeling.

Zhejiang University

Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors.

Zhejiang University

Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.

Zhejiang University

Synthesis and biological evaluation of novel 2-arylamino-3-(arylsulfonyl)quinoxalines as PI3Ka inhibitors.

Zhejiang University

Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation.

Zhejiang University

'Click' assembly of selective inhibitors for MAO-A.

Zhejiang University

Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities.

Zhejiang University

Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.

Zhejiang University

QSAR study of Akt/protein kinase B (PKB) inhibitors using support vector machine.

Zhejiang University

Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3beta (GSK-3beta) inhibitors.

Zhejiang University

Identification of pharmacophore model, synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE 1 inhibitors.

Zhejiang University

2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity.

Zhejiang University

Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors.

Zhejiang University

Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.

Zhejiang University

Complex sesquiterpenoids with tyrosinase inhibitory activity from the leaves of Chloranthus tianmushanensis.

Zhejiang University

2,3-Disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines: a novel class of antitumor agents.

Zhejiang University

Design, Synthesis, and Biological Evaluation of an Orally Bioavailable, Potent, and Selective ROCK2 Inhibitor for Psoriasis Treatment.

Zhejiang University

Design, synthesis and biological evaluation of 2-aminopyrimidine derivatives as potent FLT3 inhibitors.

Zhejiang University

Synthesis and structure-activity optimization of 7-azaindoles containing aza-β-amino acids targeting the influenza PB2 subunit.

Zhejiang University

Discovery of unglycosylated indolocarbazoles as ROCK2 isoform-selective inhibitors for the treatment of breast cancer metastasis.

Zhejiang University

Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity.

Zhejiang University

Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor.

Zhejiang University

Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1.

Zhejiang University

Insight from Linker Investigations: Discovery of a Novel Phenylbenzothiazole Necroptosis Inhibitor Targeting Receptor-Interacting Protein Kinase 1 (RIPK1) from a Phenoxybenzothiazole Compound with Dual RIPK1/3 Targeting Activity.

Zhejiang University

Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment.

Zhejiang University

Discovery of Highly Selective and Orally Bioavailable PI3Kδ Inhibitors with Anti-Inflammatory Activity for Treatment of Acute Lung Injury.

Zhejiang University

Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors.

Zhejiang University

PepScaf: Harnessing Machine Learning with In Vitro Selection toward De Novo Macrocyclic Peptides against IL-17C/IL-17RE Interaction.

Zhejiang University

Diselenide Covalent Allosteric Inhibitors of Glutaminase with Strong

Zhejiang University

Discovery of novel non-nucleoside inhibitors with high potency and selectivity for DNA methyltransferase 3A.

Zhejiang University

Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches.

Zhejiang University

Discovery of Novel 1,2,3,4-Tetrahydrobenzofuro[2,3-

Zhejiang University

Carbohydrate Strengthens the Immunotherapeutic Effect of Small-Molecule PD-L1 Inhibitors.

Zhejiang University

Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs.

Zhejiang University

Recent advances in the development of EGFR degraders: PROTACs and LYTACs.

Zhejiang University

Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities.

Zhejiang University

Current advances in Vibrio harveyi quorum sensing as drug discovery targets.

Zhejiang University

Discovery of pyrido[4,3-d]pyrimidinone derivatives as novel Wee1 inhibitors.

Zhejiang University

Discovery of 4-oxo-4,5-dihydropyrazolo[1,5-a]quinoxaline-7-carboxamide derivatives as PI3Kα inhibitors via virtual screening and docking-based structure optimization.

Zhejiang University

Synthesis and Anti-Inflammatory Activity of the Natural Cyclooxygenase-2 Inhibitor Axinelline A and Its Analogues.

Zhejiang University

If small molecules immunotherapy comes, can the prime be far behind?

Zhejiang University

Discovery and Optimization of

Zhejiang University

Therapeutic potential of targeting SHP2 in human developmental disorders and cancers.

Zhejiang University

Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology.

Zhejiang University

Recent developments of small molecules with anti-inflammatory activities for the treatment of acute lung injury.

Zhejiang University

Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation.

Zhejiang University

Synthesis of Novel Kidney-Type Glutaminase Allosteric Inhibitors Targeting the Critical Lys-320 Residue.

Zhejiang University

Design, synthesis, and evaluation of pyrido.[3,4-b]pyrazin-2(1H)-one derivatives as potent FLT3 inhibitors.

Zhejiang University

Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.

Zhejiang University

Discovery of Novel Indazoles as Potent and Selective PI3Kδ Inhibitors with High Efficacy for Treatment of Hepatocellular Carcinoma.

Zhejiang University

: A Prolific Source of Bioactive Secondary Metabolites with Therapeutic Potential.

Zhejiang University

Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma.

Zhejiang University

Discovery of small-molecule compounds and natural products against Parkinson's disease: Pathological mechanism and structural modification.

Zhejiang University

Discovery of novel non-steroidal selective glucocorticoid receptor modulators by structure- and IGN-based virtual screening, structural optimization, and biological evaluation.

Zhejiang University

Protein Lysine Methyltransferase SMYD2: A Promising Small Molecule Target for Cancer Therapy.

Zhejiang University

An overview on Estrogen receptors signaling and its ligands in breast cancer.

Zhejiang University

Design, synthesis and in vitro biological evaluation of marine phidianidine derivatives as potential anti-inflammatory agents.

Zhejiang University

Discovery of 2-(1-(3-Chloro-4-cyanophenyl)-1

Zhejiang University

Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation.

Zhejiang University

Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers.

Zhejiang University

Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT.

Zhejiang University

Discovery of

Zhejiang University

Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor.

Zhejiang University

Design, synthesis and structure-activity relationship studies of 4-indole-2-arylaminopyrimidine derivatives as anti-inflammatory agents for acute lung injury.

Zhejiang University

Development of peptide epoxyketones as selective immunoproteasome inhibitors.

Zhejiang University

Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors.

Zhejiang University

Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile.

Zhejiang University

Discovery of

Zhejiang University

Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction.

Zhejiang University

Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.

Zhejiang University

Design, synthesis and biological evaluation of 2-styryl-5-hydroxy-4-pyrone derivatives and analogues as multiple functional agents with the potential for the treatment of Alzheimer's disease.

Zhejiang University

Identification of N-phenyl-3-methoxy-4-pyridinones as orally bioavailable H

Zhejiang University

Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFR

Zhejiang University

Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3Kα inhibitors via docking-based virtual screening.

Zhejiang University

Discovery of 1,5-Dihydro-4

Zhejiang University

Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities.

Zhejiang University

Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation.

Zhejiang University

Identification, Structure-Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy.

Zhejiang University

Design, synthesis and biological evaluation of 2-methyl-(1,1'-biphenyl)-pyrimidine conjugates.

Zhejiang University

Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity.

Zhejiang University

Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors.

Zhejiang University

Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants.

Zhejiang University

Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies.

Zhejiang University

Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kδ-selective inhibitors for treating B-cell-mediated malignancies.

Zhejiang University

CN128: A New Orally Active Hydroxypyridinone Iron Chelator.

Zhejiang University

Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).

Zhejiang University

Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors.

Zhejiang University

Discovery of 3,6-diaryl-1H-pyrazolo[3,4-b]pyridines as potent anaplastic lymphoma kinase (ALK) inhibitors.

Zhejiang University

Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity.

Zhejiang University

Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease.

Zhejiang University

Design and synthesis of biotinylated Hexylselen as a probe to identify KGA allosteric inhibitors by a convenient biomolecular interaction assay.

Zhejiang University

Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors.

Zhejiang University

Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors.

Zhejiang University

Discovery of small-molecule candidates against inflammatory bowel disease.

Zhejiang University

Discovery of novel quinoline-based mTOR inhibitors via introducing intra-molecular hydrogen bonding scaffold (iMHBS): The design, synthesis and biological evaluation.

Zhejiang University

Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists.

Zhejiang University

Design and synthesis of novel 3-substituted-indole derivatives as selective H3 receptor antagonists and potent free radical scavengers.

Zhejiang University

Structure-based drug design using GPCR homology modeling: toward the discovery of novel selective CysLT2 antagonists.

Zhejiang University

Molecular cloning and pharmacological characterisation of a tyramine receptor from the rice stem borer, Chilo suppressalis (Walker).

Zhejiang University

Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1.

Zhejiang University

Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines.

Zhejiang University

3D QSAR studies on GSK-3 inhibition by aloisines.

Zhejiang University

Resveratrol-maltol hybrids as multi-target-directed agents for Alzheimer's disease.

Zhejiang University

Bioactive Indolocarbazoles from the Marine-Derived Streptomyces sp. DT-A61.

Zhejiang University

Medermycin-Type Naphthoquinones from the Marine-Derived Streptomyces sp. XMA39.

Zhejiang University

Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.

Zhejiang University

Cyclizidine-Type Alkaloids from Streptomyces sp. HNA39.

Zhejiang University

High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction.

Zhejiang University

Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies.

Zhejiang University

Development of Quinazoline/Pyrimidine-2,4(1

Zhejiang University

Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases.

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