41 articles for thisTarget
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Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents.

Soochow University
Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.

Soochow University
4-Carbonyl-2,6-dibenzylidenecyclohexanone derivatives as small molecule inhibitors of STAT3 signaling pathway.

Soochow University
Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold.

Soochow University
Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors.

Soochow University
Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors.

Soochow University
Combination of 4-anilinoquinazoline and rhodanine as novel epidermal growth factor receptor tyrosine kinase inhibitors.

Soochow University
Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization.

Soochow University
Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.

Soochow University
Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and the Extracellular Signaling Pathway.

Soochow University
Design, synthesis and molecular docking ofa,ß-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity.

Soochow University
Design and synthesis of 4,6-substituted-(diaphenylamino)quinazolines as potent EGFR inhibitors with antitumor activity.

Soochow University
Discovery of vinylogous carbamates as a novel class ofß-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.

Soochow University
Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into β-position to the carboxylic acid.

Soochow University
Investigating the interactions of flavonoids with human OATP2B1: inhibition assay, IC

Soochow University
Design, synthesis, and structure-activity relationship of novel RIPK2 inhibitors.

Soochow University
Recent advances in the discovery of protein tyrosine phosphatase SHP2 inhibitors.

Soochow University
Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y

Soochow University
Development of 6-Methanesulfonyl-8-nitrobenzothiazinone Based Antitubercular Agents.

Soochow University
Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity.

Soochow University
Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family.

Soochow University
Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents.

Soochow University
Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity.

Soochow University
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.

Soochow University
Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents.

Soochow University
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.

Soochow University
Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.

Soochow University
Structural optimization on a virtual screening hit of smoothened receptor.

Soochow University
Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists.

Soochow University
Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity.

Soochow University
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein.

Soochow University
Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout.

Soochow University
Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor.

Soochow University
Design, synthesis, and structure-activity-relationship of a novel series of CXCR4 antagonists.

Soochow University
Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays.

Soochow University