Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50018458
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 318nMAssay Description:Inhibition of human SHP2 (205 to 593 residues) using DiFMUP as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50608347(CHEMBL5289244)
Affinity DataIC50: 400nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50546233(CHEMBL4757579)
Affinity DataIC50: 630nMAssay Description:Inhibition of human SHP2 (225 to 541 residues) using pNPP as substrate by microplate reader based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50342004(4-(2-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human SHP2 (225 to 541 residues) using pNPP as substrate by microplate reader based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50342002((2S,3aR,6S,6aR)-N-(cyclohexylmethyl)-6-(5-((R)-3-(...)
Affinity DataIC50: 2.47E+3nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50593513(CHEMBL5184184)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of SHP2 (unknown origin) using pNPP as substrate by spectrophotometer analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50608350(CHEMBL5279772)
Affinity DataIC50: 9.97E+3nMAssay Description:Inhibition of GST fused SHP2 PTP domain (unknown origin) using EFpYAEVGRSPPDPAK peptide as substrate incubated for 30 mins by malachite green stainin...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50608348(CHEMBL521390)
Affinity DataIC50: 1.39E+4nMAssay Description:Inhibition of GST fused SHP2 PTP domain (unknown origin) using Thr-Arg-Asp-Ile-Tyr[PO3H2]-Glu-Thr-Asp-Tyr-Tyr as substrate incubated for 30 mins by m...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50546211(CHEMBL4796034)
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50546213(CHEMBL4754197)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50404071(CHEMBL5268667)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human His6-tagged wild type SHP2 PTP domain using pNPP as substrate by absorbance based analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50608350(CHEMBL5279772)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SHP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetReceptor-type tyrosine-protein phosphatase O(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50608349(CHEMBL4063482)
Affinity DataKi:  123nMAssay Description:Binding affinity to GLEPP1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50608349(CHEMBL4063482)
Affinity DataKi:  652nMAssay Description:Binding affinity to SHP2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails
PubMed