PMID

Data

Article Title

Organization

Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioximeß-Catenin Pathway Inhibitors.

University of Utah

Discovery of Selective Small-Molecule Inhibitors for theß-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety.

University of Utah

Marine natural products as inhibitors of cystathionine beta-synthase activity.

University of Utah

Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity.

University of Utah

Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis.

University of Utah

Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor.

University of Utah

Hot spot-based design of small-molecule inhibitors for protein-protein interactions.

University of Utah

High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.

University of Utah

Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling.

University of Utah

Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.

University of Utah

Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.

University of Utah

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

University of Utah

Antiviral amphipathic oligo- and polyribonucleotides: analogue development and biological studies.

University of Utah

Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).

University of Utah

Rational design of enzyme inhibitors: multisubstrate analogue inhibitors.

University of Utah

A pyrimidine-based"flexible" bisubstrate analogue inhibitor of human thymidylate synthase.

University of Utah

Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria.

University of Utah

Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria.

University of Utah

Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria.

University of Utah

Oxidative inactivation of the lymphoid tyrosine phosphatase mediated by both general and active site directed NO donors.

University of Utah

Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.

University of Utah

Synthesis and applications of polyamine amino acid residues: improving the bioactivity of an analgesic neuropeptide, neurotensin.

University of Utah

Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp.

University of Utah

Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.

University of Utah

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

University of Utah

Combining pharmacophore models derived from DNA-encoded chemical libraries with structure-based exploration to predict Tankyrase 1 inhibitors.

University of Utah

Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.

University of Utah

Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.

University of Utah

Neuroactive Type-A γ-Aminobutyric Acid Receptor Allosteric Modulator Steroids from the Hypobranchial Gland of Marine Mollusk,

University of Utah

Oxidosqualene cyclase inhibitors as antimicrobial agents.

University of Utah

Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors.

University of Utah

Chemical Space of DNA-Encoded Libraries.

University of Utah

Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions.

University of Utah

Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity.

University of Utah

Naamidine A is an antagonist of the epidermal growth factor receptor and an in vivo active antitumor agent.

University of Utah

Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analogue with Enhanced Stability.

University of Utah

Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors.

University of Utah

Neuroactive diol and acyloin metabolites from cone snail-associated bacteria.

University of Utah

High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein-Protein Interactions.

University of Utah

Thiazoline peptides and a tris-phenethyl urea from Didemnum molle with anti-HIV activity.

University of Utah

Strongylophorines: natural product inhibitors of hypoxia-inducible factor-1 transcriptional pathway.

University of Utah

Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-β-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease.

University of Utah